SIGNALMED+
SignalMed+ is a Paris-based medtech startup that develops EEG brain-state monitoring and prediction software for anesthesiologists during surgery, spun out of ENS Paris and AP-HP. It sells S-MED for real-time depth-of-sedation monitoring and ORA for post-operative analysis to hospitals.
- Company typePrivate
- Founded-
- HeadquartersParis, France
- Headcount1–10
- GTM typeB2B
- OfferingSoftware
SIGNALMED+ firmographics
Firmographics- Name
- SIGNALMED+
- Legal name
- SignalMed+ SAS
- Website
- https://signalmedplus.com
- Company type
- Private
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- SignalMed+ is a Paris-based medtech startup that develops EEG brain-state monitoring and prediction software for anesthesiologists during surgery, spun out of ENS Paris and AP-HP. It sells S-MED for real-time depth-of-sedation monitoring and ORA for post-operative analysis to hospitals.
- Ownership category
- akta.pro rank
SIGNALMED+ industry classification
Industry- Product category
- EEG Monitoring Software
- NAICS
- Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (33451)
- SIC
- Electromedical & Electrotherapeutic Apparatus (3845)
- akta.pro primary industry
- Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE)
- akta.pro secondary industry
- SaMD – Imaging & Signal Analysis (AI/ML) (HLACANAG)
Keywords
Where SIGNALMED+ is headquartered
LocationHeadquarters
- HQ city
- Paris
- HQ country
- France
- HQ region
- Europe
Offices1 record
Markets served
SIGNALMED+ business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Operations
Revenue model
- Software Licensing/Subscription: B2B medical device software sold to hospitals and clinical institutions. Given the SaaS nature implied by the company structure (SignalMed+ SAS) and software delivery model, revenue likely derives from software licensing or subscription contracts with healthcare facilities.
Go-to-market motion2 records
Distribution channels1 record
Marketing channels2 records
SIGNALMED+ product offering
Product offeringCore offering
SignalMed+ develops intelligent algorithms and software for EEG-based monitoring and prediction of brain states during anesthesia. Its core product S-MED provides real-time intraoperative monitoring of depth of sedation, patient sensitivity, and EEG signal history with annotations, while ORA offers post-operative data analysis and visualization of EEG recordings collected during surgery. Together the products form an integrated workflow for anesthesiologists and clinical researchers.
Product overview
SignalMed+ offers a dual-product portfolio centered on EEG monitoring for anesthesia. The core product S-MED provides real-time intraoperative brain state monitoring with five distinct modules (EEG Signal + Spectrogram, State Chart + Curve History, Sensitivity Score, Annotation Part, and IES Probability + Curve History). ORA serves as the post-operative companion product for data visualization and summary analysis. Together, S-MED and ORA form an integrated workflow enabling continuous EEG monitoring during surgery followed by comprehensive post-operative data review.
Differentiator
Problem solved
Functional benefit
Brands
- S-MED: EEG monitoring software for measuring the depth of sedation during anesthesia. Includes modules for EEG Signal + Spectrogram, State Chart + Curve History, Sensitivity Score, Annotation Part, and IES Probability + Curve History. Features real-time monitoring and prediction of brain states.
- ORA
Products and services
- S-MED Real-time EEG monitoring software that measures depth of sedation during anesthesia for anesthesiologists and clinical teams. Includes modules for EEG Signal + Spectrogram, State Chart + Curve History, Sensitivity Score, real-time Annotation, and IES Probability + Curve History. Enables intraoperative brain state monitoring and post-operative review of EEG signals via recorded annotations.
- ORA Post-operative data analysis software providing a Visualization Page and a Summary Page for clinicians and researchers to review, analyze, and summarize EEG recordings captured during surgery. Functions as the companion product to S-MED in the intraoperative-to-post-operative workflow.
Companies that use SIGNALMED+
Customer profileSegments2 records
Ideal customer profiles2 records
SIGNALMED+ technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability4 records
Feature3 records
SIGNALMED+ partnerships and signals
Strategic signalPartnerships
Seven partnerships are on record, tiered core and minor.
- AP-HP (Assistance Publique - Hôpitaux de Paris)coreAP-HP is a major hospital system in Paris. SignalMed+ is a spin-off from AP-HP and ENS Paris. The company emerged from research conducted at AP-HP Lariboisière Hospital, with co-founder Nathalie Kubis serving as head of the Clinical Physiology Department at Lariboisière Hospital.
- ENS Paris (École Normale Supérieure)coreSignalMed+ is a spin-off from ENS Paris. Scientific Director David Holcman is a research director at ENS Paris and developed the algorithms through his research group. The company connects academic research to real-time clinical applications.
- CNRS (Centre National de la Recherche Scientifique)minorNational French research center that is part of the institutional ecosystem from which SignalMed+ emerged. The company leverages research developed in collaboration with CNRS-affiliated laboratories.
- Université Paris CitéminorUniversity partner connected through co-founder Nathalie Kubis who is a professor at Université Paris Cité. SignalMed+ is a spin-off from this institution.
- INSERMminorFrench national institute for health and medical research. Co-director Nathalie Kubis leads an INSERM team 'Hemostasis, Thrombo-Inflammation and Neuro-Vascular Repair' at the Laboratory of Vascular Translational Science.
- French TechminorFrench Tech is a French government initiative supporting digital tech startups. SignalMed+ displays the French Tech logo as a recognized member of the French startup ecosystem.
- Challenge+minorInnovation support organization in the French healthcare ecosystem. Listed among SignalMed+ partners with logo displayed on the website.
Scale indicators2 records
Recent moves7 records
Expansion highlights5 records
SIGNALMED+ competitors and assessment
Company assessmentDirect peers
- GE HealthCare: GE HealthCare's Entropy module and related EEG-based depth-of-anesthesia monitoring are integrated into its Aisys and Carestation anesthesia platforms. It is a direct competitor offering EEG-derived brain-state indices for the same hospital customer.
- Medtronic: Medtronic's BIS (Bispectral Index) system is the historical market leader in EEG depth-of-anesthesia monitoring and is bundled with Medtronic anesthesia workstations. SignalMed+ competes directly for the same anesthesiology budget line.
- Masimo: Masimo's SedLine brain function monitoring is the leading EEG-based depth-of-anesthesia platform sold to anesthesiologists in hospitals. It is the most direct comparable to SignalMed+'s S-MED because both target the same procedure, the same buyer, and the same EEG-derived signal domain.
- Persyst: Persyst develops EEG analysis and review software used in clinical neurophysiology and ICU/critical care EEG monitoring. It is directly comparable as a software-only EEG signal interpretation layer that partners with EEG hardware vendors in hospital neurology and monitoring settings.
Emerging players
- Ceribell: Ceribell offers AI-enabled EEG point-of-care monitoring (primarily for seizure detection in non-ICU settings). It is comparable as an emerging EEG-software player using AI/ML on real-time EEG signals for clinical decision support, although the specific use case differs from anesthesia.
- BrainScope: BrainScope applies AI-interpreted EEG to brain injury assessment in emergency and acute care. It is comparable as an AI-EEG software company selling clinically validated decision support into acute hospital workflows, comparable in technology stack though not anesthesia-specific.
Broad incumbents
- Nihon Kohden: Nihon Kohden is a major manufacturer of clinical EEG systems, neurology monitors, and anesthesia-adjacent patient monitoring hardware used in hospitals. It is comparable as a broader incumbent whose EEG hardware and software can serve anesthesia depth monitoring use cases.
- Philips (Patient Monitoring): Philips IntelliVue and related perioperative monitoring lines include EEG-capable patient monitoring in hospital OR and ICU settings. As a broad incumbent in perioperative monitoring, it competes for the same hospital monitoring budget that SignalMed+ targets.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks6 records
Key highlights6 records
Customer concentration
SIGNALMED+ social profiles
Digital presenceSIGNALMED+ financial estimates
Financial estimateRevenue estimate
Valuation estimate
SIGNALMED+ leadership team
Management profileNumber of profiles
Profiles6 records
SIGNALMED+ funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
SIGNALMED+ M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about SIGNALMED+
What does SIGNALMED+ do?
SignalMed+ develops intelligent algorithms and software for EEG-based monitoring and prediction of brain states during anesthesia. Its core product S-MED provides real-time intraoperative monitoring of depth of sedation, patient sensitivity, and EEG signal history with annotations, while ORA offers post-operative data analysis and visualization of EEG recordings collected during surgery. Together the products form an integrated workflow for anesthesiologists and clinical researchers.
Is SIGNALMED+ a public or private company?
SIGNALMED+ is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was SIGNALMED+ founded?
SIGNALMED+ was founded in -1. It employs 1 to 10 people.
Where is SIGNALMED+ based?
SIGNALMED+ is headquartered in Paris, France, in the Europe region.
How does SIGNALMED+ make money?
One revenue line is on record: software Licensing/Subscription.
Who are SIGNALMED+'s main competitors?
Direct peers on record are GE HealthCare, Medtronic, Masimo and Persyst. Emerging players are Ceribell and BrainScope. Broad incumbents are Nihon Kohden and Philips (Patient Monitoring).
Does SIGNALMED+ have an API?
No public API is recorded for SIGNALMED+.
What industry is SIGNALMED+ in?
SIGNALMED+'s product category is EEG Monitoring Software. Its primary akta.pro industry code is HLAHACAE, Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables), with a secondary code of HLACANAG, SaMD – Imaging & Signal Analysis (AI/ML). Its NAICS code is 33451 and its SIC code is 3845.