codon one
Codon One is a Leuven-based genomics software company whose Arun platform uses AI language models to automatically reanalyze archived WES/WGS data, helping clinical genetics laboratories and hospitals diagnose rare disease patients faster.
- Company typePrivate
- Founded2023
- HeadquartersLeuven, Belgium
- Headcount—
- GTM typeB2B
- OfferingSoftware
What codon one does
Codon One, BV is a Leuven, Belgium-based genomics software company developing AI-driven tools for clinical genome interpretation. Its flagship product, Arun, launched in November 2025 and is positioned as the first software platform purpose-built for fully automated genome reanalysis of archived whole exome sequencing (WES) and whole genome sequencing (WGS) data. Arun uses advanced language models to extract phenotypes from clinical notes and build structured Human Phenotype Ontology (HPO) profiles, then continuously reinterprets variants against the latest gene-disease insights and ACMG clinical guidelines. The platform analyzes an exome in under one minute and a whole genome in under five minutes — roughly 100x faster than legacy interpretation tools — and self-evaluates case-level confidence to flag only high-probability diagnoses for human review. In a pilot at Antwerp University Hospital led by Prof. Bart Loeys, Arun ranked the causal variant in the top 3 in 99% of solved cases with an average of 4.8 prioritized variants per case and reduced manual review burden by 50%.
codon one firmographics
Firmographics- Name
- codon one
- Legal name
- Codon One, BV
- Website
- https://codon.one
- Company type
- Private
- Founded year
- 2023
- Operating status
- Operating
- Short description
- Codon One is a Leuven-based genomics software company whose Arun platform uses AI language models to automatically reanalyze archived WES/WGS data, helping clinical genetics laboratories and hospitals diagnose rare disease patients faster.
- Ownership category
- akta.pro rank
codon one industry classification
Industry- Product category
- Clinical Genomics Software
- NAICS
- Software Publishers (5132)
- SIC
- Services-Computer Programming, Data Processing, Etc. (7370)
- akta.pro primary industry
- Molecular Diagnostics (PCR/NAAT/NGS-based IVD) (HLAHAAAD)
- akta.pro secondary industry
- Electronic Data Capture (EDC) Platforms (HLACAOAA)
Keywords
Where codon one is headquartered
LocationHeadquarters
- HQ city
- Leuven
- HQ country
- Belgium
- HQ region
- Europe
Offices1 record
Markets served
codon one business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Infrastructure, Marketing or Sales, Operations
Revenue model
- Software Platform Subscription: Arun is offered as a software-as-a-service platform with free trial access. Labs sign up through the self-serve portal and likely pay subscription fees for ongoing access to automated reanalysis capabilities.
- Enterprise Licensing: Direct enterprise licensing to clinical genetics centers and hospitals for clinical diagnostics use, evidenced by pilot study partnerships with academic medical centers.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Freemium | Monthly | Free trial access |
Go-to-market motion2 records
Distribution channels2 records
Marketing channels4 records
codon one product offering
Product offeringCore offering
Codon One develops Arun, a software platform that performs fully automated reanalysis of archived whole exome and whole genome sequencing data for clinical genetics labs. The platform extracts phenotypes from clinical notes using language models, prioritizes likely causal variants, and reinterprets cases continuously as new gene-disease knowledge emerges, enabling hospital labs to deliver rare disease diagnoses without manual intervention.
Product overview
Codon One offers a unified product portfolio centered on genomic analysis software for rare disease diagnostics. The primary product is Arun, the world's first fully automated genome reanalysis platform that reinterprets archived WES/WGS data using the latest clinical insights. The company also built and later sold Moon, the pioneering AI-driven rare disease diagnostic software, through its predecessor company Diploid. Arun represents the next generation of this technology, engineered specifically for the genomic era where WGS is routine.
Differentiator
Problem solved
Functional benefit
Brands
- Arun: The world's first software platform built specifically for fully automated genome reanalysis. Arun continuously re-examines archived genomic data using the latest gene-disease insights, updated variant classifications, and evolving phenotypic information. Capable of analyzing an exome in under one minute and a whole genome in under five minutes.
Products and services
- Arun Arun is a SaaS platform that performs fully automated reanalysis of archived WES/WGS data for clinical genetics centers and hospital diagnostic labs. It automatically extracts phenotypes from clinical notes, builds structured HPO profiles, reinterprets variants, and prioritizes likely causal diagnoses, with an exome analyzed in under one minute and a whole genome in under five minutes.
Quantifiable outcome
- 99% of solved cases with causal variant in top 3 prioritized variants
- +4 more outcomes
Companies that use codon one
Customer profileNamed customers1 record
Segments2 records
Ideal customer profiles2 records
codon one technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability6 records
Feature5 records
codon one partnerships and signals
Strategic signalPartnerships
One partnership is on record.
- Antwerp University Hospital / Centre of Medical GeneticscoreAntwerp University Hospital served as the primary pilot study partner for validating Arun's automated genome reanalysis capabilities. Prof. Bart Loeys from the Centre of Medical Genetics led the validation, demonstrating 99% accuracy with causal variants in top 3. This partnership provided clinical validation critical for product development and market positioning.
Scale indicators6 records
Recent moves5 records
Expansion highlights5 records
codon one competitors and assessment
Company assessmentMarket position
Weaknesses4 records
Competitive moat4 records
Customer concentration
codon one social profiles
Digital presencecodon one financial estimates
Financial estimateRevenue estimate
Valuation estimate
codon one leadership team
Management profileNumber of profiles
Profiles1 record
codon one funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
codon one M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about codon one
What does codon one do?
Codon One develops Arun, a software platform that performs fully automated reanalysis of archived whole exome and whole genome sequencing data for clinical genetics labs. The platform extracts phenotypes from clinical notes using language models, prioritizes likely causal variants, and reinterprets cases continuously as new gene-disease knowledge emerges, enabling hospital labs to deliver rare disease diagnoses without manual intervention.
Is codon one a public or private company?
codon one is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was codon one founded?
codon one was founded in 2023.
Where is codon one based?
codon one is headquartered in Leuven, Belgium, in the Europe region.
How does codon one make money?
Two revenue lines are on record. Software Platform Subscription is the primary driver. The others are enterprise Licensing.
Does codon one have an API?
No public API is recorded for codon one.
What industry is codon one in?
codon one's product category is Clinical Genomics Software. Its primary akta.pro industry code is HLAHAAAD, Molecular Diagnostics (PCR/NAAT/NGS-based IVD), with a secondary code of HLACAOAA, Electronic Data Capture (EDC) Platforms. Its NAICS code is 5132 and its SIC code is 7370.