.406 Ventures
- Company typePrivate
- Founded2005
- HeadquartersBoston, United States
- Headcount11–50
- GTM typeB2B
- OfferingServices
.406 Ventures firmographics
Firmographics- Name
- .406 Ventures
- Legal name
- 406 Ventures Management, L.P.
- Website
- https://406ventures.com
- Company type
- Private
- Founded year
- 2005
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Ownership category
- akta.pro rank
.406 Ventures industry classification
Industry- Product category
- Venture Capital
- NAICS
- Portfolio Management and Investment Advice (52394)
- SIC
- Investment Advice (6282)
- akta.pro primary industry
- Early-Stage Venture Capital (Series A/B) (FSANAAAB)
- akta.pro secondary industry
- Sector-Focused Venture Capital (Vertical Specialists) (FSANAAAD)
Keywords
Where .406 Ventures is headquartered
LocationHeadquarters
- HQ city
- Boston
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
.406 Ventures business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Marketing or Sales, Others
Revenue model
- Management Fees: Venture capital firms typically charge management fees (typically 2% of assets under management) to cover operational expenses. .406 Ventures manages $1.3B+ in capital.
- Carried Interest: Performance-based carried interest from successful portfolio company exits. Notable exits include AbleTo (acquired by Optum for $470M), Corvus (acquired by Travelers), Iora Health (acquired by One Medical/Amazon), and Health Dialog (acquired by Bupa). These exits demonstrate successful realization of carried interest.
Go-to-market motion1 record
Distribution channels1 record
Marketing channels6 records
.406 Ventures product offering
Product offeringCore offering
.406 Ventures is a venture capital firm that provides seed and Series A equity capital to early-stage technology companies, primarily in healthcare, data + AI, and cybersecurity sectors. Beyond capital, the firm supplies founders with strategic guidance, talent and customer introductions through its Executive Councils, and operational support via its Executives in Residence and Student Fellows programs. The firm manages over $1.3B in capital across 94 portfolio companies.
Product overview
.406 Ventures is an early-stage venture capital firm that operates as a single investment fund/product. The firm provides venture capital investment services alongside complementary programs including the Student Fellows Program for aspiring entrepreneurs, the Executives in Residence (EIR) Program for senior executives, and Executive Councils spanning Healthcare, Data + AI, and Cybersecurity sectors. The firm's primary offering is its VC fund managing $1.3B+ capital across 94 portfolio companies focused on healthcare, data + AI, and cybersecurity.
Differentiator
Problem solved
Functional benefit
Products and services
- .406 Ventures VC Fund Venture capital fund investing seed and Series A equity capital into early-stage technology companies in healthcare, data + AI, and cybersecurity. The firm manages over $1.3B in capital across 94 portfolio companies and provides practical resources beyond capital including strategic guidance, network access, and operational support.
Companies that use .406 Ventures
Customer profileNamed customers13 records
Segments4 records
Ideal customer profiles3 records
.406 Ventures technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
.406 Ventures partnerships and signals
Strategic signalPartnerships
Three partnerships are on record, tiered core.
- Healthcare Executive Council Memberscore50+ executives from leading healthcare organizations including Amazon Web Services, Ascension, BCBS North Carolina, Boston Children's Hospital, Cigna Evernorth, Cleveland Clinic, and others who provide insights and connections for portfolio companies.
- Data + AI Executive Council Memberscore75+ executives from data and AI-focused companies including American Express, AWS, Blue Health Intelligence, Fidelity, IBM, JP Morgan, Netflix, Salesforce, and others who provide market intelligence and potential customer connections.
- Cybersecurity Executive Council Memberscore100+ cybersecurity leaders from organizations including JPMC, Wells Fargo, Target, GE, Johnson & Johnson, Oracle, and others who provide expertise and potential customer access for cybersecurity portfolio companies.
Scale indicators8 records
Recent moves6 records
Expansion highlights5 records
.406 Ventures competitors and assessment
Company assessmentDirect peers
- Flare Capital Partners: Boston-based early-stage venture firm exclusively focused on healthcare technology and services. Closest direct peer because of overlapping healthcare thesis, similar early-stage check sizes, and shared Boston/Northeast ecosystem that competes for the same founders.
- Define Ventures: Early-stage venture firm dedicated to digital health companies, co-led by Lynne Chou O'Keefe and backed by strategic LPs. Directly comparable in healthcare-only thesis, seed/Series A focus, and portfolio-level category-defining bar.
- LRVHealth: Boston-headquartered early-stage venture firm investing exclusively in healthcare. Co-investor with .406 in Diana Health and operates in the same New England healthcare innovation corridor, creating direct overlap on deals.
- Cyberstarts: Early-stage venture firm exclusively focused on cybersecurity with concentrated thesis in offensive and defensive security software. Direct peer in the cybersecurity vertical of .406's three-pillar model.
- New Markets Venture Partners: Early-stage venture firm focused on healthcare innovation in underserved markets. Co-investor with .406 in FamilyWell Health's Series A; comparable on healthcare-only vertical and similar seed/Series A posture.
Broad incumbents
- Norwest Venture Partners: Large multi-stage venture firm with a dedicated healthcare practice. Lead investor in Diana Health alongside .406; broadly comparable on healthcare investing but competes from a much larger AUM base and writes later/follow-on checks .406 cannot.
- Bessemer Venture Partners: Multi-stage venture firm with deep healthcare, data, and cybersecurity exposure and similar long-dated early-stage posture. Broader incumbent that overlaps on theses and exits but competes from significantly larger AUM and global footprint.
- Andreessen Horowitz (a16z): Multi-stage venture firm with dedicated bio/health, infrastructure, and security funds that mirror .406's three pillars. Much larger AUM and broader platform; competes for the same category-defining breakout rounds but typically at growth-stage check sizes.
- Bain Capital Ventures: Multi-stage venture arm of Bain Capital with fintech, application software, and infra practices. Overlaps with .406 on the data/AI and enterprise security theses at larger check sizes and from a broader LP base.
Emerging players
- M12 (Microsoft's Venture Fund): Corporate venture fund backed by Microsoft investing in enterprise software, AI infrastructure, and cybersecurity. Comparable through its AI/data and cybersecurity focus, but offers portfolio companies hyperscaler distribution that .406 cannot match on its own.
Market position
Strengths5 records
Weaknesses4 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
.406 Ventures social profiles
Digital presence.406 Ventures financial estimates
Financial estimateRevenue estimate
Valuation estimate
.406 Ventures leadership team
Management profileNumber of profiles
Profiles15 records
.406 Ventures funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
.406 Ventures M&A and investment
M&A and investmentM&A
Investments220 records
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about .406 Ventures
What does .406 Ventures do?
.406 Ventures is a venture capital firm that provides seed and Series A equity capital to early-stage technology companies, primarily in healthcare, data + AI, and cybersecurity sectors. Beyond capital, the firm supplies founders with strategic guidance, talent and customer introductions through its Executive Councils, and operational support via its Executives in Residence and Student Fellows programs. The firm manages over $1.3B in capital across 94 portfolio companies.
Is .406 Ventures a public or private company?
.406 Ventures is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was .406 Ventures founded?
.406 Ventures was founded in 2005. It employs 11 to 50 people.
Where is .406 Ventures based?
.406 Ventures is headquartered in Boston, United States, in the North America region.
How does .406 Ventures make money?
Two revenue lines are on record. Management Fees are the primary driver. The others are carried Interest.
Who are .406 Ventures's main competitors?
Direct peers on record are Flare Capital Partners, Define Ventures, LRVHealth, Cyberstarts and New Markets Venture Partners. Broad incumbents are Norwest Venture Partners, Bessemer Venture Partners, Andreessen Horowitz (a16z) and Bain Capital Ventures. M12 (Microsoft's Venture Fund) is listed as an emerging player.
Does .406 Ventures have an API?
No public API is recorded for .406 Ventures.
What industry is .406 Ventures in?
.406 Ventures's product category is Venture Capital. Its primary akta.pro industry code is FSANAAAB, Early-Stage Venture Capital (Series A/B), with a secondary code of FSANAAAD, Sector-Focused Venture Capital (Vertical Specialists). Its NAICS code is 52394 and its SIC code is 6282.