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Loyal

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uuid00004nc

Namestring
Loyal
Legal namestring
Loyal Animal Health, Inc.
Company typeenum
Private
Founded yearint
2019
Descriptiontext

Loyal (legal entity: Loyal Animal Health, Inc.) is a clinical-stage veterinary biopharmaceutical company founded in 2019 and headquartered in San Francisco. Its mission is to develop longevity drugs that extend the healthy lifespan of senior dogs, with lead program LOY-002 — a once-daily, beef-flavored prescription pill targeting metabolic dysfunction via IGF-1 hormone reduction, a mechanism designed to mimic the effects of caloric restriction on age-related decline. The drug candidate is intended for dogs aged 10+ and weighing at least 14 lb, and three drug programs are in development across the portfolio. LOY-002 has completed two of the three major FDA technical sections (Reasonable Expectation of Effectiveness and Target Animal Safety) required for Expanded Conditional Approval, with the manufacturing/CMC section still in progress.

The company's clinical evidence base is anchored by the STAY trial — described as the largest clinical trial in veterinary medicine history — with 1,317 dogs enrolled across approximately 70 veterinary clinics. Loyal plans to commercialize LOY-002 through a direct-to-consumer prescription model comparable to Hims & Hers and Ro, complemented by its existing veterinary clinic network for prescription fulfillment and patient monitoring. Pricing has not been disclosed, and the company is pre-revenue pending regulatory clearance. Loyal has raised more than $250 million in total private capital across rounds from 2020 through 2026, most recently a $100 million Series C in February 2026 led by age1 with participation from Baillie Gifford and The Longevity Fund. Customer-facing channels beyond drug distribution include the Loyal Learning Hub, a RACE-approved continuing-education platform for veterinarians, plus content marketing and earned media in major national outlets.

Short descriptiontext

Loyal is a clinical-stage veterinary biopharmaceutical company developing longevity drugs for senior dogs, with lead candidate LOY-002 targeting metabolic dysfunction via a once-daily prescription pill, pursuing FDA Expanded Conditional Approval and a DTC go-to-market model.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
51–100
akta.pro rankint
HeadquartersSan Francisco, United States
HQ citystring
San Francisco
HQ countrystring
United States
HQ regionstring
North America
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
veterinary pharmaceuticals, canine longevity drugs, animal health therapeutics, pet prescription medication, veterinary continuing education
Industry1 code
1Companion Animal Therapeutic Diets (Prescription Diets)
CodeHLAMAHAAPrimaryYes
NAICS code1 code
  • Veterinary Services54194
SIC code1 code
  • Pharmaceutical Preparations2834
Product category
Veterinary Pharmaceuticals
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model1 record
1Prescription Drug Sales
TypeSubscription Recurring
Description

Loyal plans to generate revenue through sales of its longevity drug LOY-002 as a prescription medication for senior dogs. The company intends to commercialize independently through a direct-to-consumer model similar to Hims & Hers and Ro.

finsmes.com
Marketing channels5 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels2 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Technology or R&D, Personnel, Marketing or Sales, Operations, Supply Chain
GTM typeB2C
B2C
Offering typeServices
Services
Core offering1 text field

Loyal is developing a portfolio of prescription longevity drugs for senior dogs, with LOY-002 as its lead program. LOY-002 is a once-daily beef-flavored prescription pill designed for dogs age 10 and older (14+ lb) that targets metabolic dysfunction to extend healthy lifespan. The company also offers the Loyal Learning Hub, a free library of RACE-approved continuing education courses for veterinary teams on canine aging.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 3 values shown
  • 1,317 dogs enrolled in pivotal STAY clinical trial across approximately 70 veterinary clinics
+2 more records
Product overview1 text field

Loyal is developing a portfolio of longevity drugs for dogs, with LOY-002 as the lead program. LOY-002 is a once-daily prescription pill targeting metabolic dysfunction in senior dogs (age 10+). The company also offers the Loyal Learning Hub, a veterinary education platform with RACE-approved CE courses on canine aging. Loyal has 3 drug programs in development and is pursuing FDA Expanded Conditional Approval for LOY-002.

Product and service1 record
1LOY-002
Scale indicator7 records

Each record includes

Type, Value, Description, Source

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight6 records

Each record includes

Type, Description

Peers10 records
TypeBroad incumbent
Description

The world's largest pure-play animal health company, offering veterinary pharmaceuticals, vaccines, diagnostics, and parasiticides across companion and livestock animals. Zoetis is comparable as a broad incumbent that could enter or acquire into the canine longevity drug category once Loyal validates the market.

TypeBroad incumbent
Description

Major global animal health company with a broad portfolio of companion animal therapeutics. Elanco is comparable as a broad incumbent competitor and potential fast-follower in canine healthspan / longevity pharmaceuticals.

TypeBroad incumbent
Description

Leading veterinary diagnostics and reference-lab company expanding into software and practice management. IDEXX is comparable as a deep veterinary-channel incumbent that controls significant touchpoints with U.S. companion animal practices.

TypeDirect peer
Description

Public telehealth and direct-to-consumer prescription drug company cited by Loyal as the model for its LOY-002 distribution. Comparable on go-to-market mechanics (DTC prescription acquisition and fulfillment), not on therapeutic area.

5Ro
TypeDirect peer
Description

Direct-to-consumer telehealth and prescription pharmacy company that has built its own vertically integrated compounding and fulfillment capabilities. Comparable to Loyal's stated DTC commercialization blueprint for LOY-002.

TypeBroad incumbent
Description

Global veterinary pharmaceutical company with a large companion animal portfolio including behavioral and therapeutic products. Comparable as a broad incumbent with the R&D and distribution reach to compete in canine therapeutics.

TypeBroad incumbent
Description

Independent global animal health company specializing in veterinary pharmaceuticals across companion and production animals. Comparable as a mid-sized incumbent with active companion animal therapeutic franchises.

TypeBroad incumbent
Description

Diversified animal health and nutrition company with companion animal and livestock pharmaceutical lines. Comparable as a broad incumbent operating in the veterinary therapeutics market.

TypeEmerging player
Description

Membership-based veterinary clinic chain with a digitally enabled, consumer-grade experience. Comparable as an emerging player shaping how pet owners access prescription veterinary care, a channel Loyal plans to leverage.

TypeEmerging player
Description

Large longitudinal research initiative studying aging in companion dogs, including the rapamycin-based TRIAD trial. Comparable as the leading academic longevity-in-dogs effort and a potential scientific collaborator or competitor for evidence generation.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat4 records

Each record includes

Type, Details

Key risks7 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Segment2 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile2 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature3 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles4 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds9 records

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors22 records

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Loyal

Veterinary Pharmaceuticalsloyalfordogs.com

Loyal is a clinical-stage veterinary biopharmaceutical company developing longevity drugs for senior dogs, with lead candidate LOY-002 targeting metabolic dysfunction via a once-daily prescription pill, pursuing FDA Expanded Conditional Approval and a DTC go-to-market model.

What Loyal does

Loyal (legal entity: Loyal Animal Health, Inc.) is a clinical-stage veterinary biopharmaceutical company founded in 2019 and headquartered in San Francisco. Its mission is to develop longevity drugs that extend the healthy lifespan of senior dogs, with lead program LOY-002 — a once-daily, beef-flavored prescription pill targeting metabolic dysfunction via IGF-1 hormone reduction, a mechanism designed to mimic the effects of caloric restriction on age-related decline. The drug candidate is intended for dogs aged 10+ and weighing at least 14 lb, and three drug programs are in development across the portfolio. LOY-002 has completed two of the three major FDA technical sections (Reasonable Expectation of Effectiveness and Target Animal Safety) required for Expanded Conditional Approval, with the manufacturing/CMC section still in progress.

The company's clinical evidence base is anchored by the STAY trial — described as the largest clinical trial in veterinary medicine history — with 1,317 dogs enrolled across approximately 70 veterinary clinics. Loyal plans to commercialize LOY-002 through a direct-to-consumer prescription model comparable to Hims & Hers and Ro, complemented by its existing veterinary clinic network for prescription fulfillment and patient monitoring. Pricing has not been disclosed, and the company is pre-revenue pending regulatory clearance. Loyal has raised more than $250 million in total private capital across rounds from 2020 through 2026, most recently a $100 million Series C in February 2026 led by age1 with participation from Baillie Gifford and The Longevity Fund. Customer-facing channels beyond drug distribution include the Loyal Learning Hub, a RACE-approved continuing-education platform for veterinarians, plus content marketing and earned media in major national outlets.

Loyal firmographics

Firmographics
Name
Loyal
Legal name
Loyal Animal Health, Inc.
Website
https://loyalfordogs.com
Company type
Private
Founded year
2019
Operating status
Operating
Headcount range
51–100 employees
Short description
Loyal is a clinical-stage veterinary biopharmaceutical company developing longevity drugs for senior dogs, with lead candidate LOY-002 targeting metabolic dysfunction via a once-daily prescription pill, pursuing FDA Expanded Conditional Approval and a DTC go-to-market model.
Ownership category
akta.pro rank

Loyal industry classification

Industry
Product category
Veterinary Pharmaceuticals
NAICS
Veterinary Services (54194)
SIC
Pharmaceutical Preparations (2834)
akta.pro primary industry
Companion Animal Therapeutic Diets (Prescription Diets) (HLAMAHAA)

Keywords

  • Veterinary pharmaceuticals
  • Canine longevity drugs
  • Animal health therapeutics
  • Pet prescription medication
  • Veterinary continuing education

Where Loyal is headquartered

Location

Headquarters

HQ city
San Francisco
HQ country
United States
HQ region
North America

Offices1 record

Markets served

Loyal business model

Business model
GTM type
B2C
Offering type
Services
Cost components
Technology or R&D, Personnel, Marketing or Sales, Operations, Supply Chain

Revenue model

  1. Prescription Drug Sales: Loyal plans to generate revenue through sales of its longevity drug LOY-002 as a prescription medication for senior dogs. The company intends to commercialize independently through a direct-to-consumer model similar to Hims & Hers and Ro.

Go-to-market motion1 record

Distribution channels2 records

Marketing channels5 records

Loyal product offering

Product offering

Core offering

Loyal is developing a portfolio of prescription longevity drugs for senior dogs, with LOY-002 as its lead program. LOY-002 is a once-daily beef-flavored prescription pill designed for dogs age 10 and older (14+ lb) that targets metabolic dysfunction to extend healthy lifespan. The company also offers the Loyal Learning Hub, a free library of RACE-approved continuing education courses for veterinary teams on canine aging.

Product overview

Loyal is developing a portfolio of longevity drugs for dogs, with LOY-002 as the lead program. LOY-002 is a once-daily prescription pill targeting metabolic dysfunction in senior dogs (age 10+). The company also offers the Loyal Learning Hub, a veterinary education platform with RACE-approved CE courses on canine aging. Loyal has 3 drug programs in development and is pursuing FDA Expanded Conditional Approval for LOY-002.

Differentiator

Problem solved

Functional benefit

Products and services

  • LOY-002

Quantifiable outcome

  • 1,317 dogs enrolled in pivotal STAY clinical trial across approximately 70 veterinary clinics
  • +2 more outcomes

Companies that use Loyal

Customer profile

Segments2 records

Ideal customer profiles2 records

Loyal technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature3 records

Loyal partnerships and signals

Strategic signal

Scale indicators7 records

Recent moves6 records

Expansion highlights6 records

Loyal competitors and assessment

Company assessment

Broad incumbents

  • Zoetis: The world's largest pure-play animal health company, offering veterinary pharmaceuticals, vaccines, diagnostics, and parasiticides across companion and livestock animals. Zoetis is comparable as a broad incumbent that could enter or acquire into the canine longevity drug category once Loyal validates the market.
  • Elanco Animal Health: Major global animal health company with a broad portfolio of companion animal therapeutics. Elanco is comparable as a broad incumbent competitor and potential fast-follower in canine healthspan / longevity pharmaceuticals.
  • IDEXX Laboratories: Leading veterinary diagnostics and reference-lab company expanding into software and practice management. IDEXX is comparable as a deep veterinary-channel incumbent that controls significant touchpoints with U.S. companion animal practices.
  • Ceva Santé Animale: Global veterinary pharmaceutical company with a large companion animal portfolio including behavioral and therapeutic products. Comparable as a broad incumbent with the R&D and distribution reach to compete in canine therapeutics.
  • Virbac: Independent global animal health company specializing in veterinary pharmaceuticals across companion and production animals. Comparable as a mid-sized incumbent with active companion animal therapeutic franchises.
  • Phibro Animal Health: Diversified animal health and nutrition company with companion animal and livestock pharmaceutical lines. Comparable as a broad incumbent operating in the veterinary therapeutics market.

Direct peers

  • Hims & Hers Health: Public telehealth and direct-to-consumer prescription drug company cited by Loyal as the model for its LOY-002 distribution. Comparable on go-to-market mechanics (DTC prescription acquisition and fulfillment), not on therapeutic area.
  • Ro: Direct-to-consumer telehealth and prescription pharmacy company that has built its own vertically integrated compounding and fulfillment capabilities. Comparable to Loyal's stated DTC commercialization blueprint for LOY-002.

Emerging players

  • Modern Animal: Membership-based veterinary clinic chain with a digitally enabled, consumer-grade experience. Comparable as an emerging player shaping how pet owners access prescription veterinary care, a channel Loyal plans to leverage.
  • Dog Aging Project: Large longitudinal research initiative studying aging in companion dogs, including the rapamycin-based TRIAD trial. Comparable as the leading academic longevity-in-dogs effort and a potential scientific collaborator or competitor for evidence generation.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks7 records

Key highlights7 records

Customer concentration

Loyal social profiles

Digital presence

Loyal financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Loyal leadership team

Management profile

Number of profiles

Profiles4 records

Loyal funding detail

Funding detail

Funding overview

Funding rounds9 records

Investors22 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Loyal M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Loyal

What does Loyal do?

Loyal is developing a portfolio of prescription longevity drugs for senior dogs, with LOY-002 as its lead program. LOY-002 is a once-daily beef-flavored prescription pill designed for dogs age 10 and older (14+ lb) that targets metabolic dysfunction to extend healthy lifespan. The company also offers the Loyal Learning Hub, a free library of RACE-approved continuing education courses for veterinary teams on canine aging.

Is Loyal a public or private company?

Loyal is a private company. It is classified as venture growth investor backed and is currently operating.

When was Loyal founded?

Loyal was founded in 2019. It employs 51 to 100 people.

Where is Loyal based?

Loyal is headquartered in San Francisco, United States, in the North America region.

How does Loyal make money?

One revenue line is on record: prescription Drug Sales.

Who are Loyal's main competitors?

Broad incumbents on record are Zoetis, Elanco Animal Health, IDEXX Laboratories, Ceva Santé Animale, Virbac and Phibro Animal Health. Direct peers are Hims & Hers Health and Ro. Emerging players are Modern Animal and Dog Aging Project.

Does Loyal have an API?

No public API is recorded for Loyal.

What industry is Loyal in?

Loyal's product category is Veterinary Pharmaceuticals. Its primary akta.pro industry code is HLAMAHAA, Companion Animal Therapeutic Diets (Prescription Diets). Its NAICS code is 54194 and its SIC code is 2834.

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Live signals
Longevity.TechnologyLoyal’s big-dog lifespan drug clears third FDA hurdleThe FDA accepted RXE for LOY-003, Loyal's daily tablet for large and giant-breed dogs, marking the third such milestone for the company's lifespan drug program. The drug targets growth hormone and IGF-1 pathways, which Loyal says accelerate aging in big dogs. No launch date or efficacy data was disclosed.Longevity.TechnologyLoyal advances daily pill designed to extend large dogs’ lifespansLoyal reported that LOY-003 completed the Reasonable Expectation of Effectiveness section of its Expanded Conditional Approval application with the FDA for a daily pill to extend healthy lifespans in large and giant breed dogs. The company says this is a first for any pharmaceutical company, and LOY-002 has also met efficacy requirements. Loyal has raised over $250 million to date.PetageLoyal Earns Third Efficacy Acceptance from the FDA for Canine Lifespan ExtensionLoyal announced that LOY-003, a pill for large dogs, completed the RXE section of its Expanded Conditional Approval application. The company's three lifespan extension drugs now satisfy the efficacy requirement for XCA, a first for any pharma company. LOY-002 is in its pivotal field study, with approval on track to be the first lifespan extension drug in any species.MintAfter humans, Bryan Johnson now wants dogs to live forever because they're ‘amazing’Biohacker Bryan Johnson told Business Insider he plans to apply his longevity protocols to his Belgian Malinois, Katara, after adopting her a month ago, calling her "the most measured dog in the world." He said veterinary drug approval is faster than for humans and that dog owners invest more in pets than themselves. Startups Loyal and Rejuvenate Bio are already pursuing lifespan-extension drugs and gene therapy for dogs.Business InsiderBryan Johnson tackled human longevity. Now he wants dogs to live forever.Tech entrepreneur Bryan Johnson, known for his "Don't die" longevity mission, said he will subject his Belgian Malinois guard dog Katara to the same rigorous data collection and longevity interventions he tracks for his followers. Johnson declined to launch a canine health company, citing faster drug approval paths for dogs, and noted several startups including Loyal and Rejuvenate Bio are already developing lifespan-extension drugs.KoreajoongangdailyHuman drug breakthroughs find new life in pet medicineKorean and overseas biotech firms are developing pet treatments for obesity, arthritis, dementia, and aging, as demand rises with longer-lived companion animals. The global pet pharmaceuticals market is projected to grow from $21.38 billion this year to $38.87 billion by 2034. Obesity treatment is a fast-growing area, with GLP-1-based therapies in development.New Market PitchHow's the longevity market doing these days?The longevity market remains active but is shifting toward evidence-based investments, with capital concentrating in fewer, larger rounds tied to clinical development, scaled diagnostics, or measurable healthspan infrastructure rather than broad anti-aging branding. Recent milestones include NewLimit's $435 million Series C for epigenetic reprogramming, Life Biosciences dosing its first human patient with ER-100 for optic neuropathies, and Loyal advancing its dog-longevity drug LOY-002 through FDA review, while GLP-1s are establishing the strongest near-term bridge between mainstream medicine and longevity interventions.Contrary ResearchThe Anti-Aging Therapeutics BoomIn January 2026, the FDA cleared ER-100, the first Yamanaka-factor partial reprogramming therapy for human testing, targeting optic nerve conditions including glaucoma and NAION in a five-year Phase 1 trial—a landmark event for anti-aging therapeutics. The article reviews the history of anti-aging approaches including telomerase, sirtuins, rapamycin, and senolytics, all of which showed strong preclinical results but failed in human clinical trials, illustrating the scientific and regulatory challenges facing the field. The piece also surveys the current anti-aging company landscape including Altos Labs, NewLimit, YouthBio Therapeutics, Retro Biosciences, and Loyal, alongside the broader funding environment, which raised $3.7 billion in Q1 2026 despite ongoing clinical failures.Castle PlacementTop 10 Pet Tech/Pet Care Capital Raises and Investors in the U.S.This quarterly market intelligence report covers pet tech and pet care capital raises and acquisitions in the U.S. from January 1 to March 31, 2026, listing multiple LBOs, venture rounds, and seed-stage deals in the sector. Notable transactions include Loyal's $100 million Series C funding led by Age 1, Snout's $10 million Series A led by Footwork, and three LBO acquisitions involving I and love and you, A Place for Rover, and Journey Legacy Partners. The report, published by investment bank Castle Placement, aggregates deal flow data from sources including Bloomberg, Crunchbase, and PitchBook.The AtlanticYour Next Dog May Live LongerLoyal, a canine longevity biotech founded in 2019, received a positive FDA assessment in February 2025 for its insulin-sensitivity drug designed to extend dogs' lives, with conditional approval pending a manufacturing requirement. The company has launched the largest-ever clinical trial for an animal drug, enrolling over 1,300 dogs in a five-year study, and aims to launch commercially next year at approximately $100 per month. The FDA's willingness to evaluate a drug specifically for life extension rather than a targeted disease marks a notable regulatory shift, with the company ultimately seeking to apply learnings from canine trials to human longevity medicine.