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First Spark Ventures

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uuid0000csm

Namestring
First Spark Ventures
Legal namestring
First Spark Ventures
Company typeenum
Private
Founded yearint
2021
Descriptiontext

First Spark Ventures is a deep-tech venture capital firm founded in 2021 and headquartered in Silicon Valley (Menlo Park). The firm invests in early-stage startups developing breakthrough technologies across three verticals: Advanced Compute (including AI infrastructure, generative AI, and edge inference), Digital Biology & Biotech (computational biology, therapeutics, personalized medicine), and CyberPhysical Systems (physical systems with software-like scaling potential). It deploys capital at Pre-seed, Seed, and Series A, with a separate First Spark Opportunities vehicle led by General Partner Danny Chen that participates in later-stage and follow-on rounds. The portfolio spans 22+ companies including Radical Numerics, Unnatural Products, Vitara Biomedical, Xona Space Systems, Inworld AI, Latent AI, Curve Biosciences, and Tidal Metals.

The firm's core differentiation is its relationship with SRI International (formerly Stanford Research Institute), one of the most prolific US deep-tech research institutes. Founding Managing Partner Manish Kothari is the former President of SRI, and several team members (Jennifer Wu, formerly Associate Director on SRI's Ventures team) are SRI alumni, creating a proprietary deal-flow channel from laboratory to commercial formation. Eric Schmidt (former Google CEO/Chairman) serves as Strategic Advisor & Founding Non-Managing Partner, anchoring brand credibility and connecting First Spark to Schmidt Sciences and Schmidt Futures networks.

Economically, First Spark operates as a traditional venture capital fund: it charges management fees on committed capital and earns carried interest (typically ~20%) on investment profits above a hurdle rate. Distribution is direct — equity investments via term sheets, typically with board participation — to early-stage deep-tech founders globally. The firm does not publicly disclose fund size, AUM, LP composition, or revenue, and its ~8–10 investment professionals are distributed across Investing (Founding Managing Partner, three Founding General Partners, one Partner), First Spark Opportunities, and Principal/operating roles.

Short descriptiontext

First Spark Ventures is a Silicon Valley deep-tech venture capital firm founded in 2021 that invests Pre-seed through Series A in startups across Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems, with a proprietary deal-flow pipeline via SRI International.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
11–50
akta.pro rankint
HeadquartersMenlo Park, United States
HQ citystring
Menlo Park
HQ countrystring
United States
HQ regionstring
North America
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
deep tech venture capital, early stage investing, seed stage funding, venture capital fund, deep tech startups
Industry1 code
PRIMARYFSANAAAB
Early-Stage Venture Capital (Series A/B)
NAICS code4 codes
  • Portfolio Management and Investment Advice523940
  • Portfolio Management and Investment Advice52394
  • All Other Financial Investment Activities52399
  • Funds, Trusts, and Other Financial Vehicles525
SIC code1 code
  • Investment Advice6282
Product category
Venture Capital
Social media profiles1 record
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model1 record
1Management Fees and Carried Interest
TypeManaged Services
Description

First Spark Ventures generates returns through traditional venture capital economics: management fees on committed capital during the fund lifecycle and carried interest (typically 20%) on investment profits above the hurdle rate, distributed to General Partners after Limited Partners receive their initial investment back.

firstsparkventures.com
Marketing channels5 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels1 record

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Personnel, Operations, Marketing or Sales, Technology or R&D, Others
GTM typeB2B
B2B
Offering typeServices
Services
Core offering1 text field

First Spark Ventures is a deep tech venture capital fund that invests in breakthrough technology startups at Pre-seed, Seed, and Series A stages. The fund focuses on three verticals—Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems—and provides portfolio companies with capital plus operational support through an interdisciplinary team of investment professionals, leveraging a strategic partnership with SRI International.

Differentiator
Functional benefit
Problem solved
Product overview1 text field

First Spark Ventures is a Deep Tech venture capital fund that invests in breakthrough technologies. The firm focuses on three primary investment areas: Advanced Compute (including AI infrastructure, generative AI, and computing platforms), Digital Biology & Biotech (encompassing computational biology, therapeutics, and personalized medicine), and CyberPhysical Systems (physical systems with software-like scaling potential). The fund invests in companies at Pre-seed, Seed, and Series A funding stages, seeking stellar teams, large accessible markets, and massive sustainable differentiation. First Spark Ventures provides portfolio companies with support throughout their journey via an interdisciplinary team of investment professionals.

Product and service2 records
1First Spark Seed Fund
CategoryVenture Capital Fund
2First Spark Opportunities Fund
CategoryVenture Capital Fund
Scale indicator3 records

Each record includes

Type, Value, Description, Source

Partnership1 partner
Strategic tierCoreTypeStrategic or Co-development Partner
Description

First Spark Ventures has a strategic partnership with SRI International (formerly Stanford Research Institute), a leading scientific research institute with labs across biosciences, AI, robotics, advanced imaging, computer vision, and cyber and formal methods. SRI's 75 years of innovation have created new industries and lasting benefits to society. This partnership provides First Spark with access to cutting-edge research and innovation pipeline for deal sourcing.

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight5 records

Each record includes

Type, Description

Peers10 records
TypeDirect peer
Description

Premier early-stage deep tech VC investing in science-driven startups across AI, biotech, robotics, and advanced compute. Directly comparable to First Spark on stage focus, vertical coverage, and interdisciplinary team structure.

TypeDirect peer
Description

Deep tech VC investing in science- and engineering-led companies in compute, biotech, and cyber-physical systems. Closely comparable thesis, often leads rounds (e.g., Tidal Metals, where First Spark also participated).

TypeDirect peer
Description

Eric Schmidt's other deep tech venture firm, also backing breakthrough technology in AI, biotech, and cyber-physical systems. Most directly comparable peer given shared Schmidt brand and overlapping thesis areas.

TypeDirect peer
Description

Long-running early-stage firm with a deep tech and 'bold, early' thesis spanning AI, biotech, robotics, and clean energy. Compares on stage focus and willingness to back capital-intensive breakthrough science.

TypeDirect peer
Description

Veteran deep tech VC specializing in biotech, advanced materials, and physical sciences, with significant crossover and co-investor activity. Comparable on deep tech and biotech concentration.

TypeDirect peer
Description

Deep tech VC investing in startups combining frontier hardware, AI, and advanced engineering. Directly comparable on the CyberPhysical Systems and Advanced Compute theses.

TypeDirect peer
Description

Early-stage VC with a long history of backing ambitious deep tech and frontier science companies. Compares on early-stage, high-conviction, science-led investment posture.

TypeDirect peer
Description

Early-stage VC backing purpose-driven deep tech and biotech startups. Comparable on stage focus and willingness to invest in technically complex, mission-driven founders.

TypeBroad incumbent
Description

Strategic deep tech investor affiliated with the U.S. intelligence community; comparable on deep tech and defense-adjacent AI/quantum investing. A broader incumbent in the institutional deep tech ecosystem.

TypeBroad incumbent
Description

Large, science-tilted investment vehicles with a long history of biotech, climate, and advanced compute investing. Comparable as broader incumbent deep tech capital pools.

Market position
Strengths4 records

Each record includes

Headline, Details, Source

Weaknesses4 records

Each record includes

Headline, Details, Source

Competitive moat5 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights6 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers21 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment1 record

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile1 record

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles9 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment31 records

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

First Spark Ventures

Venture Capitalfirstsparkventures.com

First Spark Ventures is a Silicon Valley deep-tech venture capital firm founded in 2021 that invests Pre-seed through Series A in startups across Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems, with a proprietary deal-flow pipeline via SRI International.

What First Spark Ventures does

First Spark Ventures is a deep-tech venture capital firm founded in 2021 and headquartered in Silicon Valley (Menlo Park). The firm invests in early-stage startups developing breakthrough technologies across three verticals: Advanced Compute (including AI infrastructure, generative AI, and edge inference), Digital Biology & Biotech (computational biology, therapeutics, personalized medicine), and CyberPhysical Systems (physical systems with software-like scaling potential). It deploys capital at Pre-seed, Seed, and Series A, with a separate First Spark Opportunities vehicle led by General Partner Danny Chen that participates in later-stage and follow-on rounds. The portfolio spans 22+ companies including Radical Numerics, Unnatural Products, Vitara Biomedical, Xona Space Systems, Inworld AI, Latent AI, Curve Biosciences, and Tidal Metals.

The firm's core differentiation is its relationship with SRI International (formerly Stanford Research Institute), one of the most prolific US deep-tech research institutes. Founding Managing Partner Manish Kothari is the former President of SRI, and several team members (Jennifer Wu, formerly Associate Director on SRI's Ventures team) are SRI alumni, creating a proprietary deal-flow channel from laboratory to commercial formation. Eric Schmidt (former Google CEO/Chairman) serves as Strategic Advisor & Founding Non-Managing Partner, anchoring brand credibility and connecting First Spark to Schmidt Sciences and Schmidt Futures networks.

Economically, First Spark operates as a traditional venture capital fund: it charges management fees on committed capital and earns carried interest (typically ~20%) on investment profits above a hurdle rate. Distribution is direct — equity investments via term sheets, typically with board participation — to early-stage deep-tech founders globally. The firm does not publicly disclose fund size, AUM, LP composition, or revenue, and its ~8–10 investment professionals are distributed across Investing (Founding Managing Partner, three Founding General Partners, one Partner), First Spark Opportunities, and Principal/operating roles.

First Spark Ventures firmographics

Firmographics
Name
First Spark Ventures
Legal name
First Spark Ventures
Website
https://firstsparkventures.com
Company type
Private
Founded year
2021
Operating status
Operating
Headcount range
11–50 employees
Short description
First Spark Ventures is a Silicon Valley deep-tech venture capital firm founded in 2021 that invests Pre-seed through Series A in startups across Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems, with a proprietary deal-flow pipeline via SRI International.
Ownership category
akta.pro rank

First Spark Ventures industry classification

Industry
Product category
Venture Capital
NAICS
Portfolio Management and Investment Advice (523940), Portfolio Management and Investment Advice (52394), All Other Financial Investment Activities (52399), Funds, Trusts, and Other Financial Vehicles (525)
SIC
Investment Advice (6282)
akta.pro industry
PRIMARYFSANAAAB
Early-Stage Venture Capital (Series A/B)

Keywords

  • Deep tech venture capital
  • Early stage investing
  • Seed stage funding
  • Venture capital fund
  • Deep tech startups

Where First Spark Ventures is headquartered

Location

Headquarters

HQ city
Menlo Park
HQ country
United States
HQ region
North America

Offices1 record

Markets served

First Spark Ventures business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Operations, Marketing or Sales, Technology or R&D, Others

Revenue model

  1. Management Fees and Carried Interest: First Spark Ventures generates returns through traditional venture capital economics: management fees on committed capital during the fund lifecycle and carried interest (typically 20%) on investment profits above the hurdle rate, distributed to General Partners after Limited Partners receive their initial investment back.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels5 records

First Spark Ventures product offering

Product offering

Core offering

First Spark Ventures is a deep tech venture capital fund that invests in breakthrough technology startups at Pre-seed, Seed, and Series A stages. The fund focuses on three verticals—Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems—and provides portfolio companies with capital plus operational support through an interdisciplinary team of investment professionals, leveraging a strategic partnership with SRI International.

Product overview

First Spark Ventures is a Deep Tech venture capital fund that invests in breakthrough technologies. The firm focuses on three primary investment areas: Advanced Compute (including AI infrastructure, generative AI, and computing platforms), Digital Biology & Biotech (encompassing computational biology, therapeutics, and personalized medicine), and CyberPhysical Systems (physical systems with software-like scaling potential). The fund invests in companies at Pre-seed, Seed, and Series A funding stages, seeking stellar teams, large accessible markets, and massive sustainable differentiation. First Spark Ventures provides portfolio companies with support throughout their journey via an interdisciplinary team of investment professionals.

Differentiator

Problem solved

Functional benefit

Products and services

  • First Spark Seed Fund
  • First Spark Opportunities Fund

Companies that use First Spark Ventures

Customer profile

Named customers21 records

Segments1 record

Ideal customer profiles1 record

First Spark Ventures technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

First Spark Ventures partnerships and signals

Strategic signal

Partnerships

One partnership is on record.

  • SRI InternationalcoreStrategic or Co-development PartnerFirst Spark Ventures has a strategic partnership with SRI International (formerly Stanford Research Institute), a leading scientific research institute with labs across biosciences, AI, robotics, advanced imaging, computer vision, and cyber and formal methods. SRI's 75 years of innovation have created new industries and lasting benefits to society. This partnership provides First Spark with access to cutting-edge research and innovation pipeline for deal sourcing.

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

First Spark Ventures competitors and assessment

Company assessment

Direct peers

  • Lux Capital: Premier early-stage deep tech VC investing in science-driven startups across AI, biotech, robotics, and advanced compute. Directly comparable to First Spark on stage focus, vertical coverage, and interdisciplinary team structure.
  • DCVC (Data Collective): Deep tech VC investing in science- and engineering-led companies in compute, biotech, and cyber-physical systems. Closely comparable thesis, often leads rounds (e.g., Tidal Metals, where First Spark also participated).
  • Innovation Endeavors: Eric Schmidt's other deep tech venture firm, also backing breakthrough technology in AI, biotech, and cyber-physical systems. Most directly comparable peer given shared Schmidt brand and overlapping thesis areas.
  • Khosla Ventures: Long-running early-stage firm with a deep tech and 'bold, early' thesis spanning AI, biotech, robotics, and clean energy. Compares on stage focus and willingness to back capital-intensive breakthrough science.
  • ARCH Venture Partners: Veteran deep tech VC specializing in biotech, advanced materials, and physical sciences, with significant crossover and co-investor activity. Comparable on deep tech and biotech concentration.
  • Playground Global: Deep tech VC investing in startups combining frontier hardware, AI, and advanced engineering. Directly comparable on the CyberPhysical Systems and Advanced Compute theses.
  • Founders Fund: Early-stage VC with a long history of backing ambitious deep tech and frontier science companies. Compares on early-stage, high-conviction, science-led investment posture.
  • Obvious Ventures: Early-stage VC backing purpose-driven deep tech and biotech startups. Comparable on stage focus and willingness to invest in technically complex, mission-driven founders.

Broad incumbents

  • In-Q-Tel: Strategic deep tech investor affiliated with the U.S. intelligence community; comparable on deep tech and defense-adjacent AI/quantum investing. A broader incumbent in the institutional deep tech ecosystem.
  • Allen & Company / Vulcan Capital: Large, science-tilted investment vehicles with a long history of biotech, climate, and advanced compute investing. Comparable as broader incumbent deep tech capital pools.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

First Spark Ventures social profiles

Digital presence

First Spark Ventures financial estimates

Financial estimate

Revenue estimate

Valuation estimate

First Spark Ventures leadership team

Management profile

Number of profiles

Profiles9 records

First Spark Ventures funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

First Spark Ventures M&A and investment

M&A and investment

M&A

Investments31 records

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about First Spark Ventures

What does First Spark Ventures do?

First Spark Ventures is a deep tech venture capital fund that invests in breakthrough technology startups at Pre-seed, Seed, and Series A stages. The fund focuses on three verticals—Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems—and provides portfolio companies with capital plus operational support through an interdisciplinary team of investment professionals, leveraging a strategic partnership with SRI International.

Is First Spark Ventures a public or private company?

First Spark Ventures is a private company. It is classified as founder individual operated bootstrapped and is currently operating.

When was First Spark Ventures founded?

First Spark Ventures was founded in 2021. It employs 11 to 50 people.

Where is First Spark Ventures based?

First Spark Ventures is headquartered in Menlo Park, United States, in the North America region.

How does First Spark Ventures make money?

One revenue line is on record: management Fees and Carried Interest.

Who are First Spark Ventures's main competitors?

Direct peers on record are Lux Capital, DCVC (Data Collective), Innovation Endeavors, Khosla Ventures, ARCH Venture Partners, Playground Global, Founders Fund and Obvious Ventures. Broad incumbents are In-Q-Tel and Allen & Company / Vulcan Capital.

Does First Spark Ventures have an API?

No public API is recorded for First Spark Ventures.

What industry is First Spark Ventures in?

First Spark Ventures's product category is Venture Capital. Its primary akta.pro industry code is FSANAAAB, Early-Stage Venture Capital (Series A/B). Its NAICS code is 523940 and its SIC code is 6282.

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Live signals
The SaaS NewsRadical Numerics Raises $50M SeedRadical Numerics, a San Francisco-based AI research lab focused on general biological intelligence, has launched with $50 million in seed funding led by Emergence Capital, with participation from Obvious Ventures, Triatomic Capital, Factory, and First Spark Ventures. The company specializes in generative genomics, building multimodal models that learn from biological data including DNA, RNA, and proteins to facilitate cancer diagnostics, drug target identification, and biosecurity efforts. Radical Numerics plans to use the capital to scale its next-generation models and expand its team by hiring frontier AI research talent.Business Wire BlogAI Lab Radical Numerics Launches with $50M Seed Round To Build General Biological IntelligenceRadical Numerics, an AI research lab founded by the team that created generative genomics, launched with $50 million in seed funding led by Emergence Capital, with participation from Obvious Ventures, Triatomic Capital, Factory, and First Spark Ventures. The company is building general biological intelligence—AI that can read, write, and design across all of biology—with a dual mandate to advance biological design for human health and build biodefenses. The funding will be used to scale next-generation models, expand the research team, and advance applications including cancer diagnostics and biosecurity.FortuneExclusive: The researchers who built AI-generated DNA just raised $50 million to reinvent biologyRadical Numerics, a biotech AI startup founded by researchers who pioneered generative genomics, emerged from stealth with a $50 million seed round led by Emergence Capital, with participation from Obvious Ventures, Triatomic Capital, Factory, and First Spark Ventures. The company built Evo and Evo 2, the first AI models capable of generating DNA at scale trained on more than 100,000 species, and plans to use the funding to commercialize its multimodal AI platform for understanding entire biological systems for drug discovery. The company has two early commercial partnerships for cancer detection and pathogen detection, while acknowledging biosecurity concerns since its open-source work enabled the world's first AI-designed functional genome.TechStartupsVenture Capital & Startup Funding Roundup, June 15, 2026On June 15, 2026, venture capital funding focused on AI infrastructure, identity, payments, and biotech, with Sarvam raising $234 million at a $1.5 billion valuation. Other rounds included Hydra Host's $100 million and NewCore's $66 million, with strategic investors like HCLTech and Morgan Stanley participating.Venture Capital Access OnlineAI Lab Radical Numerics Launches with $50M Seed Round To Build General Biological IntelligenceRadical Numerics launched with $50M seed funding led by Emergence Capital. Its Omnii model sets state-of-the-art in identifying causal regulatory variants and detecting AI-generated pathogens. The company will use funds to scale models and expand its team.FinSMEsRadical Numerics Raises $50M in Seed FundingRadical Numerics, a San Francisco AI research lab, raised $50M in seed funding led by Emergence Capital. The company builds general biological intelligence from DNA, RNA, and proteins, with applications in cancer diagnostics and drug discovery. The round followed a pre-seed investment from Patrick Collison.CtolAltera Raises $11.1M for AI Digital HumansAltera, a startup led by former MIT professor Robert Yang, has secured $11.1 million in funding to develop AI technology for creating digital humans with human-like behaviors and empathy. Notable investors in the round include Patron, First Spark Ventures, and A16z Speedrun. The company's AI agent has already demonstrated capabilities by playing Minecraft and achieving Nvidia Research Lab benchmarks.Venture Capital Access OnlineAltera Closes $9M Seed Round to Build Digital Human Beings and Redefine AI AgentsAltera, a startup founded by former MIT researchers, has closed a $9 million seed funding round, bringing its total capital raised to $11.1 million since its inception in December 2023. The company intends to use the funds to develop autonomous AI agents with human-like qualities, building on previous achievements such as creating an agent capable of playing Minecraft. Key investors in this round include Patron and First Spark Ventures, alongside participants from Andreessen Horowitz (a16z) and various industry veterans.M12Why We Invested In Synth Labs, A Company Focusing On Automating LLM AlignmentM12 co-led with First Spark Ventures on the seed round for Synth Labs.ai, a startup building an auditable, transparent AI alignment platform using reinforcement learning from AI feedback. The company, led by Nathan Lile and Louis Castricato, will use the funding to expand its team, advance research and launch its initial offering. Francis deSouza joins as co-founder, with Stella Biderman continuing in advisory.The RegisterWe've solved smartphone GPS accuracy issues, says startupColorado-based startup Zephr has emerged from stealth with a networked GPS software solution that achieves sub-meter accuracy by having smartphones share correction data to mitigate multi-path errors. The company secured $3.5 million in seed funding led by Space Capital and First Spark Ventures, following field trials conducted with SRI International that demonstrated positioning precision within 50cm. Zephr plans to release its SDK in the first half of next year for applications in autonomous vehicles and augmented reality.