Nest Genomics (YC W22)

What Nest Genomics (YC W22) does

Nest Genomics, founded in 2022 and headquartered in New York, is an AI-native clinical software platform that helps health systems, hospitals, and specialty clinics integrate genomic testing and risk assessment into routine patient care. The company sells the Nest Genetics Copilot, a modular platform covering patient triage, education and consent, lab-agnostic smart ordering, guideline-driven clinical decision support, longitudinal follow-up, program analytics, and a pedigree builder, with native EHR integrations through SMART on FHIR and FHIR APIs into Epic, athenahealth, eClinicalWorks, AdvancedMD, REDCap, and Redox. The platform is HIPAA compliant, SOC 2 Type II certified, and built on AWS infrastructure.

Nest's commercial model is enterprise SaaS subscription, with monthly, annual, volume-based, and per-case billing options sold via direct field sales to health systems, channel partnerships with labs (Ambry, Natera, Invitae, MyOme, GeneType, Myriad), and marketplace distribution through the athenahealth Marketplace program added in October 2024. The company reports 10+ health systems and 50+ clinics using the platform, including Mount Sinai, Dana-Farber Cancer Institute, Geisinger, Baptist Health, Rady Children's Hospital, UI Health, Miami Cancer Institute, Moffitt Cancer Center, Ms. Medicine, and the State of Florida, with pilot data showing high patient engagement and measurable clinical and economic outcomes. Nest is backed by Y Combinator (W22) and an investor group led by B Capital, with total disclosed funding of approximately $9M.

Name

Nest Genomics (YC W22)

Legal name

Nest Health Tech Inc.

Website

https://nestgenomics.com

Company type

Private

Founded year

2022

Operating status

Operating

Headcount range

1–10 employees

Short description

Nest Genomics is an AI-native, lab-agnostic clinical SaaS platform that enables health systems, hospitals, and specialty clinics to integrate genomic risk assessment, testing, and longitudinal management into routine care via EHR-embedded workflows. It serves oncology, women's health, and rare disease programs at providers across the United States.

Ownership category

akta.pro rank

Product category

Clinical Genomics Software

NAICS

Computer Systems Design and Related Services (54151)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

Population Genomics & Preventive Precision Health Programs (HLAAANAL)

akta.pro secondary industry

Genetic Counseling & Prenatal Testing Telehealth (carrier screening, NIPT counseling) (HLALAHAK)

Keywords

• Genomic clinical software
• EHR-integrated genomics
• Lab-agnostic platform
• AI patient triage
• Clinical decision support

Headquarters

HQ city

New York

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Marketing or Sales, Infrastructure, Operations

Revenue model

1. Subscription Software Platform: Subscription-based SaaS model with plans billed on a recurring periodic basis (monthly or annual billing cycles). Organizations can also subscribe on a per case or volume basis. Some parts of services offered on a subscription basis with trials available.
2. Volume-Based Subscription: Billing cycles set by volume depending on the type of subscription plan selected, allowing scaling based on organization size and usage volume.

Pricing tiers

Go-to-market motion3 records

Distribution channels3 records

Marketing channels6 records

Core offering

Nest Genomics sells the Nest Genetics Copilot, an AI-native, lab-agnostic SaaS platform that enables healthcare providers to identify patients eligible for genetic testing, order tests from any lab partner, deliver guideline-based clinical decision support, and manage longitudinal genomic care. The platform integrates with major EHRs via SMART on FHIR and is licensed on a subscription basis to health systems, hospitals, specialty clinics, labs, and government programs.

Product overview

Nest Genomics offers the Nest Genetics Copilot as a unified AI-native platform designed to integrate genomics into routine patient care. The platform consists of a core product with integrated modules including Patient Triage (AI-powered eligibility identification), Education & Consent (digital pre-test education), Smart Ordering (lab-agnostic test ordering), Clinical Decision Support (guideline-driven recommendations), Genome for Life (longitudinal management), EHR Integration (SMART on FHIR), Program Analytics & Insights, and the recently launched Pedigree Builder. The platform is modular, allowing organizations to automate end-to-end care delivery or use only the capabilities they need. The Genetics Copilot provides AI-powered assistance trained on genomic datasets to identify patterns and suggest workflows, with human-in-the-loop verification for clinical validation.

Differentiator

Problem solved

Functional benefit

Products and services

• Nest Genetics Copilot AI-native, lab-agnostic, HIPAA-compliant, SOC 2 Type II certified clinical decision-support platform that helps clinicians find at-risk patients earlier, order genetic tests from any lab partner, generate guideline-driven recommendations, and manage lifelong personalized care. Integrates natively with major EHRs via SMART on FHIR + FHIR APIs. Sold as a subscription to health systems, hospitals, specialty clinics, labs, and government programs.
• Pedigree Builder Standalone pedigree tool within the Nest platform that lets care teams create, edit, and automatically generate family pedigrees from history collected through Nest assessments. Marketed with its own product page. For clinical genetics workflows.

Quantifiable outcome

• 80% of patients complete Nest risk assessment (vs. traditional workflows)
• +6 more outcomes

Named customers12 records

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration19 records

AI capability8 records

Feature6 records

Partnerships

Nine partnerships are on record, tiered core and minor.

• MyOmecoreTechnology or Integration · 3 December 2025MyOme's clinical whole-genome testing and Proactive Health portfolio (monogenic disease screening, pharmacogenomic insights, polygenic risk scores) is available through Nest Genomics' clinical decision-support platform. Nest integrates MyOme tests into provider workflows for early risk identification and personalized prevention strategies.
• Genome MedicalcoreStrategic or Co-development Partner · 15 January 2025Partnership to scale access to genetic services, improve decision-making, and enhance patient outcomes. Patients and providers using Nest Platform can access Genome Medical's experts for genetic test ordering, medical consultations, and genetic counseling. Genome Medical can scale patient outreach for clinical trials through Nest Genomics platform.
• athenahealthcoreTechnology or Integration · 24 October 2024Nest Genomics' genetics copilot integrated with athenahealth's Marketplace program. Nest is available to athenahealth's extensive network of healthcare providers, offering the first comprehensive EHR-integrated solution covering the entire patient journey from intake to long-term management.
• Florida Institute for Pediatric Rare Diseases at Florida State UniversityminorStrategic or Co-development PartnerExpanded partnership to improve access to genetic screening and pediatric rare disease care. Leverages Sunshine Genetics Act state funding for newborn whole-genome sequencing pilot program and genetic screening initiatives.
• Ambry GeneticscoreTechnology or IntegrationLab partner integrated with Nest's platform for one-click genetic test ordering and results delivery. Part of Nest's lab-agnostic approach supporting multiple lab partners.
• NateracoreTechnology or IntegrationLab partner integrated with Nest's platform for one-click genetic test ordering and results delivery. Part of Nest's lab-agnostic approach supporting multiple lab partners.
• InvitaecoreTechnology or IntegrationLab partner integrated with Nest's platform for one-click genetic test ordering and results delivery. Part of Nest's lab-agnostic approach supporting multiple lab partners.
• Myriad GeneticscoreTechnology or IntegrationLab partner integrated with Nest's platform for one-click genetic test ordering and results delivery. Part of Nest's lab-agnostic approach supporting multiple lab partners.
• GeneTypecoreTechnology or IntegrationLab partner integrated with Nest's platform for one-click genetic test ordering and results delivery. Part of Nest's lab-agnostic approach supporting multiple lab partners.

Scale indicators10 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• PhenoTips: PhenoTips provides genetics workflow software including pedigree tools, variant analysis, and clinical genetics data capture — directly competing with Nest's clinical workflow and pedigree-builder functionality for genetics providers.
• ActX: ActX delivers genomic decision support embedded directly inside EHRs (Epic and others), surfacing drug-genome and genetic risk alerts at the point of care — overlapping with Nest's EHR-integrated genomic CDS positioning.
• Genome Medical: Genome Medical is a nationwide genetic counseling and clinical genetics services network and a current Nest channel partner; it offers virtual genetic counseling that complements Nest's patient-facing workflow, making it both a partner and a comparable genetic-services platform.
• SOPHiA Genetics: SOPHiA Genetics operates an AI-driven genomic analysis platform used by hospitals and labs worldwide, similar to Nest in combining genomics-specific AI, lab integration, and clinical reporting for precision medicine use cases.
• InformedDNA: InformedDNA is one of the largest US genetic counseling services providers, offering telehealth genetic counseling and hereditary risk assessment — directly comparable to the genetic counseling and risk-assessment workflow Nest digitizes.

Broad incumbents

• Tempus: Tempus is a much larger AI-powered precision medicine platform spanning genomics, clinical data, and imaging; it operates broadly across the same genomics-in-clinical-care category but with deeper modalities (testing lab + AI + data library) than Nest's software-only model.

Emerging players

• Strata Oncology: Strata Oncology provides precision oncology testing with decision support to identify targeted therapies and clinical trials for cancer patients — overlapping with Nest's oncology genetic testing and CDS focus, but centered on a tumor-normal testing workflow.
• 2bPrecise: 2bPrecise (a 2b Genomics company) delivers a precision medicine platform integrating genomic results into the EHR, focused on oncology and hereditary disease workflows — comparable in EHR-integrated genomic decision support to Nest.

Others

• Truveta: Truveta aggregates de-identified clinical and genomics data across US health systems for research and analytics — adjacent infrastructure that competes for the same health-system genomics attention and partnerships rather than for the same clinical workflow slot.
• DNAstack: DNAstack builds federated genomic data and AI infrastructure for research and clinical discovery; it sits adjacent to Nest as enabling infrastructure rather than a direct competitor for clinical genetics workflow.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/nestgenomics
• LinkedInlinkedin.com/company/nesthealth

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Funding overview

Funding rounds2 records

Investors11 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Nest Genomics (YC W22)