EpiCypher
EpiCypher is a privately held biotechnology company founded in 2012 in Durham, North Carolina that develops chromatin mapping assays, nucleosome reagents, and bioinformatics tools for epigenetics research, serving academic, pharmaceutical, and biotech customers globally through direct sales and distributor partnerships.
- Company typePrivate
- Founded2012
- HeadquartersChapel Hill, United States
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What EpiCypher does
EpiCypher is a privately held biotechnology company founded in 2012 and headquartered in Research Triangle Park, Durham, North Carolina. The company develops and manufactures products and tools for epigenetics and chromatin biology research, serving academic and research institutions, pharmaceutical companies, and biotech firms. Its customer base is organized horizontally around chromatin biology use cases including chromatin profiling, gene regulation studies, disease mechanism investigation, and epigenomics-based drug discovery.
The company's core technology is the CUTANA platform, which encompasses CUT&RUN and CUT&Tag chromatin profiling assays that map histone post-translational modifications and chromatin-associated proteins with higher sensitivity and lower input requirements than traditional ChIP-seq. Recent extensions include the Fiber-seq Kit (a multiomic long-read sequencing assay licensed exclusively from the Altius Institute for Biomedical Sciences that simultaneously profiles chromatin accessibility, DNA methylation, protein footprints, and genetic variants at single-molecule resolution), the meCUT&RUN Kit for DNA methylation profiling using engineered MeCP2, the SNAP-Certified Antibody and spike-in control system for assay validation, over 190 unique nucleosome products with defined PTM states, EpiDyne chromatin remodeling assay substrates, and the CUTANA Cloud bioinformatics platform. EpiCypher holds granted patents on CUT&Tag in the US, EU, Japan, and China, and has multiple pending applications around Fiber-seq.
EpiCypher generates revenue through product sales (kits priced $145-$2,395, antibodies $110-$545, recombinant and designer nucleosomes $425-$575), custom laboratory services (CUT&RUN, Fiber-seq, DNA methylation sequencing, custom nucleosome development), and usage-based bioinformatics credits on CUTANA Cloud ($20-$40 per credit). Distribution is hybrid: direct-to-consumer e-commerce and quote-based sales in the US, plus international distributors and a recently expanded strategic partnership with New England Biolabs covering international markets. The company maintains a presence at industry conferences, runs webinars and a co-authored publication program, and operates dedicated support channels for academic and industrial customers.
EpiCypher firmographics
Firmographics- Name
- EpiCypher
- Legal name
- EPICYPHER, INC.
- Website
- https://epicypher.com
- Company type
- Private
- Founded year
- 2012
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- EpiCypher is a privately held biotechnology company founded in 2012 in Durham, North Carolina that develops chromatin mapping assays, nucleosome reagents, and bioinformatics tools for epigenetics research, serving academic, pharmaceutical, and biotech customers globally through direct sales and distributor partnerships.
- Ownership category
- akta.pro rank
EpiCypher industry classification
Industry- Product category
- Epigenetics Research Tools
- NAICS
- Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- SIC
- In Vitro & In Vivo Diagnostic Substances (2835)
- akta.pro primary industry
- Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF)
- akta.pro secondary industries
- Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI), Epigenomics & Chromatin Profiling Services (HLAGANAF), Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization) (HLAAAIAC)
Keywords
Where EpiCypher is headquartered
LocationHeadquarters
- HQ city
- Chapel Hill
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
EpiCypher business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Operations, Supply Chain, Marketing or Sales
Revenue model
- Product Sales - Kits and Reagents: Sale of chromatin mapping assay kits, nucleosome products, antibodies, and reagents directly through the company website and via international distributors
- Custom Services: Laboratory services including CUTANA CUT&RUN Services, Fiber-seq Assay Services, DNA Methylation Sequencing Services, and Custom Nucleosome Development Services
- Cloud Bioinformatics Credits: Pay-as-you-go credits for CUTANA Cloud data analysis platform, with tiered pricing based on volume
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Unit Pricing | Pay-as-you-go | CUTANA Fiber-seq Kit - 8 Reactions: $695.00, 24 Reactions: $1,795.00 |
| Unit Pricing | Pay-as-you-go | CUTANA CUT&Tag Kit v4 - 24 Reactions: $1,295.00, 48 Reactions: $2,395.00 |
| Unit Pricing | Pay-as-you-go | meCUT&RUN Kit for DNA Methylation Sequencing: $685.00 (24 reactions) |
| Usage-based | Pay-as-you-go | CUTANA Cloud: $25 per credit (introductory), $20-$40 standard pricing |
| Unit Pricing | Pay-as-you-go | CUT&RUN Kits: $595-$945; SNAP-CUTANA K-MetStat Panel: $325; Antibodies: $110-$545 |
| Unit Pricing | Pay-as-you-go | Recombinant Nucleosomes: $425-$575; Designer Nucleosomes (dNucs): $525-$575 |
Go-to-market motion2 records
Distribution channels4 records
Marketing channels6 records
EpiCypher product offering
Product offeringCore offering
EpiCypher develops, manufactures, and sells proprietary kits, reagents, and assays for chromatin mapping and epigenomics research, including CUTANA CUT&RUN, CUT&Tag, Fiber-seq, and meCUT&RUN kits, over 190 recombinant and modified nucleosome products, SNAP spike-in controls, SNAP-certified antibodies, and the CUTANA Cloud bioinformatics platform. The company also offers fee-for-service laboratory execution for chromatin profiling and custom nucleosome development.
Product overview
EpiCypher offers a comprehensive portfolio of epigenetics research products centered on the CUTANA platform, including CUTANA CUT&Tag Kits (v4), CUTANA CUT&RUN Kits and Assays, Fiber-seq Kits for long-read sequencing, meCUT&RUN DNA Methylation Sequencing Kits, and Multiomic CUT&RUN assays. The company provides over 190 unique nucleosome products including recombinant, modified, mutant, and cell-derived nucleosomes with defined PTMs. Additional offerings include SNAP-Certified Antibodies, SNAP Spike-in Controls, EpiDyne Chromatin Remodeling Assays, and the CUTANA Cloud bioinformatics platform. EpiCypher also provides laboratory services including CUT&RUN Services, Fiber-seq Assay Services, DNA Methylation Sequencing Services, Custom Nucleosome Development, Captify Assay Services, and an FFPE Grant Program. The products work together as an integrated ecosystem where CUT&Tag and CUT&RUN assays generate data analyzed by CUTANA Cloud, while spike-in controls and nucleosomes enable workflow optimization and validation.
Differentiator
Problem solved
Functional benefit
Brands
- CUTANA: CUTANA is EpiCypher's flagship platform for chromatin mapping assays including CUT&RUN and CUT&Tag technologies.
- EpiDyne
- SNAP-CUTANA
- Captify
- CUTANA Cloud
Products and services
- CUTANA CUT&Tag Kit Complete solution for ultra-sensitive mapping of histone post-translational modifications featuring direct-to-PCR protocol, pAG-Tn5 tagmentation, and all reagents from cells to sequencing libraries.
- CUTANA CUT&RUN Assays
Quantifiable outcome
- 80% DNA methylation capture with input as low as 10,000 cells using meCUT&RUN
- +3 more outcomes
Companies that use EpiCypher
Customer profileSegments2 records
Ideal customer profiles2 records
EpiCypher technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration3 records
Feature6 records
EpiCypher partnerships and signals
Strategic signalPartnerships
Three partnerships are on record, tiered core.
- New England Biolabs (NEB)coreExpanded strategic partnership where NEB distributes EpiCypher's genomic products in international markets. Partnership builds on prior collaboration and focuses on developing innovative technologies for gene regulation, chromatin biology, and disease mechanisms.
- Altius Institute for Biomedical SciencescoreEpiCypher licensed Fiber-seq technology from the Altius Institute for Biomedical Sciences. This exclusive licensing arrangement provides EpiCypher rights to commercialize the breakthrough single-molecule chromatin mapping technology.
- Pacific Biosciences (PacBio)corePartnership announced alongside PacBio's Revio and Vega platform innovations to expand sample preparation and chromatin analysis capabilities. EpiCypher's Fiber-seq and chromatin mapping products integrate with PacBio's long-read sequencing platforms for enhanced epigenomics research.
Scale indicators3 records
Recent moves6 records
Expansion highlights6 records
EpiCypher competitors and assessment
Company assessmentDirect peers
- Active Motif: Active Motif is a direct competitor in chromatin and epigenetics research kits, including CUT&RUN and ChIP-seq reagents, antibodies, and nucleosomes sold to the same academic and pharma customer base as EpiCypher.
- Diagenode: Diagenode offers CUT&RUN and CUT&Tag kits, antibody portfolios, and epigenetics services that directly compete with EpiCypher's CUTANA franchise, serving overlapping academic and translational customers.
- Cell Signaling Technology: CST provides CUT&RUN-validated antibodies and is a direct competitor in histone PTM reagents and chromatin profiling consumables, with overlapping SNAP-Certified-style antibody validation use cases.
- Zymo Research: Zymo Research sells DNA methylation and epigenetics kits (e.g., bisulfite conversion, Methylated DNA IP) that compete with EpiCypher's meCUT&RUN offering for the same DNA methylation research budgets.
Broad incumbents
- New England Biolabs: NEB is both EpiCypher's international distribution partner and a broad incumbent in molecular biology reagents and enzymes, offering overlapping capabilities in nucleic acid processing and chromatin research tools.
- Abcam: Abcam is a broad incumbent supplying antibodies and reagent kits including histone PTM antibodies used in CUT&RUN/CUT&Tag, competing with EpiCypher's SNAP-Certified Antibody line for the same research budgets.
- Millipore Sigma: MilliporeSigma supplies a broad catalog of life science reagents, nucleosomes, and antibodies used in chromatin research, providing overlapping but less specialized offerings compared to EpiCypher's curated epigenetics portfolio.
- Thermo Fisher Scientific: Thermo Fisher offers broad life sciences reagents, instruments, and bioservices including chromatin immunoprecipitation and methylation products that compete indirectly with EpiCypher's kit and service portfolio.
Emerging players
- Watchmaker Genomics: Watchmaker Genomics is an emerging player in DNA sequencing library prep and molecular biology reagents with partial overlap to EpiCypher's library prep and enzyme product lines.
- 10x Genomics: 10x Genomics provides single-cell ATAC and multiome chromatin accessibility assays that serve the same single-cell chromatin profiling customer base as EpiCypher's CUTANA-based assays, representing an adjacent emerging competitor.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat4 records
Key risks5 records
Key highlights7 records
Customer concentration
EpiCypher social profiles
Digital presenceEpiCypher financial estimates
Financial estimateRevenue estimate
Valuation estimate
EpiCypher leadership team
Management profileNumber of profiles
Profiles7 records
EpiCypher funding detail
Funding detailFunding overview
Funding rounds4 records
Investors2 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
EpiCypher M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about EpiCypher
What does EpiCypher do?
EpiCypher develops, manufactures, and sells proprietary kits, reagents, and assays for chromatin mapping and epigenomics research, including CUTANA CUT&RUN, CUT&Tag, Fiber-seq, and meCUT&RUN kits, over 190 recombinant and modified nucleosome products, SNAP spike-in controls, SNAP-certified antibodies, and the CUTANA Cloud bioinformatics platform. The company also offers fee-for-service laboratory execution for chromatin profiling and custom nucleosome development.
Is EpiCypher a public or private company?
EpiCypher is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was EpiCypher founded?
EpiCypher was founded in 2012. It employs 11 to 50 people.
Where is EpiCypher based?
EpiCypher is headquartered in Chapel Hill, United States, in the North America region.
How does EpiCypher make money?
Three revenue lines are on record. Product Sales - Kits and Reagents are the primary driver. The others are custom Services and cloud Bioinformatics Credits.
Who are EpiCypher's main competitors?
Direct peers on record are Active Motif, Diagenode, Cell Signaling Technology and Zymo Research. Broad incumbents are New England Biolabs, Abcam, Millipore Sigma and Thermo Fisher Scientific. Emerging players are Watchmaker Genomics and 10x Genomics.
Does EpiCypher have an API?
No public API is recorded for EpiCypher.
What industry is EpiCypher in?
EpiCypher's product category is Epigenetics Research Tools. Its primary akta.pro industry code is HLAGAIAF, Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays), with a secondary code of HLAGAIAI, Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes). Its NAICS code is 541714 and its SIC code is 2835.