brain4care
brain4care is a Brazilian medical technology company that sells the FDA-cleared B4C System 2.0, a non-invasive headband sensor plus cloud and mobile platform that monitors intracranial compliance and intracranial hypertension risk in hospital ICUs and outpatient neurology clinics on a monthly subscription.
- Company typePrivate
- Founded2012
- HeadquartersGeorgia, United States
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What brain4care does
brain4care is a privately held Brazilian medical technology company that has developed the B4C System 2.0, a non-invasive intracranial compliance monitoring platform cleared by the FDA (510(k) K240821) and registered with ANVISA. The system comprises a headband-mounted extensometer sensor (b4c Sensor) that detects nanometer-scale skull micro-movements correlated with intracranial compliance, a companion mobile/tablet application (b4c Mobile App) for real-time visualization over Bluetooth, and a cloud platform (b4c Cloud) for data storage and PDF report generation. From the surrogate ICP waveform the platform derives the P2/P1 ratio and normalized time-to-peak (nTTP), with reported 90% specificity (P2/P1 > 1.4) and 92% specificity (nTTP > 0.3) for intracranial hypertension risk assessment, supported by 144+ peer-reviewed publications and clinical outcomes including an ICU mortality reduction from 37.25% to 5.88% in monitored neurocritical care patients.
The company sells via a point-of-care monthly subscription that bundles the equipment, training and cloud platform without consumables or disposables, targeting inpatient ICU (Cerebral Edema Management module) and outpatient neurology/neurosurgery clinics (Shunt Dysfunction Assessment module). Reference customers include Hospital 9 de Julho, Hospital das Clínicas (São Paulo), Hospital Pequeno Príncipe and HUGV-UFAM, with operations in São Carlos and São Paulo, Brazil and a US regional office in Johns Creek, Georgia. brain4care has raised approximately US$9.7M in disclosed equity funding across rounds led by Miletus Fund, Loyall Capital Partners and Green Rock between 2016 and 2020, supplemented by a R$5.4M FINEP non-dilutive grant in 2024, and reports 210+ active accounts, 55,626+ patients monitored and 95,647+ monitoring sessions to date.
brain4care firmographics
Firmographics- Name
- brain4care
- Legal name
- brain4care
- Website
- https://brain4.care
- Company type
- Private
- Founded year
- 2012
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- brain4care is a Brazilian medical technology company that sells the FDA-cleared B4C System 2.0, a non-invasive headband sensor plus cloud and mobile platform that monitors intracranial compliance and intracranial hypertension risk in hospital ICUs and outpatient neurology clinics on a monthly subscription.
- Ownership category
- akta.pro rank
brain4care industry classification
Industry- Product category
- Intracranial Pressure Monitoring Devices
- NAICS
- Medical and Diagnostic Laboratories (6215), Medical and Diagnostic Laboratories (62151)
- SIC
- Electromedical & Electrotherapeutic Apparatus (3845), Surgical & Medical Instruments & Apparatus (3841)
- akta.pro primary industry
- Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE)
- akta.pro secondary industry
- Clinical-Grade Vital Signs Monitoring (ECG, SpO2, BP, Temp, Respiration) (HLACAPAI)
Keywords
Where brain4care is headquartered
LocationHeadquarters
- HQ city
- Georgia
- HQ country
- United States
- HQ region
- North America
Offices3 records
Markets served
brain4care business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales, Others
Revenue model
- Monthly Subscription (Point of Care Model): The company operates on a subscription model with monthly billing. Healthcare facilities receive equipment and training as part of the service. No consumables or disposable supplies required. The model includes equipment provision, training, and ongoing support with TUSS code established for billing purposes.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Monthly | Monthly subscription with equipment and training included |
Go-to-market motion1 record
Distribution channels1 record
Marketing channels6 records
brain4care product offering
Product offeringCore offering
brain4care develops and sells the B4C System 2.0, a non-invasive intracranial compliance monitoring platform consisting of a headband-worn sensor (extensometer), a cloud data platform, and a companion mobile/tablet application. The system detects skull micro-movements to derive surrogate ICP waveforms and parameters (P2/P1 ratio, nTTP) for early assessment of intracranial hypertension risk. The company offers clinical application modules for cerebral edema management in ICU settings and shunt dysfunction assessment in outpatient clinics.
Product overview
Brain4care offers the B4C System 2.0, a unified non-invasive intracranial compliance monitoring platform comprising three integrated components: a wearable headband sensor (b4c Sensor) that captures skull micro-movements via an extensometer, a companion mobile/tablet application (b4c Mobile App) for real-time data display and Bluetooth connectivity, and a cloud platform (b4c Cloud) for data storage and PDF report generation. The system delivers two clinical application modules—Cerebral Edema Management (for ICU inpatient monitoring) and Shunt Dysfunction Assessment (for outpatient clinic use)—both powered by derived waveform parameters (P2/P1 ratio and nTTP) to assess intracranial compliance and hypertension risk.
Differentiator
Problem solved
Functional benefit
Products and services
- B4C System 2.0 A unified non-invasive intracranial compliance monitoring system consisting of a headband sensor (b4c Sensor), cloud platform (b4c Cloud), and mobile application (b4c Mobile App) that measures skull micro-movements to derive surrogate ICP waveforms and parameters (P2/P1 ratio, nTTP) for early assessment of intracranial hypertension risk. Sold to healthcare facilities as a monthly subscription with equipment and training included; no consumables required.
- b4c Sensor A headband-worn non-invasive sensor with an extensometer that detects skull micro-movements correlated with intracranial compliance and transmits data via Bluetooth to the companion app. For use by healthcare professionals in ICU, neurology, neurosurgery, and outpatient clinic settings.
- b4c Cloud A cloud-based platform for storing and analyzing patient intracranial monitoring data, enabling trend analysis and PDF report generation from monitoring sessions. Provided to healthcare facilities as part of the B4C subscription service.
- b4c Mobile App A companion tablet/mobile application providing real-time waveform display, P2/P1 ratio trends, nTTP monitoring, clinical observation entry, and Bluetooth sensor management. Used by clinicians during patient monitoring sessions.
- Cerebral Edema Management Application An ICU clinical application module for monitoring patients at risk or under suspicion of cerebral edema. Supports baseline and trend monitoring using P2/P1 ratio and nTTP thresholds for intracranial hypertension risk assessment in neurocritical care patients.
- Shunt Dysfunction Assessment Application An outpatient clinic clinical application module for assessing shunt dysfunction in hydrocephalus patients by monitoring intracranial pressure dynamics across three positional changes (lying down, 30 degrees supine, standing) and analyzing P2/P1 ratio stability.
Quantifiable outcome
- Mortality reduction from 37.25% to 5.88% in monitored ICU patients
- +5 more outcomes
Companies that use brain4care
Customer profileNamed customers4 records
Segments4 records
Ideal customer profiles2 records
brain4care technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability2 records
Feature5 records
brain4care partnerships and signals
Strategic signalScale indicators9 records
Recent moves6 records
Expansion highlights6 records
brain4care competitors and assessment
Company assessmentDirect peers
- Ceribell: Ceribell provides non-invasive brain monitoring (point-of-care EEG) for seizure detection in ICU patients — directly comparable to brain4care's non-invasive intracranial monitoring for ICU neurocritical care, targeting similar hospital buyers with a hardware + cloud + subscription model.
- Integra LifeSciences: Integra is the market-leading vendor of invasive ICP monitors (Camino) used in neurocritical care — the incumbent alternative brain4care is positioning against in the ICP/intracranial monitoring category, selling to the same neurosurgery and ICU buyers.
- Spiegelberg: Spiegelberg produces intracranial pressure monitors and related neurosurgical devices — a direct competitor in ICP monitoring equipment sold to neurosurgery departments and ICUs globally.
- Raumedic: Raumedic manufactures ICP monitoring catheters and cranial measurement devices for neurosurgical applications — a direct peer in invasive ICP monitoring serving the same neurocritical care hospital customer base.
- Sophysa: Sophysa manufactures invasive intracranial pressure monitoring devices and accessories for neurosurgery and neuro-ICU — a direct competitor in the ICP monitoring category serving the same neurosurgical hospital customers.
Emerging players
- NovaSignal: NovaSignal develops non-invasive cerebral blood flow and hemodynamics monitoring using ultrasound — an emerging peer in non-invasive neurological/cerebral monitoring with overlapping interest in brain health diagnostics but a different physiological parameter than ICP.
Broad incumbents
- Edwards Lifesciences: Edwards acquired CASMED and offers FORE-SIGHT cerebral oximetry — non-invasive brain oxygenation monitoring in the OR and ICU. Adjacent in physiological parameter but overlapping in non-invasive cerebral monitoring positioning to neurocritical care buyers.
- Medtronic: Medtronic has historically offered neurosurgery/neuro-monitoring products and is a broad incumbent in hospital neurocare — its scale and neurosurgery sales channel represent both the partnership opportunity and the competitive threat for brain4care.
- Masimo: Masimo is a broad patient monitoring incumbent with non-invasive cerebral oximetry (O3) — overlapping with brain4care's non-invasive brain monitoring paradigm but spanning a much wider portfolio of vital signs monitoring across the hospital.
- Natus Medical: Natus Medical offers a broad portfolio of neurodiagnostic and neuro-monitoring devices (EEG, EMG, sleep) — an incumbent in neurological monitoring whose broader portfolio includes products in adjacent categories to brain4care's intracranial monitoring focus.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks5 records
Key highlights7 records
Customer concentration
brain4care social profiles
Digital presencebrain4care compliance and trust
Trust signalCompliance4 records
brain4care financial estimates
Financial estimateRevenue estimate
Valuation estimate
brain4care leadership team
Management profileNumber of profiles
Profiles9 records
brain4care funding detail
Funding detailFunding overview
Funding rounds4 records
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
brain4care M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about brain4care
What does brain4care do?
brain4care develops and sells the B4C System 2.0, a non-invasive intracranial compliance monitoring platform consisting of a headband-worn sensor (extensometer), a cloud data platform, and a companion mobile/tablet application. The system detects skull micro-movements to derive surrogate ICP waveforms and parameters (P2/P1 ratio, nTTP) for early assessment of intracranial hypertension risk. The company offers clinical application modules for cerebral edema management in ICU settings and shunt dysfunction assessment in outpatient clinics.
Is brain4care a public or private company?
brain4care is a private company. It is classified as venture growth investor backed and is currently operating.
When was brain4care founded?
brain4care was founded in 2012. It employs 11 to 50 people.
Where is brain4care based?
brain4care is headquartered in Georgia, United States, in the North America region.
How does brain4care make money?
One revenue line is on record: monthly Subscription (Point of Care Model).
Who are brain4care's main competitors?
Direct peers on record are Ceribell, Integra LifeSciences, Spiegelberg, Raumedic and Sophysa. NovaSignal is listed as an emerging player. Broad incumbents are Edwards Lifesciences, Medtronic, Masimo and Natus Medical.
Does brain4care have an API?
No public API is recorded for brain4care.
What industry is brain4care in?
brain4care's product category is Intracranial Pressure Monitoring Devices. Its primary akta.pro industry code is HLAHACAE, Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables), with a secondary code of HLACAPAI, Clinical-Grade Vital Signs Monitoring (ECG, SpO2, BP, Temp, Respiration). Its NAICS code is 6215 and its SIC code is 3845.