Evinature

What Evinature does

Evinature Ltd. is a privately held Israeli nutraceutical company founded in 2021 in Binyamina, Israel, that develops and sells clinically validated, evidence-based supplements for chronic gut health conditions including IBD, ulcerative colitis, IBS, and diverticulitis. Its flagship offering is CurQD, a proprietary full-formula combination of curcumin and Qing Dai (Indigo Naturalis) designed to activate the aryl hydrocarbon receptor (AhR) and restore mucosal barrier integrity. The product line was developed over a decade starting in 2011 at Sheba Medical Center (ranked #7 globally by Newsweek) by co-founders Nir Salomon, formerly Director of Sheba's Integrative Gastroenterology Unit, and Professor Shomron Ben-Horin, Chief of Gastroenterology at Sheba and author of more than 200 peer-reviewed publications. The portfolio is organized into color-coded 6-week protocols (BLUE/BLUE+ for maintenance, GREEN/YELLOW for moderate support, ORANGE/RED for intensive) and adjunct supplements (DivertX for gut-wall support, Exhale for stress/gut-brain, Agile for joints), with formulations cGMP-certified in the US and Israel and Halal/Kosher/Vegan-compliant.

The company operates a dual go-to-market: a product-led direct-to-consumer e-commerce channel at evinature.com where customers complete an online gut-health assessment to receive a personalized protocol recommendation and purchase as a one-time order or subscription, alongside an enterprise/clinical channel in which CurQD is used in over 50 leading GI centers across the U.S., Europe and beyond. Revenue is generated through one-time product purchases ranging from roughly $29 (Pillbox) to $165 (Protocol GREEN), and through recurring monthly subscriptions ($79 for DivertX, $95 for CurQD) plus a higher-touch 'Evinature Program' that bundles assessment, monthly check-ups, and a dedicated personal representative. The company has been incorporated into the European Crohn's and Colitis Organisation (ECCO) 2025 consensus guidelines for IBD treatment and was selected in 2026 for a U.S. Department of Defense-funded clinical trial (up to $11M potential funding) led by Mount Sinai Hospital with University of Chicago Medicine, signaling an active shift from supplement-only positioning toward regulated clinical validation.

Name

Evinature

Legal name

Evinature Ltd.

Website

https://evinature.com

Company type

Private

Founded year

2021

Operating status

Operating

Headcount range

11–50 employees

Short description

Evinature is an Israeli nutraceutical company selling clinically validated supplements for chronic gut health conditions (IBD, IBS, diverticulitis) via direct-to-consumer e-commerce and 50+ GI centers, anchored by its proprietary CurQD curcumin-Qing Dai formulation developed at Sheba Medical Center.

Ownership category

akta.pro rank

Product category

Clinical Nutraceuticals for Digestive Health

NAICS

Medicinal and Botanical Manufacturing (325411), Food (Health) Supplement Retailers (456191)

SIC

Food And Kindred Products (2000)

akta.pro primary industry

Probiotics & Digestive Health Supplements (CRADAGAF)

akta.pro secondary industry

Herbal & Botanical Supplements (CRADAGAD)

Keywords

• Clinical nutraceuticals
• Gut health supplements
• IBD natural treatments
• Curcumin formulations
• Evidence-based digestive wellness

Headquarters

HQ city

Binyamina

HQ country

Israel

HQ region

Middle East

Offices2 records

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Marketing or Sales, Operations, Supply Chain, Infrastructure

Revenue model

1. Product Sales - Direct to Consumer: Sale of nutraceutical products (CurQD protocols, DivertX, Exhale, Agile) directly to consumers through e-commerce storefront. Products sold as one-time purchases or subscription plans with recurring revenue potential.
2. The Evinature Program Subscription: Comprehensive care program providing personalized protocols with ongoing guidance, check-ups, optimization, and seamless delivery for chronic gut health management. Includes dedicated personal representative and management interface.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels7 records

Core offering

Evinature develops, manufactures, and sells clinically validated nutraceutical supplements for chronic gut health, anchored by its flagship CurQD formulation combining curcumin and Qing Dai (Indigo Naturalis) that activates the aryl hydrocarbon receptor (AhR) pathway to support mucosal barrier integrity. The company sells color-coded 6-week personalized CurQD protocols, complementary supplements (DivertX, Exhale, Agile, Cura, QD1), and bundles direct-to-consumer via evinature.com through subscriptions, one-time purchases, and a managed care program, while also distributing through 50+ GI medical centers globally.

Product overview

Evinature is a nutraceutical company offering evidence-based supplements developed at Sheba Medical Center. The core product is CurQD, a proprietary formulation combining curcumin and Qing Dai (Indigo Naturalis) that activates the aryl hydrocarbon receptor (AhR) pathway. The portfolio includes color-coded 6-week protocols (BLUE/Blue+ for maintenance, GREEN/YELLOW for moderate support, ORANGE/RED for intensive support), along with standalone supplements like DivertX (gut wall support with Coptis and curcumin), Exhale (stress relief with Ashwagandha and Chamomile), and Agile (joint health). Products are available through subscription programs, bundles, or individual purchase, with a personalized Evinature Program offering ongoing care, check-ups, and protocol adjustments.

Differentiator

Problem solved

Functional benefit

Brands

• CurQD: The company's flagship nutraceutical protocol for gut health, based on a molecular activator combining curcumin and Qing Dai to activate the AhR gut receptor.
• DivertX
• Exhale
• Agile

Products and services

• CurQD Protocol System Flagship 6-week personalized nutraceutical protocol line combining curcumin and Qing Dai (Indigo Naturalis) to activate the aryl hydrocarbon receptor (AhR) pathway for gut mucosal integrity. Delivered as five color-coded intensity levels: Protocol BLUE and BLUE+ for long-term maintenance and homeostasis, Protocol GREEN and YELLOW for moderate intestinal support, and Protocol ORANGE and RED for moderate-to-intensive and maximum-strength intervention. Targeted at adults managing chronic gut conditions including IBD and ulcerative colitis.
• CurQD Subscription Program Monthly subscription service delivering CurQD products every 4 weeks at $95.00 USD per month (2 bottles), with a dedicated account manager, monthly check-ins, protocol optimization, ongoing savings, and a 15% lifetime discount on other products. Designed for customers managing chronic bowel conditions who need ongoing protocol support.
• DivertX Dual-action intestinal support supplement combining Coptis and gut-directed curcumin (95%) to support gut wall integrity and promote regular digestion. Offered in multiple variants—DivertX Plus (60-day program), DivertX Max (30-day intensive higher-dose 6-capsule-daily protocol), and DivertX Bundle—priced from $55 to $125. Targeted at individuals managing diverticulitis and digestive wellness concerns.
• DivertX Subscription Program Monthly subscription service for DivertX at $79.00 USD per month (2 bottles every 4 weeks), with 50% off the first month and 15% lifetime discount on other Evinature products. Designed for customers with chronic digestive and gut wall support needs.
• Exhale Stress relief supplement combining Ashwagandha, Chamomile, and Mimosa Bark to support healthy cortisol levels and stress response. Available as a subscription-based product and as bundles including the Exhale Bundle ($99.00) and Exhale 3-Pack ($135.00). Targeted at health-conscious consumers managing daily stress and gut-brain axis sensitivity.
• Agile Joint care and flexibility supplement designed to support joint health and mobility, available as a single product ($45.00) and as the Agile Bundle ($72.00) for extended supply. Targeted at health-conscious consumers seeking evidence-based joint support.
• Cura & QD1 Individual Ingredient Supplements Individual-ingredient and concentrated nutraceutical products sold as single components of the CurQD system. Includes Cura (Curcuma longa curcumin 95% at $52.00), QD1 (Qing Dai/Indigo Naturalis at $48.00), and the CurQD-1 through CurQD-5 graduated intensity sub-formulations. Targeted at customers seeking single-ingredient or lower-intensity CurQD components.
• Gut-Brain Bundle Bundle pairing Exhale (stress relief) and DivertX (gut wall support) priced at $93.00, also offered as a monthly subscription program (Gut-Brain Subscription Program) with 15% discount on future products. Targeted at customers experiencing stress-related gut sensitivity and seeking holistic gut-brain support.
• Pillbox Pill organizer container sold at $29.00 to help customers manage daily supplement routines. Targeted at existing Evinature customers using multi-product protocols.
• The Evinature Program Comprehensive personalized care program offering gut health assessment, protocol customization, monthly check-ups, a dedicated personal representative, and a flexible management interface for chronic gut health management. Sold as part of the subscription and protocol purchase flow. Designed for chronic-condition customers requiring ongoing support and protocol optimization.

Quantifiable outcome

• 85.7% clinical response rate in randomized double-blinded placebo-controlled trial
• +4 more outcomes

Named customers3 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Four partnerships are on record, tiered core and regional.

• Mount Sinai HospitalcoreStrategic or Co-development Partner · 18 March 2026Mount Sinai Hospital in New York is leading a U.S. Department of Defense-funded clinical trial evaluating CurQD combined with vedolizumab for ulcerative colitis treatment. This represents Evinature's most significant clinical validation partnership to date, with potential funding up to $11 million.
• University of Chicago MedicinecoreStrategic or Co-development Partner · 18 March 2026University of Chicago Medicine researchers are collaborating on the DoD-funded combination therapy trial for ulcerative colitis. Dr. David T. Rubin serves on Evinature's advisory board as Chief of Gastroenterology.
• Sheba Medical CentercoreStrategic or Co-development Partner · 18 March 2026Sheba Medical Center (ranked #7 globally by Newsweek) is where Evinature products were developed and validated. Co-founders Prof. Ben-Horin and Nir Salomon maintain active positions at Sheba's Gastroenterology Department and Integrative Gastroenterology Unit.
• ADACYTE THERAPEUTICSregionalChannel Partner/ Reseller/ Distributor · 12 March 2026ADACYTE THERAPEUTICS represents Evinature operations in Portugal and Spain, establishing a dedicated booth at ECCO 2026 congress to showcase clinical data and scientific infrastructure to gastroenterologists and researchers.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Broad incumbents

• Thorne: Thorne is a clinical-grade supplement brand with practitioner channels and a broad portfolio including gut and inflammation products. Comparable to Evinature on scientific credibility and premium pricing across the practitioner/wellness channel.
• Align: Align is a mainstream probiotic brand owned by Procter & Gamble, widely distributed in retail for everyday digestive health. Competes with Evinature's CurQD for the same consumer problem but without the IBD-specific clinical positioning.
• Designs for Health: Designs for Health is a practitioner-grade supplement brand with gut and inflammatory-support protocols. Comparable to Evinature on clinician-channel distribution and clinical evidence emphasis.
• Culturelle: Culturelle is one of the most distributed digestive health probiotic brands (Lactobacillus rhamnosus GG). Overlaps with Evinature on digestive health consumer occasions but at a much broader, mass-market positioning.
• Integrative Therapeutics: Integrative Therapeutics is a practitioner-channel supplement company with a strong gastrointestinal product line (e.g., Similase, Motility Activator). Comparable to Evinature in targeting gastroenterology-friendly nutraceuticals via clinicians.
• Pure Encapsulations: Pure Encapsulations is a practitioner-grade supplement brand (owned by Nestlé Health Science) offering a broad gastrointestinal and inflammation product line. Overlaps with Evinature on clinically oriented nutraceuticals sold through healthcare professionals.

Direct peers

• Microbiome Labs: Microbiome Labs (Megasporebiotic, HU58) is a practitioner-channel focused gut health supplement brand built on published clinical studies. Comparable to Evinature in targeting clinicians and health-conscious consumers with science-backed digestive health products.
• Seed Health: Seed Health sells clinically studied synbiotic/microbial formulations with a science-first brand narrative. It mirrors Evinature's positioning of evidence-based microbiome therapeutics sold via DTC subscriptions.
• Visbiome: Visbiome (formerly VSL#3) is a high-potency multi-strain probiotic medical food indicated for GI conditions including IBD and IBS. It is the closest direct competitor to CurQD on the clinical evidence/IBD positioning axis.
• Pendulum: Pendulum offers microbiome-based supplements with patented strains and published clinical studies in metabolic and digestive health. Comparable to Evinature on using patented, clinically validated formulations sold DTC at premium price points.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/evinature
• LinkedInlinkedin.com/company/evinature
• Instagraminstagram.com/evinature
• TikToktiktok.com/@evinature
• Xx.com/evinature_

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Funding overview

Funding rounds3 records

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Evinature