Nested Knowledge
Nested Knowledge provides a cloud-based evidence synthesis platform combining AutoLit® literature review workflow with Synthesis visualization tools, serving academic medical researchers, HEOR consultancies, medical device firms, and biopharma evidence teams.
- Company typePrivate
- Founded2018
- HeadquartersSaint Paul, United States
- Headcount11–50
- GTM typeB2B
- OfferingSoftware
What Nested Knowledge does
Nested Knowledge, Inc. is a Delaware-incorporated, privately held software company founded in 2018 and headquartered in St. Paul, Minnesota. The company provides a two-part cloud-based evidence synthesis platform composed of AutoLit® — covering the systematic review workflow of literature search, AI-assisted screening, structured data extraction, and critical appraisal — and Synthesis, which delivers qualitative concept summarization, no-code quantitative meta-analysis, shareable dashboards, and living manuscript drafting with auto-updating tables and figures. The platform is designed to serve academic medical researchers, evidence synthesis consultancies, medical device and HEOR specialists, and increasingly biopharma and healthcare media organizations. The company is led by co-founder and CEO Kevin Kallmes, with Karl Holub as CTO and Keith Kallmes as President.
The business model combines a freemium self-serve layer with enterprise subscriptions and embedded professional services. Individual researchers can complete an entire systematic review project for free with no time limits and no credit card required, creating a product-led growth top-of-funnel; enterprise teams are onboarded through tailored pilot projects that include complimentary research support, with annual contract pricing available on request. The company's stated customer base includes HEOR and evidence synthesis firms (ECRI, ICER, FIECON, HEOR Ltd, NAMSA, OPEN Health, RTI Health Solutions, Medlior, Red Nucleus, Decisive Consulting, Indence Health, Marksman Healthcare, Mednavigate, Synex), medical device consultancies (Sterling Medical Devices, Superior Medical Experts, Zoll Medical), and academic institutions (Stanford Neurosurgery, Health Sciences Library), and the company claims to be trusted by thousands of researchers worldwide.
The company is venture-backed, having raised approximately $5.98 million cumulatively across disclosed rounds, including a $4.3 million exempt offering filed in January 2026 (with TCA Venture Group disclosed) and a prior $1.5 million round from Groove Capital in June 2021. Its go-to-market is supported by strategic partnerships announced in late 2025 and early 2026 with Prezent Vivo (biopharma competitive intelligence), Cliniphai (HTA dossier localization), and Pharmacy Podcast Network (healthcare podcasting), reflecting an explicit effort to extend the platform beyond academic systematic reviews into commercial life sciences and media verticals.
Nested Knowledge firmographics
Firmographics- Name
- Nested Knowledge
- Legal name
- Nested Knowledge, Inc.
- Website
- https://nested-knowledge.com
- Company type
- Private
- Founded year
- 2018
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Nested Knowledge provides a cloud-based evidence synthesis platform combining AutoLit® literature review workflow with Synthesis visualization tools, serving academic medical researchers, HEOR consultancies, medical device firms, and biopharma evidence teams.
- Ownership category
- akta.pro rank
Nested Knowledge industry classification
Industry- Product category
- Evidence Synthesis Software
- NAICS
- Software Publishers (5132), Web Search Portals, Libraries, Archives, and Other Information Services (519)
- SIC
- Services-Prepackaged Software (7372)
- akta.pro primary industry
- Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF) (HLAGAJAM)
Keywords
Where Nested Knowledge is headquartered
LocationHeadquarters
- HQ city
- Saint Paul
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Nested Knowledge business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Operations, Infrastructure
Revenue model
- Platform Subscription: Nested Knowledge operates on a freemium model where users can complete their first systematic review project for free with no time limits. The platform then likely offers paid subscription tiers for expanded usage, teams, and advanced features.
- Enterprise Onboarding Services: The company offers tailored pilot project onboarding with complimentary research support for enterprise customers, suggesting professional services as a revenue component.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Freemium | Monthly | Free tier for individual researchers |
| Subscription | Annual | Enterprise team plans |
Go-to-market motion2 records
Distribution channels2 records
Marketing channels5 records
Nested Knowledge product offering
Product offeringCore offering
Nested Knowledge sells a two-part cloud SaaS platform that enables medical researchers and life sciences organizations to conduct systematic literature reviews and meta-analyses. AutoLit® handles search, AI-augmented screening, structured data extraction, and critical appraisal, while Synthesis powers qualitative synthesis, no-code quantitative meta-analysis, shareable dashboards, and living manuscript drafting. The platform is offered via freemium self-serve access for individuals and tailored enterprise pilot engagements for teams.
Product overview
Nested Knowledge is a two-part platform composed of AutoLit® and Synthesis. AutoLit® provides the systematic review workflow (search, screening, data extraction, critical appraisal, and export), while Synthesis enables visualization, analysis, publication, and sharing of evidence derived from AutoLit data. Together, they enable medical researchers to accelerate, collaborate, automate, and share evidence synthesis for systematic reviews and meta-analyses.
Differentiator
Problem solved
Functional benefit
Brands
- AutoLit: Evidence synthesis platform for literature search, screening, data extraction, and critical appraisal workflow.
- Synthesis
Products and services
- AutoLit®
Quantifiable outcome
- Reduces competitive intelligence preparation time from weeks to hours
- +1 more outcomes
Companies that use Nested Knowledge
Customer profileNamed customers3 records
Segments3 records
Ideal customer profiles3 records
Nested Knowledge technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability4 records
Feature8 records
Nested Knowledge partnerships and signals
Strategic signalPartnerships
Three partnerships are on record, tiered core and minor.
- Prezent VivocoreStrategic partnership to deliver AI-powered competitive intelligence services for life sciences organizations. Combines Prezent Vivo's AI + human expertise communication model with Nested Knowledge's AutoLit evidence synthesis platform. The integrated solution enables pharmaceutical and biotech teams to receive congress-ready competitive intelligence packages and monthly living evidence updates, reducing preparation time from weeks to hours. Partnership launched ahead of June congress season including ASCO, EHA, and ISTH.
- Pharmacy Podcast NetworkminorStrategic collaboration to integrate AI-powered evidence synthesis into healthcare podcasting. Aims to improve credibility and accuracy of clinical education content. First episodes scheduled to launch in late January 2026.
- CliniphaicoreStrategic partnership announced at ISPOR Europe 2025 to improve and accelerate the localization of Health Technology Assessment (HTA) dossiers globally. Combines AI-enabled evidence synthesis, expert-led translations, and rapid dossier adaptation to meet global regulatory needs. Enhances efficiency and compliance of HTA dossier localization for global health authorities.
Scale indicators2 records
Recent moves5 records
Expansion highlights5 records
Nested Knowledge competitors and assessment
Company assessmentOthers
- LitCovid: NLM-hosted curated literature hub for COVID-19 research. Adjacent as a literature-discovery resource in the same clinical-research evidence ecosystem, though not a commercial competitor.
Direct peers
- Covidence: Leading systematic review management platform used widely by Cochrane and academic researchers for screening, data extraction, and risk-of-bias assessment. Most directly comparable product offering to AutoLit's screening/extraction workflow.
- DistillerSR (Evidence Partners): Enterprise-grade systematic review and literature surveillance software used by regulatory, HTA, and medical device organizations. Targets the same biopharma/HEOR enterprise buyer as Nested Knowledge.
- Rayyan: AI-assisted systematic review screening platform widely used in academic research; comparable PLG motion (free tier + paid) and serves overlapping academic medical researcher segment.
Emerging players
- EPPI-Reviewer: Web-based systematic review software from UCL with strong academic adoption, including meta-analysis and machine-learning-assisted screening. Comparable in core systematic review functionality though more research-oriented than commercial.
- PICO Portal: Systematic review and evidence synthesis platform focused on clinical and public health research workflows. Comparable feature set with narrower commercial footprint.
- OpenEvidence: AI-powered clinical evidence search and synthesis platform for clinicians. Targets overlapping medical-research audience with a more consumer-facing AI question-answering experience.
- Mendel AI: Enterprise AI platform for life sciences focused on clinical and commercial evidence workflows, including medical affairs. Comparable in targeting biopharma evidence/medical-affairs buyers with AI-first positioning.
Broad incumbents
- Clarivate (EndNote / Cortellis): Large incumbent providing scientific literature tools (EndNote), research intelligence (Cortellis), and life sciences data. Overlaps with Nested Knowledge's research-workflow and biopharma intelligence use cases as part of a much broader portfolio.
- Elsevier (Embase / Scopus): Global publisher and data analytics incumbent owning Embase, Scopus, and other life sciences databases that Nested Knowledge integrates with. Strategic both as competitor and data source.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks5 records
Key highlights6 records
Customer concentration
Nested Knowledge social profiles
Digital presenceNested Knowledge financial estimates
Financial estimateRevenue estimate
Valuation estimate
Nested Knowledge leadership team
Management profileNumber of profiles
Profiles3 records
Nested Knowledge funding detail
Funding detailFunding overview
Funding rounds4 records
Investors2 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Nested Knowledge M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Nested Knowledge
What does Nested Knowledge do?
Nested Knowledge sells a two-part cloud SaaS platform that enables medical researchers and life sciences organizations to conduct systematic literature reviews and meta-analyses. AutoLit® handles search, AI-augmented screening, structured data extraction, and critical appraisal, while Synthesis powers qualitative synthesis, no-code quantitative meta-analysis, shareable dashboards, and living manuscript drafting. The platform is offered via freemium self-serve access for individuals and tailored enterprise pilot engagements for teams.
Is Nested Knowledge a public or private company?
Nested Knowledge is a private company. It is classified as venture growth investor backed and is currently operating.
When was Nested Knowledge founded?
Nested Knowledge was founded in 2018. It employs 11 to 50 people.
Where is Nested Knowledge based?
Nested Knowledge is headquartered in Saint Paul, United States, in the North America region.
How does Nested Knowledge make money?
Two revenue lines are on record. Platform Subscription is the primary driver. The others are enterprise Onboarding Services.
Who are Nested Knowledge's main competitors?
LitCovid is listed as an others. Direct peers are Covidence, DistillerSR (Evidence Partners) and Rayyan. Emerging players are EPPI-Reviewer, PICO Portal, OpenEvidence and Mendel AI. Broad incumbents are Clarivate (EndNote / Cortellis) and Elsevier (Embase / Scopus).
Does Nested Knowledge have an API?
No public API is recorded for Nested Knowledge.
What industry is Nested Knowledge in?
Nested Knowledge's product category is Evidence Synthesis Software. Its primary akta.pro industry code is HLAGAJAM, Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF). Its NAICS code is 5132 and its SIC code is 7372.