What Trellus Health does

Trellus Health is a digital health company that develops and commercializes the Trellus Elevate® behavioral intelligence platform, built on the GRITT™ resilience-based methodology originally developed at the Icahn School of Medicine at Mount Sinai's IBD Center and exclusively licensed to the company. The platform measures resilience and behavioral readiness, segments individuals by activation profile, and deploys personalized activation pathways designed to improve therapy initiation, adherence, and persistence in chronic conditions and clinical trials. Two principal modules operate on top of the core platform: Trellus TrialSet™, a clinical trial readiness layer deployed between eligibility confirmation and formal screening to improve randomization rates, and a patient support program layer that integrates into existing PSP/hub ecosystems as a behavioral activation overlay. The initial condition focus is inflammatory bowel disease (Crohn's disease and ulcerative colitis).

The company serves enterprise customers in three primary segments: pharmaceutical companies (clinical trial sponsorship, addressed via the TrialSet vertical and CRO partnerships with ICON plc and PSI Inc.), pharmaceutical companies (patient support programs, addressed via a flagship Johnson & Johnson Health Care Systems contract extended through mid-2026), and health plans and self-insured employers (chronic condition management). Revenue is generated on a B2B subscription basis using fixed monthly management fees, distributed via direct enterprise sales rather than consumer channels. The company operates from a US headquarters in White Plains, NY and a UK office in Cardiff, is publicly listed on AIM, and holds SOC 2 Type 2 certification alongside peer-reviewed clinical validation.

The business is currently in significant financial distress. AIM trading has been suspended since May 8, 2026, the board has engaged restructuring advisors, and management is exploring strategic options including a potential sale of the U.S. operating subsidiary. The company has funded ongoing operations through a series of small, related-party debt facilities from Mount Sinai-affiliated entities and a £5 million convertible loan note facility, in lieu of equity capital. Against this backdrop, customer-facing commercial activity — the J&J extension and TrialSet CRO implementations — has continued but at pilot scale relative to enterprise peer benchmarks.

Name

Trellus Health

Legal name

Trellus Health Inc.

Website

https://trellushealth.com

Company type

Public

Founded year

2020

Operating status

Operating

Headcount range

11–50 employees

Short description

Trellus Health is a digital health company that operates the Trellus Elevate® behavioral intelligence platform, built on the GRITT™ resilience methodology licensed from Mount Sinai. It serves pharmaceutical companies, CROs, and health plans with behavioral activation tools for IBD chronic care, clinical trial readiness, and patient support programs.

Ownership category

akta.pro rank

Product category

Digital Health Platform

NAICS

Computer Systems Design and Related Services (54151), Computer Systems Design Services (541512)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

eCOA/ePRO/eDiary & Patient-Facing Data Collection (HLACAOAB)

Keywords

• Behavioral health platform
• Digital chronic care
• Clinical trial readiness
• Patient support programs
• IBD condition management

Headquarters

HQ city

White Plains

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Operations, Marketing or Sales, Technology or R&D, Others

Revenue model

1. Clinical Trial Services: Trellus TrialSet vertical providing behavioral readiness activation for clinical trial recruitment and retention. Revenue generated through fixed monthly management fees and per-program contracts with pharmaceutical sponsors. Company reports progress with ICON plc for Takeda-sponsored trials and PSI Inc for Sanofi-sponsored late-stage trials.
2. Patient Support Program Services: Trellus Elevate digital platform provided to healthcare organizations for patient support programs. Extended contract with Johnson & Johnson Health Care Systems through mid-2026 with fixed monthly management fee structure.
3. Digital Chronic Condition Management: Platform-based services for employers and health plans using GRITT™ resilience-based methodology and Trellus Elevate® platform for remote telemedicine care. Initially focused on IBD (Crohn's Disease and ulcerative colitis).

Go-to-market motion2 records

Distribution channels3 records

Marketing channels5 records

Core offering

Trellus Health sells the Trellus Elevate® behavioral intelligence platform, a digital health solution that activates behavioral readiness for therapy success across clinical trials and commercial patient support programs. Built on the GRITT™ resilience-based methodology exclusively licensed from the Icahn School of Medicine at Mount Sinai, the platform is initially focused on inflammatory bowel disease (IBD) and is delivered through a HIPAA-compliant web portal, iOS/Android apps, and enterprise contracts with pharma companies, CROs, and health plans.

Product overview

Trellus Health offers Trellus Elevate® — a unified behavioral intelligence platform built on a clinically validated resilience-based methodology developed at Mount Sinai. The platform activates behavioral readiness for therapy success across clinical trials and commercial patient support programs. Key modules include Trellus TrialSet™ for clinical trial recruitment and readiness, and Trellus Elevate® for Patient Support Programs that integrates as a behavioral layer within existing PSP ecosystems. The GRITT™ methodology (exclusively licensed from ISMMS) underpins the platform's approach to chronic condition resilience building. Members access the platform via the Trellus Elevate™ web portal and mobile app (iOS/Android).

Differentiator

Problem solved

Functional benefit

Brands

• Trellus Elevate: A behavioral intelligence platform designed to build resilience, strengthen engagement, and improve readiness across treatment and clinical trial journeys for chronic condition management.
• Trellus TrialSet

Products and services

• Trellus Elevate® Behavioral Intelligence Platform A behavioral intelligence platform that activates behavioral readiness for therapy success, improving recruitment, retention, and real-world engagement across clinical trials and patient support programs. Built on a clinically validated, resilience-based methodology, it identifies readiness barriers and strengthens skills needed to sustain participation and persistence. Delivered to enterprise customers in pharma, CRO, health plan, and employer channels.
• Trellus TrialSet™
• Trellus Elevate® for Patient Support Programs A behavioral activation layer integrated into patient support program and hub ecosystems that strengthens activation, adherence, and persistence without adding clinical services. Designed to align with pharmaceutical compliance frameworks, it focuses on behavioral and self-management skills throughout the treatment journey for pharmaceutical PSP and hub clients.

Quantifiable outcome

• Over 85% reduction in unplanned healthcare use
• +5 more outcomes

Named customers3 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Three partnerships are on record, tiered flagship and core.

• Johnson & Johnson Health Care SystemsflagshipStrategic or Co-development Partner · 18 February 2026Six-month contract extension through mid-2026 to continue providing Trellus Elevate digital platform for inflammatory bowel disease patients. Extension follows successful pilot phase beginning January 2025 with achievement of engagement and satisfaction metrics. Program expanded patient enrollment channels. Same economic terms including fixed monthly management fee.
• ICON plccoreStrategic or Co-development PartnerTrialSet vertical implementation for Takeda-sponsored immunology trial. Represents CRO partnership for clinical trial behavioral activation deployment.
• PSI Inc.coreStrategic or Co-development PartnerTrialSet implementation for two Sanofi-sponsored late-stage clinical trials. CRO partnership for behavioral readiness activation in late-stage pharmaceutical trials.

Scale indicators10 records

Recent moves6 records

Expansion highlights4 records

Emerging players

• Meru Health: Digital mental health and chronic condition management platform offering therapist-led online programs with employer and health plan distribution. Comparable in digital behavioral health delivery model and health plan/employer GTM.
• Curebase: Decentralized clinical trial platform enabling patient recruitment and remote trial conduct for sponsors. Comparable to Trellus TrialSet in clinical trial patient engagement, though broader across therapeutic areas.
• Big Health: Digital therapeutics company focused on behavioral health conditions (insomnia, anxiety) with employer and health plan distribution. Comparable to Trellus Elevate's health plan and employer GTM and behavioral activation methodology, though in mental health rather than GI.

Direct peers

• Mahana Therapeutics: Developer of prescription digital therapeutics for IBS and other gastrointestinal conditions, with FDA authorization for its Parallel digital therapeutic. Directly comparable to Trellus's regulated, clinically validated behavioral approach for chronic GI conditions.
• Click Therapeutics: Prescription digital therapeutics company partnering with pharma to develop software-based treatments across multiple therapeutic areas including chronic conditions. Comparable in clinical rigor, pharma partnership model, and digital therapeutic regulatory pathway.
• Science 37: Decentralized clinical trial technology platform enabling remote patient participation and improving trial recruitment/retention. Overlaps with Trellus TrialSet's clinical trial patient readiness and retention focus.
• Medable: Patient-centric clinical trial technology platform enabling decentralized trials with eCOA/ePRO and patient engagement tools. Direct competitor in clinical trial patient readiness and digital data collection, intersecting with Trellus TrialSet.
• Happify Health: Digital behavioral health platform offering evidence-based mental health and chronic condition management solutions to pharma and payers. Closely comparable to Trellus Elevate's behavioral intelligence and activation framework across chronic conditions.
• Bold Health (Bold Care): Digital therapeutics company focused specifically on gastrointestinal conditions including IBS, offering digital behavioral interventions very similar to Trellus's IBD focus. Direct competitor in the GI behavioral health space with comparable patient-facing digital program model.

Broad incumbents

• Veeva Systems: Enterprise cloud software provider for life sciences with clinical trial management and patient engagement capabilities. Serves the same pharma customers as Trellus with broader portfolio including CTMS and Vault platforms.

Market position

Weaknesses5 records

Competitive moat4 records

Key risks3 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/trellushealth/about/?viewAsMember=true
• Xx.com/trellushealth

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles10 records

Subsidiaries1 record

Funding overview

Funding rounds4 records

Investors3 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Trellus Health