Base Pair Biotechnologies
Base Pair Biotechnologies is a Pearland, Texas-based CRO providing custom aptamer discovery and development services using proprietary SELEX and Multiplex SELEX technology, serving academic researchers, pharmaceutical companies, and diagnostic developers globally.
- Company typePrivate
- Founded2017
- HeadquartersPearland, United States
- Headcount1–10
- GTM typeB2B
- OfferingServices
What Base Pair Biotechnologies does
Base Pair Biotechnologies is a Pearland, Texas-based contract research organization that provides custom aptamer discovery and development services to academic, pharmaceutical, diagnostic, food-safety, and environmental-testing clients. The company builds on SELEX (Systematic Evolution of Ligands by Exponential Enrichment) chemistry and proprietary oligonucleotide libraries of approximately 10^15 unique sequences to select DNA and RNA aptamers against a wide range of targets, with documented specialization in small molecules, toxic compounds, and non-immunogenic targets that are difficult to address with antibodies. Its differentiated platform centers on patented Multiplex SELEX and VENNmultiplex™ SELEX methods that enable simultaneous selection of aptamers to up to 30 targets in a single project, supported by a proprietary bioinformatics pipeline that evaluates up to 10 million sequences per selection.
Base Pair Biotechnologies firmographics
Firmographics- Name
- Base Pair Biotechnologies
- Legal name
- Base Pair Biotechnologies
- Website
- https://basepairbio.com
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- Base Pair Biotechnologies is a Pearland, Texas-based CRO providing custom aptamer discovery and development services using proprietary SELEX and Multiplex SELEX technology, serving academic researchers, pharmaceutical companies, and diagnostic developers globally.
- Ownership category
- akta.pro rank
Base Pair Biotechnologies industry classification
Industry- Product category
- Custom Aptamer Discovery & Development Services
- NAICS
- Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- SIC
- Laboratory Analytical Instruments (3826)
- akta.pro primary industry
- Library & Diversity Generation Platforms (display libraries, DNA-encoded libraries for biologics, variant libraries) (HLAAAIAL)
- akta.pro secondary industry
- Target Identification & Validation Platforms (omics-driven, chemoproteomics, genetic validation) (HLAAAIAI)
Keywords
Where Base Pair Biotechnologies is headquartered
LocationHeadquarters
- HQ city
- Pearland
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Base Pair Biotechnologies business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure
Revenue model
- Custom Aptamer Discovery & Development: Full-service custom aptamer discovery and development from initial consultation through selection, screening, and maturation. Projects follow a phased approach (Consult, Design, Select, Screen, Apply, Evaluate, Mature) with customized strategies for each client. Pricing and timelines provided in project proposals.
- Aptamer Bioinformatics Services: Next generation sequencing and bioinformatics services offered as independent aptamer services. Analysis of sequenced libraries using proprietary methods to identify best aptamer candidates.
- Catalog Aptamers & Reagents: Pre-developed aptamers to a wide range of targets available for research purposes through online ordering system. Webstore currently noted as inactive; direct contact for inquiries.
- Assay Development Services: Aptamer-based assay development for lateral flow assays (LFA), ELISA-like assays (ELASA), dot blots, western blots, and other applications. Includes optimization services for aptamer modifications.
- Custom Cell Culture Services: Mammalian and bacterial cell culture services including cell line expansion, custom engineering (transfections, viral production), cell-based assay development, recombinant protein expression, and plasmid preparation.
- Affinity Determination Services: BLI (Bio-Layer Interferometry) and ITC (Isothermal Titration Calorimetry) services for characterizing aptamer-target binding characteristics. Available as part of discovery projects or stand-alone services.
- Aptamer Maturation Services: Post-selection optimization including truncation analysis, nucleotide replacement, modified nucleotide substitutions, aptamer dimerization, and conjugation services for enhanced stability and functionality.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Multi-year contract | Custom project-based pricing |
Go-to-market motion2 records
Distribution channels3 records
Marketing channels6 records
Base Pair Biotechnologies product offering
Product offeringCore offering
Base Pair Biotechnologies provides custom aptamer discovery, development, and characterization services using proprietary SELEX-based selection technology. Its Multiplex SELEX platform enables simultaneous selection of aptamers to up to 30 targets per project, with supporting services including bioinformatics analysis of up to 10 million sequences, affinity determination (BLI and ITC), aptamer maturation, and assay development for diagnostics and therapeutics. The company also sells catalog aptamers and reagents and provides custom cell culture services.
Product overview
Base Pair Biotechnologies offers a comprehensive suite of aptamer discovery and development services organized around their core SELEX-based selection technology. The portfolio centers on Custom Aptamer Discovery & Development as the primary service, supplemented by proprietary Multiplex SELEX & VENNmultiplex™ SELEX technology for multi-target selection. Supporting services include Bioinformatics for Aptamer Selection, Affinity Determination (BLI), and NGS for Aptamers for sequencing needs. Post-selection optimization is available through Aptamer Maturation services. The company also provides Assay Development Services for downstream applications including LFAs, ELASA, and western blots, plus Catalog Aptamers & Reagents for off-the-shelf needs. Additional offerings include Custom Cell Culture Services, Isothermal Titration Calorimetry (ITC) Binding Services, and the AptaTracker™ cloud-based project management tool. Specialized product lines include COVID-19 Aptamers.
Differentiator
Problem solved
Functional benefit
Brands
- AptaTracker™ Tool: Cloud-based collaborative project management tool for aptamer discovery projects
- Multiplex SELEX™
- VENNmultiplex™ SELEX
Products and services
- Custom Aptamer Discovery & Development Comprehensive aptamer selection and development service using SELEX technology, covering all phases from consultation through maturation. Enables selection to up to 30 targets simultaneously via proprietary Multiplex SELEX technology. Aimed at academic researchers, pharmaceutical/biotech companies, and diagnostic developers.
- Bioinformatics for Aptamer Selection Proprietary bioinformatics analysis that evaluates up to 10 million sequences using clustering and alignment methods to identify optimal aptamer candidates from sequenced libraries, evaluating sequence length, frequency count, predicted stability, and sequence motifs.
- Affinity Determination (BLI) Bio-Layer Interferometry (BLI) service measuring binding characteristics of aptamer-target interactions, calculating association rate, dissociation rate, and binding affinity. Functions in complex buffers and sample matrices.
- Isothermal Titration Calorimetry (ITC) Binding Services High-resolution ITC services providing direct measurements of binding affinity (Kd), enthalpy (ΔH), entropy (ΔS), and stoichiometry (n) for biomolecular interactions, available as part of discovery projects or as a stand-alone service.
- Aptamer Maturation Services Post-selection optimization including truncation analysis, nucleotide replacement, modified nucleotide substitutions, aptamer dimerization, and conjugation services to enhance aptamer stability, immobilization, and functionality.
- Catalog Aptamers & Reagents Pre-developed aptamers to a wide range of targets available for purchase for research purposes, including a dedicated COVID-19 aptamer product line. Webstore currently noted as inactive; customers contact [email protected] for inquiries.
- Assay Development Services Aptamer-based assay development for lateral flow assays (LFA), ELISA-like assays (ELASA), dot blots, western blots, and other applications, including optimization services for aptamer modifications.
- Custom Cell Culture Services
- NGS for Aptamer Selection Next Generation Sequencing service for aptamer pools, providing high-throughput sequencing data paired with proprietary bioinformatics analysis to characterize selection results.
- AptaTracker™ Tool Cloud-based collaborative project management tool providing real-time status updates, document sharing, and interactive activity streams for Base Pair scientists and client project participants.
- Multiplex SELEX & VENNmultiplex™ SELEX Patented multiplex aptamer selection technology enabling simultaneous selection of aptamers to multiple targets in a single project, identifying specific- and pan-binders using proprietary DNA barcoding and Venn diagram analysis.
Quantifiable outcome
- Selection time of 1-3 months compared to 4-6 months for traditional antibody development
- +3 more outcomes
Companies that use Base Pair Biotechnologies
Customer profileSegments5 records
Ideal customer profiles4 records
Base Pair Biotechnologies technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature7 records
Base Pair Biotechnologies partnerships and signals
Strategic signalScale indicators3 records
Recent moves6 records
Expansion highlights6 records
Base Pair Biotechnologies competitors and assessment
Company assessmentDirect peers
- SomaLogic (Standard BioTools): SomaLogic operates a large-scale aptamer-based proteomics platform (SOMAmers) and offers proteomic discovery services to pharma and academic researchers. It is the most direct large-scale aptamer discovery peer and serves overlapping customer segments in biomarker and drug discovery.
- NeoVentures Biotechnology: NeoVentures is a CRO specializing in custom aptamer selection and development for diagnostics, therapeutics, and research applications. Like Base Pair, it sells custom services rather than a therapeutic pipeline, with overlapping aptamer-discovery capabilities.
- Aptagen: Aptagen is a custom aptamer development company offering aptamer selection and synthesis services to academic and industrial researchers. It competes head-to-head with Base Pair for custom aptamer discovery contracts.
- Creative Biolabs: Creative Biolabs is a CRO offering antibody, aptamer, and other biologics discovery services. Its aptamer discovery and maturation services directly overlap with Base Pair's custom selection and post-selection optimization offerings.
- TriLink BioTechnologies (Maravai LifeSciences): TriLink manufactures oligonucleotides and offers custom nucleic acid services including aptamer-related synthesis. It is comparable to Base Pair in serving the nucleic-acid-based reagent and discovery market, though with a manufacturing-oriented model.
- ATDBio (Biotage): ATDBio (now part of Biotage) specializes in synthetic oligonucleotide chemistry and custom nucleic-acid services including aptamer-related oligonucleotides. It is comparable to Base Pair on the nucleic-acid custom-synthesis side of the workflow.
Broad incumbents
- Bio-Techne: Bio-Techne is a large life-sciences tools company that sells aptamer-based reagents (e.g., via its ProteinSimple and ExoDx franchises) alongside a broad proteomics and immunoassay portfolio. It is a broad incumbent that overlaps with Base Pair in supplying aptamer-based assay content to researchers.
- Charles River Laboratories: Charles River is a global CRO offering biologics discovery, including antibody and custom reagent development. While not aptamer-specialized, it competes for the same custom-discovery budgets from pharma and academic clients.
- AbCellera Biologics: AbCellera is a biologics-discovery platform focused on antibody discovery via single-cell screening and partnerships with pharma. As a broader incumbent in custom biologics discovery, it competes with Base Pair for drug-discovery and reagent-development budgets.
Emerging players
- Twist Bioscience: Twist Bioscience provides high-throughput DNA synthesis and antibody-oligonucleotide libraries used in biologic discovery workflows. It intersects with Base Pair through synthetic DNA libraries that can be leveraged in SELEX-style aptamer discovery.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights6 records
Customer concentration
Base Pair Biotechnologies social profiles
Digital presenceBase Pair Biotechnologies financial estimates
Financial estimateRevenue estimate
Valuation estimate
Base Pair Biotechnologies leadership team
Management profileNumber of profiles
Profiles1 record
Base Pair Biotechnologies funding detail
Funding detailFunding overview
Funding rounds2 records
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Base Pair Biotechnologies M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Base Pair Biotechnologies
What does Base Pair Biotechnologies do?
Base Pair Biotechnologies provides custom aptamer discovery, development, and characterization services using proprietary SELEX-based selection technology. Its Multiplex SELEX platform enables simultaneous selection of aptamers to up to 30 targets per project, with supporting services including bioinformatics analysis of up to 10 million sequences, affinity determination (BLI and ITC), aptamer maturation, and assay development for diagnostics and therapeutics. The company also sells catalog aptamers and reagents and provides custom cell culture services.
Is Base Pair Biotechnologies a public or private company?
Base Pair Biotechnologies is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Base Pair Biotechnologies founded?
Base Pair Biotechnologies was founded in 2017. It employs 1 to 10 people.
Where is Base Pair Biotechnologies based?
Base Pair Biotechnologies is headquartered in Pearland, United States, in the North America region.
How does Base Pair Biotechnologies make money?
Seven revenue lines are on record. Custom Aptamer Discovery & Development is the primary driver. The others are aptamer Bioinformatics Services, catalog Aptamers & Reagents, assay Development Services, custom Cell Culture Services, affinity Determination Services and aptamer Maturation Services.
Who are Base Pair Biotechnologies's main competitors?
Direct peers on record are SomaLogic (Standard BioTools), NeoVentures Biotechnology, Aptagen, Creative Biolabs, TriLink BioTechnologies (Maravai LifeSciences) and ATDBio (Biotage). Broad incumbents are Bio-Techne, Charles River Laboratories and AbCellera Biologics. Twist Bioscience is listed as an emerging player.
Does Base Pair Biotechnologies have an API?
No public API is recorded for Base Pair Biotechnologies.
What industry is Base Pair Biotechnologies in?
Base Pair Biotechnologies's product category is Custom Aptamer Discovery & Development Services. Its primary akta.pro industry code is HLAAAIAL, Library & Diversity Generation Platforms (display libraries, DNA-encoded libraries for biologics, variant libraries), with a secondary code of HLAAAIAI, Target Identification & Validation Platforms (omics-driven, chemoproteomics, genetic validation). Its NAICS code is 541714 and its SIC code is 3826.