UpSurgeOn
UpSurgeOn is a Milan-based MedTech company founded in 2017 that builds hybrid surgical simulation platforms combining physical anatomical models with AR/VR, real-time telemetry, and educational software for neurosurgery, spine, and adjacent surgical training. It serves surgical trainees, medical institutions, and MedTech companies across 110+ countries.
- Company typePrivate
- Founded2017
- HeadquartersMilan, Italy
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What UpSurgeOn does
UpSurgeOn is a Milan-based MedTech company founded in 2017 that develops hybrid surgical simulation platforms combining hyper-realistic physical anatomical models with augmented reality (AR), virtual reality (VR), and digital analytics tools for surgical training. The company's core technology — patent-pending via the Academy Platform Architecture filed in 2019 — integrates physical simulator workstations (Brainbox hardware including the Spine Series with seven+ specialized boxes such as Endoscopic LumbarBox, Anterior CervicalBox, and OccipitocervicalBox, plus the Cranial Series, Skill Series, Fluorescence Series, and Anatomy Series) with mobile applications (Neurosurgery App for Mobile X-Ray, Spine Deformity App) and the UpSurgeOn Academy educational portal. Embedded sensors in physical simulators capture real-time surgical performance metrics via Bluetooth, enabling objective measurement of Cobb angle, vertebral derotation, and length recovery during spinal deformity correction. The platform is compatible with DICOM-format CT scans, surgical navigation systems, and fluoroscopy, allowing trainees to practice navigation-guided procedures with fiducial marker alignment.
UpSurgeOn serves three primary customer segments: individual surgical trainees and residents seeking cadaver-free practice, educational and medical institutions (universities, hospitals, training centers) establishing simulation labs, and MedTech companies using the platform for product demonstrations and sponsored training courses. The company monetizes through a mix of one-time hardware sales with recurring disposable consumables (spine/skin levels), training courses and services at its SpaceUp Surgical Training Center in Milan, custom MedTech partnership projects, and a direct-to-consumer e-commerce storefront at store.upsurgeon.com. Distribution combines direct enterprise sales (quote-based), a strategic exclusive distribution partnership with Inovus Medical for the USA, UK, and Ireland, and digital channels. The company reports commercial presence across 110+ countries with 500+ scientific institution partnerships and 300+ MedTech company relationships.
The company has raised over €8 million in total institutional funding, including a €3 million round in 2022 and a €5 million Series A in March 2026 led by CDP Venture Capital with participation from SIMEST, Deep Blue Ventures, Azimut Libera Impresa SGR, and FBH S.p.A. The Series A proceeds are earmarked for global expansion and entry into new surgical specialties including orthopedics and ENT. UpSurgeOn is supported by EU H2020 Research and Innovation Programme grant n. 880895 and received the San Camillo-Forlanini National Innovation Prize in 2025. The leadership team includes CEO Federico Nicolosi, founder Giannantonio Spena, and Chairman Paolo Raimondo.
UpSurgeOn firmographics
Firmographics- Name
- UpSurgeOn
- Legal name
- UpSurgeOn Srl
- Website
- https://upsurgeon.com
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- UpSurgeOn is a Milan-based MedTech company founded in 2017 that builds hybrid surgical simulation platforms combining physical anatomical models with AR/VR, real-time telemetry, and educational software for neurosurgery, spine, and adjacent surgical training. It serves surgical trainees, medical institutions, and MedTech companies across 110+ countries.
- Ownership category
- akta.pro rank
UpSurgeOn industry classification
Industry- Product category
- Surgical Simulation and Medical Training
- NAICS
- Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Professional and Management Development Training (611430), Technical and Trade Schools (61151)
- SIC
- Surgical & Medical Instruments & Apparatus (3841), Electromedical & Electrotherapeutic Apparatus (3845), Services-Educational Services (8200)
- akta.pro primary industry
- Healthcare & Clinical Simulation (Surgery, Nursing, EMT, Patient Interaction) (EDAFAJAC)
- akta.pro secondary industries
- Digital Twins & Scenario-Based Systems Training (Equipment/Process Simulators) (EDAFAJAJ), Surgical Navigation, Robotics & Patient-Matched Instrumentation (Ortho/Spine) (HLAHAEAL), Surgical Navigation, Tracking & Intraoperative Guidance (Ortho/Neuro/ENT) (HLAHADAG)
Keywords
Where UpSurgeOn is headquartered
LocationHeadquarters
- HQ city
- Milan
- HQ country
- Italy
- HQ region
- Europe
Offices2 records
Markets served
UpSurgeOn business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales, Supply Chain, Infrastructure
Revenue model
- Physical Simulation Hardware Sales: Sale of physical anatomical simulators (Brainbox series, Spine series, Cranial series, etc.) as reusable workstations with disposable replaceable levels. Customers (institutions, hospitals) purchase one-time workstation components and recurring disposable spine/skin level modules.
- Digital Products and Apps: Sale of software applications including the Neurosurgery App (Mobile X-Ray), Spine Deformity App, and other training apps for iOS/Android. The Academy platform provides educational content integrated with hardware.
- Training Courses and Services: Psychomotor Skills Training Courses, hands-on surgical training workshops, and sponsored courses offered at SpaceUp surgical training center or organized at partner institutions.
- MedTech Company Partnerships: Custom projects, product development collaborations, and sponsored courses with medical device companies seeking to showcase their technologies on UpSurgeOn's simulation platform.
- B2C E-commerce: Direct-to-consumer sales of simulators, disposable parts, and accessories through the UpSurgeOn online store for individual trainees, residents, and medical professionals.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Multi-year contract | Quote-based institutional pricing for simulation hardware |
| Unit Pricing | Pay-as-you-go | Basic Spine Instruments Set - limited time offer at 50% discount |
| Other | Pay-as-you-go | Individual consumer purchases via e-commerce store |
Go-to-market motion3 records
Distribution channels4 records
Marketing channels8 records
UpSurgeOn product offering
Product offeringCore offering
UpSurgeOn designs, manufactures, and sells hyper-realistic physical surgical simulators (Cranial, Spine, Skill, Fluorescence, and Anatomy series) paired with AR/VR-enabled mobile applications and the UpSurgeOn Academy educational platform. The platform enables cadaver-free psychomotor skill development for neurosurgery, spine, and other surgical specialties, capturing real-time telemetry and objective performance metrics. Revenue is generated through hardware sales, recurring consumables (disposable spine/skin levels), software/app subscriptions, training courses at SpaceUp in Milan, and MedTech partnership programs.
Product overview
UpSurgeOn is a Milan-based deep-tech MedTech company offering a comprehensive surgical simulation platform that combines physical anatomical models with virtual reality (VR), augmented reality (AR), and digital tools. The product portfolio centers on the hybrid simulation technology approach, which includes physical simulator boxes (Cranial Series, Spine Series with 7+ distinct boxes including Endoscopic LumbarBox, Posterior LumbarBox, Anterior CervicalBox, ThoracolumbarBox, OccipitocervicalBox, and Spine Deformity Platform), mobile applications (Neurosurgery App, Spine Deformity App), and the UpSurgeOn Academy educational platform. The company serves neurosurgery, spine surgery, plastic surgery, orthopedics, and ENT specialties across 110+ countries, supporting institutions, trainees, and MedTech companies with cadaver-free psychomotor skill training.
Differentiator
Problem solved
Functional benefit
Brands
- SpaceUp: Surgical Training Center operated by UpSurgeOn in Milan, Italy for hands-on training courses.
Products and services
- Cranial Series A line of hyper-realistic physical simulators for cranial neurosurgery procedures, combining life-like anatomical models with digital tools for immersive training. Designed for neurosurgery residents, practicing surgeons, and institutional training programs.
- Spine Series Complete training system for spine surgery covering cervical, thoracic, and lumbar procedures with multiple simulator boxes for different approaches and pathologies. Aimed at spine surgery residents, fellows, and institutional training labs.
- Endoscopic LumbarBox Spine endoscopic simulator featuring hyper-realistic anatomy, modular spine level inserts for herniations, stenosis, and vertebroplasty pathologies, plus integrated water management. Designed for spine surgeons training in endoscopic techniques.
- Endoscopic Posterior CervicalBox Spinal surgery simulator for posterior cervical approaches (C2-C6) supporting microdecompression and fixation procedures, with water management and integrated mobile X-ray. Used by spine surgeons and trainees for cervical endoscopic practice.
- Anterior CervicalBox Surgical simulator for anterior cervical approaches featuring hyperrealistic skin with bleeding, multiple layers of suturable tissue, and support for discectomies, corpectomies, and instrumented surgery from C3 to C7.
- Posterior LumbarBox Spinal surgery simulator for PLIF, TLIF, laminectomies, and instrumented surgeries covering L1 to S5, with multiple discectomy and corpectomy training scenarios.
- Anterior-Lateral LumbarBox Spinal surgery simulator for anterior, oblique, and lateral approaches to the lumbar spine (L2-S1) with modular disposable skin and spine levels for ALIF, OLIF, and XLIF procedures.
- ThoracolumbarBox High-fidelity surgery practice simulator covering T8-S1 with modular technology supporting open and minimally invasive approaches, decompression, fixation, and pedicle screw fixation training.
- OccipitocervicalBox Spinal surgery simulator for posterior approaches to the occipitocervical spine (C0-T3), supporting multilevel laminectomies, laminoplasties, flavectomies, and occipito-cervical fixation. Fully compatible with CT scans in DICOM format.
- Spine Deformity Platform Advanced spine deformity simulator with real-time telemetry, Cobb angle measurement, vertebral derotation tracking, and length recovery metrics via a Bluetooth-connected app for iPad and Android tablets. Enables practice of posterior column osteotomies (e.g., Smith-Petersen) and Direct Vertebral Rotation techniques.
- Skill Series Physical training simulators for microsurgical skills including suture techniques and anastomoses. Used by surgical trainees learning fine motor and suturing skills.
- Fluorescence Series Training technologies for fluorescence-based neurosurgical procedures, enabling practice of ICG (indocyanine green) angiography and other fluorescence-guided techniques.
- Anatomy Series High-fidelity physical models dedicated to the study of anatomy, serving as the foundational step before surgical training with detailed anatomical structures.
- Lab-in-a-Box Turnkey infrastructure package that enables institutions to transform any room into a Surgical Training Lab, providing the components needed for comprehensive simulation-based training programs.
- Neurosurgery App Mobile application for Apple devices that enables Mobile X-Ray simulation, real-time fluoroscopic navigation, and trajectory planning integrated with UpSurgeOn physical simulators.
- Spine Deformity App Telemetry command center app for iPad and Android tablets that streams live Cobb angles, derotation percentages, and length recovery metrics via Bluetooth, featuring interactive 3D digital twin visualization and gamified performance challenges.
- UpSurgeOn Academy Educational portal integrating mobile apps, augmented reality, and physical Brainbox simulators into a high-tech curriculum for anatomical knowledge, surgical skills, and procedural ability. Includes theoretical knowledge, step-by-step guides, and video tutorials.
- SpaceUp Surgical Training Center Physical training center in Milan, Italy offering hands-on surgical training courses for various procedures including microsuture techniques and psychomotor skills workshops. Bookable as discrete training events by individuals and institutions.
- Psychomotor Skill Training Courses Hands-on training courses focused on psychomotor skill augmentation using life-like cadaver-free simulations combined with AR/VR to enhance surgical learning curves and expedite mastery, delivered at SpaceUp or partner institutions.
Quantifiable outcome
- Operates in 110+ countries with 500+ scientific institutions and 300+ MedTech companies using the platform
- +3 more outcomes
Companies that use UpSurgeOn
Customer profileNamed customers5 records
Segments3 records
Ideal customer profiles3 records
UpSurgeOn technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration6 records
Feature9 records
UpSurgeOn partnerships and signals
Strategic signalPartnerships
One partnership is on record.
- Inovus MedicalcoreGlobal strategic partnership announced January 2025. Inovus Medical serves as the official distributor for UpSurgeOn in the USA, UK, and Ireland. UpSurgeOn technologies are also marketed alongside Inovus Medical's general surgery and gynaecology simulation products on their website, indicating broader integration. Inovus Medical is a UK-based surgical training simulator company.
Scale indicators7 records
Recent moves6 records
Expansion highlights6 records
UpSurgeOn competitors and assessment
Company assessmentDirect peers
- Surgical Science: Stockholm-based market leader in virtual reality surgical simulation, offering simulators across general surgery, endovascular, laparoscopy, and increasingly spine/neurosurgery — the most direct cross-specialty competitor to UpSurgeOn for institutional simulation procurement.
- VirtaMed: Swiss developer of high-fidelity surgical simulators across orthopedics, OB/GYN, urology, and laparoscopy. Overlaps with UpSurgeOn in offering realistic procedural training boxes with validated metrics, targeting the same institutional and trainee buyer base.
- Inovus Medical: UK-based surgical and gynaecological simulation company; simultaneously UpSurgeOn's official distributor for USA/UK/Ireland and a peer maker of physical laparoscopic and gynaecology simulators. Operational and channel overlap makes it the closest regional peer.
Broad incumbents
- CAE Healthcare: Division of CAE Inc. providing patient, ultrasound, and interventional simulation for hospitals, nursing schools, and medical device OEMs. A broad incumbent that competes for the same hospital training-lab budget lines that UpSurgeOn targets via its Lab-in-a-Box.
- Simbionix (3D Systems Healthcare): Long-established surgical simulation brand owned by 3D Systems, covering endovascular, GI/bronchoscopy, laparoscopy, and arthroscopy. Competes for the same multi-specialty hospital simulation budgets that UpSurgeOn now addresses in orthopedics and ENT.
- Mentice: Sweden-listed endovascular and neurovascular interventional simulation vendor, with growing neurovascular modules. Specialized overlap with UpSurgeOn on the neuro side of the institutional market.
Emerging players
- FundamentalVR: UK-based immersive VR surgical training platform with haptics; targets pharma/MedTech-sponsored training and academic institutions. Comparable to UpSurgeOn's digital/AR layer (Apps, Academy) on the VR training side.
- Osso VR: US-based VR surgical training platform focused on orthopedics and device-specific procedure training for both surgeons and MedTech customers. Comparable emerging player around AR/VR-only surgical education experiences.
- Anatomage: US-based maker of the Anatomage Table and virtual cadaver systems, used by medical schools and residency programs. Adjacent peer through competing for the digital anatomy education budget that sits alongside surgical simulators.
- Biomodex: France/US maker of 3D-printed patient-specific anatomical models and synthetic tissue platforms used for procedural rehearsal and training. Comparable to the physical-model layer of UpSurgeOn's hybrid stack, particularly for neurosurgery and spine pathology.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights6 records
Customer concentration
UpSurgeOn social profiles
Digital presenceUpSurgeOn financial estimates
Financial estimateRevenue estimate
Valuation estimate
UpSurgeOn leadership team
Management profileNumber of profiles
Profiles3 records
UpSurgeOn funding detail
Funding detailFunding overview
Funding rounds3 records
Investors6 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
UpSurgeOn M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about UpSurgeOn
What does UpSurgeOn do?
UpSurgeOn designs, manufactures, and sells hyper-realistic physical surgical simulators (Cranial, Spine, Skill, Fluorescence, and Anatomy series) paired with AR/VR-enabled mobile applications and the UpSurgeOn Academy educational platform. The platform enables cadaver-free psychomotor skill development for neurosurgery, spine, and other surgical specialties, capturing real-time telemetry and objective performance metrics. Revenue is generated through hardware sales, recurring consumables (disposable spine/skin levels), software/app subscriptions, training courses at SpaceUp in Milan, and MedTech partnership programs.
Is UpSurgeOn a public or private company?
UpSurgeOn is a private company. It is classified as venture growth investor backed and is currently operating.
When was UpSurgeOn founded?
UpSurgeOn was founded in 2017. It employs 11 to 50 people.
Where is UpSurgeOn based?
UpSurgeOn is headquartered in Milan, Italy, in the Europe region.
How does UpSurgeOn make money?
Five revenue lines are on record. Physical Simulation Hardware Sales are the primary driver. The others are digital Products and Apps, training Courses and Services, medTech Company Partnerships and B2C E-commerce.
Who are UpSurgeOn's main competitors?
Direct peers on record are Surgical Science, VirtaMed and Inovus Medical. Broad incumbents are CAE Healthcare, Simbionix (3D Systems Healthcare) and Mentice. Emerging players are FundamentalVR, Osso VR, Anatomage and Biomodex.
Does UpSurgeOn have an API?
No public API is recorded for UpSurgeOn.
What industry is UpSurgeOn in?
UpSurgeOn's product category is Surgical Simulation and Medical Training. Its primary akta.pro industry code is EDAFAJAC, Healthcare & Clinical Simulation (Surgery, Nursing, EMT, Patient Interaction), with a secondary code of EDAFAJAJ, Digital Twins & Scenario-Based Systems Training (Equipment/Process Simulators). Its NAICS code is 334510 and its SIC code is 3841.