Name

Duoning Biotech

Legal name

上海多宁生物科技股份有限公司

Website

https://duoningbio.com

Company type

Private

Founded year

2007

Operating status

Operating

Headcount range

501–1,000 employees

Ownership category

akta.pro rank

Product category

Bioprocess Equipment and Consumables

NAICS

Analytical Laboratory Instrument Manufacturing (334516), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Laboratory Analytical Instruments (3826), Laboratory Apparatus & Furniture (3821)

akta.pro primary industry

Upstream Bioprocessing Systems & Equipment (cell culture/fermentation, bioreactors, feeds/media) (HLAAAJAA)

akta.pro secondary industries

Cell Culture & Bioprocess Lab Equipment (Bioreactors, Single-Use Systems, Controllers) (HLAGAIAG), Bioprocess Consumables & Reagents (resins, membranes, media components, buffers) (HLAAAJAI), Downstream Processing & Purification Technologies (chromatography, filtration, centrifugation) (HLAAAJAB), Single-Use Technologies (SUT) & Disposable Fluid Management (bags, assemblies, connectors) (HLAAAJAC), Viral Clearance, Sterile Filtration & Bioburden Control Technologies (HLAAAJAL), Raw Materials & Critical Reagents Supply Services (media, resins, single-use) (HLAAAKAI)

Keywords

• Bioprocess solutions
• Cell culture media
• Single-use bioreactors
• Chromatography media
• Bioprocess filtration

Headquarters

HQ city

Shanghai

HQ country

China

HQ region

Asia

Offices8 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Supply Chain, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Equipment and Hardware Sales: Sale of capital equipment including bioreactors, high-pressure homogenizers, filtration systems, laboratory equipment, and pure water systems
2. Consumables and Single-Use Products: Recurring revenue from consumables including cell culture media, chromatography media, fluid management consumables, tubing, filters, and reagents
3. Compliance and Technical Services: Validation services, consulting, and technical support services

Go-to-market motion2 records

Distribution channels3 records

Marketing channels6 records

Core offering

Duoning Biotech manufactures and supplies a one-stop bioprocess solutions platform for biopharmaceutical manufacturers, covering bioreactors (single-use and stainless steel), serum-free cell culture media, fluid management products (single-use bags, mixers, sterile connection/sealing equipment), chromatography media, high-pressure homogenizers, filtration systems, peristaltic pumps, transfection reagents, laboratory pure water systems, bioprocess analyzers, and compliance/validation services. Products support vaccine, antibody, gene therapy, cell therapy, and recombinant protein production workflows from upstream cell culture through downstream purification.

Product overview

Duoning Biotech (多宁生物) is a one-stop bioprocess solutions provider offering a comprehensive portfolio of products across the biopharmaceutical manufacturing value chain. The company offers a platform-plus-modules architecture comprising: (1) Bioreactors including the DuoBioX® Explore parallel bioreactor system, DuoWave® wave-type single-use bioreactor, DuoBioX® Pro single-use bioreactor, stainless steel suspension bioreactor, and DuoBioX® Elite benchtop system; (2) Cell culture media including CHO cell serum-free media (Media C & DN Feed, Maxpro® 304), transient transfection media (Transpro series), HEK 293 media, insect cell media (TransInsect series), and vaccine media (TransVA series); (3) Fluid management solutions including single-use bags (2D/3D storage, DuoMix® mixing bags, GlacierStore™ freezing bags), aseptic connection/sealing equipment (SUS Welder, DuoSealer™), tubing and fittings, and DuoMix® stirring systems; (4) Laboratory equipment including CytScop® cell analyzers, AU series bioprocess analyzers (AU400, AU3X, AU200); (5) Chromatography media including His-tag purification media, Protein A/G affinity media, ion exchange media (DEAE, CM), hydrophobic interaction media, and multimodal MMC/Adhere media; (6) High-pressure homogenizers in experimental, pilot, and production scales plus microfluidizers; (7) Filtration products including hollow fiber filters, PES capsule filters, DuoTFF™ tangential flow systems, and DuoCassette membrane modules; (8) Reagents including BrPERfect® transfection reagents, detection kits, and P188 additives; (9) Laboratory pure water systems (Genie G, Genie PURIST, Super-Genie); (10) Compliance technical services; and (11) Peristaltic and diaphragm pumps from PreFluid.

Differentiator

Problem solved

Functional benefit

Brands

• DuoBioX: Product line of bioreactors including DuoBioX Explore, DuoBioX Pro, DuoBioX Elite series.
• DuoWave
• DuoMix
• DuoFill
• DuoPress
• DuoTFF
• DuoSealer
• DuoPAT
• Genie G
• Genie PURIST
• Super-Genie
• BrPERfect
• Maxpro
• Maxfeed
• Transpro
• TransInsect
• TransVA
• Media C & DN Feed
• MediaD
• BG ProA
• BG ProG
• GlacierStore
• SheerTainer
• DuoCassette
• DuoSpin
• IT Power Pro
• CytScop

Products and services

• DuoBioX® Explore Series Parallel Bioreactor System A parallel bioreactor system designed for biopharmaceutical process development, supporting both suspension and microcarrier-based cell culture applications.
• DuoBioX® Pro Series Single-use Bioreactor A professional-grade single-use bioreactor for biopharmaceutical manufacturing, designed for scalability and process reliability.
• DuoBioX® Elite Series Benchtop Bioreactor System A compact benchtop bioreactor system for laboratory-scale process development and optimization.
• DuoWave® Wave-type Single-use Bioreactor A wave-type single-use bioreactor for cell culture applications, offering gentle mixing and oxygen transfer for various bioprocessing needs.
• Stainless Steel Suspension Cell Culture Bioreactor A stainless steel bioreactor system designed for large-scale suspension cell culture in commercial biopharmaceutical production.
• Media C & DN Feed Series CHO Cell Serum-free Medium Serum-free cell culture media designed for CHO cell expression systems, supporting high-density growth and recombinant protein production.
• Maxpro® 304 Medium A proprietary cell culture medium for various bioprocessing applications, part of the Maxpro CHO media line.
• Transpro Series CHO Cell Transient Transfection Medium A specialized medium for transient transfection of CHO cells, enabling rapid protein expression.
• Transpro Series HEK 293 Cell Medium Cell culture medium designed for HEK 293 cell culture and transient transfection applications.
• TransInsect Series Insect Cell Medium Serum-free medium optimized for insect cell culture, supporting recombinant protein expression using baculovirus expression systems.
• TransVA Series Vaccine Suspension Medium Cell culture medium designed for vaccine production using suspension-adapted cell lines.
• BG ProA FF Antibody Purification Media Protein A affinity chromatography media for monoclonal antibody purification.
• AAV Affinity Chromatography Media (Type II) Affinity chromatography media specifically designed for AAV (adeno-associated virus) purification.
• His-tag Protein Purification Media (BG IDA FF, BG NTA FF, BG TED FF) His-tag affinity chromatography media available in IDA, NTA, and TED variants for histidine-tagged protein purification.
• BG MMC FF Composite Weak Cation Exchange Media Multimodal chromatography media combining cation exchange and hydrophobic interaction modes for enhanced protein purification.
• High-Pressure Homogenizers (Experimental, Pilot, Production scales) Laboratory, pilot, and production scale high-pressure homogenizers for cell disruption, nanoparticle formulation, and liposome preparation.
• High-Pressure Microfluidizer (AMH-1000/AMH-500/AMH-MINI/AMH-NANO) High-pressure microfluidizer systems for nanoparticle formulation, liposome preparation, and cell disruption applications.
• Hollow Fiber Filter Hollow fiber filtration systems for tangential flow filtration, concentration, and diafiltration applications.
• Polyethersulfone (PES) Capsule Filters Polyethersulfone membrane filters for clarification and sterile filtration in biopharmaceutical processes.
• DuoTFF™ Automated Benchtop Tangential Flow Filtration System An automated tangential flow filtration system for protein concentration and buffer exchange.
• Single-use 2D Storage Bags Single-use fluid storage bags for biopharmaceutical process applications, available in 2D configuration.
• Single-use 3D Storage Bags Single-use 3D cubical/foldable and cylindrical storage bags for large-volume fluid storage in bioprocessing.
• DuoMix® Single-use Mixing Bags Single-use mixing bags for media preparation, buffer preparation, and fluid transfer in biopharmaceutical processes.
• GlacierStore™ Single-use Freezing Bags Single-use freezing bags designed for storage and transport of temperature-sensitive biopharmaceutical solutions.
• DuoSealer™ Tiny Next-generation Aseptic Tube Sealer A next-generation tube sealing device for single-use fluid management applications.
• BrPERfect® Protein DNA Transfection Reagent A transfection reagent for protein expression via DNA transfection into eukaryotic cells.
• BrPERfect® Virus DNA Transfection Reagent A transfection reagent optimized for virus production and recombinant viral vector manufacturing.
• CytScop® Pro Fully Automatic Intelligent Cell Analyzer An automated cell analysis system for counting, viability assessment, and cell health monitoring in bioprocess applications.
• AU Series Bioprocess Analyzers (AU400, AU3X Portable, AU200) A bioprocess analyzer family for monitoring key process parameters during cell culture operations; includes portable and compact models for at-line monitoring.
• Genie Series Laboratory Pure Water Systems (Genie G, Genie PURIST, Super-Genie) Ultrapure water purification systems and centralized water purification systems for laboratory water supply, meeting ASTM Type I water standards.
• Peristaltic Pump Series (PreFluid) A comprehensive line of peristaltic pumps including basic speed-adjustable, flow metering, high-flow spring-type, explosion-proof, high-precision dispensing, and batch transfer models.
• TP810 Series Quadruple Diaphragm Pump A diaphragm pump for precise fluid transfer in biopharmaceutical applications.
• Compliance Testing and Validation Services Comprehensive compliance testing and validation services for biopharmaceutical manufacturing processes and equipment, delivered through the Ximai (Shanghai) Testing Technology Service subsidiary.
• GMP Quality System and Registration Consulting Services GMP quality system consulting, compliance training, and product registration consulting services for biopharmaceutical manufacturers.

Quantifiable outcome

• 2000+ equipment users worldwide
• +1 more outcomes

Named customers2 records

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature9 records

Partnerships

Six partnerships are on record, tiered core and strategic.

• Aipu Xi Biological (艾普西生物)coreGTM or Marketing Partner · 18 September 2025Duoning Biotech entered into exclusive cooperation with Aipu Xi Biological for biochemical analysis equipment, expanding into a new product line.
• Dingkang Biological (鼎康生物)strategicStrategic or Co-development Partner · 10 June 2025Duoning Biotech and Dingkang Biological jointly established a European Innovation Center to promote China-EU biotechnology ecosystem collaborative development.
• Kangyuan Biological (康源生物)coreStrategic or Co-development Partner · 26 May 2025Duoning Biotech took a strategic controlling stake in Kangyuan Biological to expand into virus filtration key process technology, building a more complete one-stop bioprocess platform.
• Branca BunússtrategicStrategic or Co-development Partner · 31 March 2025Irish Minister visited Shanghai to celebrate the establishment of strategic partnership between Branca Bunús and Duoning Biotech, representing international collaboration in bioprocess solutions.
• BioelectronicacoreStrategic or Co-development Partner · 1 May 2024Duoning Biotechnology Group partnered with Bioelectronica in May 2024 to commercialize high-throughput single-cell sorting for antibody discovery. This partnership strengthens Duoning's position in the antibody therapeutics market.
• PreFluid (Changzhou PreFluid Technology Co., Ltd.)coreStrategic or Co-development Partner · 18 July 2023Duoning Biotech acquired Changzhou PreFluid Technology Co., Ltd., a manufacturer of peristaltic pumps. This acquisition expands Duoning's fluid management solutions portfolio and enhances capabilities in providing comprehensive fluid solutions across medical, pharmaceutical, chemical, and environmental industries.

Scale indicators4 records

Recent moves6 records

Expansion highlights6 records

Regional players

• Asahi Kasei (Bionova / ZOLL): Japanese conglomerate whose Life Science division supplies bioprocess filtration (virus filters, hollow fiber) and medical devices. Comparable to Duoning's filtration and downstream processing offerings, primarily across Asian and global biopharma.
• OPM Biosciences: China-based bioprocess solutions provider offering serum-free media, bioreactors, single-use systems, and filtration. Direct Asia-Pacific competitor to Duoning with overlapping product portfolio, serving the same Chinese cell therapy and vaccine customers.

Direct peers

• Sartorius: Global leader in bioprocess solutions offering bioreactors, single-use technologies, filtration, and fluid management. Duoning's one-stop upstream-to-downstream portfolio is most directly comparable to Sartorius' integrated bioprocess stack, especially across CHO cell media, bioreactors, and SUT.
• Cytiva (Danaher): Bioprocess division of Danaher providing bioreactors (Xcellerex), chromatography media (MabSelect, Capto), single-use fluid management, and filtration. Direct overlap with Duoning's full upstream/downstream workflow offerings and global installed base in biopharma manufacturing.
• Merck KGaA (Life Science / MilliporeSigma): Supplies bioprocess consumables, filtration, chromatography resins, and process development tools through its Life Science segment. Comparable to Duoning in media, single-use, and downstream processing product breadth.
• Repligen: Pure-play bioprocess-focused company specializing in single-use solutions, chromatography, and filtration (including virus filtration through the 2019 Engineered Molding Technologies acquisition). Comparable to Duoning's fluid management and downstream processing franchises.
• Bio-Techne: Provides cell culture media, reagents, and GMP-grade proteins for bioprocess and cell therapy applications. Closely comparable to Duoning's serum-free media lines (Maxpro, Transpro, TransInsect, TransVA) and transfection reagents.
• Avantor: Supplies bioprocess single-use solutions, filtration, and purification products to biopharma manufacturers globally. Comparable across Duoning's single-use bag/fluid management and filtration product families.

Broad incumbents

• Thermo Fisher Scientific: Diversified life sciences tools giant whose bioproduction offering (Gibco media, single-use systems, bioreactors, chromatography, analytics) competes across every Duoning product line, but as part of a much wider analytical instruments and diagnostics portfolio.
• Lonza: Global CDMO and bioprocess solutions provider offering cell culture media (through the Vacaville/Bioscience acquisition), manufacturing services, and process development tools. Comparable to Duoning in media/formulation services and overall bioprocess enablement role.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/DuoningBio
• YouTubeyoutube.com/channel/UC4ojcYL3ek72Br6NGD5cwPA
• LinkedInlinkedin.com/company/duoning

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Subsidiaries5 records

Funding overview

Funding rounds2 records

Investors6 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Duoning Biotech