What Integrated Micro-Chromatography Systems does

Integrated Micro-Chromatography Systems (IMCS) is a privately held biotechnology company headquartered in Irmo, South Carolina, that develops and sells automated micro-chromatography products and recombinant enzymes for clinical, forensic, and biopharmaceutical laboratories. Its core technology platform is IMCStips, a patented dispersive solid-phase extraction (dSPE) pipette tip format containing loose resin that enables high-throughput protein purification, nucleic acid cleanup, and buffer exchange on standard automated liquid handlers from Hamilton, Tecan, Integra, Opentrons, Dynamic Devices, and Analytik Jena. The company's second product line, IMCSzyme, is the industry's first genetically modified recombinant beta-glucuronidase, processing over one million samples per month for clinical and forensic toxicology applications including urine drug testing.

IMCS generates revenue through three primary streams: (1) consumable product sales of IMCStips across multiple chromatography modalities (Protein A affinity, Ni-IMAC, size exclusion, ion exchange, reverse phase, and plasmid purification under the MidiPure and µPure brands), (2) enzyme product sales including IMCSzyme variants (RT, E1F) and the Sulfazyme arylsulfatase line, and (3) fee-for-service offerings including custom automation scripts, method development, enzyme validation, and workflow optimization. Pricing is quote-based and not publicly disclosed; distribution combines direct field sales, an e-commerce storefront, and integration partnerships with automation platform manufacturers. The company has received over $5.25 million in NIH grants to support glycobiology and neurodegenerative disease research and is expanding into glycolipids, activated sugars, and animal-free gangliosides for diagnostics and therapeutics applications.

Name

Integrated Micro-Chromatography Systems

Legal name

Integrated Micro-Chromatography Systems, Inc.

Website

https://imcstips.com

Company type

Private

Founded year

2012

Operating status

Operating

Headcount range

1–10 employees

Short description

IMCS is a privately held Irmo, South Carolina biotechnology company that sells patented IMCStips micro-chromatography pipette tips and IMCSzyme recombinant beta-glucuronidase enzymes to clinical, forensic toxicology, and biopharmaceutical laboratories worldwide.

Ownership category

akta.pro rank

Product category

Life Sciences Laboratory Consumables

NAICS

Analytical Laboratory Instrument Manufacturing (334516), In-Vitro Diagnostic Substance Manufacturing (325413)

SIC

In Vitro & In Vivo Diagnostic Substances (2835), Laboratory Analytical Instruments (3826)

akta.pro primary industry

Downstream Processing & Purification Technologies (chromatography, filtration, centrifugation) (HLAAAJAB)

akta.pro secondary industry

Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization) (HLAAAIAC)

Keywords

• Micro-chromatography consumables
• Recombinant beta-glucuronidase
• Automated protein purification
• Dispersive solid-phase extraction
• Lab automation reagents

Headquarters

HQ city

Columbia

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Technology or R&D, Supply Chain, Marketing or Sales, Infrastructure

Revenue model

1. Enzyme Products: Sale of recombinant enzymes including IMCSzyme beta-glucuronidases and Sulfazyme sulfatases for applications in toxicology, bioprocessing, and glycobiology research.
2. IMCStips Chromatography Products: Sale of automated micro-chromatography pipette tips for protein purification, nucleic acid purification, and buffer exchange applications across various automation platforms.
3. Glyco Reagents: Sale of glycolipids, activated sugars, biosynthetic enzymes, and small molecules for glycobiology research.
4. Custom Solutions Services: Fee-for-service including confidential method development, custom scripts with user guides, installation support, custom resin packing, enzyme validation guidance, and workflow optimization.

Pricing tiers

Go-to-market motion1 record

Distribution channels5 records

Marketing channels8 records

Core offering

IMCS manufactures and sells patented automated micro-chromatography pipette tips (IMCStips) that perform dispersive solid-phase extraction for protein purification, nucleic acid cleanup, and buffer exchange, along with a portfolio of recombinant enzymes—IMCSzyme beta-glucuronidases and Sulfazyme arylsulfatases—used in clinical and forensic toxicology drug hydrolysis. The portfolio is rounded out by Glyco Reagents (glycosyltransferases, activated sugars, glycolipids), Sphingosines/Ceramides, and plasmid DNA purification tip lines (MidiPure, µPure, µPure LE), supported by integration with major laboratory automation platforms.

Product overview

Integrated Micro-Chromatography Systems (IMCS) is a biotechnology company offering a portfolio of automated micro-chromatography products centered on two core brands: IMCStips (patented dispersive solid-phase extraction pipette tips for high-throughput biomolecule purification) and IMCSzyme (recombinant beta-glucuronidase enzymes for hydrolysis applications). The IMCStips platform integrates with major automated liquid handlers (Hamilton, Tecan, Integra, Opentrons, Dynamic Devices, Analytik Jena) and supports multiple purification modalities including affinity (Protein A, Ni-IMAC), size exclusion, ion exchange, reverse phase, and phosphopeptide enrichment. Supporting product lines include Sulfazyme (arylsulfatase enzymes), Glyco Reagents (glycosyltransferases, activated sugars, glycolipids for glycobiology research), and Sphingosines/Ceramides. IMCS also provides custom automation services, enzyme validation, and hosts a scientific podcast. The company holds multiple NIH grants for neurodegenerative disease research involving glycobiology.

Differentiator

Problem solved

Functional benefit

Brands

• IMCSzyme: Collection of genetically modified pure beta-glucuronidase enzyme products made in the United States for hydrolyzing multiple drug classes quickly and with high efficiency.
• IMCStips
• Sulfazyme
• Glyco Reagents
• MidiPure
• µPure
• Imagize More, Create Solutions

Products and services

• IMCStips Patented automated dispersive solid-phase extraction (dSPE) technology in pipette-tip format containing loose resin; used for high-throughput protein purification, nucleic acid cleanup, and buffer exchange in genomics, proteomics, and metabolomics workflows across major automated liquid-handler platforms.
• IMCSzyme Collection of genetically modified pure beta-glucuronidase enzymes manufactured in the United States that hydrolyze multiple drug classes quickly and with high efficiency for clinical and forensic toxicology urine drug testing and confirmation workflows.
• IMCSzyme RT Room-temperature beta-glucuronidase formulation designed for rapid hydrolysis of glucuronidated drugs of abuse in urine samples, offered through a free-sample evaluation program for new customers.
• IMCSzyme E1F Engineered beta-glucuronidase variant offered within the IMCSzyme product family for enhanced performance in targeted toxicology applications.
• Sulfazyme Collection of recombinant arylsulfatases (Sulfazyme PaS, Sulfazyme DS, Sulfazyme β-AS) engineered to hydrolyze steroid sulfates including DHEAS, cortisol 21-sulfate, and terbutaline sulfate in urine and other biological samples.
• Sulfazyme DS Sulfazyme DS is a genetically engineered arylsulfatase variant optimized for enhanced hydrolysis of dehydroepiandrosterone 3β-sulfate (DHEAS), with demonstrated 7x and 38x higher activity versus Sulfazyme PaS for cortisol 21-sulfate and DHEAS, respectively.
• Glyco Reagents Affordable line of glycosyltransferases, nucleotidyltransferases, activated sugars, glycan synthesis kits, glycolipids, and biosynthetic enzymes designed to expedite glycobiology research and overcome the limitations of high-cost, animal-sourced reagents.
• MidiPure Automated midi-scale plasmid DNA purification line using 5 mL IMCStips designed for automated liquid-handler workflows, including the Dynamic Devices Lynx platform.
• µPure Automated low-endotoxin plasmid purification tip product line using silica-based IMCStips to produce transfection-grade plasmid DNA.
• Protein A IMCStips Affinity purification pipette tips containing Protein A resin for high-throughput automated monoclonal antibody capture and purification, validated on Hamilton, Tecan, Opentrons, and other automation platforms.
• SizeX IMCStips Size-exclusion chromatography pipette tips used for buffer exchange, desalting, and small-molecule removal from protein samples, including SizeX150 variants validated on Opentrons Flex for antibody purification and MAM workflows.
• Sphingosines/Ceramides Catalog of sphingosine and ceramide sphingolipid reagents for research applications in cell signaling and glycobiology.
• IMCStips Automation Integration Services Fee-for-service offering including custom script development with user guides, on-site or remote installation support, and method development for labs adopting IMCStips on automated liquid handlers.
• β-Glucuronidase and Sulfatase Validation Services Fee-for-service offering covering β-glucuronidase and sulfatase enzyme validation, high-throughput toxicology workflow optimization, and custom resin packing for clinical and research customers.

Quantifiable outcome

• Reduced purification workflow time from 8 hours to 2 hours for affinity purification applications
• +3 more outcomes

Named customers8 records

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration7 records

Feature5 records

Partnerships

Seven partnerships are on record, tiered core.

• Purolite (Ecolab)coreStrategic or Co-development Partner · 1 January 2022Strategic collaboration for agarose resin technology integration with IMCStips. Purolite supplies jetted agarose chromatography resins including Praesto Protein A resins for use in IMCS's automated micro-chromatography tips. Purolite is an Ecolab company with over 40 years of experience in resin manufacturing and holds EXCiPACT and ISO 9001 certifications.
• Hamilton CompanycoreTechnology or IntegrationIntegration partnership for IMCStips with Hamilton automated liquid handling systems. IMCS provides validated methods and scripts for Hamilton platforms for various purification applications.
• Dynamic DevicescoreTechnology or IntegrationIntegration partnership for IMCStips with Dynamic Devices Lynx automation platform. Video demonstrations available for MidiPure tips on Dynamic Devices Lynx system.
• IntegracoreTechnology or IntegrationIntegration partnership for IMCStips with Integra automated liquid handling platforms for biomolecule purification workflows.
• TecancoreTechnology or IntegrationIntegration partnership for IMCStips with Tecan Fluent and other Tecan platforms. Application notes available for protein A purification workflows on Tecan systems.
• OpentronscoreTechnology or IntegrationIntegration partnership for IMCStips with Opentrons Flex and other Opentrons platforms for automated antibody purification and buffer exchange workflows.
• Analytik JenacoreTechnology or IntegrationIntegration partnership for IMCStips with Analytik Jena CyBio Felix automated liquid handler for his-tagged protein purification and desalting workflows.

Scale indicators3 records

Recent moves6 records

Expansion highlights6 records

Market position

Competitive moat5 records

Key risks1 record

Customer concentration

• Xx.com/IntegratedMCS
• Facebookfacebook.com/Integrated-Micro-Chromatography-Sy
• LinkedInlinkedin.com/company/integrated-micro-chromatography-

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds3 records

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Integrated Micro-Chromatography Systems