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Doherty Institute

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uuid00046ci

Namestring
Doherty Institute
Legal namestring
Peter Doherty Institute for Infection and Immunity
Websiteurl
doherty.edu.au
Company typeenum
Private
Founded yearint
2014
Short descriptiontext

The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital, conducting infectious disease research, public health interventions, and graduate education with 1,100+ researchers across 120+ groups serving global healthcare systems and public health agencies.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
501–1,000
akta.pro rankint
HeadquartersMelbourne, Australia
HQ citystring
Melbourne
HQ countrystring
Australia
HQ regionstring
Oceania
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
infectious disease research, public health services, clinical diagnostics, pandemic therapeutics, biomedical research training
Industry3 codes
1Academic Medical Centers (AMCs) & Teaching Hospitals
CodeHLAFAAAAPrimaryYes
2General Infectious Disease
CodeHLAKAGAAPrimaryNo
3Academic Medical Centers & Teaching Hospitals (University-Affiliated)
CodeEDAHAGAAPrimaryNo
NAICS code3 codes
  • Medical and Diagnostic Laboratories62151
  • Scientific Research and Development Services5417
  • Medical Laboratories621511
SIC code3 codes
  • Services-Hospitals8060
  • Services-Medical Laboratories8071
  • Services-Commercial Physical & Biological Research8731
Product category
Infectious Disease Research
GTM motion2 records

Each record includes

Type, Description, Source

Revenue model3 records
1Research Grants
TypeSubscription Recurring
Description

Competitive research grants from global health organizations such as CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) providing AUD$2.68 million for antibiotic-resistant pneumonia research.

doherty.edu.au
2Philanthropic Funding
TypeLicensing Royalties
Description

The Cumming Global Centre for Pandemic Therapeutics has secured $100 million in competitive global funding. Donations support the institute's vision to improve health globally through discovery research.

doherty.edu.au
3Education and Training
TypeSubscription Recurring
Description

Revenue from educational programs including PhD, Honours, Masters, undergraduate courses, and professional development offerings.

doherty.edu.au
Marketing channels6 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels3 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Personnel, Technology or R&D, Infrastructure, Operations, Others
GTM typeB2B
B2B
Offering typeServices
Services
Brand1 record
1Cumming Global Centre for Pandemic Therapeutics
Description

A mission-driven, global research centre to enable rapid design and development of therapeutics for future pandemics.

doherty.edu.au
Core offering1 text field

The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital that conducts infectious disease research, delivers public health and reference laboratory services, and provides undergraduate, graduate, and postgraduate education. Its portfolio spans antimicrobial resistance, bacterial and parasitic infections, viral diseases, immunology, and computational genomics, supported by the Cumming Global Centre for Pandemic Therapeutics and advanced shared laboratory facilities (electron microscopy, flow cytometry, genomics, imaging).

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 3 values shown
  • Cefazolin reduced 90-day mortality from 17% to 15% and kidney injury from 20% to 14% compared to flucloxacillin for golden staph infections
+2 more records
Product overview1 text field

The Doherty Institute is a joint venture between the University of Melbourne and The Royal Melbourne Hospital focused on preventing, treating, and curing infectious diseases. The Institute operates as a unified research organization combining three core service areas: (1) Infectious Disease Research across themes including Antimicrobial Resistance, Bacterial and Parasitic Infections, Viral Infectious Diseases, Immunology, and Computational Science and Genomics; (2) Public Health Services addressing population-level health challenges and global health preparedness; and (3) Education and Training spanning undergraduate through PhD programs. Research Facilities including Electron Microscopy, Flow Cytometry, Genomics, and Imaging are available as shared infrastructure. The Cumming Global Centre for Pandemic Therapeutics operates as a dedicated research centre focused on platform technologies for future pandemic preparedness.

Product and service6 records
1Infectious Disease Research
CategoryInfectious Disease Research
Description

Core research activities focused on preventing, treating, and curing infectious diseases including antimicrobial resistance, bacterial infections, parasitic infections, viral diseases, and immunology. Delivered to health systems, public health agencies, and academic collaborators.

2Public Health Services
CategoryPublic Health
Description

Public health research and interventions addressing population-level infectious disease challenges, health systems optimization, and global health preparedness.

3Education and Training Programs
CategoryHigher Education
Description

Undergraduate, graduate, PhD, Honours & Masters programs, clinical graduate research training, and professional development opportunities in infectious disease and immunology.

4Shared Research Facilities
CategoryResearch Infrastructure Services
Description

Shared research facilities including Electron Microscopy, Flow Cytometry, Genomics, and Imaging services available for use by researchers across the institute and its partners.

5Cumming Global Centre for Pandemic Therapeutics
CategoryPandemic Therapeutics Research
Description

A mission-driven, global research centre dedicated to developing new platform technologies for rapid design and development of therapeutics for pathogens with pandemic potential.

6CRISPR-Based Point-of-Care STI Test
CategoryInfectious Disease Diagnostics
Description

Rapid point-of-care diagnostic combining isothermal amplification with CRISPR technology targeting two different pathogen sites to detect all major bacterial STIs (chlamydia, gonorrhea, syphilis, trichomonas, Mycoplasma genitalium) plus gonorrhea antibiotic resistance markers in under an hour, designed for clinicians and public health services in resource-limited settings.

Scale indicator6 records

Each record includes

Type, Value, Description, Source

Partnership8 partners
1Cumming Global Centre for Pandemic Therapeutics
Strategic tierFlagshipTypeStrategic or Co-development PartnerAnnounced on2026-05-21
Description

A mission-driven global research centre housed within the Doherty Institute to enable rapid design and development of therapeutics for future pandemics. The Centre has secured $100 million in competitive global funding and develops new platform technologies for pandemic preparedness.

doherty.edu.au
Strategic tierCoreTypeStrategic or Co-development Partner
Description

Co-led the SNAP Trial (world's largest international clinical trial for Staphylococcus aureus infections) alongside the Peter Doherty Institute. The landmark research published in New England Journal of Medicine and The Lancet.

3150+ International Hospitals
Strategic tierCoreTypeStrategic or Co-development Partner
Description

Over 150 hospitals across more than 14 countries participated in the SNAP Trial, the largest international clinical trial ever conducted for Staphylococcus aureus infections.

miragenews.com
Strategic tierMinorTypeStrategic or Co-development Partner
Description

Collaboration through the Moderna mRNA Access program for pandemic preparedness and therapeutic development research.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

Research partnership between the Doherty Institute and Charité University Hospital (Germany), with Expressions of Interest open for 2026 collaboration projects.

Strategic tierFlagshipTypeOthers
Description

Joint venture partner - The University of Melbourne provides academic oversight, research leadership, and student education programs including PhD, Honours, Masters, and undergraduate training.

Strategic tierFlagshipTypeOthers
Description

Joint venture partner - The Royal Melbourne Hospital provides clinical integration, hospital-based research facilities, and pathways for translating research into patient care.

8Australian Institute for Infectious Disease (AIID)
Strategic tierCoreTypeStrategic or Co-development Partner
Description

Collaborative initiative bringing together Australian expertise in infectious disease research for coordinated pandemic preparedness and response.

intranet.doherty.edu.au
Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight5 records

Each record includes

Type, Description

Peers10 records
TypeBroad incumbent
Description

London-based biomedical research institute with significant infectious-disease and immunology programs alongside broader life-science work. Comparable as a large-scale research-institute operating model with translational research capabilities.

TypeDirect peer
Description

Oxford-based vaccine and infectious-disease research institute. Closely comparable in translational infectious-disease focus, clinical-trial networks, and pandemic-preparedness orientation.

TypeBroad incumbent
Description

U.S. nonprofit research organization with deep immunology and infectious-disease programs. Comparable as a high-impact, grant-funded research enterprise that frequently publishes in NEJM/Cell-tier journals.

TypeDirect peer
Description

Also Melbourne-based and focused on infectious disease, immunology, and public-health research. Highly comparable in mission, geography, and operating model — Burns and Doherty routinely collaborate and compete for the same Australian grant and philanthropic dollars.

TypeBroad incumbent
Description

Paris-based global flagship for infectious-disease research with a comparable combination of reference-laboratory services, public-health mission, and graduate training. Comparable in scope and scientific brand, though materially larger in scale.

6Australian Institute for Infectious Disease (AIID)
TypeDirect peer
Description

Doherty's named collaborative partner for coordinated pandemic preparedness. Directly comparable as an Australian infectious-disease research consortium with overlapping translational and public-health mandates.

TypeBroad incumbent
Description

MIT/Harvard-affiliated genomics and infectious-disease institute. Comparable through its infectious-disease and genomic-surveillance programs (e.g., the Broad's viral sequencing leadership during COVID-19) and large, multi-source funding model.

TypeBroad incumbent
Description

Australia's oldest medical research institute, located adjacent to the Royal Melbourne Hospital. Operates in adjacent infectious-disease and immunology themes but with a broader biomedical mandate, making it a strong incumbent peer for talent, grants, and clinical-translation partnerships.

TypeBroad incumbent
Description

U.S. federal lead agency for infectious-disease and immunology research. Comparable through its pandemic-preparedness, AMR, and clinical-trials portfolio, though operating at dramatically larger scale.

10The Kirby Institute
TypeDirect peer
Description

UNSW-affiliated Australian institute dedicated to HIV, viral hepatitis, STIs, and infectious-disease epidemiology. Mirrors Doherty's infectious-disease research mandate with overlapping themes in STIs, AMR, and public-health translation.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat5 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers2 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment3 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile3 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature3 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles1 record

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

Subsidiaries1 record

Each record includes

Name, Acquired on, Relationship type, Type, Business focus

No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds1 record

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors1 record

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Doherty Institute

Infectious Disease Researchdoherty.edu.au

The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital, conducting infectious disease research, public health interventions, and graduate education with 1,100+ researchers across 120+ groups serving global healthcare systems and public health agencies.

Doherty Institute firmographics

Firmographics
Name
Doherty Institute
Legal name
Peter Doherty Institute for Infection and Immunity
Website
https://doherty.edu.au
Company type
Private
Founded year
2014
Operating status
Operating
Headcount range
501–1,000 employees
Short description
The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital, conducting infectious disease research, public health interventions, and graduate education with 1,100+ researchers across 120+ groups serving global healthcare systems and public health agencies.
Ownership category
akta.pro rank

Doherty Institute industry classification

Industry
Product category
Infectious Disease Research
NAICS
Medical and Diagnostic Laboratories (62151), Scientific Research and Development Services (5417), Medical Laboratories (621511)
SIC
Services-Hospitals (8060), Services-Medical Laboratories (8071), Services-Commercial Physical & Biological Research (8731)
akta.pro primary industry
Academic Medical Centers (AMCs) & Teaching Hospitals (HLAFAAAA)
akta.pro secondary industries
General Infectious Disease (HLAKAGAA), Academic Medical Centers & Teaching Hospitals (University-Affiliated) (EDAHAGAA)

Keywords

  • Infectious disease research
  • Public health services
  • Clinical diagnostics
  • Pandemic therapeutics
  • Biomedical research training

Where Doherty Institute is headquartered

Location

Headquarters

HQ city
Melbourne
HQ country
Australia
HQ region
Oceania

Offices1 record

Markets served

Doherty Institute business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Technology or R&D, Infrastructure, Operations, Others

Revenue model

  1. Research Grants: Competitive research grants from global health organizations such as CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) providing AUD$2.68 million for antibiotic-resistant pneumonia research.
  2. Philanthropic Funding: The Cumming Global Centre for Pandemic Therapeutics has secured $100 million in competitive global funding. Donations support the institute's vision to improve health globally through discovery research.
  3. Education and Training: Revenue from educational programs including PhD, Honours, Masters, undergraduate courses, and professional development offerings.

Go-to-market motion2 records

Distribution channels3 records

Marketing channels6 records

Doherty Institute product offering

Product offering

Core offering

The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital that conducts infectious disease research, delivers public health and reference laboratory services, and provides undergraduate, graduate, and postgraduate education. Its portfolio spans antimicrobial resistance, bacterial and parasitic infections, viral diseases, immunology, and computational genomics, supported by the Cumming Global Centre for Pandemic Therapeutics and advanced shared laboratory facilities (electron microscopy, flow cytometry, genomics, imaging).

Product overview

The Doherty Institute is a joint venture between the University of Melbourne and The Royal Melbourne Hospital focused on preventing, treating, and curing infectious diseases. The Institute operates as a unified research organization combining three core service areas: (1) Infectious Disease Research across themes including Antimicrobial Resistance, Bacterial and Parasitic Infections, Viral Infectious Diseases, Immunology, and Computational Science and Genomics; (2) Public Health Services addressing population-level health challenges and global health preparedness; and (3) Education and Training spanning undergraduate through PhD programs. Research Facilities including Electron Microscopy, Flow Cytometry, Genomics, and Imaging are available as shared infrastructure. The Cumming Global Centre for Pandemic Therapeutics operates as a dedicated research centre focused on platform technologies for future pandemic preparedness.

Differentiator

Problem solved

Functional benefit

Brands

  • Cumming Global Centre for Pandemic Therapeutics: A mission-driven, global research centre to enable rapid design and development of therapeutics for future pandemics.

Products and services

  • Infectious Disease Research Core research activities focused on preventing, treating, and curing infectious diseases including antimicrobial resistance, bacterial infections, parasitic infections, viral diseases, and immunology. Delivered to health systems, public health agencies, and academic collaborators.
  • Public Health Services Public health research and interventions addressing population-level infectious disease challenges, health systems optimization, and global health preparedness.
  • Education and Training Programs Undergraduate, graduate, PhD, Honours & Masters programs, clinical graduate research training, and professional development opportunities in infectious disease and immunology.
  • Shared Research Facilities Shared research facilities including Electron Microscopy, Flow Cytometry, Genomics, and Imaging services available for use by researchers across the institute and its partners.
  • Cumming Global Centre for Pandemic Therapeutics A mission-driven, global research centre dedicated to developing new platform technologies for rapid design and development of therapeutics for pathogens with pandemic potential.
  • CRISPR-Based Point-of-Care STI Test Rapid point-of-care diagnostic combining isothermal amplification with CRISPR technology targeting two different pathogen sites to detect all major bacterial STIs (chlamydia, gonorrhea, syphilis, trichomonas, Mycoplasma genitalium) plus gonorrhea antibiotic resistance markers in under an hour, designed for clinicians and public health services in resource-limited settings.

Quantifiable outcome

  • Cefazolin reduced 90-day mortality from 17% to 15% and kidney injury from 20% to 14% compared to flucloxacillin for golden staph infections
  • +2 more outcomes

Companies that use Doherty Institute

Customer profile

Named customers2 records

Segments3 records

Ideal customer profiles3 records

Doherty Institute technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature3 records

Doherty Institute partnerships and signals

Strategic signal

Partnerships

Eight partnerships are on record, tiered flagship, core and minor.

  • Cumming Global Centre for Pandemic TherapeuticsflagshipStrategic or Co-development Partner · 21 May 2026A mission-driven global research centre housed within the Doherty Institute to enable rapid design and development of therapeutics for future pandemics. The Centre has secured $100 million in competitive global funding and develops new platform technologies for pandemic preparedness.
  • University of NewcastlecoreStrategic or Co-development PartnerCo-led the SNAP Trial (world's largest international clinical trial for Staphylococcus aureus infections) alongside the Peter Doherty Institute. The landmark research published in New England Journal of Medicine and The Lancet.
  • 150+ International HospitalscoreStrategic or Co-development PartnerOver 150 hospitals across more than 14 countries participated in the SNAP Trial, the largest international clinical trial ever conducted for Staphylococcus aureus infections.
  • Moderna mRNA Access ProgramminorStrategic or Co-development PartnerCollaboration through the Moderna mRNA Access program for pandemic preparedness and therapeutic development research.
  • Charité University HospitalcoreStrategic or Co-development PartnerResearch partnership between the Doherty Institute and Charité University Hospital (Germany), with Expressions of Interest open for 2026 collaboration projects.
  • The University of MelbourneflagshipOthersJoint venture partner - The University of Melbourne provides academic oversight, research leadership, and student education programs including PhD, Honours, Masters, and undergraduate training.
  • The Royal Melbourne HospitalflagshipOthersJoint venture partner - The Royal Melbourne Hospital provides clinical integration, hospital-based research facilities, and pathways for translating research into patient care.
  • Australian Institute for Infectious Disease (AIID)coreStrategic or Co-development PartnerCollaborative initiative bringing together Australian expertise in infectious disease research for coordinated pandemic preparedness and response.

Scale indicators6 records

Recent moves6 records

Expansion highlights5 records

Doherty Institute competitors and assessment

Company assessment

Broad incumbents

  • Francis Crick Institute: London-based biomedical research institute with significant infectious-disease and immunology programs alongside broader life-science work. Comparable as a large-scale research-institute operating model with translational research capabilities.
  • The Scripps Research Institute: U.S. nonprofit research organization with deep immunology and infectious-disease programs. Comparable as a high-impact, grant-funded research enterprise that frequently publishes in NEJM/Cell-tier journals.
  • Institut Pasteur: Paris-based global flagship for infectious-disease research with a comparable combination of reference-laboratory services, public-health mission, and graduate training. Comparable in scope and scientific brand, though materially larger in scale.
  • Broad Institute: MIT/Harvard-affiliated genomics and infectious-disease institute. Comparable through its infectious-disease and genomic-surveillance programs (e.g., the Broad's viral sequencing leadership during COVID-19) and large, multi-source funding model.
  • Walter and Eliza Hall Institute of Medical Research (WEHI): Australia's oldest medical research institute, located adjacent to the Royal Melbourne Hospital. Operates in adjacent infectious-disease and immunology themes but with a broader biomedical mandate, making it a strong incumbent peer for talent, grants, and clinical-translation partnerships.
  • National Institute of Allergy and Infectious Diseases (NIAID): U.S. federal lead agency for infectious-disease and immunology research. Comparable through its pandemic-preparedness, AMR, and clinical-trials portfolio, though operating at dramatically larger scale.

Direct peers

  • Jenner Institute: Oxford-based vaccine and infectious-disease research institute. Closely comparable in translational infectious-disease focus, clinical-trial networks, and pandemic-preparedness orientation.
  • Burnet Institute: Also Melbourne-based and focused on infectious disease, immunology, and public-health research. Highly comparable in mission, geography, and operating model — Burns and Doherty routinely collaborate and compete for the same Australian grant and philanthropic dollars.
  • Australian Institute for Infectious Disease (AIID): Doherty's named collaborative partner for coordinated pandemic preparedness. Directly comparable as an Australian infectious-disease research consortium with overlapping translational and public-health mandates.
  • The Kirby Institute: UNSW-affiliated Australian institute dedicated to HIV, viral hepatitis, STIs, and infectious-disease epidemiology. Mirrors Doherty's infectious-disease research mandate with overlapping themes in STIs, AMR, and public-health translation.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

Doherty Institute social profiles

Digital presence

Doherty Institute financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Doherty Institute leadership team

Management profile

Number of profiles

Profiles1 record

Doherty Institute subsidiaries and ownership

Company hierarchy

Subsidiaries1 record

Doherty Institute funding detail

Funding detail

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Doherty Institute M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Doherty Institute

What does Doherty Institute do?

The Doherty Institute is a joint venture between The University of Melbourne and The Royal Melbourne Hospital that conducts infectious disease research, delivers public health and reference laboratory services, and provides undergraduate, graduate, and postgraduate education. Its portfolio spans antimicrobial resistance, bacterial and parasitic infections, viral diseases, immunology, and computational genomics, supported by the Cumming Global Centre for Pandemic Therapeutics and advanced shared laboratory facilities (electron microscopy, flow cytometry, genomics, imaging).

Is Doherty Institute a public or private company?

Doherty Institute is a private company. It is classified as state government owned and is currently operating.

When was Doherty Institute founded?

Doherty Institute was founded in 2014. It employs 501 to 1,000 people.

Where is Doherty Institute based?

Doherty Institute is headquartered in Melbourne, Australia, in the Oceania region.

How does Doherty Institute make money?

Three revenue lines are on record. Research Grants are the primary driver. The others are philanthropic Funding and education and Training.

Who are Doherty Institute's main competitors?

Broad incumbents on record are Francis Crick Institute, The Scripps Research Institute, Institut Pasteur, Broad Institute, Walter and Eliza Hall Institute of Medical Research (WEHI) and National Institute of Allergy and Infectious Diseases (NIAID). Direct peers are Jenner Institute, Burnet Institute, Australian Institute for Infectious Disease (AIID) and The Kirby Institute.

Does Doherty Institute have an API?

No public API is recorded for Doherty Institute.

What industry is Doherty Institute in?

Doherty Institute's product category is Infectious Disease Research. Its primary akta.pro industry code is HLAFAAAA, Academic Medical Centers (AMCs) & Teaching Hospitals, with a secondary code of HLAKAGAA, General Infectious Disease. Its NAICS code is 62151 and its SIC code is 8060.

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Live signals
News-MedicalMalaria infection causes permanent damage to the spleen immune cellsResearchers at the University of Bonn and the Peter Doherty Institute at the University of Melbourne have demonstrated that malaria infection causes permanent damage to resident CD163 macrophages in the spleen, which are critical immune cells responsible for filtering blood, recycling iron, and coordinating immune responses. The study found that even months after infection subsided, the CD163 macrophage population had not recovered, with replacement cells originating from bone marrow unable to achieve the same level of specialization as the originals. The findings, published in the journal Immunity, suggest that a single malaria episode can leave lasting damage to the spleen that worsens prognosis for repeat infections and may impact vaccine effectiveness in endemic regions.Mirage NewsMalaria Permanently Damages Spleen PhagocytesResearchers at the University of Bonn and the Peter Doherty Institute for Infection and Immunity at the University of Melbourne have demonstrated that malaria infection causes permanent damage to CD169 macrophages in the spleen, the cells responsible for cleaning the blood, recycling iron, and coordinating immune responses. Their study found that months after the infection subsided, the CD163 macrophage population had not recovered, with bone marrow-derived replacement cells failing to achieve the same level of specialization as the originals. The findings indicate that a single malaria episode can leave lasting effects on immunological memory, particle filtering, and iron metabolism in the spleen, which could significantly impact vaccine effectiveness and the prognosis for repeat infections in endemic regions.MedicalxpressPregnancy recruits killer T cells that may guard breasts against cancer for yearsAustralian researchers at Peter Mac and the Peter Doherty Institute discovered that pregnancy induces tissue-resident memory T cells that remain in breast tissue for years after childbirth, providing long-term protection against breast cancer. The study found that these killer T cells are recruited during pregnancy and continue patrolling breast tissue for abnormal cells for up to a decade. The researchers also demonstrated that hormone treatments can mimic pregnancy changes to induce the same protective T cells without requiring conception, potentially offering a new preventive approach for high-risk women.Mirage NewsResearch Identifies Top Antibiotics for Staph InfectionsThe SNAP Trial, the largest international clinical trial ever conducted for golden staph infections involving over 150 hospitals across more than 14 countries, has found that cefazolin and benzylpenicillin are safer and equally effective alternatives to the standard antibiotic flucloxacillin for treating bloodstream infections. The landmark research, led by the Peter Doherty Institute and University of Newcastle and published in the New England Journal of Medicine and The Lancet, showed cefazolin reduced 90-day mortality from 17% to 15% and kidney injury from 20% to 14%, while benzylpenicillin showed mortality of 14% versus 22% for flucloxacillin. The findings challenge decades of clinical practice and signal a shift in treatment guidelines for Staphylococcus aureus infections, which cause over one million deaths annually.MedicalxpressHow gene-targeting technology is transforming STI diagnosisResearchers at the Doherty Institute in Melbourne have developed the world's first rapid, point-of-care test capable of detecting all major bacterial sexually transmitted infections—including syphilis—on a single platform in under an hour, using CRISPR-Cas technology. The test also detects antibiotic resistance markers in gonorrhea, enabling clinicians to prescribe targeted treatment faster. Australia declared syphilis a Communicable Disease Incident of National Significance in August 2025, with infectious syphilis diagnoses more than doubling in the past decade to 6,000 cases in 2024.GenomeWebCRISPR-Based Point-of-Care STI Test Developed by Australian ResearchersResearchers at the University of Melbourne's Peter Doherty Institute for Infection and Immunity in Australia have developed a CRISPR-based point-of-care panel test capable of detecting multiple sexually transmitted infections including chlamydia, gonorrhea, syphilis, and herpes within an hour, using isothermal amplification combined with CRISPR technology targeting two different pathogen sites. The test demonstrated sensitivity rates ranging from 73% for chlamydia to 97% for HSV1 after validation with 400-500 clinical samples, and the team is now conducting field testing at urban and low-resource clinical sites in Melbourne. The researchers indicated openness to commercial licensing while emphasizing their primary goal is to enable and empower public health services, clinicians, and patients in regions with limited access to traditional STI testing.ABCSixth case of flesh-eating Buruli ulcer appears on NSW South CoastHealth authorities on the New South Wales South Coast have detected the sixth case of Buruli ulcer, a flesh-eating bacterial infection, in the Batemans Bay-Moruya area, with all six cases since 2021 linked to local acquisition and the latest three emerging within the past year. Researchers at the Doherty Institute at the University of Melbourne have developed a genomic detection tool that can identify potential hotspots by testing possum feces for the bacterium before human cases appear. The research indicates the bacteria were present in newly affected areas two to six years before human infections were observed, potentially enabling earlier public health interventions.Doherty WebsiteShaping the future of outbreak response hand-in-hand with the communityThe Doherty Institute is working with public health units and community partners to co-create inclusive outbreak response protocols, focusing initially on communities affected during COVID-19 in Victoria, Australia. The project involves engaging communities such as the Somali Australian community to better understand their experiences and needs for future public health emergencies.Doherty WebsiteMRFF injects $6m into infectious disease genomics research at the Doherty InstituteThe Medical Research Future Fund has awarded nearly $6 million in funding to two University of Melbourne research projects at the Doherty Institute to enhance Australia's infectious disease response capabilities. The grants support the AusPathoGen program for real-time genomic surveillance and the MITIGATE project for developing next-generation diagnostic platforms.European Medical JournalBreakthrough mRNA Delivery Technology Could Reverse HIV LatencyResearchers at the Peter Doherty Institute in Melbourne have developed a new lipid nanoparticle formulation called LNP X that can deliver mRNA into resting CD4+ T cells to activate latent HIV, which could aid in HIV cure strategies. The formulation successfully enhanced HIV transcription in ex vivo tests without harming the cells, representing a significant technical breakthrough.