Klarisana

What Klarisana does

Klarisana is a private, multi-site mental health clinic operator founded in 2015 by Dr. Carl J. Bonnett, MD, and headquartered in San Antonio, Texas. The company delivers intramuscular (IM) ketamine therapy, FDA-approved SPRAVATO (esketamine), ketamine-assisted psychotherapy (KAP), medication management, talk therapy, and telemedicine services to patients with treatment-resistant depression, PTSD, severe anxiety, chronic pain, and related conditions. As of December 2024, Klarisana operates six physical clinics across Texas (San Antonio, Austin) and Colorado (Denver, Longmont, Thornton, Centennial), with telemedicine available in both states. The company has performed over 20,000 IM ketamine sessions (2022) and published peer-reviewed clinical research in the Annals of Clinical Psychiatry (2019) and Journal of Psychiatry and Mental Health (2021, 2023), with documented outcome data including a 50% reduction in PHQ-9 depression scores and 44% reduction in PCL-5 PTSD scores among 30 studied veterans.

The company's core clinical differentiator is its proprietary Psychotropic Therapeutic Response (PTR) methodology and IM administration protocol — two intramuscular injections spaced 10–15 minutes apart — supported by aviation-inspired safety procedures (dual syringe verification, "no rank in the cockpit" escalation culture). Klarisana employs over 25 medical providers and is led by founder/CMO Dr. Bonnett, a Board Certified emergency medicine physician, 20-year Army National Guard veteran, and founding Board Member of the American Society of Ketamine Physicians, Psychotherapists, & Practitioners (ASKP3). In 2017, Klarisana established a precedent at the Texas Medical Board by securing dismissal of a complaint and confirming that clinical ketamine use falls under Ketamine for Non-Anesthetic Indications (KNAI) rather than Office Based Anesthesia — a meaningful regulatory wedge in its home state.

Klarisana generates revenue primarily through packaged treatment series (Induction, Guided, Transformation, and standalone psychotherapy) billed via self-pay and in-network insurance arrangements. It is an in-network provider for Aetna, United Healthcare, Blue Cross Blue Shield, and Cigna, and holds an exclusive relationship with HealthFirst Colorado (Medicaid) for ketamine treatment in Colorado. The company is privately held, founder/physician-controlled, and completed a $1.25M SEC Form D exempt securities offering in 2023 ($300K sold). Klarisana operates a provider-referral channel plus content marketing (blog, patient testimonials, social media, newsletter) as its primary go-to-market motions, targeting treatment-resistant patients, military veterans, and chronic pain sufferers.

Name

Klarisana

Legal name

Klarisana Health

Website

https://klarisana.com

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

11–50 employees

Short description

Klarisana is a private multi-site mental health clinic operator running six locations in Texas and Colorado that delivers intramuscular ketamine therapy, SPRAVATO, and ketamine-assisted psychotherapy to patients with treatment-resistant depression, PTSD, anxiety, and chronic pain.

Ownership category

akta.pro rank

Product category

Mental Health Services (Ketamine Therapy Clinics)

NAICS

Outpatient Mental Health and Substance Abuse Centers (621420), Offices of Physicians, Mental Health Specialists (621112)

SIC

Services-Specialty Outpatient Facilities, Nec (8093), Services-Health Services (8000)

akta.pro primary industry

Outpatient Mental Health & Counseling Clinics (HLAFABAC)

akta.pro secondary industry

Outpatient Mental Health Clinics & Counseling Centers (HLAFACAA)

Keywords

• Ketamine therapy services
• Mental health treatment
• Treatment resistant depression
• PTSD chronic pain care
• Psychedelic assisted psychotherapy

Headquarters

HQ city

San Antonio

HQ country

United States

HQ region

North America

Offices6 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Infrastructure, Marketing or Sales, Technology or R&D, Others

Revenue model

1. Ketamine Treatment Services: Revenue generated from intramuscular ketamine therapy sessions, ketamine-assisted psychotherapy, and related treatment services. Services include induction series (6 IM ketamine sessions), guided series, transformation series, and maintenance sessions. Treatment packages are customized based on patient needs.
2. Spravato (Esketamine) Treatment: FDA-approved nasal spray treatment for treatment-resistant depression, administered under supervision at clinics.
3. Behavioral Health Services: Medication management, talk therapy, preparation sessions, integration sessions, and coaching sessions, some covered by insurance.
4. Telemedicine Services: Virtual consultations and treatment plans for patients in Colorado and Texas.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels6 records

Core offering

Klarisana operates dedicated ketamine therapy clinics that deliver intramuscular (IM) ketamine treatment, FDA-approved Spravato (esketamine) nasal spray, and ketamine-assisted psychotherapy (KAP) for individuals with treatment-resistant depression, PTSD, severe anxiety, and chronic pain. Treatment is delivered as structured packages (Induction Series of six IM sessions, Guided Series with coaching, Transformation Series with KAP and maintenance) along with medication management, talk therapy, and telemedicine services. The company runs six clinics in Texas and Colorado and accepts major commercial insurance and Medicaid Colorado.

Product overview

Klarisana is a mental health clinic offering ketamine therapy and related psychiatric services through a multi-location practice. The core offering consists of Intramuscular (IM) Ketamine Therapy, SPRAVATO (Esketamine), and Ketamine-Assisted Psychotherapy (KAP), complemented by Medication Management, Talk Therapy, and Telemedicine services. The company delivers treatment through six clinic locations in Texas (Austin, San Antonio) and Colorado (Denver, Longmont, Thornton, Centennial). Treatment is structured around packages including the Induction Series (6 IM Ketamine sessions), Guided Series (induction plus coaching), Transformation Series (KAP plus maintenance), and standalone Psychotherapy packages. All treatments are administered under clinical supervision with video monitoring, targeting conditions including depression, PTSD, anxiety, chronic pain, OCD, and ADHD.

Differentiator

Problem solved

Functional benefit

Products and services

• Intramuscular (IM) Ketamine Therapy Two intramuscular ketamine injections spaced 10-15 minutes apart, delivered in a private treatment room under continuous clinical observation, used to treat depression, anxiety, PTSD, and chronic pain. Service is for individual adult patients with treatment-resistant conditions and is administered by the clinical team across all Klarisana locations.
• SPRAVATO (Esketamine) FDA-approved esketamine nasal spray administered under clinical supervision in conjunction with an oral antidepressant for adults with treatment-resistant depression who have not responded to traditional therapies. Delivered at Klarisana clinics as a supervised treatment program.
• Ketamine-Assisted Psychotherapy (KAP) Blends ketamine administration with structured therapeutic guidance from trained therapists who work with patients to explore thoughts, emotions, and past experiences and process trauma during and after the session. Designed for patients seeking combined pharmacological and psychotherapeutic intervention.
• Medication Management Comprehensive psychiatric medication evaluation, monitoring, prescribing, and adjustment provided by psychiatric nurse practitioners on staff and tailored to each patient's mental health needs. Currently available at Klarisana's Colorado clinic locations.
• Talk Therapy Traditional psychotherapy sessions with licensed therapists providing a supportive environment for patients to discuss thoughts and feelings, develop coping strategies, and foster personal growth. Available as standalone counseling and as preparation/integration support for ketamine therapy.
• Telemedicine Secure video-based virtual consultations and treatment plans from licensed Klarisana providers for patients located in Colorado and Texas. Used for intake, follow-up, and ongoing care coordination around ketamine and behavioral health services.
• Induction Series Initial treatment package comprising evaluation of medical and behavioral health history plus six intramuscular ketamine sessions, positioned as the entry-point treatment bundle for new patients beginning ketamine therapy at Klarisana.
• Guided Series Treatment package that bundles the Induction Series with two 30-minute coaching sessions to provide additional guidance and support during the ketamine healing journey.
• Transformation Series Advanced treatment package comprising one 30-minute coaching session, one ketamine-assisted psychotherapy session, and one IM ketamine maintenance session for ongoing healing and integration.
• Psychotherapy Package Standalone talk therapy package including three 60-minute psychotherapy or integration sessions, or two 30-minute psychotherapy or coaching sessions, focused on talk therapy without ketamine administration.

Quantifiable outcome

• 50% reduction in depression symptoms (PHQ-9 score from 18.9 to 9.5) in veteran PTSD study participants
• +3 more outcomes

Named customers6 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

Feature3 records

Partnerships

Eight partnerships are on record, tiered core.

• AetnacoreOthersIn-network insurance provider for Klarisana's medical and behavioral health services, expanding patient accessibility to ketamine therapy treatments.
• United HealthcarecoreOthersIn-network insurance provider for Klarisana's services, enabling coverage for ketamine therapy and behavioral health treatments.
• Blue Cross Blue ShieldcoreOthersIn-network insurance provider offering coverage for Klarisana's ketamine treatment and behavioral health services.
• CignacoreOthersIn-network insurance provider for Klarisana's services, providing access to ketamine therapy for insured patients.
• HealthFirst ColoradocoreOthersMedicaid provider with exclusive coverage for ketamine treatment at Klarisana in Colorado. This is the only Medicaid coverage for ketamine therapy at Klarisana.
• Colorado AccesscoreOthersColorado-based health plan partner providing coverage options for behavioral health services at Klarisana.
• Community Health AlliancecoreOthersHealth alliance partner providing coverage for Klarisana's behavioral health and ketamine treatment services in Colorado.
• ASKP3 (American Society of Ketamine Physicians, Psychotherapists and Practitioners)coreStrategic or Co-development PartnerProfessional society co-founded by Klarisana's founder Dr. Carl J. Bonnett. Works on establishing ethical and scientific standards for ketamine providers, best practices, and education including for at-home prescribing. Klarisana's CMO serves on the Expert Faculty Committee.

Scale indicators8 records

Recent moves8 records

Expansion highlights6 records

Emerging players

• Nue Life Health: Telehealth ketamine therapy platform offering IM and sublingual protocols with clinician oversight; comparable patient population and payer model to Klarisana but operating without a physical clinic footprint.
• Compass Pathways: Clinical-stage psychedelic therapy company developing psilocybin for treatment-resistant depression; overlapping patient indication and clinic-network ambitions, but a different molecule and stage of development.
• Lykos Therapeutics: Former MAPS Public Benefit Corporation focused on MDMA-assisted therapy for PTSD. Highly comparable on patient population (treatment-resistant PTSD) and therapy-assisted model, though centered on MDMA rather than ketamine.

Broad incumbents

• Amen Clinics: Multi-location outpatient psychiatric and brain health clinic chain that addresses treatment-resistant mental health conditions. Comparable as a larger, established outpatient behavioral health operator with a national footprint.
• Cerebral: Larger national telehealth mental health platform offering medication management and therapy; relevant as a broader incumbent that competes for the same outpatient behavioral health demand that funnels into ketamine clinics like Klarisana.
• Talkiatry: Tech-enabled outpatient psychiatry group practice offering medication management and psychotherapy. Comparable as a competing outpatient mental health delivery model that could absorb ketamine referrals under broader psychiatric care contracts.

Direct peers

• Field Trip Health: Former publicly traded ketamine and psychedelic-assisted therapy clinic chain. Directly comparable specialty outpatient model targeting treatment-resistant mental health conditions, though it wound down most US clinic operations in 2023.
• Ketamine Wellness Centers: Multi-location ketamine infusion clinic operator that acquired Field Trip Health's US clinic assets in 2023; comparable to Klarisana in modality (IV/IM ketamine), payor strategy, and multi-state clinic footprint.
• Mindbloom: At-home ketamine therapy provider serving treatment-resistant depression and anxiety patients in multiple US states; competes for the same self-pay patient segment that funds Klarisana's induction packages, but via telehealth rather than clinics.
• Sage Clinics: Specialty outpatient ketamine clinic operator offering IM and IV ketamine for depression, PTSD and chronic pain; directly comparable clinical model and patient indications to Klarisana.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/KlarisanaKetamine
• Facebookfacebook.com/klarisana
• Instagraminstagram.com/klarisana.ketamine

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds1 record

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Klarisana