What Innosyn does

InnoSyn B.V. is a Dutch contract development and manufacturing organisation (CDMO) and contract research organisation (CRO) headquartered at the Brightlands Chemelot Campus in Geleen, Netherlands. Founded in 2017 as a spin-off from DSM's Innovative Synthesis Research Center, the company specialises in small-molecule process research and development for pharmaceutical, agrochemical, flavours & fragrances, and specialty chemical customers. InnoSyn employs approximately 60 highly skilled full-time equivalents and serves blue-chip enterprise clients through dedicated commercial and business development functions.

The company's offering is built around six integrated technology platforms — biocatalysis, chemocatalysis, flow chemistry (including in-house 3D metal-printed reactors), photochemistry, chiral crystallisation (Viedma ripening and TCID), and biobased & circular chemistry — supported by a non-GMP pilot plant operating at 20L to 300L volumes. Services span the full development lifecycle from route scouting and process safety through to pilot-scale manufacturing, complemented by proprietary products including recombinant PLE isoenzymes, hydroxynitrile lyases, glucose dehydrogenase, Keto-ABNO, and Shvo catalyst, plus the in-house Multifunctional Skid process equipment. AI-driven capabilities are delivered through the SynSilico joint venture with Genzai.

InnoSyn operates a B2B enterprise sales model combining milestone billing for phased project delivery with multi-year FTE Program engagements that embed dedicated scientific resources within client programmes. The company is majority-owned by Mérieux Equity Partners following a January 2024 buyout, with founders and management reinvesting alongside. Distribution is global across 12 countries and is anchored by participation in CPHI, BioEurope, Chemspec Europe, and other industry events, plus a substantial portfolio of peer-reviewed scientific publications that drive inbound enterprise demand.

Name

Innosyn

Legal name

InnoSyn B.V.

Website

https://innosyn.com

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

11–50 employees

Short description

InnoSyn is a Dutch CDMO/CRO that develops scalable chemical processes for pharmaceutical, agrochemical, flavours & fragrances, and specialty chemical clients using flow chemistry, biocatalysis, chemocatalysis, photochemistry, and chiral crystallisation, from route scouting through to non-GMP pilot-scale manufacturing.

Ownership category

akta.pro rank

Product category

Chemical Process R&D / CDMO Services

NAICS

Chemical Manufacturing (325)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Small-Molecule API & Intermediates CDMO (HLAGABAA)

akta.pro secondary industries

Flow Chemistry & Process Intensification Services (HLAGAHAK), Process Development & Tech Transfer Services (CDMO) (HLAGABAL), Contract Development & Manufacturing for Generics (CDMO/CMO) (HLAIABAI)

Keywords

• Contract process development
• Flow chemistry services
• Biocatalysis manufacturing
• Pharmaceutical CDMO
• Specialty chemical synthesis

Headquarters

HQ city

Geleen

HQ country

Netherlands

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Infrastructure, Operations, Marketing or Sales, Supply Chain

Revenue model

1. Contract Research and Process Development Services: Tailored R&D services spanning route scouting, process development, process safety, and analytical services. Delivered through milestone billing phases or dedicated FTE program models for long-term engagements. Revenue is project-based and recurring from a blue-chip client base.
2. Pilot Plant Manufacturing: Non-GMP pilot-scale manufacturing of chemical products from 20L to 300L volumes, enabling clients to produce representative kilograms for market purposes or specific chemical manufacturing needs.
3. Enzyme and Chemical Products: Sale of proprietary enzyme products (Recombinant Pig Liver Esterase, Hydroxynitrile Lyases, Glucose Dehydrogenase) and specialty chemicals (Keto-ABNO, Shvo Catalyst) in bulk amounts from 50mg to 1000kg scale.
4. Joint Venture - SynSilico: Through the SynSilico joint venture with Genzai, InnoSyn participates in AI-driven R&D services for life sciences, material science, and chemical industries, expanding the service revenue portfolio.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels5 records

Core offering

InnoSyn is a Contract Development and Manufacturing Organization (CDMO) that delivers chemical process research, development, and pilot-scale manufacturing services for small molecules. Its core work spans route scouting, process development, process safety, and analytical services supported by flow chemistry, biocatalysis, chemocatalysis, photochemistry, and crystallization technologies. The company also sells proprietary enzyme products (PLE, HNL, GDH-01), chemical catalysts (Keto-ABNO, Shvo Catalyst), and a multifunctional process skid for continuous flow production.

Product overview

InnoSyn is a CDMO (Contract Development and Manufacturing Organization) offering a unified portfolio of chemical process R&D services and products. The core offering comprises enzyme products (Recombinant Pig Liver Esterase/PLE, Hydroxynitrile Lyases/HNL, Glucose Dehydrogenase/GDH-01), process equipment (Multifunctional Skid), and chemical catalysts (Keto-ABNO, Shvo Catalyst). Services span the full development lifecycle from Route Scouting and Process Development through Pilot Plant manufacturing, enabled by six technology platforms: Biocatalysis, Crystallization, Flow Chemistry, Photochemistry, Chemocatalysis, and Biobased & Circular. AI-powered capabilities are delivered through affiliate SynSilico for enzyme engineering and process optimization.

Differentiator

Problem solved

Functional benefit

Products and services

• Route Scouting Method-agnostic service for identifying new, efficient synthesis routes for target chemical compounds, including biocatalysis-based solutions. Delivered from concept on paper through delivery for pharmaceutical, agrochemical, F&F, and specialty chemical clients.
• Process Development Optimization of existing chemical processes with over 30 years of expertise, supported by analytical chemistry services, to improve cost efficiency and product quality for fine and specialty chemical clients.
• Process Safety Safety assessment and development services for chemical processes, enabling handling of hazardous and challenging chemistries including those requiring cryogenic or flow processing.
• Analytical Services Comprehensive analytical chemistry support integrated into process development and optimization services delivered alongside route scouting, process development, and process safety.
• AI Services (via SynSilico) AI-powered services for chemistry and process optimization delivered through affiliate SynSilico, including enzyme engineering, process optimization, and R&D acceleration using AI-driven computational models.
• Pilot Plant Manufacturing Non-GMP pilot-scale manufacturing of chemical products from 20L to 300L volumes, enabling clients to produce representative kilograms for market purposes or specific chemical manufacturing needs, either at InnoSyn's facility or at the customer's preferred location.
• Recombinant Pig Liver Esterase (PLE) A set of seven isoenzymes of pig liver esterases recombinantly prepared in E. coli, used for racemic resolutions and desymmetrizations in asymmetric synthesis of chiral alcohols or esters. Available as a screening kit of seven isoforms in cell-free extract format and as immobilized enzymes for improved stability.
• Hydroxynitrile Lyases (HNL) Enzymes catalysing the reversible cleavage of cyanohydrins and the enantioselective synthesis of cyanohydrins from aldehydes or ketones and HCN. Available as HNL-1, HNL-2, HNL-3 (S-HNL from Hevea brasiliensis) and HNL-4, HNL-5 (R-HNL from Prunus amygdalus), all recombinantly expressed in Pichia pastoris, for chiral building blocks in pharmaceuticals and agrochemicals.
• Glucose Dehydrogenase (GDH-01) Enzyme enabling NAD(P)H regeneration from NAD(P)+ by catalysing oxidation of D-glucose to D-glucono-1,5-lactone, used for cofactor regeneration in NAD(P)H-consuming biocatalytic reactions and driving reactions quantitatively toward product formation.
• Multifunctional Skid Modular process skid with interchangeable modules for mixing, heating, cooling, and downstream processing (distillation, filtration), featuring advanced automation, integrated process control systems, and 3D-printed reactors in stainless steel, Hastelloy, or tantalum for continuous flow production and rapid reconfiguration.
• Keto-ABNO Nitroxyl radical catalyst used for aerobic alcohol oxidations, applied in both batch and continuous flow reactors for selective oxidation of primary and secondary alcohols.
• Shvo Catalyst Organometallic catalyst used in hydrogen transfer and other catalytic reactions, sold by InnoSyn as a specialty product offering.

Quantifiable outcome

• 3,000x productivity increase and 1,700x reduction in residence time using 3D-printed flow reactors vs. batch methods
• +3 more outcomes

Named customers3 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability3 records

Feature6 records

Partnerships

Seven partnerships are on record, tiered core and minor.

• HyFINE ConsortiumcoreStrategic or Co-development Partner · 11 February 2026InnoSyn B.V. is a co-funder and founding member of the HyFINE consortium, awarded €19.3 million by NWO and GroenvermogenNL, with total project value of approximately €24 million. The consortium brings together 9 universities, 3 universities of applied sciences, 3 research institutes, and 20 companies to shift specialty and fine chemical production from fossil resources to sustainable sources using green hydrogen and renewable electricity. InnoSyn contributes expertise in biocatalysis, flow chemistry, and process development.
• toolcraftcoreTechnology or Integration · 1 January 2025Partnership with toolcraft for additive manufacturing (3D metal printing) of industrial flow reactors. toolcraft holds certification as a material manufacturer under the Pressure Equipment Directive 2014/68/EU, enabling industrial use of high-performance components. The partnership produced custom Hastelloy C22 reactors with complex internal geometries and integrated sensor interfaces for InnoSyn's pilot plant operations.
• SynSilicocoreStrategic or Co-development Partner · 1 January 2025InnoSyn and SynSilico (their affiliate JV with Genzai) collaborate in enzyme engineering. SynSilico provides an enzyme engineering platform integrating structure-sequence-function relationships, advanced biophysics, and AI-driven tools to complement InnoSyn's existing enzyme screening, production, and scale-up capabilities. This partnership enables InnoSyn to offer a full spectrum of enzyme innovation services from engineering to industrial reality.
• GenzaicoreStrategic or Co-development Partner · 1 January 2024InnoSyn and Genzai jointly formed SynSilico, a joint venture combining InnoSyn's expertise in biochemical synthesis and process technology with Genzai's AI capabilities. SynSilico aims to transform R&D in life sciences, material science, and chemical industries by integrating AI with biochemical expertise to accelerate scientific discoveries and industrial applications. Roy Lenders is CEO of Genzai; Oliver May is Managing Director of SynSilico.
• LUMEN Consortium (Interreg)minorStrategic or Co-development Partner · 1 January 2021LUMEN is an Interreg Flanders-Netherlands project involving TNO, Hasselt University, Zuyd University, IMEC, InnoSyn, and Ecosynth. The project develops technology to use sunlight directly as a 'fuel' for sustainable chemical processes, addressing both the transition from fossil fuels and CO2 reduction. Supported by Interreg Flanders-Netherlands, Dutch government, and provincial authorities.
• De Dietrich Process Systems (DDPS)coreTechnology or Integration · 1 January 2020Partnership for the development and co-presentation of the CryoFlowSkid, a cryogenic flow chemistry skid system for pilot plant scale. InnoSyn contributed flow chemistry expertise while DDPS provided modular equipment manufacturing. The skid was jointly presented at a Scientific Update webinar in March 2020 and is marketed for cryogenic chemistry applications up to 5 kg product/hr throughput.
• Brightlands Chemelot CampuscoreOthers · 1 January 2017Brightlands Chemelot Campus in Sittard-Geleen is InnoSyn's host location. The campus took a share in InnoSyn at spin-out, providing an ecosystem for chemical innovation. CEO Bert Kip of Brightlands Chemelot Campus described the unique capabilities of InnoSyn as having a strong synergistic fit with the campus ambitions.

Scale indicators8 records

Recent moves7 records

Expansion highlights6 records

Broad incumbents

• Lonza Group: Global CDMO leader with extensive small-molecule API capabilities including flow chemistry, biocatalysis, and process development. Indirect competitor in the process R&D stage; represents the strategic benchmark for scale.
• Johnson Matthey: UK-headquartered specialty chemicals and catalyst company. Overlaps with InnoSyn's chemocatalysis and process technology offerings, particularly in catalyst screening and heterogeneous catalysis for pharma and specialty chemical applications.
• Novozymes (Novonesis): Global enzyme manufacturer with industrial biocatalysis portfolio. Overlaps with InnoSyn's proprietary enzyme products and biocatalysis platform but at vastly greater scale and broader industrial customer base.
• Siegfried Holding: Swiss-listed CDMO with full GMP API manufacturing and process development. Overlaps with InnoSyn's small-molecule process R&D but operates at much larger scale with commercial supply capabilities that InnoSyn lacks.

Direct peers

• Hovione: Portugal-headquartered CDMO specialising in API development and manufacturing with strong flow chemistry capabilities, including continuous manufacturing platforms. Most direct competitor to InnoSyn's integrated route-scouting-to-pilot offering for small-molecule APIs.
• Carbogen Amcis: Swiss-based CDMO offering API process development, scale-up, and GMP manufacturing for small molecules. Directly comparable in process development, route scouting, and scale-up services across pharma and agrochemical customers.
• Codexis: US-listed enzyme engineering company developing biocatalysts for pharmaceutical manufacturing. Direct overlap with InnoSyn's proprietary enzyme products (PLE, HNL, GDH-01) and biocatalysis platform, serving similar pharma CDMO customers.
• ChemPartner: China-headquartered CRO/CDMO offering chemistry services, process development, and custom synthesis. Comparable as a route-scouting and process optimisation partner for global pharma and specialty chemical customers.
• Curia (formerly AMRI): Global CDMO with API process development and small-molecule manufacturing capabilities. Competes in flow chemistry and process R&D, with broader GMP commercial manufacturing that represents the next step above InnoSyn's current non-GMP offering.
• Sai Life Sciences: India-based CRO/CDMO offering process chemistry, route scouting, and custom synthesis for pharma clients. Comparable in providing discovery-to-pilot process development services for small-molecule APIs.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/innosyn

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Innosyn