What iS CLINICAL does

iS Clinical (legal entity: Innovative Skincare) is a privately held, professional-grade skincare company founded in 2002 by Alec Call and Bryan Johns, headquartered in the Los Angeles area (Burbank). The company develops, manufactures, and sells a pharmaceutical-quality skincare portfolio spanning more than 40 products across cleansers, serums, moisturizers, eye care, sunscreens, body care, and specialty treatments, organized around a proprietary Cleanse-Treat-Hydrate-Protect regimen. Formulas are built in the company's own laboratories and feature three core proprietary technology platforms: Extremozyme Technology (extremophile-derived enzymes for environmental defense), GeneXC Technology (combining Extremozyme extracts with Vitamin C for brightening and tone correction), and Exosome Technology (plankton-extract and peptide systems for elasticity and barrier support).

The company operates a hybrid go-to-market combining direct-to-consumer e-commerce via isclinical.com with a Professional Partner Program that supplies dermatologists, estheticians, and medical spas. Products range from $25 to $420 with free shipping thresholds at $200 and gift-with-purchase promotions used for acquisition. Beyond retail skincare, iS Clinical licenses professional-only in-clinic treatments such as the Fire & Ice Facial, Prodigy Peel Systems, Honey Enzyme Facial, and Flash Brightening Peel to licensed practitioners. Distribution spans 120+ countries through its own site, authorized online retailers, and the professional channel. The company also runs the iS Cancer Care program (founded 2003), which delivers skincare support to oncology patients at major institutions including Cedars-Sinai, Cleveland Clinic, Mayo Clinic, and Washington Cancer Institute.

In June 2026 the founders extended the platform with Icon Skincare, a wholly-owned sub-brand under the Innovative Skincare parent, positioned at a more accessible $32-$68 price point with a simplified nine-SKU assortment. The business is founder-controlled with no disclosed institutional capital, no public listing, and no M&A activity beyond organic sub-brand creation.

Name

iS CLINICAL

Legal name

Innovative Skincare

Website

https://isclinical.com

Company type

Private

Founded year

2003

Operating status

Operating

Headcount range

101–250 employees

Short description

iS Clinical is a private, professional-grade skincare manufacturer founded in 2002 in the Los Angeles area, selling 40+ pharmaceutical-quality skincare products directly to consumers and through a global network of dermatologists, estheticians, and medical spas spanning 120+ countries.

Ownership category

akta.pro rank

Product category

Professional Skincare

NAICS

Soap and Cleaning Compound Manufacturing (32561), Medicinal and Botanical Manufacturing (325411)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844), Medicinal Chemicals & Botanical Products (2833)

akta.pro primary industry

Dermocosmetics & Medical-Grade Skincare (CRABAAAF)

akta.pro secondary industries

Professional/Backbar Skincare (Esthetician & Spa Use) (CRABAAAK), Sensitive Skin & Barrier Repair (CRABAAAG), Professional Skincare & Facial Treatments (CRABALAF)

Keywords

• Professional skincare products
• Pharmaceutical-grade skincare
• Anti-aging treatments
• Clinical skincare formulations
• Skincare serums cleansers

Headquarters

HQ city

Burbank

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Operations, Supply Chain, Personnel, Marketing or Sales, Technology or R&D

Revenue model

1. Direct-to-Consumer Skincare Sales: Primary revenue stream from direct sales of professional-grade skincare products through the company's e-commerce website, with products ranging from cleansers to specialized treatments
2. Professional Partner Program: Revenue from supplying skincare products to dermatologists, estheticians, and medical spas through their professional partner program

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels6 records

Core offering

iS Clinical manufactures and sells a professional-grade skincare line of 40+ products — including cleansers, serums, moisturizers, sunscreens, eye care, and specialty treatments — developed and produced in its own Los Angeles laboratories. The formulations combine botanically derived actives with pharmaceutical-grade science, powered by proprietary technologies including Extremozyme, GeneXC, and Exosome. Products are sold directly to consumers via isclinical.com and distributed through a network of dermatologists, estheticians, and medical spas across 120+ countries. The company also offers professional in-clinic treatments and an AI skin analysis tool for personalized routine recommendations.

Product overview

iS Clinical is a professional-grade skincare brand offering a comprehensive portfolio of pharmaceutical-quality skincare products organized around the Cleanse, Treat, Hydrate, Protect regimen. The product lineup includes over 40+ distinct products spanning cleansers (Cleansing Complex, Cream Cleanser, Warming Honey Cleanser, Cleansing Complex Polish), serums (Active Serum, Pro-Heal Serum Advance+, Hydra-Cool Serum, GeneXC Serum, Youth Serum, Super Serum Advance+, Brightening Serum, Brightening Complex), moisturizers (Daily Dynamic Hydrator, Reparative Moisture Emulsion, Moisturizing Complex, Youth Intensive Crème, Sheald Recovery Balm), sunscreens (Eclipse SPF 50+, Extreme Protect SPF 30, Extreme Protect SPF 40, PerfecTint Powder SPF 40), eye care (Youth Eye Complex, GeneXC Firming Eye Gel, Eye Complex, C Eye Serum Advance+), and specialty treatments (Retinol+ Emulsion 0.3, NeckPerfect Complex, Tri-Active Exfoliating Masque). The brand also offers professional-only treatments (Fire & Ice Facial, Prodigy Peel Systems, Honey Enzyme Facial, Exfoliating Clear Skin Facial, Foaming Enzyme Facial, Harmony Facial, Flash Brightening Peel) available through licensed skincare professionals. Additionally, the company provides an AI-powered Skin Quiz tool for personalized routine recommendations. The formulations are backed by clinical research and feature proprietary technologies including GeneXC Technology and Extremozyme technology. Products are sold directly to consumers via isclinical.com and through a network of authorized professional partners in 120+ countries.

Differentiator

Problem solved

Functional benefit

Brands

• Icon Skincare: A skincare brand launched on June 1, 2026, offering updated formulations inspired by Madam Renna's beauty recipes from Hollywood's Golden Age. Products are priced from $32 to $68 and positioned as more affordable and accessible than iS Clinical.

Products and services

• Cleansing Complex Award-winning resurfacing gel cleanser combining bionutrients, antioxidants, and botanically sourced acids to cleanse without stripping natural moisture, suitable for all skin types.
• Cream Cleanser Hydrating, non-foaming cream cleanser with coconut oil, glycerin, safflower seed oil, and squalane formulated for dry or sensitive skin types.
• Warming Honey Cleanser Luxury cleanser with Honey, Royal Jelly, and Propolis providing a warming sensation, gentle exfoliation with papaya enzymes, and Green Tea Extract.
• Active Serum Best-selling fast-acting formula reducing fine lines, improving uneven skin tone, and supporting a clearer-looking complexion with bilberry, mushroom, and white willow bark.
• Pro-Heal Serum Advance+ Vitamin C serum featuring advanced L-Ascorbic Acid combined with Olive Leaf Extract and pure Vitamins E and A for antioxidant protection and smoother, more revitalized skin.
• Hydra-Cool Serum Award-winning hydrating serum with antioxidants, botanicals, and bionutrients including Centella Asiatica, Hyaluronic Acid, and mushroom extract for cooling, soothing, and refreshing skin.
• GeneXC Serum Protective, restorative, age-defying serum powered by proprietary GeneXC Technology combining Vitamin C and Extremozyme plant extracts to brighten, protect, and restore youthful-looking skin tone, texture, and radiance.
• Youth Serum Tightening, smoothing, and restorative serum targeting visible signs of aging with peptide technology.
• Super Serum Advance+ Award-winning restorative serum with super antioxidant blend and reparative properties.
• Retinol+ Emulsion 0.3 Allure Best of Beauty-winning retinol formula combining botanical-origin retinol with Bakuchiol, Extremozymes, and Vitamin C to reduce fine lines, wrinkles, and even skin tone.
• Daily Dynamic Hydrator 3-in-1 formula combining GeneXC Technology with exosomes and peptides to treat aging signs, defend against environmental stressors, and deliver deep hydration with proven results in 2-week clinical studies (33% hydration improvement, 27% decrease in glabellar frown lines).
• Reparative Moisture Emulsion Barrier-supporting moisturizer with ceramides and peptides formulated with Extremozymes and Superoxide Dismutase for deep hydration and environmental protection.
• Sheald Recovery Balm Protective, soothing, nourishing balm for compromised or post-procedure skin with intensive barrier support.
• Youth Intensive Crème Rich, deeply nourishing overnight formula for firmer, more youthful-looking skin with age-defying, hydrating, and firming properties.
• GeneXC Firming Eye Gel Advanced eye treatment powered by proprietary GeneXC Technology with two forms of Vitamin C, Hyaluronic Acids, Palmitoyl Tripeptide-5, and Bacillus Ferment for firming, smoothing, and brightening the eye area.
• Youth Eye Complex Anti-aging eye cream with Tripeptide-1 (Copper Tripeptide-1), Acetyl Octapeptide-3, Hyaluronic Acid, and Marine Extremozyme to reduce fine lines, wrinkles, and brighten the under-eye area.
• C Eye Serum Advance+ Vitamin C eye serum to brighten and reduce visible signs of aging around the eye area.
• Eclipse SPF 50+ Ultra-sheer physical sunscreen with Titanium Dioxide, micronized Zinc Oxide, and Vitamin E providing water-resistant broad-spectrum UVA/UVB protection with PerfecTint technology.
• Extreme Protect SPF 30 Daily sunscreen with broad-spectrum SPF 30, microfine Zinc Oxide, and organic sunscreens combined with Extremozyme technology for hydration and environmental defense.
• Extreme Protect SPF 40 Mineral sunscreen with transparent micronized Zinc Oxide and Titanium Dioxide providing broad-spectrum UVA/UVB protection with a PerfecTint Bronze option.
• NeckPerfect Complex Award-winning tightening, sculpting, and smoothing treatment for the neck and décolleté area.
• Active Peel System Age-defying, exfoliating, and rejuvenating 15-treatment peel system for professional and home use.
• Youth Body Serum Award-winning hydrating, nourishing, and protective serum for body with lightweight formula.
• Lip Polish Award-winning smoothing, renewing, and hydrating lip treatment.
• Fire & Ice Facial Award-winning resurfacing and rejuvenation facial treatment available through licensed skincare professionals.
• Prodigy Peel Systems Professional peel system targeting mild acne, signs of aging, uneven skin tone, and fine lines.
• Honey Enzyme Facial Gentle yet effective treatment exfoliating, hydrating, and leaving all skin types smoother, brighter, and glowing.
• AI Skin Quiz AI-powered skin analysis tool providing customized clinical skincare routine recommendations based on individual skin analysis.

Quantifiable outcome

• 33% improvement in hydration, 12% improvement in elasticity, 27% decrease in glabellar frown lines, 23% decrease in forehead lines, 17% decrease in periorbital lines in 2-week clinical study
• +1 more outcomes

Named customers5 records

Segments3 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

Seven partnerships are on record, tiered core and minor.

• iS Cancer Care ProgramcoreStrategic or Co-development Partner · 1 January 2003Founded in 2003, iS Cancer Care provides skincare solutions and education programs to patients during their breast cancer journey. The program helps address physical and emotional challenges cancer patients commonly face through products that help improve skin issues during treatment such as dryness, cracking, sensitivity, redness and irritation. Spa Day events have expanded to leading institutions like Cedars-Sinai, Cleveland Clinic, and Mayo Clinic.
• National Breast Cancer CoalitioncoreStrategic or Co-development PartnerOrganization committed to ending breast cancer through action and advocacy since 1991. iS Clinical founders co-chair NBCC's Les Girls Cabaret in Los Angeles. Since 1991, NBCC has initiated a federal research program awarding more than $4 billion in grants to the scientific community.
• Foster LoveminorOthersNonprofit dedicated to children in foster care. The company supports this organization as part of their charitable initiatives and community giving programs.
• Washington Cancer InstitutecoreStrategic or Co-development PartnerOriginal partner institution where the iS Cancer Care program launched, hosting Spa Day events for cancer patients.
• Cedars-Sinai Breast Medical CentercoreStrategic or Co-development PartnerLeading institution hosting iS Cancer Care Spa Day events for breast cancer patients.
• Cleveland CliniccoreStrategic or Co-development PartnerMajor healthcare institution hosting iS Cancer Care Spa Day events for cancer patients.
• Mayo CliniccoreStrategic or Co-development PartnerLeading medical institution hosting iS Cancer Care Spa Day events for cancer patients internationally.

Scale indicators2 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• SkinMedica: Professional skincare line sold through dermatologists and plastic surgeons, focused on growth factors, retinoids, and clinically validated formulations. Directly comparable on medical-channel distribution and clinical efficacy claims.
• Revision Skincare: Physician-dispensed clinical skincare brand focused on anti-aging and corrective formulations. Comparable on professional-channel model and clinical-ingredient positioning.
• Alastin Skincare: Medical-grade skincare brand focused on procedure-related skin recovery and anti-aging, sold through physicians and med-spas. Comparable on clinical-grade positioning and post-procedure use cases.
• PCA Skin: Professional skincare brand offering chemical peels, retinoids, and clinical formulations sold through licensed estheticians and dermatologists. Comparable on professional-only treatments and clinical skincare regimen.
• EltaMD: Professional-grade sun care and skincare brand with strong adoption by dermatologists. Comparable on medical-channel distribution and broad skincare-with-SPF regimen offerings.
• Jan Marini Skin Research: Clinical skincare brand with patented and proprietary formulas sold through physicians and skin care professionals. Comparable on physician-channel distribution and clinical/anti-aging positioning.
• ZO Skin Health: Physician-dispensed skincare line founded by Dr. Zein Obagi focused on therapeutic, results-driven formulations. Comparable on medical-grade positioning and dermatologist-led formulations.
• Obagi Medical: Physician-dispensed skincare with pharmaceutical-grade formulations including retinoids and Vitamin C systems. Directly comparable to iS Clinical's medical-grade, professional-channel positioning.
• SkinCeuticals: A medical-grade skincare brand built around Vitamin C and antioxidant science, sold through physicians, med-spas, and DTC. Closely comparable to iS Clinical in clinical positioning, professional channel strategy, and premium pricing.
• Dermalogica: Professional skincare brand sold through skin therapists and licensed estheticians globally with education-driven go-to-market. Comparable on professional partner network and premium global distribution.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/isclinical
• YouTubeyoutube.com/c/isclinical
• Facebookfacebook.com/isclinical
• Instagraminstagram.com/isclinical
• Pinterestpinterest.com/isclinical
• TikToktiktok.com/@isclinical

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about iS CLINICAL