CSBio

What CSBio does

CSBio is a privately held, vertically integrated peptide technology company founded in 1993 in Silicon Valley, California. It designs and manufactures automated solid-phase peptide synthesizers (SPPS) spanning benchtop research systems (6 mL reaction vessels) through custom commercial-scale GMP manufacturing systems (up to 1000 L), under product lines branded CSBio II, CS136X, CS136M, CS536X, CS936S, and CS936/CS936X. All systems run on the proprietary CSPEPM software platform, which supports consistent workflow translation from research through GMP manufacturing, including 21 CFR Part 11 compliance for clinical and commercial production. Core proprietary technologies include patented 180° inversion mixing, conduction heating with -20°C to 90°C precision, overhead stirring for scale-up, optional PAT integration (UV-vis, refractive index, Raman), and solvent-reduction options.

The company's business model is a hybrid of high-value capital equipment sales and contract manufacturing services. Instrument sales are quote-based, custom-built to order, and priced from under $35,000 for the entry-level CSBio II to multi-million-dollar configurations for 1000 L commercial systems, sold via direct enterprise field sales from the Mountain View, California headquarters and supported by regional offices in Shanghai and Taiwan and exclusive distributors in Europe, India, Japan, and South Korea. In parallel, the company operates a cGMP-certified peptide manufacturing facility in Milpitas, California, producing custom clinical and commercial peptide APIs under exclusive long-term strategic partnerships with pharmaceutical clients. The company is ISO 9001 certified for instrumentation and cGMP certified for peptide manufacturing, and its customer base spans top-tier pharmaceutical companies, CDMOs, government agencies (CDC), and leading academic institutions.

Name

CSBio

Legal name

CSBio

Website

https://csbio.com

Company type

Private

Founded year

1993

Operating status

Operating

Headcount range

101–250 employees

Short description

CSBio designs and manufactures automated peptide synthesizers spanning research (6 mL) to commercial GMP scale (1000 L) and operates a cGMP peptide manufacturing services business, serving pharmaceutical companies, CDMOs, government agencies, and academic institutions globally.

Ownership category

akta.pro rank

Product category

Peptide Synthesis Instrumentation

NAICS

Biological Product (except Diagnostic) Manufacturing (325414), Pharmaceutical Preparation Manufacturing (325412), Analytical Laboratory Instrument Manufacturing (334516), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Pharmaceutical Preparations (2834), Biological Products, (No Disgnostic Substances) (2836), Laboratory Analytical Instruments (3826)

akta.pro primary industry

Therapeutic Peptides & Protein/Peptide Biologics (HLAAAAAH)

akta.pro secondary industries

CMC & Pharmaceutical Development (Formulation/Process/Analytical Development) (HLAIALAD), GMP Scale-Up, Tech Transfer & Process Validation (PPQ) (HLAGAHAL)

Keywords

• Peptide synthesizers
• Solid phase peptide synthesis
• CGMP peptide manufacturing
• Oligonucleotide synthesis instruments
• Automated laboratory synthesizers

Headquarters

HQ city

Menlo Park

HQ country

United States

HQ region

North America

Offices8 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Supply Chain, Operations, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Peptide Synthesizer Hardware Sales: CSBio manufactures and sells automated peptide synthesizers ranging from compact benchtop research systems to large-scale commercial GMP manufacturing systems. Products include CSBio II, CS136X, CS136M, CS536X, CS936S, and custom commercial-scale systems (10L to 1000L). Systems are sold directly and through international distributors.
2. DNA/RNA Oligonucleotide Synthesizers: CSBio also manufactures and sells DNA synthesizers for pilot and process scale oligonucleotide synthesis, complementing their peptide synthesizer product line.
3. cGMP Peptide Manufacturing Services: CSBio operates cGMP certified peptide manufacturing facilities producing custom clinical peptides and commercial peptide APIs for pharmaceutical clients through exclusive long-term strategic partnerships.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels5 records

Core offering

CSBio designs, manufactures, and sells automated peptide synthesizers ranging from 6 mL benchtop research systems to 1000 L custom commercial-scale GMP manufacturing systems, using proprietary conduction heating, 180° inversion mixing, and the CSPEPM software platform. The company also operates cGMP-certified facilities producing custom clinical and commercial peptide APIs for pharmaceutical clients through long-term strategic partnerships.

Product overview

CSBio offers a comprehensive platform of automated peptide synthesizers spanning research, pilot, and commercial scales, designed to support the entire peptide lifecycle from discovery through commercial manufacturing. The product line includes the CSBio II (compact benchtop research system), CS136X and CS136M (flexible research-scale platforms), CS536X (pilot-scale process development), CS936S (GMP-ready pilot production), and CS936/CS936X (custom commercial-scale manufacturing systems from 10L to 1000L). All systems share the proprietary CSPEPM software platform for consistent workflow across scales. The company also offers DNA/RNA oligonucleotide synthesizers at pilot and process scales. The platform is designed to enable seamless scale-up from initial discovery through commercial production using consistent software and configurable options including temperature control, PAT integration, and solvent reduction technologies.

Differentiator

Problem solved

Functional benefit

Brands

• CSPEPM: Proprietary peptide synthesis software platform used across CSBio's research, pilot, and commercial-scale peptide synthesizers for consistent workflow from small-scale method development to larger-scale production.
• CSBio II
• CS136X
• CS136M
• CS536X
• CS936S
• CS936/CS936X

Products and services

• CSBio II Peptide Synthesizer Compact, fully automated research-scale peptide synthesizer with 6 mL or 15 mL reaction vessels, preloaded protocols, and heated synthesis for fast cycle times. Targets academic and biotech labs seeking in-house research-scale peptide synthesis.
• CS136X Peptide Synthesizer Flexible research-scale peptide synthesizer with 20-200 mL reaction vessels, supporting up to 3 parallel reaction vessels, flexible chemistry options, and temperature control. Used for R&D, process development, and small-scale manufacturing.
• CS136M Peptide Synthesizer High-throughput research-scale peptide synthesizer with six parallel reaction vessels (20-100 mL each) for synthesizing multiple different peptides simultaneously.
• CS536X Peptide Synthesizer Pilot-scale automated peptide synthesizer with 200 mL to 2 L reaction vessels for process development, scale-up, and medium-scale clinical production, with configurable process-development options.
• CS936S Peptide Synthesizer GMP-ready pilot-scale peptide synthesizer with 2 L to 10 L reaction vessels for robust pilot-scale synthesis and clinical-stage peptide production.
• CS936 and CS936X Commercial-Scale Peptide Synthesizers Custom fully automated commercial-scale peptide synthesizers for GMP manufacturing from 10 L to 1000 L reaction vessels, tailored to customer workflow and facility requirements.
• DNA/RNA Oligonucleotide Synthesizers Pilot and process scale DNA synthesizers for oligonucleotide synthesis, complementing CSBio's peptide synthesizer product line.
• cGMP Peptide Manufacturing Services cGMP certified peptide manufacturing services producing custom clinical and commercial peptide APIs for pharmaceutical clients through exclusive long-term strategic partnerships; CSBio no longer offers individual or small batch orders.

Quantifiable outcome

• 20-mer peptide synthesis completed in less than 5 hours with under 1L solvent consumption on CSBio II
• +2 more outcomes

Named customers16 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Four partnerships are on record, tiered regional.

• CHEMGO Organica AGregionalChannel Partner/ Reseller/ DistributorExclusive European distribution partner for CSBio instrumentation. Located in Muenchenstein, Switzerland, providing sales, service, and support for European customers.
• CHEMETregionalChannel Partner/ Reseller/ DistributorExclusive Indian distribution partner for CSBio instrumentation. Located in Mumbai, India, providing local sales and support services.
• AS ONEregionalChannel Partner/ Reseller/ DistributorExclusive Japanese distribution partner for CSBio instrumentation. Located in Osaka, Japan, providing local sales and distribution services.
• MJ ScienceregionalChannel Partner/ Reseller/ DistributorExclusive South Korean distribution partner for CSBio instrumentation. Located in Daejeon, South Korea, providing local sales and support.

Scale indicators4 records

Recent moves5 records

Expansion highlights6 records

Direct peers

• PolyPeptide Group: Global peptide CDMO comparable to CSBio's peptide manufacturing services, producing custom peptide APIs for pharma and biotech customers across clinical and commercial stages.
• AAPPTec: Direct competitor in peptide synthesis instruments and reagents, including the Apex 396 parallel synthesizer and various research-scale systems. Comparable niche focus on peptide chemistry instrumentation.
• Bachem: Largest independent peptide CDMO globally, comparable to CSBio's cGMP peptide manufacturing services business. Competes for the same clinical and commercial peptide API contracts from pharma customers.
• Biotage: Competes in peptide purification ( Isolera and Selekt systems) and adjacent peptide workflow tools, often co-sold alongside peptide synthesizers in pharma peptide manufacturing workflows.
• CEM Corporation: Direct competitor in automated peptide synthesis instrumentation, particularly known for microwave-assisted peptide synthesizers (Liberty series) at research and pilot scale. Most direct head-to-head competitor in CSBio's CS136X and CS536X segments.
• Gyros Protein Technologies (now part of Cytiva): Direct competitor in peptide synthesizers (Prelude and PurePep product lines), targeting research-scale peptide synthesis and offering parallel synthesis capabilities comparable to CSBio's CS136M. Now backed by Cytiva/Danaher resources.

Broad incumbents

• Lonza: Largest global CDMO with peptide manufacturing capabilities among broader modalities (mAbs, cell therapy, small molecules). Competes with CSBio's cGMP peptide manufacturing services for high-value commercial peptide contracts.
• Thermo Fisher Scientific: Broad life sciences tools incumbent with peptide synthesis offerings through its bioproduction and analytical segments, plus the Patheon CDMO business competing in cGMP peptide manufacturing. Massively larger scale and global service network.
• WuXi AppTec: Global CRDMO with peptide manufacturing capabilities serving pharma customers; notably also a CSBio customer purchasing CSBio synthesizers. Represents both competitor (for CDMO service revenue) and customer (for instrument sales).
• Cytiva (Danaher): Broad bioprocessing incumbent that acquired Gyros Protein Technologies; offers peptide workflow solutions alongside larger bioprocessing portfolio. Competes for pharma/CDMO peptide manufacturing capex with bundled offerings.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/c-s-bio-co-

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles5 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments1 record

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about CSBio