What NanoTemper Technologies does

NanoTemper Technologies GmbH, founded in 2008 in Munich by Dr. Stefan Duhr and Dr. Philipp Baaske, develops and sells biophysical characterization instruments that help scientists characterize proteins and molecular interactions during drug discovery and development. The company's portfolio spans proprietary measurement technologies — MicroScale Thermophoresis (MST), nanoDSF, Dynamic and Static Light Scattering (DLS/SLS), Backreflection, Spectral Shift, Temperature-Related Intensity Change (TRIC), and (since November 2025) Nanofluidic Scattering Microscopy (NSM) acquired from Envue Technologies. These are commercialized through four core instrument platforms: Prometheus Panta (multi-parameter protein stability), Dianthus and Dianthus uHTS (affinity screening, including high-throughput), Monolith and Monolith Omni (affinity measurement via MST), and Andromeda (crude-lysate protein stability), supported by Tycho for rapid quality checks. End customers are biopharmaceutical companies developing protein therapeutics and biologics, researchers working on Targeted Protein Degradation (TPD) and membrane proteins, contract research organizations, and academic scientists.

NanoTemper generates revenue through four streams: one-time instrument sales (Prometheus Panta, Monolith, Dianthus, Andromeda, Tycho), recurring consumables (proprietary capillary chips, 384-well plates, labeling kits, buffer exploration kits) sold via shop.nanotempertech.com, software licenses, and multi-year service and maintenance contracts. Instruments and software are quote-priced for enterprise buyers, while consumables carry listed online pricing. The company distributes via nine direct regional offices (Munich, South San Francisco, Boston, Toronto, Bangalore, Beijing, Shanghai, Yokohama, Krakow) and a global distributor network covering 15+ additional countries including Japan, South Korea, Australia/NZ, India, China, Brazil, Mexico, South Africa, and Israel. The Japan NanoDSF capillaries segment is a notable scale signal, with NanoTemper holding 60–70% of installed instruments. The company remains privately held and founder-owned, with no disclosed external funding rounds or institutional investors.

Name

NanoTemper Technologies

Legal name

NanoTemper Technologies GmbH

Website

https://nanotempertech.com

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

101–250 employees

Short description

NanoTemper Technologies develops biophysical characterization instruments and proprietary consumables for protein stability, affinity, and molecular interaction analysis, serving biopharmaceutical drug discovery teams, contract research organizations, and academic researchers across global markets.

Ownership category

akta.pro rank

Product category

Biophysical Characterization Instruments

NAICS

Analytical Laboratory Instrument Manufacturing (334516), Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (3345)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Material Characterization & Spectroscopy (NMR/FTIR/MS) (HLAGADAK)

akta.pro secondary industries

Solid-State Chemistry & Preformulation (Polymorph/Crystallization) (HLAGAHAI), Crystallization, Particle Engineering & Micronization Services (HLAGAHAJ)

Keywords

• Biophysical characterization
• Protein stability instruments
• Label-free binding assays
• Molecular interaction analysis
• Drug discovery tools

Headquarters

HQ city

Munich

HQ country

Germany

HQ region

Europe

Offices9 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Supply Chain, Personnel, Marketing or Sales, Operations, Infrastructure

Revenue model

1. Instruments and Hardware: Sale of biophysical characterization instruments including Prometheus Panta, Monolith, Dianthus, Dianthus uHTS, Andromeda, and Tycho systems.
2. Consumables and Reagents: Capillaries, capillary chips, protein labeling kits, buffer exploration kits, control kits, and assay development kits sold through online store.
3. Software Licenses: Software solutions for instrument control and data analysis.
4. Service and Maintenance: Service contracts and maintenance offerings for instruments.

Pricing tiers

Go-to-market motion2 records

Distribution channels6 records

Marketing channels7 records

Core offering

NanoTemper Technologies develops and manufactures biophysical characterization instruments, proprietary consumables, and analysis software that enable drug discovery and protein research scientists to measure protein stability, aggregation, and molecular binding interactions. The core product lines — Prometheus Panta, Dianthus / Dianthus uHTS, Monolith / Monolith Omni, Andromeda, and Tycho NT.6 — are supported by labeling kits, capillary chips, and plates sold via the company's online shop and direct sales channels.

Product overview

NanoTemper Technologies develops a comprehensive portfolio of biophysical characterization instruments and consumables for drug discovery and protein research. The product ecosystem is organized around four core instrument lines: Prometheus Panta for multi-parameter protein stability analysis, Dianthus for affinity screening (including high-throughput Dianthus uHTS), Monolith for affinity measurement using MST technology (including Monolith Omni), and Andromeda for crude lysate analysis. The portfolio also includes Tycho for rapid quality checks. These instruments are supported by a comprehensive range of proprietary labeling kits (RED-NHS, RED-Maleimide, His-Tag, Biotin, Fc-specific), assay development kits, and precision capillary consumables. Key technology platforms include nanoDSF, Dynamic Light Scattering (DLS), Static Light Scattering (SLS), Backreflection, Spectral Shift, MicroScale Thermophoresis (MST), and Temperature-Related Intensity Change (TRIC), enabling measurements from protein stability to molecular interaction analysis. Recent expansion includes the acquisition of Envue Technologies and its Nanofluidic Scattering Microscopy (NSM) technology for single-molecule, label-free analysis.

Differentiator

Problem solved

Functional benefit

Products and services

• Prometheus Panta Multi-parameter protein stability instrument combining nanoDSF, DLS, SLS, and Backreflection to measure thermal unfolding and colloidal stability of proteins in a single run, used by biopharma and academic researchers for biologics characterization.
• Dianthus Affinity screening instrument enabling in-solution binding analysis for tough drug-discovery targets via Spectral Shift technology, supporting confident candidate decisions in targeted protein degradation and biologics programs.
• Dianthus uHTS High-throughput screening version of the Dianthus platform designed to accelerate screening and discovery workflows with faster turnaround for affinity measurements.
• Monolith Affinity measurement instrument based on MicroScale Thermophoresis (MST), requiring minimal sample while delivering molecular interaction insights for protein research and drug discovery.
• Monolith Omni Affinity measurement instrument variant of the Monolith platform offering more answers with less complexity in molecular interaction analysis.
• Andromeda Protein stability characterization instrument designed for analysis of crude lysates, enabling early-stage decision-making without purification requirements for biologics and protein research workflows.
• Tycho NT.6 Rapid protein quality check instrument using capillary-based technology suitable for virtually all buffers and sample concentrations, used as a fast triage tool before deeper characterization.
• Protein Labeling Kit RED-NHS 2nd Generation Amine-reactive NHS-ester labeling kit for affinity studies that delivers higher binding amplitudes and improved signal-to-noise ratios for proteins larger than 5 kDa.
• Protein Labeling Kit RED-MALEIMIDE 2nd Generation Cysteine-reactive labeling kit enabling site-specific labeling and affinity studies with improved data quality for previously challenging targets.
• His-Tag Labeling Kit RED-tris-NTA 2nd Generation Site-specific, purification-free labeling kit for His-tagged proteins and peptides, compatible with both purified and crude samples.
• Andromeda His-Tag Labeling Kit Site-specific labeling kit for polyhistidine-tagged proteins in crude lysate, completing labeling in 30 minutes without dye removal required.
• Biotinylated Target Labeling Kit Site-directed labeling kit for biotin-tagged proteins and peptides with a 15-minute labeling protocol and no dye removal required.
• Human Fc Labeling Kit Site-specific labeling kit for human Fc antibody regions with a purification-free workflow optimized for Spectral Shift technology.
• Buffer Exploration Kit 96 deep-well plate containing various buffer conditions for MST, TRIC, protein stability, purification, and storage assay development.
• Monolith NT.Automated Capillary Chips High-precision glass capillaries for automated Monolith instruments, providing 384 data points per package for high-throughput affinity measurements.
• Prometheus NT.Plex Capillary Chips nanoDSF-grade capillary chips for use with Prometheus Panta instruments, available in standard and high-sensitivity variants for different protein concentration ranges.
• Dianthus 384-well Plates Barcoded 384-well plates for TRIC measurements with the Dianthus system, featuring hard-sided black/black construction with clear bottom and 18-25 µL working volume.

Quantifiable outcome

• From data to decisions - enabling breakthrough biophysical characterization

Named customers2 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature7 records

Partnerships

One partnership is on record.

• Envue TechnologiescoreStrategic or Co-development Partner · 5 November 2025Acquisition of Swedish startup Envue Technologies specializing in Nanofluidic Scattering Microscopy (NSM). This acquisition enhances NanoTemper's biophysical analysis portfolio and supports early-stage biopharmaceutical research, particularly in nucleic acid and protein therapeutic discovery. Integration of NSM technology with spectral shift analysis expands capabilities.

Scale indicators5 records

Recent moves7 records

Expansion highlights5 records

Broad incumbents

• Cytiva (formerly GE Healthcare Life Sciences): Broad incumbent with Biacore SPR systems that compete directly with Monolith/Dianthus for affinity and kinetic analysis, plus a large bioprocessing and protein purification portfolio that gives Cytiva significant cross-sell leverage against NanoTemper in biopharma accounts.
• Bruker: Broad incumbent in analytical instruments with mass spectrometry and biophysical tools that overlap with NanoTemper's protein characterization workflows in structural biology and biologics development.
• Thermo Fisher Scientific: Broad incumbent offering a full analytical and life-sciences instrument stack, including chromatography, mass spectrometry, and protein interaction tools that compete with NanoTemper's biophysical portfolio as part of larger procurement deals.
• Waters Corporation: Broad incumbent in analytical instruments and chromatography with growing presence in biologics characterization, competing with NanoTemper at the workflow level for biopharma QC and characterization budgets.
• Sartorius (incl. FortéBio): Broad incumbent through FortéBio's BLI (Bio-Layer Interferometry) Octet platform, which competes with MST and TRIC for label-free protein interaction and quantitation, and brings significant scale and bioprocess bundling power.

Direct peers

• Malvern Panalytical: Direct competitor in biophysical characterization, offering Zetasizer (DLS), light scattering, and protein characterization tools that overlap directly with NanoTemper's Prometheus and DLS portfolio for biologics development and formulation.
• Wyatt Technology: Closest direct peer in light-scattering-based protein characterization, with DLS/SLS/MALS instruments and microcalorimetry used for the same biologics, formulation, and biophysics workflows that NanoTemper's Prometheus Panta platform addresses.
• Creoptix: Direct competitor in label-free affinity measurement, offering the WAVEsystem (a grating-coupled interferometry platform) that competes head-to-head with NanoTemper's Monolith/MST and Dianthus/TRIC instruments for kinetic and affinity analysis.
• Dynamic Biosensors: Direct competitor using switchSENSE technology for real-time kinetic and affinity measurements on DNA nanolevers, overlapping with Monolith/MST and Dianthus use cases in protein interaction and drug discovery characterization.

Emerging players

• Unchained Labs: Emerging player in biologics characterization tools (including Uncle for stability and Hunky for stability/aggregation), competing with portions of NanoTemper's Prometheus and Tycho offerings in the biologics formulation and developability workflow.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/user/NanoTemper
• LinkedInlinkedin.com/company/nanotemper-technologies-gmbh
• Xx.com/NanoTemper

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Subsidiaries7 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A2 records

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NanoTemper Technologies