Origene Technologies

What Origene Technologies does

OriGene Technologies, founded in 1996 and headquartered in Rockville, Maryland, is a private life sciences tools company that develops, manufactures, and sells genome-wide research reagents and related services. Its core offering centers on one of the world's largest catalogs of gene-centric tools, including over 1 million cDNA clones, 37,000+ TrueORF expression-validated clones, 20,000+ recombinant proteins (MVPro), 8,000+ antibody targets (TrueMAB, TrueRAB, UltraMAB), viral vectors (lentiviral and AAV), RNAi reagents (shRNA, Trilencer-27 siRNA), CRISPR/Cas9 tools, and transfection reagents (ProteanFect, EZ-LNP, TurboFectin). The proprietary PrecisionShuttle system enables researchers to shuttle TrueORF clones across destination vectors with different tags, promoters, and selection markers, creating platform interoperability across the product line. Services span custom cloning, lentivirus/AAV packaging, CRISPR cloning, stable cell line generation, custom protein production, antibody development, conjugation, ELISA development, and SPR analysis.

The company serves a horizontal customer base of academic researchers, pharmaceutical and biotech drug discovery teams, and cell and gene therapy developers, with named users including the University of Pennsylvania, University of Michigan, Case Western Reserve, Icahn School of Medicine at Mount Sinai, UT Southwestern, BC Cancer Research Centre, the CDC, and CiPA Lab. Revenue is generated through one-time catalog product sales, fee-for-service custom work, and promotional volume pricing (e.g., $99 sample antibodies, 20% off Lentivirus/AAV controls, $100 off siRNA), distributed primarily via the company's own e-commerce storefront with separate US and EUR pricing, an international distributor network, and a strategic channel partnership with Nanoportal Biotech. OriGene also operates a wholly-owned EU subsidiary (OriGene Technologies GmbH) and has built its catalog partly through acquisitions including Acris Antibodies (2015), BioCheck (2014), Blue Heron Biotechnology (2010), Beijing Zhongshan Golden Bridge Biotechnology (2012), and earlier transactions in 2009.

Name

Origene Technologies

Legal name

OriGene Technologies, Inc.

Website

https://origene.com

Company type

Private

Founded year

1996

Operating status

Operating

Headcount range

101–250 employees

Short description

OriGene Technologies is a Rockville, Maryland-based life sciences tools company that sells one of the world's largest catalogs of cDNA clones, validated antibodies, recombinant proteins, viral vectors, RNAi reagents, and CRISPR tools to academic, pharmaceutical, and cell/gene therapy researchers worldwide via direct e-commerce and distributor channels.

Ownership category

akta.pro rank

Product category

Life Sciences Research Reagents

NAICS

Biological Product (except Diagnostic) Manufacturing (325414), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Scientific Research and Development Services (5417)

SIC

Biological Products, (No Disgnostic Substances) (2836), Services-Commercial Physical & Biological Research (8731)

akta.pro industry

PRIMARYHLAAACAJ

Gene Therapy Vector Manufacturing & CDMO Services

Healthcare & Life Sciences/Biotechnology & Biologics/Gene Therapy (AAV/lentiviral/other vectors)

SECONDARYHLAAAKAD

Viral Vector Manufacturing Services (AAV, lentiviral, adenoviral)

Healthcare & Life Sciences/Biotechnology & Biologics/Biomanufacturing Services

Keywords

• CDNA clones
• Research antibodies
• Lentiviral vectors
• Gene delivery reagents
• CRISPR tools

Headquarters

HQ city

Rockville

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Technology or R&D, Supply Chain, Marketing or Sales, Infrastructure

Revenue model

1. Research Reagents and Biological Materials: One-time product sales of validated antibodies, cDNA clones, proteins, viral vectors, RNAi products, and CRISPR tools to academic and pharmaceutical researchers
2. Custom Services: Fee-for-service offerings including custom cloning, lentivirus production, AAV packaging, shRNA services, CRISPR cloning, stable cell line development, and protein services
3. Promotional Volume Sales: Discount-driven promotions on specific product categories (20% off Lentivirus/AAV, 20% off proteins, $100 off siRNA) to drive trial and repeat purchases

Pricing tiers

Go-to-market motion3 records

Distribution channels3 records

Marketing channels8 records

Core offering

OriGene Technologies develops, manufactures, and sells genome-wide life sciences research reagents including cDNA clones, ORF clones, validated antibodies, recombinant proteins, lentiviral and AAV vectors, RNAi products, CRISPR tools, and transfection reagents, along with fee-for-service custom cloning, virus packaging, antibody development, and protein production services for academic and pharmaceutical researchers.

Product overview

OriGene Technologies is a life sciences tools company that develops, manufactures, and sells genome-wide research and diagnostic products. The portfolio is organized as a comprehensive platform with multiple interconnected product categories: (1) Genomics products centered on cDNA clones (TrueClone®, TrueORF®, TrueORF® Gold, LentiORF®, Viral ORF Clones, 3' UTR Reporter Clones, Mutant ORF Plasmids, Organelle Markers) and clone sets for various applications; (2) Viral Gene Delivery solutions including lentiviral and AAV products; (3) RNAi products including shRNA plasmids, shRNA lentiviral particles, siRNA oligo duplexes (trilencer-27), and microRNA expression plasmids; (4) CRISPR Tools comprising knockout kits, CRISPR/Cas9 vectors (all-in-one, T7, nickase, xCas9 variants), CRISPRa/CRISPRi, and transgene knock-in vectors; (5) Transfection Reagents including ProteanFect™ TuffCell (for primary cells), EZ-LNP™ (instrument-free RNA delivery), TurboFectin 8.0™, MegaTran™, 293Tran™, siTran™, and LentiTran™; (6) Proteomics products including primary antibodies (TrueMAB™, TrueRAB™, UltraMAB™, recombinant, carrier-free, anti-tag, phospho-specific, KO/KD validated, flow cytometry validated, Simple Western validated), IHC products (validated antibodies, detection kits, CytoSections™ controls), assay kits (ELISA, lateral flow), recombinant proteins (MVPro with 20,000+ proteins), and tissues (TissueScan arrays, FFPE sections, tissue blocks); (7) Cloning tools including competent cells, qPCR tools, and seamless cloning master mix; (8) Specialty products like EV isolation reagents, DDKTrap affinity resin, stable cell lines, luciferase assays, and forensic DNA; supported by (9) Comprehensive services including custom cloning, custom lentivirus/AAV packaging, custom shRNA, CRISPR cloning, stable cell line generation, custom protein service, antibody development, conjugation service, specificity validation (UltraMAB), ELISA development, and SPR analysis. The PrecisionShuttle System enables flexible vector shuttling across the product ecosystem.

Differentiator

Problem solved

Functional benefit

Brands

• TrueClone: Untagged cDNA clones product line
• TrueORF
• TrueORF Gold
• LentiORF
• ProteanFect
• EZ-LNP
• CellPainter
• Truesample
• MVPro
• UltraMAB
• PrecisionShuttle

Products and services

• cDNA Clones (TrueClone, TrueORF, TrueORF Gold, LentiORF, Viral ORF, 3' UTR Reporter, Mutant ORF) Tagged and untagged full-length cDNA/ORF clones for human, mouse, and rat genes delivered as transfection-ready plasmids for protein over-expression, gene function studies, miRNA target validation, and disease mutation research.
• cDNA Clone Sets Pre-assembled pathway-focused plasmid collections of over 100,000 expression plasmids delivered as transfection-ready DNA for high-throughput screening and pathway studies.
• Organelle Markers (CellPainter) Fluorescent protein-tagged TrueORF clones (GFP, RFP, BFP) for direct visualization of cellular organelles and structures.
• Lentiviral Products and Services Genome-wide lentiviral vectors, particles, and packaging services for gene delivery into dividing and non-dividing cells.
• AAV Products and Services Adeno-associated viral vectors and packaging services for in-vivo gene delivery applications.
• RNAi Products (shRNA Plasmids, shRNA Lentiviral Particles, siRNA Oligo Duplexes, MicroRNA Expression Plasmids) RNAi reagents including short hairpin RNA expression vectors and lentiviral particles for stable gene silencing, dicer-substrate 27mer siRNA duplexes with guaranteed >70% knockdown, and miRNA over-expression vectors for human, mouse, and rat species.
• CRISPR Tools (Knockout Kits, CRISPR/Cas9 Vectors, CRISPRa/CRISPRi, Transgene Knock-in Vectors) Complete CRISPR/Cas9 tools including knockout kits, all-in-one vectors with gRNA and Cas9 expression, T7 vectors for in vitro gRNA production, Cas9 nickase and xCas9 variants, CRISPR activation/interference vectors, and transgene knock-in vectors for AAVS1 and ROSA26 safe harbor loci.
• Transfection Reagents (ProteanFect TuffCell, EZ-LNP, TurboFectin 8.0, MegaTran, 293Tran, siTran, LentiTran) Reagents for nucleic acid delivery into mammalian cells including coacervate-based transfection for difficult-to-transfect primary cells, instrument-free lipid nanoparticle RNA transfection, and specialized reagents for HEK293 cells, siRNA, and lentiviral production.
• Primary Antibodies (TrueMAB, TrueRAB, UltraMAB, Recombinant, Carrier Free, Anti-Tag, Phospho-Specific, KO/KD Validated, Flow Cytometry, Simple Western) Validated monoclonal and polyclonal antibodies for Western blot, IHC, ELISA, immunofluorescence, and flow cytometry, including ultra-specific antibodies validated on high-density protein microarrays covering more than 8,000 targets.
• IHC Products (IHC Validated Antibodies, Detection Kits, CytoSections, Secondary Antibodies) Immunohistochemistry products including validated primary antibodies, ready-to-use detection kits, CytoSections cellular controls, and secondary antibodies for tissue section applications.
• Assay Kits (ELISA Kits, ELISA Pairs, Lateral Flow Assays, Conjugation Kits) Ready-to-use assay kits for quantitative protein detection including ELISA kits and matched antibody pairs, rapid lateral flow diagnostic assays, and antibody conjugation kits for labeling.
• Recombinant Proteins (MVPro, Mutant Proteins, Transmembrane Proteins, Heavy-Labeled Proteins) Full-length human recombinant proteins expressed in HEK293 cells retaining native structure and post-translational modifications, covering over 20,000 proteins across 9,000+ gene targets, including disease mutant variants, transmembrane proteins, and isotope-labeled mass spectrometry standards.
• Tissue Products (TissueScan cDNA Arrays, FFPE & Frozen Sections, Tissue Blocks) Pathologist-verified tissue cDNA arrays covering normal and cancer tissues for gene expression profiling, plus formalin-fixed paraffin-embedded and frozen tissue sections and tissue blocks for histology and IHC applications.
• Custom Cloning and cDNA Clone Set Services Fee-for-service custom gene cloning from mutagenesis to gene synthesis, plus pre-assembled pathway-focused clone set assembly for high-throughput screening.
• Custom Lentivirus Production Service Custom lentiviral particle production for user-specified genes, supporting gene delivery into dividing and non-dividing cells.
• AAV Packaging Service Custom adeno-associated virus packaging services for in-vivo gene delivery applications.
• Custom shRNA Service Custom short hairpin RNA design and production services for stable gene silencing experiments.
• CRISPR Cloning Service CRISPR/Cas9 gRNA cloning and donor template construction services for genome editing experiments.
• Custom Stable Cell Lines Service Custom generation of stable cell lines with over-expression of genes of interest.
• Antibody Development and Conjugation Services One-stop antibody development from monoclonal and polyclonal production to conjugation and affinity testing, plus ultra-specific antibody validation using high-density protein microarray technology.
• ELISA Development and SPR Analysis Services Custom ELISA assay development services and surface plasmon resonance (SPR) analysis for protein-protein interaction studies.
• Custom Protein Service End-to-end custom protein services from gene cloning to purification across multiple expression systems with flexible tagging and biotinylation options.

Quantifiable outcome

• Over 1 million cDNA clones and 37,000+ TrueORF clones available
• +2 more outcomes

Named customers10 records

Segments3 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

One partnership is on record.

• Nanoportal BiotechcoreChannel Partner/ Reseller/ Distributor · 11 November 2025Strategic partnership for global distribution and co-marketing of ProteanFect™, OriGene's gene delivery reagent that uses endogenous proteins to efficiently transfer nucleic acids into difficult-to-transfect cells. The technology aims to advance research in regenerative medicine, immunology, and neuroscience fields.

Scale indicators9 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• GeneCopoeia: Provider of ORF cDNA clones, lentiviral vectors, CRISPR tools, and recombinant proteins with a similar genome-wide catalog and services approach.
• GenScript: Gene synthesis and recombinant protein provider serving academic and pharma researchers with overlapping product lines in ORF clones, antibodies, and viral vectors.
• Sino Biological: Chinese recombinant protein and antibody manufacturer with global reach. Direct competitor in recombinant proteins (MVPro line) and research antibodies.
• Twist Bioscience: Synthetic DNA and NGS provider with antibody and gene fragment offerings. Overlaps with OriGene's cDNA clone and synthetic biology-adjacent product lines.
• Cell Signaling Technology: Premium antibody and reagent supplier focused on validated research antibodies for cell signaling. Direct competitor in the primary antibody market alongside TrueMAB/UltraMAB.
• Addgene: Non-profit plasmid repository selling cDNA, ORF, lentiviral, and CRISPR clones globally to academic researchers. Direct overlap with OriGene's TrueClone, TrueORF, and LentiORF catalog.

Broad incumbents

• ATCC: Global biological materials resource center providing cell lines, microorganisms, and reagents. Overlaps in supporting tools, cell lines, and reference materials used by OriGene's customer base.
• Abcam (Danaher): Global leader in research antibodies and life science reagents, now owned by Danaher. Competes across OriGene's antibody portfolio with much broader catalog scale.
• Bio-Techne: Major life sciences tools provider with R&D Systems, Novus Biologicals, and Tocris brands spanning proteins, antibodies, and reagents. Overlaps with OriGene's proteomics catalog.

Emerging players

• VectorBuilder: Custom vector design and viral vector manufacturing service for research and gene therapy. Direct overlap with OriGene's custom lentivirus and AAV packaging services.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/origenebio
• YouTubeyoutube.com/user/origenesocial
• LinkedInlinkedin.com/company/origene-technologies-inc
• Instagraminstagram.com/origene_technologies_official
• Facebookfacebook.com/223204764370979

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Subsidiaries1 record

Funding overview

Funding rounds5 records

Investors11 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A6 records

Investments1 record

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Origene Technologies