What Cleveland HeartLab does

Cleveland HeartLab, Inc. is a specialty clinical laboratory headquartered in Cleveland, Ohio, focused exclusively on cardiometabolic disease testing. Founded in 2000 by Stanley Hazen and Jake Orville, the company operates as the Quest® Cardiometabolic Center of Excellence™ at Cleveland HeartLab® under the corporate umbrella of Quest Diagnostics Incorporated (NYSE: DGX), a wholly-owned subsidiary structure that provides national laboratory infrastructure, billing systems, and provider network reach.

The company's core offering is a proprietary multimarker test menu spanning inflammation biomarkers (F2-Isoprostanes, hsCRP, Oxidized LDL, Lp-PLA2 Activity, Myeloperoxidase, Microalbumin, ADMA/SDMA), advanced lipid testing (HDL Function Panel with HDLfx pCAD Score, NMR LipoFraction, Apolipoprotein B/A1, Small-Dense LDL, Lipoprotein(a)), metabolic markers (TMAO, Adiponectin), vitamin and supplement testing (OmegaCheck™, CoQ10, Vitamin D), genetic assays (ApoE genotyping, CYP2C19 polymorphism), and additional cardiovascular markers (AspirinWorks®, Galectin-3, High Sensitivity Troponin T). These assays are performed at the company's Cleveland laboratory using proprietary chemistry methods and are supported by clinical education, peer consultation services, and an extensive clinical references library.

Commercially, Cleveland HeartLab operates a B2B sales-led model targeting healthcare providers — physicians, cardiologists, primary care practices, and clinical groups — who order tests on behalf of patients. Specimens are collected at provider offices or Quest Diagnostics Patient Service Centers and shipped to Cleveland for analysis. Tests are billed through standard insurance, Medicare, or Medicaid reimbursement channels. Distribution occurs through direct sales relationships, the Cleveland HeartLab web portal, and integration with Quest Diagnostics' Quanum Lab Services Manager. The company holds CLIA certification and HIPAA compliance, and prior to its acquisition by Quest Diagnostics had raised approximately $48M in venture funding between 2010 and 2016.

Name

Cleveland HeartLab

Legal name

Cleveland HeartLab, Inc.

Website

http://www.clevelandheartlab.com

Company type

Private

Founded year

2000

Operating status

Operating

Headcount range

51–100 employees

Short description

Cleveland HeartLab is a specialty clinical laboratory that provides proprietary cardiometabolic and inflammation biomarker testing to healthcare providers. Operating as a Quest Diagnostics subsidiary, it serves physicians, cardiologists, and primary care practices ordering advanced cardiovascular risk assessment tests.

Ownership category

akta.pro rank

Product category

Specialty Clinical Laboratory / Cardiometabolic Diagnostics

NAICS

Medical Laboratories (621511)

SIC

Services-Medical Laboratories (8071)

akta.pro primary industry

Specialty & Biomarker Laboratory Services (Immunoassays/Flow/Cytometry) (HLAGAEAB)

akta.pro secondary industry

Clinical Biomarker Testing Services (central labs, trial enrollment/monitoring assays) (HLAAAMAC)

Keywords

• Cardiometabolic diagnostics
• Inflammation biomarker testing
• Cardiovascular risk assessment
• Advanced lipid testing
• Specialty clinical laboratory

Headquarters

HQ city

Cleveland

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales, Supply Chain, Infrastructure

Revenue model

1. Laboratory Testing Services: Cleveland HeartLab provides specialized cardiometabolic laboratory testing services to healthcare providers. Tests are ordered by physicians and billed through standard laboratory billing processes, likely insurance or government healthcare programs. The company offers a comprehensive test menu covering inflammation, lipids, metabolic, and genetic markers.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels4 records

Core offering

Cleveland HeartLab is a specialty clinical laboratory that performs cardiometabolic diagnostic testing ordered by healthcare providers, covering inflammation biomarkers, advanced lipid panels, metabolic markers, genetic tests, and cardiovascular assays. Samples are collected at provider offices or Quest Diagnostics Patient Service Centers, shipped to the Cleveland laboratory, and results are returned via a secure web portal. The company also supplies specimen collection materials and offers clinical education and consultation services to support provider adoption and patient management.

Product overview

Cleveland HeartLab operates as the Quest® Cardiometabolic Center of Excellence™ at Cleveland HeartLab®, providing specialized laboratory testing services focused on identifying clinically silent risk factors for cardiometabolic diseases. The company's testing portfolio includes inflammation testing (F2-Isoprostanes, hsCRP, Oxidized LDL, Lp-PLA2 Activity, Myeloperoxidase, Microalbumin, ADMA/SDMA), advanced lipid testing (HDL Function Panel with HDLfx, LipoFraction NMR, Apolipoprotein testing, Small-Dense LDL, Lipoprotein(a)), metabolic testing (TMAO, Adiponectin), vitamin and supplement testing (OmegaCheck™, CoQ10, Vitamin D), genetic testing (Apolipoprotein E, CYP2C19), and other cardiovascular tests (AspirinWorks®, Galectin-3, High Sensitivity Troponin T). The company offers a web portal for providers to access patient test results and provides clinical consultation services.

Differentiator

Problem solved

Functional benefit

Brands

• Quest® Cardiometabolic Center of Excellence™: A national cardiometabolic center of excellence focused on identifying hidden heart disease risk through advanced diagnostic testing.

Products and services

• Inflammation Testing Panel Comprehensive inflammation biomarker testing panel measuring F2-Isoprostanes (oxidative stress), hsCRP (general inflammation), Oxidized LDL, Lp-PLA2 Activity (vascular inflammation), Myeloperoxidase (MPO), ADMA/SDMA, and Microalbumin for cardiovascular risk assessment, ordered by healthcare providers.
• Advanced Lipid Testing Advanced lipid testing services including HDL Function Panel with HDLfx pCAD Score, NMR LipoFraction analysis, Apolipoprotein B and A1 testing, Small-Dense LDL measurement, and Lipoprotein(a) analysis for cardiovascular risk stratification, offered to healthcare providers.
• Metabolic Testing Metabolic testing services including TMAO (gut microbiome metabolite), Adiponectin, OmegaCheck™ (omega-3/omega-6 fatty acid profile), Coenzyme Q10 (CoQ10), and Vitamin D (25 OH) for comprehensive cardiometabolic risk evaluation, ordered by healthcare providers.
• Genetic Cardiovascular Testing Genetic testing services including Apolipoprotein E (ApoE) genotyping for lipid regulation polymorphisms and CYP2C19 polymorphism testing to support personalized cardiovascular drug metabolism decisions (e.g., clopidogrel), offered to healthcare providers.
• AspirinWorks® ELISA test measuring 11-dehydrothromboxane B2 levels to detect aspirin effect in apparently healthy individuals, ordered by healthcare providers to assess aspirin therapy effectiveness.
• Galectin-3 Laboratory test measuring Galectin-3, a marker of cardiac fibrosis and adverse cardiac remodeling, complementary to natriuretic peptides, ordered by healthcare providers for cardiovascular risk assessment.
• High-Sensitivity Troponin T High-sensitivity cardiac troponin T test for diagnosis of myocardial infarction and prediction of cardiovascular mortality, ordered by healthcare providers for acute and chronic cardiac risk evaluation.
• Clinical Education and Consultation Services Clinical education and consultation services providing peer-to-peer engagement with PhDs, clinical lipid specialists, and clinical educators who support healthcare providers in test interpretation, risk factor identification, and patient management considerations across the cardiometabolic continuum of care.

Quantifiable outcome

• 50% of patients who have a heart attack or stroke have normal cholesterol levels
• +1 more outcomes

Segments2 records

Ideal customer profiles1 record

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

One partnership is on record.

• Quest DiagnosticscoreOthersCleveland HeartLab operates as a subsidiary of Quest Diagnostics, branded as the Quest® Cardiometabolic Center of Excellence™ at Cleveland HeartLab®. This integration provides national laboratory infrastructure, billing systems, provider network access, and operational support. Quest Diagnostics is a leading provider of diagnostic information services with significant market presence in the United States.

Scale indicators1 record

Recent moves6 records

Expansion highlights4 records

Direct peers

• Boston Heart Diagnostics: Boston Heart Diagnostics is a specialty clinical laboratory offering advanced cardiovascular and metabolic disease testing, including advanced lipid panels, inflammation markers, and cardiometabolic risk assessment—directly comparable to Cleveland HeartLab's core focus area.
• Health Diagnostics Laboratory (HDL): HDL was a specialty clinical laboratory focused on cardiometabolic disease testing using advanced biomarkers and was acquired by Quest Diagnostics in 2015, making it a direct functional peer and now a sibling asset within the same parent.
• True Health Diagnostics: True Health Diagnostics is a specialty laboratory offering advanced cardiovascular, metabolic, and inflammation-related testing panels to healthcare providers—a closely comparable commercial specialty lab in the cardiometabolic testing niche.
• Genova Diagnostics: Genova Diagnostics is a specialty clinical laboratory offering advanced cardiovascular inflammation and metabolic testing panels to healthcare providers, comparable to Cleveland HeartLab's specialty biomarker focus.
• ARUP Laboratories: ARUP Laboratories is a national specialty reference laboratory affiliated with the University of Utah, offering an extensive esoteric test menu including cardiovascular and inflammatory biomarkers—comparable as a specialized clinical reference lab serving hospital systems.
• Mayo Clinic Laboratories: Mayo Clinic Laboratories is an academic specialty reference laboratory offering a broad esoteric test menu including advanced cardiovascular and inflammation biomarkers—comparable as a specialty lab with deep clinical expertise serving complex testing needs.

Broad incumbents

• LabCorp (Laboratory Corporation of America): LabCorp is one of the two largest U.S. clinical laboratory networks and offers an extensive menu of routine and specialty testing including cardiovascular and inflammation panels—overlapping with Cleveland HeartLab but as part of a much broader routine testing portfolio.
• Quest Diagnostics Incorporated: Quest Diagnostics is the parent company of Cleveland HeartLab and the largest U.S. clinical laboratory network, offering a broad portfolio including cardiovascular risk testing—relevant both as parent and as the broader incumbent whose routine testing portfolio encompasses the specialty niche.

Emerging players

• Singulex: Singulex is a specialty biomarker company developing high-sensitivity immunoassays for cardiac and inflammatory disease detection—an emerging player with technology focused on similar cardiovascular biomarker measurement challenges addressed by Cleveland HeartLab's panels.
• SpectraCell Laboratories: SpectraCell Laboratories is a specialty clinical laboratory offering advanced cardiovascular and metabolic testing including inflammation and lipid-related markers—an emerging specialty player with a comparable boutique clinical lab model.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/cleveland-heartlab-inc-
• Xx.com/CLEHeartLab
• Facebookfacebook.com/ClevelandHeartLab

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Funding overview

Funding rounds6 records

Investors9 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Cleveland HeartLab