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Fralin Biomedical Research Institute

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uuid000a4jw

Namestring
Fralin Biomedical Research Institute
Legal namestring
Virginia Polytechnic Institute and State University
Websiteurl
fbri.vtc.vt.edu
Company typeenum
Private
Founded yearint
2010
Descriptiontext

Fralin Biomedical Research Institute at VTC is a university-affiliated academic biomedical research enterprise operating within Virginia Tech and located in Roanoke, Virginia. Founded in 2010, the institute conducts fundamental and translational research across brain disorders, heart disease, cancer, exercise medicine, health behaviors, and pediatric rehabilitation through specialized centers including the Center for Vascular and Heart Research, Center for Exercise Medicine Research, Center for Health Behaviors Research, Center for Neurobiology Research, Cancer Research Center–Roanoke, and the National Pediatric Rehabilitation Resource Center (C-PROGRESS). It supports graduate and medical student training through Virginia Tech and the VTC School of Medicine.

The institute's core technical infrastructure comprises advanced shared core facilities — large-bore MRI, CT (small and large bore), PET imaging, ABSL-3, metabolomics, bioprinting, focused ultrasound, confocal microscopy, and an FDA-grade clean room opened in April 2026 — supplemented by proprietary research outputs such as a patent-pending milk-derived exosome drug delivery platform (commercialized via the 2018 spinout Tiny Cargo Company). It does not sell commercial products; rather, it operates a research-services and technology-transfer model comprising federally funded research (primarily NIH), philanthropy, industry partnerships, technology licensing, and contract access to its core facilities and clean room. Go-to-market is relationship-driven through formal research collaborations, sponsored research, licensing agreements, and startup incubation via the Fralin Commercialization Fellows Program.

The institute employs 101–250 staff and faculty and serves a hybrid set of customers/participants: graduate and medical students seeking research training, academic and clinical research collaborators, biotechnology and pharmaceutical industry partners, and community research volunteers. The institute also plays an active regional economic development role, exemplified by its key participation in recruiting Austrian firm RINGANA to establish its U.S. headquarters in Roanoke. Revenue is not separately disclosed but is materially dependent on NIH grant funding awarded to Virginia Tech — $58.6M in 2024 declining to $23.7M in 2026 — supplemented by private philanthropy (notably a $50M Red Gates Foundation gift in 2023) and state/GO Virginia support.

Short descriptiontext

Fralin Biomedical Research Institute at VTC is a university-affiliated academic biomedical research enterprise within Virginia Tech, conducting translational research on brain disorders, heart disease, cancer, and exercise medicine through specialized centers and shared core facilities, funded primarily by NIH grants and philanthropy.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
101–250
akta.pro rankint
HeadquartersRoanoke, United States
HQ citystring
Roanoke
HQ countrystring
United States
HQ regionstring
North America
Markets served

Serves global market

Keyword5 values
biomedical research, cancer research, neuroscience research, cardiovascular research, exercise medicine
Industry4 codes
1Biomedical Sciences & Medical Research Institutes (University-Based)
CodeEDAHAGAIPrimaryYes
2Molecular Diagnostics & Genomics Laboratories
CodeHLAFAMAEPrimaryNo
3Transcriptomics & Gene Expression Profiling Services
CodeHLAGANAEPrimaryNo
4Laboratory Developed Tests (LDTs) & Specialized Clinical Lab Assays
CodeHLAAALANPrimaryNo
NAICS code3 codes
  • Research and Development in Biotechnology (except Nanobiotechnology)541714
  • Medical Laboratories621511
  • Scientific Research and Development Services5417
SIC code3 codes
  • Services-Commercial Physical & Biological Research8731
  • Services-Medical Laboratories8071
  • In Vitro & In Vivo Diagnostic Substances2835
Product category
Biomedical Research Services
Marketing channels5 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels4 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Personnel, Technology or R&D, Infrastructure, Operations, Others
GTM typeB2B
B2B
Offering typeServices
Services
Brand1 of 9 records shown
1Center for Exercise Medicine Research
Description

Research center focused on understanding how exercise improves mitochondrial function and promotes health

fbri.vtc.vt.edu
+8 more records
Core offering1 text field

Fralin Biomedical Research Institute is an academic biomedical research enterprise that conducts world-class research aimed at preventing, diagnosing, and treating leading causes of death and suffering, including cancer, brain disorders, heart disease, and metabolic conditions. It operates multiple specialized research centers, shared core service facilities (imaging, metabolomics, behavioral testing, 3D printing), education and training programs, and commercialization support for translating research into commercial applications.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 3 values shown
  • Virginia Tech received $58.6 million in NIH funding for 152 awards in 2024
+2 more records
Product overview1 text field

The Fralin Biomedical Research Institute at VTC is one of the nation's fastest-growing academic biomedical research enterprises, operating as a single integrated research institution rather than a platform with modular products. The institute encompasses multiple specialized research centers (including vascular/heart research, exercise medicine, health behaviors, neurobiology, cancer research, and pediatric rehabilitation) along with shared core service facilities (imaging, metabolomics, behavioral testing, 3D printing). The institute also provides education/training programs and commercialization support for research translation. Rather than selling products or services externally, the institute conducts fundamental biomedical research and provides training in partnership with Virginia Tech and the VTC School of Medicine.

Product and service10 records
1Core Services Facilities
CategoryResearch Services
Description

Shared research facilities including MRI (large bore), CT scanning (small and large bore), PET imaging, cellular and molecular imaging, metabolomics, behavioral testing, 3D printing, focused ultrasound, confocal microscopy, tissue processing, bioprinting, molecular analysis, and cell sorting capabilities. Available to internal researchers and external collaborators.

2Center for Vascular and Heart Research
CategoryResearch Center
Description

Research center advancing understanding of vascular and cardiovascular health, hosting annual symposiums and conducting research on heart disease, vascular biology, and related conditions.

3Center for Exercise Medicine Research
CategoryResearch Center
Description

Dedicated to understanding how exercise improves mitochondrial function and promotes health, led by internationally recognized researchers in exercise science.

4Center for Health Behaviors Research
CategoryResearch Center
Description

Studies the neuroscience of food choice, addiction, and health behaviors, including research on ultra-processed foods, obesity, and substance use.

5Cancer Research Center - Roanoke
CategoryResearch Center
Description

Comprehensive cancer research facility focused on understanding cancer biology and developing new therapeutic approaches.

6Center for Neurobiology Research
CategoryResearch Center
Description

Research focused on understanding brain function, neurological disorders, and developing treatments for conditions affecting the nervous system.

7National Pediatric Rehabilitation Resource Center (C-PROGRESS)
CategoryResearch Center
Description

Pediatric rehabilitation research center providing resources and conducting studies on child health and development.

8Education and Training Programs
CategoryEducational Services
Description

Postdoctoral opportunities, graduate research programs, undergraduate research, and training for future biomedical researchers at Virginia Tech and the VTC School of Medicine.

9Fralin Commercialization Fellows Program
CategoryCommercialization Support
Description

Program supporting the translation of research discoveries into commercial applications and startup companies.

10Clean Room Manufacturing Facility
CategoryManufacturing Services
Description

Clean room facility enabling local companies to manufacture clinical-grade materials meeting FDA standards without leaving the region.

Scale indicator5 records

Each record includes

Type, Value, Description, Source

Recent move8 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight6 records

Each record includes

Type, Description

Peers10 records
TypeDirect peer
Description

Independent, non-profit biomedical research institute specializing in genetics, genomics, and mouse models for disease research. Comparable as a non-profit research enterprise with core service facilities and industry partnerships.

TypeDirect peer
Description

Independent, non-profit biomedical research institute in La Jolla, California. Closely comparable as a multi-center, university-affiliated style research enterprise conducting basic and translational biomedical research across cancer, neuroscience, and metabolism.

TypeDirect peer
Description

University of Wisconsin-Madison-affiliated, non-profit biomedical research institute conducting research in regenerative biology, medical engineering, and virology. Direct peer in the university-affiliated research institute model.

TypeDirect peer
Description

Non-profit basic biomedical research institute with ~20 research programs in gene regulation, regeneration, and cancer. Direct peer in the university-affiliated / independent biomedical research institute category.

TypeDirect peer
Description

University-affiliated (UCSF) independent biomedical research institute with focused centers in cardiovascular, neurological, and immune disease research. Directly comparable organizational model to FBRI's center-based structure and university affiliation.

TypeDirect peer
Description

Non-profit research organization with large-scale research programs in neuroscience, cell science, and brain science. Comparable in mission, scale, and translational orientation to FBRI's neuroscience and health behavior centers.

TypeDirect peer
Description

MIT-affiliated, non-profit biomedical research institute with ~30 principal investigators working in cancer, immunology, regenerative biology, and neuroscience. Direct structural and mission peer to FBRI.

TypeDirect peer
Description

University of Pennsylvania-affiliated, non-profit biomedical research institute focused on cancer, vaccines, and infectious disease. Direct peer in the university-affiliated biomedical research institute category.

TypeDirect peer
Description

Non-profit medical research institute with multi-center structure covering cancer, neurodegeneration, and metabolic disorders. Direct peer in academic-style biomedical research with multiple disease-focused centers.

TypeDirect peer
Description

Independent, non-profit biomedical research and education institute in Grand Rapids, Michigan. Direct peer as a mid-sized, multi-center research institute with cancer, neurodegenerative, and metabolic disease focus areas.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses5 records

Each record includes

Headline, Details, Source

Competitive moat4 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Segment4 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile5 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
No
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature3 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles10 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Fralin Biomedical Research Institute

Biomedical Research Servicesfbri.vtc.vt.edu

Fralin Biomedical Research Institute at VTC is a university-affiliated academic biomedical research enterprise within Virginia Tech, conducting translational research on brain disorders, heart disease, cancer, and exercise medicine through specialized centers and shared core facilities, funded primarily by NIH grants and philanthropy.

What Fralin Biomedical Research Institute does

Fralin Biomedical Research Institute at VTC is a university-affiliated academic biomedical research enterprise operating within Virginia Tech and located in Roanoke, Virginia. Founded in 2010, the institute conducts fundamental and translational research across brain disorders, heart disease, cancer, exercise medicine, health behaviors, and pediatric rehabilitation through specialized centers including the Center for Vascular and Heart Research, Center for Exercise Medicine Research, Center for Health Behaviors Research, Center for Neurobiology Research, Cancer Research Center–Roanoke, and the National Pediatric Rehabilitation Resource Center (C-PROGRESS). It supports graduate and medical student training through Virginia Tech and the VTC School of Medicine.

The institute's core technical infrastructure comprises advanced shared core facilities — large-bore MRI, CT (small and large bore), PET imaging, ABSL-3, metabolomics, bioprinting, focused ultrasound, confocal microscopy, and an FDA-grade clean room opened in April 2026 — supplemented by proprietary research outputs such as a patent-pending milk-derived exosome drug delivery platform (commercialized via the 2018 spinout Tiny Cargo Company). It does not sell commercial products; rather, it operates a research-services and technology-transfer model comprising federally funded research (primarily NIH), philanthropy, industry partnerships, technology licensing, and contract access to its core facilities and clean room. Go-to-market is relationship-driven through formal research collaborations, sponsored research, licensing agreements, and startup incubation via the Fralin Commercialization Fellows Program.

The institute employs 101–250 staff and faculty and serves a hybrid set of customers/participants: graduate and medical students seeking research training, academic and clinical research collaborators, biotechnology and pharmaceutical industry partners, and community research volunteers. The institute also plays an active regional economic development role, exemplified by its key participation in recruiting Austrian firm RINGANA to establish its U.S. headquarters in Roanoke. Revenue is not separately disclosed but is materially dependent on NIH grant funding awarded to Virginia Tech — $58.6M in 2024 declining to $23.7M in 2026 — supplemented by private philanthropy (notably a $50M Red Gates Foundation gift in 2023) and state/GO Virginia support.

Fralin Biomedical Research Institute firmographics

Firmographics
Name
Fralin Biomedical Research Institute
Legal name
Virginia Polytechnic Institute and State University
Website
https://fbri.vtc.vt.edu
Company type
Private
Founded year
2010
Operating status
Operating
Headcount range
101–250 employees
Short description
Fralin Biomedical Research Institute at VTC is a university-affiliated academic biomedical research enterprise within Virginia Tech, conducting translational research on brain disorders, heart disease, cancer, and exercise medicine through specialized centers and shared core facilities, funded primarily by NIH grants and philanthropy.
Ownership category
akta.pro rank

Fralin Biomedical Research Institute industry classification

Industry
Product category
Biomedical Research Services
NAICS
Research and Development in Biotechnology (except Nanobiotechnology) (541714), Medical Laboratories (621511), Scientific Research and Development Services (5417)
SIC
Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071), In Vitro & In Vivo Diagnostic Substances (2835)
akta.pro primary industry
Biomedical Sciences & Medical Research Institutes (University-Based) (EDAHAGAI)
akta.pro secondary industries
Molecular Diagnostics & Genomics Laboratories (HLAFAMAE), Transcriptomics & Gene Expression Profiling Services (HLAGANAE), Laboratory Developed Tests (LDTs) & Specialized Clinical Lab Assays (HLAAALAN)

Keywords

  • Biomedical research
  • Cancer research
  • Neuroscience research
  • Cardiovascular research
  • Exercise medicine

Where Fralin Biomedical Research Institute is headquartered

Location

Headquarters

HQ city
Roanoke
HQ country
United States
HQ region
North America

Markets served

Fralin Biomedical Research Institute business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Technology or R&D, Infrastructure, Operations, Others

Distribution channels4 records

Marketing channels5 records

Fralin Biomedical Research Institute product offering

Product offering

Core offering

Fralin Biomedical Research Institute is an academic biomedical research enterprise that conducts world-class research aimed at preventing, diagnosing, and treating leading causes of death and suffering, including cancer, brain disorders, heart disease, and metabolic conditions. It operates multiple specialized research centers, shared core service facilities (imaging, metabolomics, behavioral testing, 3D printing), education and training programs, and commercialization support for translating research into commercial applications.

Product overview

The Fralin Biomedical Research Institute at VTC is one of the nation's fastest-growing academic biomedical research enterprises, operating as a single integrated research institution rather than a platform with modular products. The institute encompasses multiple specialized research centers (including vascular/heart research, exercise medicine, health behaviors, neurobiology, cancer research, and pediatric rehabilitation) along with shared core service facilities (imaging, metabolomics, behavioral testing, 3D printing). The institute also provides education/training programs and commercialization support for research translation. Rather than selling products or services externally, the institute conducts fundamental biomedical research and provides training in partnership with Virginia Tech and the VTC School of Medicine.

Differentiator

Problem solved

Functional benefit

Brands

  • Center for Exercise Medicine Research: Research center focused on understanding how exercise improves mitochondrial function and promotes health
  • Center for Vascular and Heart Research
  • Center for Health Behaviors Research
  • Center for Neurobiology Research
  • Center for Human Neuroscience Research
  • Addiction Recovery Research Center
  • Cancer Research Center - Roanoke
  • Virginia Tech Molecular Diagnostics Lab
  • National Pediatric Rehabilitation Resource Center (C-PROGRESS)

Products and services

  • Core Services Facilities Shared research facilities including MRI (large bore), CT scanning (small and large bore), PET imaging, cellular and molecular imaging, metabolomics, behavioral testing, 3D printing, focused ultrasound, confocal microscopy, tissue processing, bioprinting, molecular analysis, and cell sorting capabilities. Available to internal researchers and external collaborators.
  • Center for Vascular and Heart Research Research center advancing understanding of vascular and cardiovascular health, hosting annual symposiums and conducting research on heart disease, vascular biology, and related conditions.
  • Center for Exercise Medicine Research Dedicated to understanding how exercise improves mitochondrial function and promotes health, led by internationally recognized researchers in exercise science.
  • Center for Health Behaviors Research Studies the neuroscience of food choice, addiction, and health behaviors, including research on ultra-processed foods, obesity, and substance use.
  • Cancer Research Center - Roanoke Comprehensive cancer research facility focused on understanding cancer biology and developing new therapeutic approaches.
  • Center for Neurobiology Research Research focused on understanding brain function, neurological disorders, and developing treatments for conditions affecting the nervous system.
  • National Pediatric Rehabilitation Resource Center (C-PROGRESS) Pediatric rehabilitation research center providing resources and conducting studies on child health and development.
  • Education and Training Programs Postdoctoral opportunities, graduate research programs, undergraduate research, and training for future biomedical researchers at Virginia Tech and the VTC School of Medicine.
  • Fralin Commercialization Fellows Program Program supporting the translation of research discoveries into commercial applications and startup companies.
  • Clean Room Manufacturing Facility Clean room facility enabling local companies to manufacture clinical-grade materials meeting FDA standards without leaving the region.

Quantifiable outcome

  • Virginia Tech received $58.6 million in NIH funding for 152 awards in 2024
  • +2 more outcomes

Companies that use Fralin Biomedical Research Institute

Customer profile

Segments4 records

Ideal customer profiles5 records

Fralin Biomedical Research Institute technology and API

Technology

Technology focussed No

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature3 records

Fralin Biomedical Research Institute partnerships and signals

Strategic signal

Scale indicators5 records

Recent moves8 records

Expansion highlights6 records

Fralin Biomedical Research Institute competitors and assessment

Company assessment

Direct peers

  • Jackson Laboratory: Independent, non-profit biomedical research institute specializing in genetics, genomics, and mouse models for disease research. Comparable as a non-profit research enterprise with core service facilities and industry partnerships.
  • Salk Institute for Biological Studies: Independent, non-profit biomedical research institute in La Jolla, California. Closely comparable as a multi-center, university-affiliated style research enterprise conducting basic and translational biomedical research across cancer, neuroscience, and metabolism.
  • Morgridge Institute for Research: University of Wisconsin-Madison-affiliated, non-profit biomedical research institute conducting research in regenerative biology, medical engineering, and virology. Direct peer in the university-affiliated research institute model.
  • Stowers Institute for Medical Research: Non-profit basic biomedical research institute with ~20 research programs in gene regulation, regeneration, and cancer. Direct peer in the university-affiliated / independent biomedical research institute category.
  • Gladstone Institutes: University-affiliated (UCSF) independent biomedical research institute with focused centers in cardiovascular, neurological, and immune disease research. Directly comparable organizational model to FBRI's center-based structure and university affiliation.
  • Allen Institute: Non-profit research organization with large-scale research programs in neuroscience, cell science, and brain science. Comparable in mission, scale, and translational orientation to FBRI's neuroscience and health behavior centers.
  • Whitehead Institute for Biomedical Research: MIT-affiliated, non-profit biomedical research institute with ~30 principal investigators working in cancer, immunology, regenerative biology, and neuroscience. Direct structural and mission peer to FBRI.
  • Wistar Institute: University of Pennsylvania-affiliated, non-profit biomedical research institute focused on cancer, vaccines, and infectious disease. Direct peer in the university-affiliated biomedical research institute category.
  • Sanford Burnham Prebys: Non-profit medical research institute with multi-center structure covering cancer, neurodegeneration, and metabolic disorders. Direct peer in academic-style biomedical research with multiple disease-focused centers.
  • Van Andel Institute: Independent, non-profit biomedical research and education institute in Grand Rapids, Michigan. Direct peer as a mid-sized, multi-center research institute with cancer, neurodegenerative, and metabolic disease focus areas.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

Fralin Biomedical Research Institute social profiles

Digital presence

Fralin Biomedical Research Institute financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Fralin Biomedical Research Institute leadership team

Management profile

Number of profiles

Profiles10 records

Fralin Biomedical Research Institute funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Fralin Biomedical Research Institute M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Fralin Biomedical Research Institute

What does Fralin Biomedical Research Institute do?

Fralin Biomedical Research Institute is an academic biomedical research enterprise that conducts world-class research aimed at preventing, diagnosing, and treating leading causes of death and suffering, including cancer, brain disorders, heart disease, and metabolic conditions. It operates multiple specialized research centers, shared core service facilities (imaging, metabolomics, behavioral testing, 3D printing), education and training programs, and commercialization support for translating research into commercial applications.

Is Fralin Biomedical Research Institute a public or private company?

Fralin Biomedical Research Institute is a private company. It is classified as state government owned and is currently operating.

When was Fralin Biomedical Research Institute founded?

Fralin Biomedical Research Institute was founded in 2010. It employs 101 to 250 people.

Where is Fralin Biomedical Research Institute based?

Fralin Biomedical Research Institute is headquartered in Roanoke, United States, in the North America region.

Who are Fralin Biomedical Research Institute's main competitors?

Direct peers on record are Jackson Laboratory, Salk Institute for Biological Studies, Morgridge Institute for Research, Stowers Institute for Medical Research, Gladstone Institutes, Allen Institute, Whitehead Institute for Biomedical Research, Wistar Institute, Sanford Burnham Prebys and Van Andel Institute.

Does Fralin Biomedical Research Institute have an API?

No public API is recorded for Fralin Biomedical Research Institute.

What industry is Fralin Biomedical Research Institute in?

Fralin Biomedical Research Institute's product category is Biomedical Research Services. Its primary akta.pro industry code is EDAHAGAI, Biomedical Sciences & Medical Research Institutes (University-Based), with a secondary code of HLAFAMAE, Molecular Diagnostics & Genomics Laboratories. Its NAICS code is 541714 and its SIC code is 8731.

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Live signals
News-MedicalPrecision psychiatry aims to match schizophrenia patients with tailored medicinesVirginia Tech's Fralin Biomedical Research Institute will host a precision psychiatry symposium on Sept. 23-24 to explore tailored schizophrenia treatments. A patient in Australia improved by about 50% after starting Cobenfy, a new FDA-approved drug. The symposium aims to use biological and computational tools to guide treatment.Mirage NewsOral Therapy Shields Mice Tissue From RadiationResearchers at the Fralin Biomedical Research Institute developed an experimental oral therapy, XOlacta, which protected mice from lethal radiation exposure while preserving the treatment's effectiveness against tumors. The study, supported by the National Institutes of Health and validated by Lovelace Biomedical, indicates the therapy could improve cancer radiotherapy outcomes and serve as a medical countermeasure for radiological emergencies. The technology is currently in preclinical development under the FDA's Animal Rule pathway.Mirage NewsBrain Experts Find Way Past Genetic BlockageScientists at the Fralin Biomedical Research Institute at VTC discovered that N-acetyl cysteine (NAC) treatment can help brain cells overcome the effects of 22q11.2 deletion syndrome by redirecting brain development rather than repairing the genetic deletion itself. The therapy activated alternative gene networks that enabled neurons to form functional circuits and improved behavioral performance in mouse models. The findings, published in Disease Models & Mechanisms, suggest a new therapeutic approach for genetic brain disorders that targets cellular mechanisms instead of attempting to correct genetic disruptions.WebProNewsWhy Pumping Iron May Outperform Running in the Fight Against Diabetes and AgingScientists at Virginia Tech's Fralin Biomedical Research Institute published a study in October 2025 showing that resistance training produces superior metabolic benefits compared to endurance exercise in mice prone to obesity and diabetes, with weightlifting outperforming running in reducing fat, improving glucose tolerance, and lowering insulin resistance through distinct signaling pathways. The research, led by director Zhen Yan, found these benefits occurred independently of added muscle mass or improved exercise capacity, driven instead by unique metabolic shifts in skeletal muscle including coordinated changes in autophagy and mTOR signaling. The findings offer practical implications for the millions of people limited by joint pain, breathing issues, or time constraints, positioning weightlifting as an accessible alternative or complement to aerobic exercise for diabetes prevention and healthy aging.Mirage NewsExercise Eases Fatigue in Kids With Developmental DisabilitiesResearchers at the Fralin Biomedical Research Institute at VTC conducted a study published in Behavioral Sciences examining the relationship between physical activity and fatigue in children with developmental disabilities, including cerebral palsy and Down syndrome. Parents reported that children who were more physically active tended to experience less fatigue, with the study also revealing differences between parent and child perspectives on fatigue recognition. The research aims to inform future interventions and support families and healthcare providers working with children with disabilities.Virginia Tech NewsArchitects of modern computational neuroscience measure the future of the fieldFralin Biomedical Research Institute neuroscientist Read Montague presented his research on measuring dopamine fluctuations in living human brains at the Neuromodulation and Computation in the Brain symposium in Aarhus, Denmark, and is traveling to Tübingen, Germany for the Braitenberg 100 conference at the Max Planck Institute for Biological Cybernetics. The conferences brought together foundational figures in computational neuroscience including reinforcement learning pioneer Peter Dayan and Wulfram Gerstner to discuss the integration of computation, biology, and direct brain measurement. These gatherings reflect the increasingly international and collaborative nature of neuroscience research connecting mathematical theories of cognition with neurochemical measurements.https://www.wdbj7.comAustrian skincare company to bring 435 jobs to RoanokeRINGANA, an Austrian skincare and nutrition company, has announced it will establish its U.S. headquarters in Roanoke, Virginia, creating 435 jobs over five years with an average salary of about $62,000 per year. The project represents the largest new location project in the region in 30 years and the largest foreign direct investment in Roanoke's history. The Virginia Tech Fralin Biomedical Research Institute played a key role in recruiting the company, which will use the facility as a manufacturing, distribution, and R&D hub for U.S. operations.WVTFGlobal exercise science conference lands in RoanokeThe International Biochemistry of Exercise Conference was held in Roanoke, Virginia this week, drawing researchers from around the world to discuss advances in exercise science at the molecular level, from stem cells to mitochondria. The event was hosted by the Fralin Biomedical Research Institute at the Hotel Roanoke and Conference Center, representing a coup for the institute following its 2022 recruitment of researcher Zhen Yan from the University of Virginia to launch its Center for Exercise Medicine Research. Conference director Thomas Rando noted concerns about reduced funding and threats to scientific research in the U.S., though attendees expressed optimism about the field's collaborative potential and the post-conference course offerings.Cardinal NewsResearchers from around the world gather in Roanoke for exercise science conferenceApproximately 250 international researchers have gathered in Roanoke, Virginia for the 20th International Biochemistry of Exercise Conference, hosted by the Fralin Biomedical Research Institute at Virginia Tech Carilion, marking the event's return to the US for the first time since 2000. The conference, led by FBRI's Center for Exercise Medicine Research Director Zhen Yan, aims to advance understanding of how exercise improves mitochondrial function and promotes health. The article also notes concerns over reduced federal NIH funding, with Virginia Tech receiving $23.7 million in NIH grants this year compared to $53.9 million in 2025, as well as visa and political climate issues affecting international scientific travel to the US.Virginia Tech News‘The right patchwork’: New studies examine tobacco regulationResearchers from Virginia Tech's Fralin Biomedical Research Institute published three studies in the journal Tobacco Control examining tobacco regulation approaches, including how menthol accessories are marketed differently in the US versus Europe to circumvent bans, how flavor restrictions affect consumer choices, and how various tax policies impact tobacco purchasing. The studies found that menthol flavoring accessories are advertised as "air refreshers" in the US while described as cigarette accessories in Europe, that flavor bans can reduce cigarette purchases while increasing substitution with e-cigarettes and nicotine replacement products, and that taxes based on nicotine content produced the largest reduction in tobacco spending across all socioeconomic groups. The research was funded by the National Institutes of Health and the Red Gates Foundation.