Regional One Health

What Regional One Health does

Regional One Health is a non-profit, 501(c)(3) healthcare system headquartered in Memphis, Tennessee, operating as the Mid-South's essential hospital. The system traces its lineage to 1829 and today spans a main hospital campus (877 Jefferson Avenue) housing the Elvis Presley Trauma Center, Firefighters Burn Center, Sheldon B. Korones Newborn Center, Extended Care Hospital, and Rehabilitation Hospital, plus an East Campus with imaging and multispecialty services, several primary care clinics, outpatient pharmacies, and the Center for Innovation. It delivers trauma, burn, neonatal intensive care, high-risk obstetrics, oncology, orthopedics, rehabilitation, sickle cell, vascular, and women's services, supported by Cerner EHR, telehealth, Zocdoc-powered online scheduling, and the RxRefill mobile app.

The organization runs several population health and research programs that extend its core clinical operations. The ONE Health complex care initiative, developed with the Camden Coalition, addresses high-utilizing uninsured patients by integrating medical care with social services (housing, transportation, food, insurance enrollment), with reported outcomes of a 95.6% cost reduction and 97.1% decrease in inpatient days for graduates. The BIG Research Initiative is a DNA biorepository partnership with the University of Tennessee Health Science Center that supports genomics and pharmacogenomics research using Illumina sequencing platforms, backed by an NIH Certificate of Confidentiality. Regional One Health Solutions, a wholly owned subsidiary, has partnered with Domo on AWS to embed AI into clinical, financial, and operational workflows, with deployed applications including SmartRev (revenue cycle) and PxEngine (patient responsiveness).

Revenue is generated primarily through patient care services billed to insurance, Medicare, Medicaid, and self-pay patients, supplemented by philanthropic support through the Regional One Health Foundation and licensing/royalty arrangements from research collaborations. Major capital is being deployed on the ONE Campus initiative, a new hospital development at 495 Union Avenue described as one of the largest infrastructure projects in Shelby County history, with demolition of the prior structure commencing June 16, 2026, and construction supported by ACS.

Name

Regional One Health

Legal name

Regional One Health

Website

https://regionalonehealth.org

Company type

Private

Founded year

1829

Operating status

Operating

Headcount range

1,001–5,000 employees

Short description

Regional One Health is a non-profit safety-net health system in Memphis, Tennessee, operating the Mid-South's only Level 1 Trauma Center, Burn Center, and NICU, serving vulnerable populations through specialty, primary, and complex care programs. It generates revenue via patient services, philanthropic support, and genomic research partnerships.

Ownership category

akta.pro rank

Headquarters

HQ city

Memphis

HQ country

United States

HQ region

North America

Offices7 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Infrastructure, Technology or R&D, Supply Chain, Marketing or Sales

Revenue model

1. Patient Care Services: Acute care hospital services, outpatient clinics, primary care, specialty services including trauma, burn, NICU, rehabilitation, and surgical services. Revenue generated through insurance reimbursements, Medicare, Medicaid, and self-pay patients.
2. ONE Health Complex Care Program: Complex care management program reducing costs for high-utilizing uninsured patients. Regional One Health serves as both payer and provider for uninsured patients.
3. Pharmacy Services: Outpatient pharmacy with RxRefill mobile app for prescription refills and specialty pharmacy services
4. Research and Genomic Services: BIG Research Initiative providing DNA samples and genomic data to approved researchers, collaborating with UTHSC and commercial partners for drug development

Pricing tiers

Go-to-market motion2 records

Distribution channels5 records

Marketing channels7 records

Core offering

Regional One Health operates an integrated non-profit hospital and outpatient healthcare system in Memphis, Tennessee, delivering acute, trauma, burn, neonatal, high-risk obstetric, primary, and specialty care across multiple campuses. It supplements clinical services with population health programs (ONE Health), genomic research (BIG Initiative), digital patient engagement tools, and an AI-powered analytics platform supporting clinical and operational workflows.

Product overview

Regional One Health is a Memphis-based health system operating as a single unified hospital and outpatient care network with specialized centers. The organization offers a broad portfolio of clinical services organized around four Centers of Excellence (Trauma, Burn, Neonatal Care, High-Risk Obstetrics) supplemented by primary care, specialty services, and digital health tools. Key service lines include Cancer Care, Orthopedics, Rehabilitation, Sickle Cell, Vascular, and Women's Services. The health system provides digital patient engagement via the RxRefill mobile app, HealtheLife patient app, and Zocdoc-powered online scheduling. Research capabilities include the BIG Initiative genomic biorepository. Infrastructure modernization is underway via the ONE Campus new hospital development project. A Domo-powered AI platform (SmartRev, PxEngine) supports operational and clinical analytics.

Differentiator

Problem solved

Functional benefit

Brands

• ONE Health: Complex care initiative addressing healthcare super-utilizers by providing integrated medical and social services, modeled after the Camden Coalition approach.
• ONE Campus
• BIG Initiative (Biorepository and Integrative Genomics)
• UT Regional One Physicians (UTROP)

Products and services

• Elvis Presley Trauma Center Level 1 trauma center providing comprehensive emergency and critical care for the Mid-South region.
• Firefighters Burn Center Specialized burn care facility providing acute burn treatment, reconstruction, rehabilitation, and wound care with hyperbaric oxygen therapy.
• Sheldon B. Korones Newborn Center (NICU) Neonatal intensive care unit providing specialized care for premature and critically ill newborns, affiliated with March of Dimes NICU Family Support Program.
• ONE Health Complex Care Initiative Population health strategy addressing healthcare super-utilizers through compassionate care coordination, connecting patients with housing, transportation, food, insurance, and primary care resources.
• Cancer Care Comprehensive oncology services including cancer treatment, dedicated care team, and targeted treatments such as Pluvicto for prostate cancer and Lutathera.
• Orthopedic Care Musculoskeletal and orthopedic services for joint, bone, and muscle conditions.
• Outpatient Surgery Surgical services featuring the da Vinci 5 robotic surgical system for minimally invasive procedures.
• Primary Care Family medicine, pediatric services, and OB/GYN care at multiple locations including Harbor of Health, South Third Primary Care, and Hollywood Primary Care. Designated Patient Centered Medical Home facilities.
• Rehabilitation Services Inpatient and outpatient rehabilitation including physical therapy, occupational therapy, gait analysis, motion/video technology, and return-to-work programs; CARF-accredited Rehabilitation Hospital.
• Sickle Cell Center Specialized care for sickle cell disease with over 80 years of innovation in treatment and management.
• Women's Services Comprehensive women's health including high-risk obstetrics, fetal therapy program, labor and delivery, midwifery, menopause care, complex contraception, and OB/GYN services.
• Outpatient Pharmacy with RxRefill App Pharmacy services with mobile app allowing patients to save prescriptions and request refills from anywhere.
• BIG Research Initiative (Biorepository and Integrative Genomics) DNA biorepository and genomic research program collecting and storing DNA samples linked to de-identified medical records for genomics-based research into gene-disease relationships, drug metabolism, and pharmacogenomics.
• Regional One Health Solutions AI Platform (SmartRev & PxEngine) AI-embedded healthcare application platform deployed on AWS that powers SmartRev (revenue cycle analytics) and PxEngine (patient responsiveness), improving operational and clinical outcomes.
• MR-Guided Focused Ultrasound Non-invasive treatment technology for conditions such as essential tremors, located at East Campus Imaging Center.
• Extended Care Hospital Long-term acute care hospital providing extended recovery and care services.

Named customers2 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration7 records

AI capability5 records

Feature7 records

Partnerships

Eight partnerships are on record, tiered core, major and minor.

• DomocoreTechnology or Integration · 3 June 2026Domo partnered with Regional One Health Solutions on AWS to embed artificial intelligence into healthcare workflows for clinical, financial, and operational processes. Joint solution combines Regional One Health's healthcare applications with Domo's AI and Data Products Platform. Deployed applications SmartRev identified $5M+ revenue opportunity in three months; PxEngine showed measurable improvements in patient responsiveness.
• ACS (Actividades de Construcción y Servicios)majorImplementation/ SI/ Consulting Partner · 9 December 2025ACS, a leading Spanish construction group with US operations, is developing a Regional One Health hospital in Memphis. Project duration estimated at 2 to 6 months.
• University of Tennessee Health Science Center (UTHSC)coreStrategic or Co-development Partner · 1 January 2020UTHSC established the Biorepository for Integrative Genomics (BIG) Initiative at Regional One Health for DNA sample collection supporting genomics research. Collaborative agreement provides whole exome sequencing and genome-wide SNP genotyping using Illumina platforms. UTHSC's Enterprise Data Warehouse supports research cohort identification via TriNetX.
• ZocdoccoreChannel Partner/ Reseller/ Distributor · 1 November 2016Zocdoc powers online appointment scheduling for Regional One Health, enabling 24/7 real-time booking across internal medicine, cardiology, endocrinology, rheumatology, urology, urogynecology, and reproductive endocrinology. Typical appointments occur within 24 hours with email and text reminders.
• Camden CoalitioncoreStrategic or Co-development PartnerRegional One Health formed partnership with Camden Coalition to launch ONE Health complex care initiative. The Camden Coalition is a nationally-recognized nonprofit that uses data-driven, human-centered practices to improve patient outcomes and reduce cost of care. Partnership enabled Regional One Health to analyze patient data and understand trends related to circumstances causing patients to need care.
• Alliance Healthcare ServicescoreStrategic or Co-development PartnerAlliance Healthcare Services, a safety net mental health provider, is a crucial partner in ONE Health initiative addressing mental health needs of super-utilizing patients. Partnership helps connect patients with mental health services, housing, food assistance, and other community resources.
• Amazon Web Services (AWS)coreTechnology or IntegrationAWS provides cloud infrastructure powering the Domo and Regional One Health joint AI solution for healthcare workflows.
• Mid-South Food BankminorStrategic or Co-development PartnerPartnership with Mid-South Food Bank for food packing volunteer events; employees packed 10,000-20,000 meals for hungry families in the Mid-South.

Scale indicators8 records

Recent moves7 records

Expansion highlights6 records

Direct peers

• Methodist Le Bonheur Healthcare: Largest competing non-profit health system in the Memphis market with comparable acute, outpatient, and specialty services. Directly competes with Regional One Health for patients and physicians in the same Mid-South geography.
• Baptist Memorial Health Care: Major non-profit regional health system headquartered in Memphis with multi-specialty hospitals across Tennessee, Mississippi, and Arkansas. Direct competitor for inpatient, outpatient, and specialty services in Regional One Health's core market.

Broad incumbents

• Parkland Health: Dallas County's public safety-net hospital system with Level 1 trauma, burn, and high-acuity specialty services for an underserved population. Comparable as a large-scale essential/safety-net academic health system with similar mission-driven payer mix.
• Boston Medical Center: Largest safety-net hospital in New England and a major academic medical center. Comparable in mission, patient population, innovation programs (e.g., complex care management), and operating model as a non-profit essential hospital.
• Denver Health: Integrated urban safety-net health system with Level 1 trauma, burn, and academic affiliation. Comparable as a vertically integrated essential hospital serving a diverse, predominantly publicly insured population.
• Grady Health System: Atlanta's safety-net health system with Level 1 trauma, burn, and large ambulatory network serving an uninsured and Medicaid-heavy population. Comparable as a regional essential hospital with similar payer mix and mission profile.
• NYC Health + Hospitals: Largest municipal hospital system in the U.S., providing essential acute, outpatient, and specialty care to underserved New Yorkers. Comparable as a publicly anchored safety-net system with similar social-determinants-of-health focus.
• Cambridge Health Alliance: Massachusetts safety-net health system with academic affiliation, serving a diverse, publicly insured population and operating innovative population health programs. Comparable as a non-profit safety-net hospital with strong community health orientation.

Regional players

• Erlanger Health System: Chattanooga-based non-profit regional academic health system serving a similar Tennessee/Mid-South catchment with Level 1 trauma and high-acuity specialty services. Comparable as a regional essential hospital system in an adjacent Tennessee market.

Others

• Camden Coalition: National non-profit pioneer of complex care models for super-utilizer patients and Regional One Health's ONE Health partner. Included as a strategic ecosystem peer rather than a direct competitor, given its focus on care model development rather than service delivery.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/regional-one-health
• Xx.com/regonehealthfdn
• Facebookfacebook.com/regonehealthfdn

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Subsidiaries3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Regional One Health