OneLegacy

What OneLegacy does

OneLegacy is a federally-designated, private 501(c)(3) non-profit Organ Procurement Organization (OPO) and the largest in the United States, serving a population of approximately 20 million across seven Southern California counties: Kern, Santa Barbara, Ventura, Los Angeles, San Bernardino, Riverside, and Orange. Founded in the 1960s as the Regional Organ Procurement Agency (ROPA) at UCLA Medical Center and re-branded as OneLegacy in 2001, the organization coordinates deceased-donor organ, eye, and tissue recovery in collaboration with 215 hospitals and 9 transplant centers, including Cedars-Sinai, UCLA, Keck/USC, Loma Linda, Children's Hospital Los Angeles, and UCI Health. It is led by CEO Prasad Garimella with a 400+ person workforce spanning clinical, social work, administrative, and IT functions, and operates from a 98,772 sq ft headquarters in Azusa, CA that includes a 50,000 sq ft Transplant Recovery Center — California's first — and a 16,000 sq ft conference and Simulation Center.

The organization's core product is end-to-end donation coordination: donor identification at partner hospitals, family communication and consent, medical evaluation, organ allocation via UNOS/OPTN match runs, surgical recovery, and delivery to transplant centers. Supporting services include the OneLegacy Eye Bank (the only full-service eye bank in Los Angeles, shipping corneas to 25+ countries), tissue donation programs, comprehensive donor family support (grief groups, memorial events, recipient correspondence), and the Circle of Support patient resource program for the 9,000+ individuals awaiting transplant locally. OneLegacy's technology backbone includes the first Electronic Donor Record and web-based Organ Offer System (which became a U.S. federal requirement in 2006) and the world's first Living Donor Electronic Referral System (co-created with Steve Jobs and Governor Schwarzenegger in 2003), alongside a real-time infectious disease RNA testing capability. Adjacent programs include the Ambassador volunteer network (donor families, recipients, living donors), the Donate Life Rose Parade Float (since 2004), the nation's largest donation-themed Run/Walk (8,000+ participants), and the OneLegacy Foundation's research, education, and OneLegacy Inspires Hollywood initiative.

Revenue is generated primarily through CMS Medicare/Medicaid reimbursement for organ acquisition costs, supplemented by charitable contributions and memorial gifts to the OneLegacy Foundation (founded 2011). Services are provided to donor families at no charge, consistent with the non-profit OPO model. Go-to-market is partnership-driven rather than sales-driven: clinical staff embed within the hospital referral network, donor registration occurs chiefly through DMV offices (95%+ of California registrations), and community outreach leverages ambassadors and signature events to grow the donor designation rate in a service area where 70% of the population is non-white and cultural barriers to registration remain significant.

Name

OneLegacy

Legal name

OneLegacy

Website

https://onelegacy.org

Company type

Private

Founded year

1960

Operating status

Operating

Short description

OneLegacy is the nation's largest non-profit Organ Procurement Organization, coordinating organ, eye, and tissue donation across seven Southern California counties (20 million people) between 215 hospitals, 9 transplant centers, donor families, and transplant recipients.

Ownership category

akta.pro rank

Product category

Organ Procurement and Donation Services

NAICS

Blood and Organ Banks (621991)

akta.pro primary industry

Blood, Organ & Tissue Donation Organizations (BPAGACAJ)

Keywords

• Organ donation services
• Tissue donation services
• Organ procurement organization
• Eye bank services
• Donor family support

Headquarters

HQ city

Azusa

HQ country

United States

HQ region

North America

Offices7 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales, Infrastructure, Supply Chain

Revenue model

1. Medicare/Medicaid OPO Reimbursement: As a federally-designated Organ Procurement Organization, OneLegacy receives reimbursement through CMS (Centers for Medicare & Medicaid Services) for organ acquisition costs, donation services, and transplantation coordination activities.
2. Donor Family Contributions and Memorial Gifts: OneLegacy Foundation accepts charitable contributions and memorial gifts from donor families and the community to support public education, research, and patient/family services programs.

Go-to-market motion1 record

Distribution channels4 records

Marketing channels10 records

Core offering

OneLegacy is the nation's largest federally-designated Organ Procurement Organization (OPO), coordinating organ, eye, and tissue donation across seven Southern California counties. The organization recovers and allocates organs, eyes, and tissues from deceased donors, manages a full-service eye bank, and supports donor families through bereavement programs. Its core activities include hospital-based donor identification, clinical organ recovery, transplant center coordination, and maintaining the donor registry infrastructure.

Product overview

OneLegacy is the nation's largest Organ Procurement Organization (OPO), serving Southern California's seven-county region as the federally-designated bridge between donors and patients awaiting transplants. The organization operates as a unified platform combining organ, eye, and tissue donation services with comprehensive support programs. The core offering consists of Organ Donation Services, Tissue Donation Services, and the OneLegacy Eye Bank (the only full-service eye bank in Los Angeles), all supported by Hospital & Professional Partnerships for clinical coordination. Beyond donation facilitation, OneLegacy provides Family Support Services including grief support groups and memorial programs, operates the Ambassador Program for community education, and delivers patient resources through the Circle of Support initiative for transplant candidates. Signature events include the annual Donate Life RunWalk (largest in the nation) and the Donate Life Rose Parade Float. The OneLegacy Foundation supports research, public education, and special programs including the OneLegacy Inspires Hollywood initiative and Connecting the Dots town halls for minority communities. The organization also operates a Simulation Center for professional training and maintains the electronic donor registry system.

Differentiator

Problem solved

Functional benefit

Brands

• OneLegacy Eye Bank: A department within OneLegacy dedicated to eye donation and helping eliminate corneal blindness. The only full-service eye bank in the Los Angeles area offering quality ocular tissue for transplant.
• OneLegacy Foundation

Products and services

• Organ Donation Services Facilitation of organ donation from deceased donors, including donor evaluation, organ matching to recipients, and coordination of recovery and transplant logistics with hospitals and transplant centers.
• Tissue Donation Services Tissue donation program enabling recovery of bone, corneas, skin, heart valves, blood vessels, and cartilage for transplantation. In 2025, 2,335 tissue donors impacted over 135,000 lives through this program.
• OneLegacy Eye Bank The only full-service eye bank in the Los Angeles area, providing corneas and ocular tissue for transplant procedures including Penetrating Keratoplasty, DSAEK, and DMEK. Has helped cure corneal blindness by providing corneas to over 25 countries worldwide.
• Family Support Services Comprehensive aftercare program for donor families including bereavement literature, virtual grief support groups, follow-up letters, correspondence facilitation between donor families and recipients, donor memorial events, and online resource folders.
• Hospital and Professional Partnerships Collaboration with 215 hospitals, transplant centers, physicians, coroners, and funeral homes to facilitate donation processes, including professional education through webinars, workshops, annual symposiums, and Simulation Center training.
• OneLegacy Simulation Center Hands-on training facility offering the world's most realistic donor management education for hospital professionals, covering recovery and transplantation procedures.
• Donor Registry Services Manages electronic donor records and the web-based organ offer system, facilitating organ, eye, and tissue donor registration through Donate Life California. Over 95% of California donors register through DMV partnerships.

Quantifiable outcome

• 51% increase in transplants over 10 years
• +4 more outcomes

Named customers8 records

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Eight partnerships are on record, tiered core and minor.

• Donate Life CaliforniacoreStrategic or Co-development PartnerOneLegacy partners with Donate Life California to operate the statewide organ and tissue donor registry. Together with Steve Jobs and Governor Schwarzenegger, they created the world's first Living Donor Electronic Referral System to enable self-referral and altruistic donation, as well as life-saving kidney chains. OneLegacy also participates in Donate Life California eCampaigns for organizational outreach.
• Donate Life AmericacoreStrategic or Co-development PartnerNational organization partner providing resources and coordination for organ donation awareness. OneLegacy utilizes Donate Life America's national observances toolkits and coordinates on national campaigns.
• Ava's Heart FoundationminorStrategic or Co-development PartnerNon-profit founded by heart transplant recipient Ava Kaufman that provides housing assistance to transplant candidates and final expense assistance to donor families. Ava Kaufman serves as a OneLegacy Ambassador.
• Danny Trejo / Trejo MusicminorGTM or Marketing PartnerPartnership with celebrity Danny Trejo and Trejo Music to host SOULDIEZ concert event, combining entertainment with donation awareness outreach to the Hispanic community.
• SanofiminorStrategic or Co-development PartnerTransplantation advocate that honored donor hero Elmer Valenzuela and recipients on the OneLegacy Donate Life Rose Parade float in January 2026.
• U.S. Department of Health and Human ServicescoreOthersOversight through CMS for Medicare/Medicaid reimbursement and HRSA oversight of the Organ Procurement and Transplantation Network (OPTN). OneLegacy operates under federal designation as an Organ Procurement Organization.
• Azusa Pacific UniversityminorGTM or Marketing PartnerAnnual host venue for the OneLegacy Donate Life Run/Walk event since 2003. The event is the largest donation-themed run/walk in the nation with 8,000+ participants.
• Loma Linda University Children's HospitalcoreStrategic or Co-development PartnerTransplant center partner where Southern California's first pediatric partial heart transplant was performed. OneLegacy provided donation coordination for this breakthrough procedure.

Scale indicators9 records

Recent moves14 records

Expansion highlights5 records

Others

• Donate Life America: National non-profit whose Donate Life brand and registry infrastructure support OneLegacy's donor registration efforts. Functions as an industry association/ecosystem partner rather than a direct operational peer.

Direct peers

• Mid-America Transplant: Federally-designated OPO serving Kansas, western Missouri, and northeastern Arkansas. Operates a similar organ, eye, and tissue recovery model with comparable accreditations and hospital network structure.
• Gift of Hope Organ & Tissue Donor Network: Federally-designated OPO serving Illinois and northwest Indiana. Non-profit OPO with comparable organ, tissue, and eye recovery services and similar hospital/transplant center partnership model.
• LiveOnNY: Federally-designated OPO serving the greater New York metropolitan area. Comparable procurement and family support mission in a dense urban service area, with organ, eye, and tissue donation programs.
• Carolina Donor Services: Federally-designated OPO serving North Carolina and a portion of Virginia. Comparable OPO operating organ, tissue, and eye recovery services under the same federal framework.
• Southwest Transplant Alliance: Federally-designated OPO serving Texas. Comparable organ, tissue, and eye procurement organization operating under CMS designation with hospital and transplant center partnerships.
• New England Donor Services: Federally-designated OPO serving Massachusetts, Connecticut, Maine, New Hampshire, Rhode Island, and Vermont. Comparable organ, eye, and tissue procurement organization serving a multi-state New England territory under the same federal framework.
• Donor Network West: Federally-designated OPO serving Northern California and Nevada. Direct peer to OneLegacy as a California-based OPO with similar organ, eye, and tissue procurement operations under CMS regulation.
• LifeCenter Northwest: Federally-designated OPO serving Washington, Alaska, Montana, and northern Idaho. Operates the same donation-services model (organ, eye, tissue procurement) with hospital and transplant center partnerships, mirroring OneLegacy's regional OPO structure.

Broad incumbents

• MTF Biologics: National tissue procurement and distribution organization. While OneLegacy focuses on regional OPO services, MTF operates a broader national tissue banking network that overlaps with OneLegacy's tissue donation activities.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/channel/UC5XfytRxRJdSP-MfPxdPxaA

Compliance7 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Subsidiaries2 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about OneLegacy