OmniTier Storage

What OmniTier Storage does

OmniTier Inc. (OmniTier Storage) develops and sells on-premise genomic analysis appliances that perform secondary and tertiary analysis of next-generation sequencing data without relying on cloud compute or specialized GPU/FPGA accelerators. Founded in February 2015 and headquartered in San Jose, California, the company has 11-50 employees and is privately held. Its core technology is MACS (Memory-Accelerated Compute and Storage), a proprietary tiered memory architecture using NVMe SSDs and small amounts of DRAM that achieves up to 7 million cache requests per second and supports cache capacities up to 4 TB per server node at a fraction of DRAM-only cost. This hardware layer is paired with a proprietary Novos variant caller that claims higher accuracy than the Broad Institute's GATK, and an AI-based variant interpretation engine in CompStor Insight that applies ACMG guidelines against 30+ standard and custom knowledge databases.

The product family is built around three flagship appliances: CompStor Novos (secondary analysis supporting Illumina, MGI, Oxford Nanopore, and PacBio sequencers with somatic, germline, SNP, indel, structural variant, CNV, and mitochondrial pipelines), CompStor Insight (tertiary analysis with AI-driven causal variant selection achieving a VCF-to-clinical-report time of roughly 7 minutes), and CompStor Spectrum (an integrated end-to-end appliance combining both, positioned at under $50 per WGS sample at scale). OmniTier also offers the CompStor Workgroup Server (a 1U rack server with 512 GB DRAM and 12 TB NVMe, configured in 1-8 node clusters) and the CompStor Assembly software stack for de novo DNA assembly.

OmniTier generates revenue through one-time hardware appliance sales, recurring annual support and maintenance contracts, and usage-based per-sample pricing for high-volume deployments. Its go-to-market is direct enterprise field sales augmented by event-driven demand generation at major conferences (ASHG, AGBT), targeting clinical diagnostics laboratories, pharmaceutical and biotech R&D, academic research institutions, sequencing service providers, government and public health agencies, and genomics data providers. Strategic investor/technology partners include Cisco, Micron, Seagate, Sanshin, RAEDI, and Intel (Optane), with reference customers including Japan's National Center for Child Health and Development (NCCHD) and A*STAR's Genome Institute of Singapore (GIS).

Name

OmniTier Storage

Legal name

OmniTier Inc.

Website

https://omnitier.com

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

11–50 employees

Short description

OmniTier Storage develops on-premise genomic analysis appliances powered by proprietary MACS memory acceleration and AI-based variant interpretation. It serves clinical diagnostics labs, pharmaceutical companies, academic researchers, and government health agencies with secondary and tertiary NGS analysis supporting all major sequencer platforms.

Ownership category

akta.pro rank

Product category

Genomic Analysis Appliances

NAICS

Computer Systems Design and Related Services (5415)

SIC

Laboratory Analytical Instruments (3826), Services-Prepackaged Software (7372)

akta.pro primary industry

Bioinformatics & Multi-omics Analysis Software (HLAGAJAD)

akta.pro secondary industries

Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF), Bioinformatics, Multi-Omics Data Analysis & Interpretation Services (HLAGANAI)

Keywords

• Genomic analysis appliances
• Secondary analysis software
• Tertiary analysis software
• Variant interpretation platforms
• On-premise genomics

Headquarters

HQ city

Santa Clara

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Supply Chain, Personnel, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Hardware Appliance Sales: Sale of CompStor genomic analysis appliances (CompStor Novos, CompStor Insight, CompStor Spectrum) as standalone on-premise hardware solutions installed in customer data centers.
2. Support and Maintenance: Annual support and maintenance contracts for existing customers including software updates and technical support. New customers receive mitochondrial analysis included at no additional charge for those on support and maintenance.
3. Per-Sample Analysis: Cost-per-analysis model achieving less than $50 per WGS sample at scale, making genomic analysis affordable for high-volume clinical and research applications.

Pricing tiers

Go-to-market motion2 records

Distribution channels1 record

Marketing channels4 records

Core offering

OmniTier designs, manufactures, and sells on-premise genomic analysis appliances that perform secondary analysis (variant calling) and tertiary analysis (variant interpretation) for whole genome, whole exome, and panel sequencing data. The CompStor product family — Novos, Insight, and the integrated Spectrum — runs on standard CPU hardware using the company's proprietary MACS tiered-memory technology, delivering end-to-end FASTQ-to-clinical-report workflows at lower cost than cloud-based alternatives.

Product overview

OmniTier Storage offers a portfolio of standalone genomic analysis appliances designed for on-premise deployment. The core product line includes CompStor Novos (secondary analysis for variant calling from sequencing data), CompStor Insight (tertiary analysis for variant interpretation), and CompStor Spectrum (integrated end-to-end solution combining both). These appliances are powered by proprietary AI and data acceleration technologies including MACS (Memory Accelerated Compute and Storage) for in-memory caching. The company supports both short-read (Illumina, MGI) and long-read (Oxford Nanopore, PacBio) sequencing platforms, with variant calling via both Broad Institute GATK and OmniTier's proprietary Novos variant caller.

Differentiator

Problem solved

Functional benefit

Brands

• CompStor: Genomic analysis platform brand for standalone appliance products including CompStor Spectrum (end-to-end), CompStor Novos (secondary analysis), and CompStor Insight (variant interpretation)
• CompStor Spectrum
• CompStor Novos
• CompStor Insight
• CompStor Workgroup Server
• MACS (Memory-Accelerated Compute and Storage)

Products and services

• CompStor Novos High-throughput secondary analysis standalone appliance for human genomic data analysis. Supports short-read (NGS) and long-read sequencer pipelines (Illumina, MGI, Oxford Nanopore, PacBio) with two variant callers (Broad Institute GATK and proprietary Novos). Calls SNPs, indels, structural variants, CNVs, and mitochondrial variants with somatic and germline pipelines.
• CompStor Insight Tertiary analysis variant interpretation standalone appliance providing fast, automated variant analysis with causal variant selection on target panels, WES, and WGS sequencing. Uses AI-based classification with ACMG guidelines to produce clinical draft reports, supporting single, trio, and family rare-disease analysis. Annotated against 30+ knowledge databases with custom database capability.
• CompStor Spectrum Complete end-to-end, secondary and tertiary analysis integrated standalone appliance combining CompStor Novos and CompStor Insight capabilities. Single plug-and-play genomics appliance taking FASTQ data to prioritized causal variants report at cost below $50 per WGS sample at scale.
• CompStor Workgroup Server High-performance 1U rack server designed for demanding genomics workloads. Powered by Intel Xeon Gold 16 Cores (3rd generation, 2 sockets), 512 GB DRAM, and 12 TB NVMe SSD, scalable in configurations of 1, 2, 4, or 8 nodes per compute cluster.

Quantifiable outcome

• 42% diagnostic rate for rare diseases (7% improvement over 35% baseline)
• +6 more outcomes

Named customers2 records

Segments6 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration7 records

AI capability5 records

Feature7 records

Partnerships

Four partnerships are on record, tiered core and flagship.

• SentieoncoreTechnology or Integration · 10 January 2025Benchmarking partnership integrating Sentieon DNAscope secondary analysis software with OmniTier's CompStor Workgroup server for end-to-end WGS analysis. DNAscope leverages machine learning for enhanced accuracy in variant calling. The integration enables processing of Illumina, PacBio, and Oxford Nanopore WGS data on a single mid-range CPU-based rack server with high accuracy (F1 scores 0.9961-0.9987).
• GenomenoncoreTechnology or Integration · 4 January 2022Integration partnership bringing Mastermind Genomic Search Engine evidence sources into CompStor Insight. This integration allows CompStor users to preview the number of published articles related to their searches and link out to view evidence in Mastermind. Mastermind is used by over 1,000 diagnostic labs and integrated into 18 clinical-grade decision support platforms. Partnership expands genomic screening capabilities at affordable cost.
• A*STAR Genome Institute of Singapore (GIS)flagshipStrategic or Co-development PartnerJoint development partnership to develop on-premise analytical infrastructure for A*STAR's lab-developed clinical NGS assays. The collaboration aims to create a more affordable, efficient, and secure clinically validated analytical platform for processing clinical samples in Singapore.
• IntelcoreTechnology or IntegrationStrategic technology partnership demonstrating novel use of Intel Optane technology paired with OmniTier's MACS product. Intel and OmniTier presented joint demonstrations at IBM Interconnect trade show and Intel Analyst and Press Workshop in Folsom, CA. Partnership showcases Optane storage-class memory technology for high-performance and cost-effective cloud-based computing solutions.

Scale indicators8 records

Recent moves6 records

Expansion highlights6 records

Others

• Genomenon: Genomic knowledgebase and evidence-search engine (Mastermind) integrated into CompStor Insight via partnership. Acts as an enabling content/informatics layer for variant interpretation rather than a competing analysis platform.

Direct peers

• PierianDx: Clinical genomics interpretation software for hereditary disease and oncology. Competes with CompStor Insight for tertiary analysis contracts with hospital systems and clinical labs, with overlapping ACMG-based classification workflows.
• BC Platforms: Genomic data management and analytics platform serving clinical, research, and pharma customers with secondary analysis and interpretation tooling. Targets similar enterprise genomic data workflows as OmniTier, including population genomics programs.
• Sentieon: Provides machine-learning-based secondary analysis software (DNAscope) for variant calling in NGS data. OmniTier has an integration partnership with Sentieon for its CompStor Workgroup server, and both target clinical and research labs seeking high-accuracy on-premise or cloud analysis.
• Fabric Genomics (formerly Omicia): Clinical genomic interpretation platform offering AI-driven variant classification and clinical reporting. Directly comparable to CompStor Insight for tertiary analysis in clinical rare-disease and hereditary disease workflows.
• Velsera (formerly Seven Bridges): Provides genomic data analysis platforms for clinical and research applications, including secondary/tertiary pipelines and interpretation. Targets similar pharma, clinical diagnostic, and research segments as OmniTier with a cloud-and-platform focus.
• Partek Incorporated: Genomic data analysis software (Partek Flow, Partek Genomics Suite) for NGS and multi-omic workflows. Comparable target market of clinical researchers and bioinformaticians, though primarily a software-only (non-appliance) model.
• DNAnexus: Cloud-based genomic and biomedical data analysis platform serving pharma, clinical labs, and research institutions. While cloud-native (vs. OmniTier's on-premise appliances), it competes for the same secondary and tertiary analysis workflows with an enterprise SaaS model.
• Golden Helix: Genomic analysis software vendor offering secondary and tertiary pipelines (including VSClinical for ACMG interpretation) used by clinical labs and research institutions. Closely comparable in target customer and product scope to OmniTier's CompStor family.

Broad incumbents

• Illumina: Dominant sequencing instrument vendor that also offers DRAGEN, a hardware-accelerated secondary and tertiary analysis platform. Directly competes with OmniTier in genomic analysis, particularly for Illumina-customer workflows, but is a broad incumbent across sequencing, arrays, and analysis rather than an analysis pure-play.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key highlights6 records

Customer concentration

• Xtwitter.com/Omnitier
• Facebookfacebook.com/OmniTier
• LinkedInlinkedin.com/company/omnitier-inc.

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds1 record

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about OmniTier Storage