Pyxis Partners

What Pyxis Partners does

Pyxis Partners is a Washington, D.C.-based public affairs and social impact consulting firm founded in July 2020 by Michael Manganiello, a long-time health equity advocate. The firm operates as a professional services boutique offering six integrated capabilities: Engagement, Government Relations, Communications, Monitoring/Evaluation/Learning, Policy and Advocacy, and Language Access Planning. Its primary clients are public health organizations, government agencies, biopharmaceutical and medical device companies, and community-based advocacy groups working on health equity, clinical trial diversity, drug pricing, and precision medicine enrollment.

The firm generates revenue through project-based consulting engagements and programmatic grants rather than through any proprietary technology or product. Notable funding sources include The Commonwealth Fund (drug pricing analysis, March 2022) and Scripps Research (NIH All of Us Research Program community partner network expansion, July 2023). Its primary structural asset is the Community Partner Gateway Initiative, a curated network of 100+ community organizations across the United States that supports client engagements such as enrolling more than 640,000 participants in the NIH All of Us Research Program.

The firm holds a District of Columbia Certified Business Enterprise designation and NGLCC Platinum-certified LGBT Business Enterprise status, both of which provide preferred procurement access. The team of approximately 20-plus professionals includes former senior federal officials, congressional staffers, and biopharma veterans. Pricing is project-based and not publicly disclosed. The firm operates from a single headquarters at 1156 15th Street NW, Washington, D.C., and serves clients exclusively in the U.S. market.

Name

Pyxis Partners

Legal name

Pyxis Partners, LLC

Website

https://pyxispartners.co

Company type

Private

Founded year

2020

Operating status

Operating

Headcount range

11–50 employees

Short description

Pyxis Partners is a Washington, D.C. public affairs and social impact consulting firm that partners with public health organizations, government agencies, biopharmaceutical companies, and communities to advance health equity through health policy, advocacy, community engagement, and language access services.

Ownership category

akta.pro rank

Headquarters

HQ city

Washington

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Marketing or Sales

Revenue model

1. Consulting Services: Pyxis Partners generates revenue through consulting engagements with public health organizations, researchers, policy makers, healthcare industry clients, and government agencies seeking expertise in health policy, advocacy, government relations, and community engagement.
2. Research Grants: The firm receives grants for specific research and analysis projects, such as the grant from The Commonwealth Fund to analyze drug pricing issues in the United States.

Go-to-market motion2 records

Distribution channels1 record

Marketing channels5 records

Core offering

Pyxis Partners is a public affairs and social impact consulting firm offering six integrated service capabilities: Engagement, Government Relations, Communications, Monitoring/Evaluation/Learning, Policy and Advocacy, and Language Access Planning. The firm partners with public health organizations, researchers, policymakers, communities, and industry clients to advance health equity, access, and affordability through evidence-based advocacy, coalition building, and trusted community relationships.

Product overview

Pyxis Partners is a public affairs and social impact consulting firm that operates as a full-service professional services organization rather than a software product company. The firm offers six integrated consulting service capabilities: Engagement (building trusted community relationships), Government Relations (navigating health policy corridors), Communications (strategic messaging and campaigns), Monitoring, Evaluation and Learning (equity-centered program assessment), Policy and Advocacy (policy research and coalition building), and Language Access Planning (multilingual healthcare communication). These services work together to help clients advance health equity, accessibility, and affordability through authentic community engagement, evidence-based policy development, and strategic advocacy campaigns.

Differentiator

Problem solved

Functional benefit

Products and services

• Engagement Meaningful engagement consulting that builds trusted relationships, authentic conversation, and human connection to support public health organizations, researchers, policy makers, communities, and industry clients.
• Government Relations Government relations consulting that helps clients navigate the rooms where health policy gets made, leveraging the firm's relationships with policymakers and regulators across federal and state government.
• Communications Strategic communications and campaign services delivering the right message from the right messenger at the right moment to move health campaigns and influence key partners. Includes campaign planning, audience segmentation, public relations, and culturally-tailored promotional strategies.
• Monitoring, Evaluation and Learning Rigorous, equity-driven evaluations that generate actionable insights for clients and communities, applying mixed-method and participatory designs to measure program impact.
• Policy and Advocacy Health policy research, analysis, and advocacy strategy development including coalition building, stakeholder alignment, and patient and community storytelling initiatives to drive health policy wins.
• Language Access Planning Services helping organizations move from ad hoc translation to intentional, sustainable language access, including assessments, translation, transcreation, and cultural adaptation for healthcare communications.

Quantifiable outcome

• More than 640,000 community members enrolled in NIH All of Us Research Program through Pyxis Partners' community partner network
• +2 more outcomes

Named customers3 records

Segments4 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Partnerships

Five partnerships are on record, tiered core and minor.

• Rx4goodcoreStrategic or Co-development Partner · 5 March 2024Pyxis Partners and Rx4good united to guide biopharmaceutical companies in diversifying clinical trials. The partnership leverages Pyxis' deep knowledge of hyper-local community organizations with Rx4good's experience in patient engagement and advocacy to help industry meet FDA guidelines on diversifying clinical trials through Diversity Action Plans.
• Scripps ResearchcoreStrategic or Co-development Partner · 17 July 2023Pyxis Partners was selected to receive funding from Scripps Research to expand the NIH All of Us Research Program national community partner network. Over five years, Pyxis will expand its community partner network in six markets to ensure engagement infrastructure alongside Scripps' enrollment infrastructure through local blood banks.
• NIH All of Us Research ProgramcoreStrategic or Co-development PartnerPyxis Partners is an initial engagement awardee of the NIH All of Us Research Program since 2016, creating the Community and Provider Gateway Initiative (CPGI) with more than 100 community partners to educate diverse communities about the precision medicine program and move them to enrollment.
• Whitman-Walker HealthminorStrategic or Co-development PartnerPyxis Partners maintains a partnership with Whitman-Walker Health rooted in longstanding commitment to health equity and healthcare access for underserved communities. CEO Michael Manganiello donated a painting of Marsha P. Johnson to Whitman-Walker's Max Robinson Center.
• Christopher and Dana Reeve FoundationminorStrategic or Co-development PartnerMichael Manganiello served as the first Senior Vice President of Government Relations for the Christopher and Dana Reeve Foundation, playing an integral role in establishing the foundation as a leading force for advancing medical research and quality of life for the mobility impaired.

Scale indicators3 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Avalere Health: Avalere Health is a healthcare-focused consulting and advisory firm serving biopharma, payers, providers, and government agencies on policy, market access, and evidence — directly comparable to Pyxis's healthcare policy and advocacy work.
• Manatt Health: Manatt Health is a leading health policy and strategic advisory practice within Manatt, Phelps & Phillips, serving similar public health, government, and provider clients with consulting and policy services comparable to Pyxis's offerings.
• Leavitt Partners: Leavitt Partners is a healthcare consulting and policy advisory firm focused on value-based care, health equity, and federal health strategy, directly comparable to Pyxis's policy and advocacy work with government and biopharma clients.
• Burness: Burness is a health and social impact communications and consulting firm supporting nonprofits, foundations, and health-focused organizations with advocacy, storytelling, and community engagement — closely overlapping with Pyxis's engagement and communications capabilities.
• Waxman Strategies: Waxman Strategies is a public affairs and health policy consultancy led by former congressional staff, working with health organizations on policy advocacy and government relations — directly comparable to Pyxis's policy and government relations work.
• HCM Strategists: HCM Strategists is a health policy and advocacy firm focused on access, equity, and public health issues for foundations, health systems, and patient organizations — closely aligned with Pyxis's mission-driven health equity consulting model.
• Rx4good: Rx4good is a patient engagement and advocacy consultancy serving biopharmaceutical companies, including recent work on FDA-mandated Diversity Action Plans — a direct strategic partner and peer to Pyxis in the clinical trial diversity space.

Broad incumbents

• SKDKnickerbocker: SKDKnickerbocker is a large public affairs and political consulting firm offering health communications, government relations, and advocacy services as part of a broader portfolio — overlapping with Pyxis's capabilities but operating at a much larger scale.
• DDC Group: DDC Group (formerly Dutko) is a public affairs firm providing advocacy, communications, and grassroots campaigns across health and other sectors — comparable in service mix but much larger and broader in scope than Pyxis.

Others

• BPC (Bipartisan Policy Center): BPC is a Washington-based think tank that develops and advances health policy recommendations and convenes stakeholders — adjacent to Pyxis's policy advocacy work but operates as a nonprofit rather than a fee-for-service consulting firm.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/@pyxispartners
• LinkedInlinkedin.com/company/pyxispartners
• Xx.com/PyxisTweets

Revenue estimate

Valuation estimate

Number of profiles

Profiles15 records

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Pyxis Partners