What Progeny Software does

Progeny Software (legally Progeny Genetics, LLC) is a US-based clinical genetics software vendor founded in 1996 and acquired by Ambry Genetics in 2015, where it operates as a subsidiary. The firm provides pedigree management, family history collection, validated cancer risk calculation, genetic test ordering, and clinical documentation tools to 800+ genetics institutions globally. Its two core products are Progeny Clinical—used by hospitals, cancer and pediatric genetic counselors, and university medical centers for end-to-end patient genetics workflows—and Progeny Research, a multi-center research data platform with API access for IRB-compliant collaboration. The position is reinforced by deep native integration with parent Ambry Genetics' AmbryPort for test ordering, trio testing, VUS reclassifications, and Patient for Life reanalysis alerts, plus EHR integration transmitting pedigree images and PDFs into electronic health records.

The platform is web-based, deployed either as Progeny Cloud or on-premise, built on MySQL data infrastructure with HIPAA/GDPR-compliant encryption, private cloud servers, double firewall protection, and role-based access control. Progeny monetizes through recurring SaaS subscriptions (monthly/annual cloud billing), perpetual on-premise licenses with annual support (Version 11 line; Versions 1–10 discontinued), a paid EHR Integration add-on, and professional services/support plan memberships. Pricing is quote-based across enterprise and mid-market segments; a 30-day free full-featured cloud trial acts as a self-serve funnel, while direct enterprise field sales targets large hospitals and academic medical centers. Distribution is amplified by Ambry Genetics' channel and by a dedicated European sales office in Needham, UK.

Customer segmentation is vertical: genetics-focused healthcare institutions (primary), academic research institutions, diagnostic laboratories, and a students/educators use case addressed through the free Online Pedigree Tool. With 11–50 employees, the firm operates with a lean vertical-SaaS cost structure characteristic of a niche-dominant software subsidiary, and revenue, financial ownership details, and headcount trends beyond the stated range are not publicly disclosed.

Name

Progeny Software

Legal name

Progeny Genetics, LLC

Website

https://progenygenetics.com

Company type

Private

Founded year

1996

Operating status

Operating

Headcount range

11–50 employees

Short description

Progeny Software, a subsidiary of Ambry Genetics since 2015, provides clinical genetics workflow software to 800+ hospitals, research institutions, and diagnostic labs globally—combining pedigree drawing, validated cancer risk models, and integrated genetic test ordering.

Ownership category

akta.pro rank

Product category

Clinical Genetics Software

NAICS

Software Publishers (513210)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

Bioinformatics & Multi-omics Analysis Software (HLAGAJAD)

akta.pro secondary industry

Genetic & Genomic Testing (germline, somatic, carrier, pharmacogenomics) (HLAAALAD)

Keywords

• Clinical genetics software
• Pedigree drawing software
• Genetic risk assessment
• Family health history
• Genetic data management

Headquarters

HQ city

South Bend

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Infrastructure, Operations, Marketing or Sales

Revenue model

1. Cloud Subscription: SaaS subscription model for Progeny Cloud platform with monthly or annual billing. Includes full feature access, technical support, and cloud infrastructure maintenance.
2. On-Premise License: Traditional software license model for organizations preferring local deployment. Version 11 currently supported; older versions (1-10) are discontinued.
3. Professional Services: Support plan memberships with dedicated phone support (800-776-4369) for support plan members. Training and implementation services available.
4. EHR Integration Add-on: Additional fee for EHR integration functionality including pedigree transmission to electronic health record systems.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels4 records

Core offering

Progeny Software provides a clinical and research genetics software platform used by healthcare genetics professionals to collect patient and family history, draw pedigrees, perform validated cancer risk assessments, order genetic tests through Ambry Genetics, generate patient letters, and manage clinical documentation. It also offers a research platform for multi-center genetic studies and a free browser-based Online Pedigree Tool for educational use.

Product overview

Progeny Software offers a comprehensive genetics software platform comprising two core products: Progeny Clinical for healthcare genetics professionals and Progeny Research for academic/institutional research. Progeny Clinical includes integrated modules for Family History Questionnaire (FHQ) patient data collection, Pedigree Drawing, Risk Assessment with multiple validated cancer risk models (Tyrer-Cuzick, BRCAPRO, etc.), Genetic Testing Orders via Ambry integration, Letter Generation, and Clinical Data Management. An optional EHR Integration add-on enables pedigree transmission to electronic health records. Progeny Research provides data collection, analysis, and multi-center collaboration tools with API access. The company also offers a free Online Pedigree Tool for educational use and a 30-day Cloud Trial for the full clinical platform.

Differentiator

Problem solved

Functional benefit

Products and services

• Progeny Clinical Comprehensive clinical genetics software platform for genetics professionals in hospitals, medical facilities, and healthcare systems. Provides tools for patient history collection, pedigree drawing, risk assessment, genetic test ordering, and clinical documentation. Used by 800+ genetics institutions.
• Progeny Research Research-focused platform for managing genetic research data across institutions. Features data collection, storage, analysis, reporting, and multi-center collaboration with IRB-compliant tools. Supports API access for data integration.
• Online Pedigree Tool Free standalone browser-based pedigree drawing tool for coursework. Allows manual drawing or auto-generation from family relationships. Export as image or print with custom specifications.

Quantifiable outcome

• More complete patient histories through pre-visit questionnaires
• +2 more outcomes

Named customers2 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature7 records

Partnerships

One partnership is on record.

• Ambry GeneticscoreOEM/ Whitelabel/ Licensing Partner · 1 January 2015In 2015, Progeny Genetics joined Ambry Genetics, creating a powerful end-to-end platform for genetic care delivery. This combination brings together deep genetics expertise with cutting-edge technology to enhance both clinical care and research capabilities. Progeny operates as a subsidiary under Ambry Genetics.

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• PhenoTips: PhenoTips provides pedigree drawing, family history, and clinical genetics workflow software used by genetic counselors and clinical geneticists. Most direct overlap with Progeny's pedigree and clinical data management modules, competing head-to-head for genetic counseling clinic deployments.
• Fabric Genomics (formerly Omicia): Fabric offers AI-driven clinical genomic interpretation and reporting platforms deployed at health systems and clinical labs. Comparable in serving clinical genomics workflows (interpretation, reporting) that interface with Progeny-style pedigree and EHR systems.
• BC Platforms: BC Platforms provides genomic data management, clinical interpretation, and research platform software for healthcare and bio-pharma. Comparable to Progeny Research in cohort/genomic data management and clinical reporting infrastructure.
• Translational Software: Translational Software provides clinical decision support for pharmacogenomics and genetic test results delivery into the EHR. Comparable in clinical genomics reporting and EHR-linked test delivery workflows adjacent to Progeny's clinical modules.

Broad incumbents

• SOPHiA Genetics: SOPHiA DDM is a cloud-based genomics analysis and clinical interpretation platform used by hospitals and labs worldwide. Overlaps with Progeny in clinical genomics workflow and hereditary cancer interpretation, but operates at a broader multi-omics scale alongside Progeny's pedigree/clinical focus.
• GeneDx: GeneDx (a subsidiary of Sema4) is a major clinical genetic testing lab offering hereditary cancer, rare disease, and prenatal testing. Comparable as both a lab competitor to Ambry and as a clinical workflow channel that Progeny could natively integrate with.
• Invitae: Invitae is a major genetic testing company with its own clinical software, patient and clinician portals. Adjacent to Progeny as both a lab competitor to Ambry and a broader clinical genomics workflow incumbent.

Emerging players

• DNAnexus: DNAnexus provides a cloud genomics and clinical data platform for sequencing data management, analysis, and clinical reporting. Partial overlap with Progeny Research in multi-center research data collaboration and clinical-grade compliance (HIPAA).
• 2bPrecise (formerly 2b Genomics): 2bPrecise delivers a precision medicine platform that integrates genomic and clinical data into the EHR workflow. Direct overlap with Progeny's Clinical data management and EHR integration functionality.
• Optra Health (GeneFAX/IQ): Optra Health's GeneFAX and conversational AI platforms deliver genetic test ordering, results interpretation, and clinical decision support. Comparable to Progeny's Letter Generation, Risk Assessment, and Genetic Testing Orders modules for hereditary cancer workflows.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/progeny
• Facebookfacebook.com/progenysoftware
• LinkedInlinkedin.com/company/progeny-software-llc

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Progeny Software