HistoGenetics
HistoGenetics is a private, CLIA-certified clinical laboratory founded in 2006 that provides HLA sequence-based typing, pharmacogenomics, and advanced genomic sequencing services to donor registries, transplant centers, hospitals, and research institutions globally, operating the largest fleet of PacBio Sequel II instruments.
- Company typePrivate
- Founded2006
- HeadquartersOssining, United States
- Headcount101–250
- GTM typeB2B
- OfferingServices
What HistoGenetics does
HistoGenetics is a privately held, CLIA-certified high-complexity clinical laboratory founded in 2006 in Ossining, New York, specializing in immunogenetics and genomic services. Its core offering is HLA sequence-based typing (SBT) for classical HLA genes (A, B, C, DRB1, DRB3/4/5, DQA1, DQB1, DPA1, DPB1) and non-classical HLA (E, G, MICA, MICB, DRA), delivered at five resolution tiers (1x through 8x). The company serves donor registries, transplant centers, HLA laboratories, cord blood centers, donor centers, hospitals, pharmacogenomics programs, and research institutions worldwide, and reports having processed millions of HLA SBT tests since founding.
The technology stack spans Illumina MiSeq/NovaSeq for short-read NGS, the largest known global fleet of PacBio Sequel II/IIe instruments for SMRT long-read sequencing, Oxford Nanopore GridION for third-generation sequencing, BioNano Saphyr for optical whole genome mapping, and 10x Genomics Chromium for single-cell applications. Beyond HLA, the company offers KIR gene typing, FCGR genotyping, molecular ABO Rh typing, CCR5 Δ32 detection, HPA platelet antigen genotyping, CMV IgG detection, T cell receptor repertoire analysis, hemoglobin beta gene sequencing, engraftment monitoring, pharmacogenomics testing, FDA EUA COVID-19 qRT-PCR, whole genome sequencing, Iso-Seq, single-cell, microbiome, RNA-seq, and microarray services. The portfolio is delivered through a multi-module client portal with configurable report delivery via FTP, ShareFile, email, and HTTP.
The business is a transaction-based laboratory services model with quote-based pricing and tiered turnaround (3 days for ultra-urgent clinical samples, 5-8 days for standard clinical, 14-28 days for registry/research), with volume and frequency discounts for large organizations. Distribution is direct enterprise field sales and inside sales targeting healthcare and research institutions globally. The company is led by founders Dr. Soo Young Yang (Chairman, 35+ years HLA genetics research at Memorial Sloan-Kettering) and Dr. Nezih Cereb (CEO, clinical HLA typing and bone marrow transplantation expert), and is accredited by ASHI, certified under CLIA, ISO/IEC 27001:2022, and SOC 2 Type II. No institutional investors, parent company, or public funding history is disclosed.
HistoGenetics firmographics
Firmographics- Name
- HistoGenetics
- Legal name
- HistoGenetics LLC
- Website
- https://histogenetics.com
- Company type
- Private
- Founded year
- 2006
- Operating status
- Operating
- Headcount range
- 101–250 employees
- Short description
- HistoGenetics is a private, CLIA-certified clinical laboratory founded in 2006 that provides HLA sequence-based typing, pharmacogenomics, and advanced genomic sequencing services to donor registries, transplant centers, hospitals, and research institutions globally, operating the largest fleet of PacBio Sequel II instruments.
- Ownership category
- akta.pro rank
HistoGenetics industry classification
Industry- Product category
- Immunogenetics & Genomic Testing Services
- NAICS
- Medical Laboratories (621511), Medical and Diagnostic Laboratories (6215), Medical and Diagnostic Laboratories (62151)
- SIC
- Services-Medical Laboratories (8071)
- akta.pro primary industry
- Genomics & Molecular Diagnostics (Trial Support) (HLAGAEAD)
- akta.pro secondary industries
- Genomic & Multi-Omic Biomarkers (NGS panels, transcriptomics, proteomics, metabolomics) (HLAAAMAJ), Transcriptomics & Gene Expression Profiling Services (HLAGANAE), Microbiome Analytics, Sequencing & Bioinformatics Platforms (HLAAAFAI), Genetic, Cytogenetic & Prenatal Screening IVD (HLAHAAAI)
Keywords
Where HistoGenetics is headquartered
LocationHeadquarters
- HQ city
- Ossining
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
HistoGenetics business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Technology or R&D, Operations, Supply Chain, Infrastructure, Marketing or Sales
Revenue model
- HLA Typing Services: High-resolution HLA tissue typing for donor registries, transplant centers, and clinical laboratories. Services include classical HLA (A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, DPB1), non-classical HLA (E, G, MICA, MICB, DRA), and multiple resolution levels from 1x to 8x.
- KIR Gene Typing: KIR Gene Content Typing on Illumina platform and KIR 3DL1, 3DS1 Gene Allele level typing on PacBio platform.
- Pharmacogenomics Testing: CLIA and New York State approved pharmacogenomics testing services for predicting individual medication responses.
- Genomic Sequencing Services: Whole genome sequencing, RNA-Sequencing, single-cell sequencing, microbiome sequencing, optical whole genome mapping, and microarray services.
- Molecular ABO Rh Typing: Molecular serotype prediction for ABO and Rh blood groups (research purpose only).
- COVID-19 Testing: Viral diagnostic testing for businesses, schools, and organizations under FDA Emergency Use Authorization.
- Additional Genetic Tests: CCR5 delta 32 detection, HPA-1a/HPA-1b Human Platelet Antigen Genotyping, CMV IgG detection, T Cell Receptor Repertoire analysis, Hemoglobin Beta Gene sequencing, and engraftment monitoring.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Transaction based/ take rate | Pay-as-you-go | Clinical samples with ultra-urgent turnaround (3 days) |
| Transaction based/ take rate | Pay-as-you-go | Clinical samples with urgent turnaround (5-8 days) |
| Transaction based/ take rate | Pay-as-you-go | Registry and research samples (14-28 days) |
Go-to-market motion2 records
Distribution channels2 records
Marketing channels3 records
HistoGenetics product offering
Product offeringCore offering
HistoGenetics provides HLA sequence-based typing (SBT) and a broader suite of immunogenetics, pharmacogenomics, and genomic sequencing services delivered through its CLIA-certified, high-complexity laboratory. Services include high-resolution HLA typing for classical and non-classical genes at multiple resolution levels (1x–8x), KIR and FCGR genotyping, molecular ABO Rh typing, engraftment monitoring, CLIA-approved pharmacogenomics testing, FDA EUA COVID-19 testing, and advanced sequencing (whole genome, single-cell, microbiome, optical mapping, RNA-Seq, microarray) for donor registries, transplant centers, HLA laboratories, cord blood centers, hospitals, and research institutions.
Product overview
HistoGenetics provides a unified suite of immunogenetics and genomics services centered on HLA sequence-based typing (SBT) as the core product. The portfolio spans five main pillars: (1) HLA Typing Services — offering classical HLA genes (A, B, C, DRB1/3/4/5, DQA1, DQB1, DPA1, DPB1) and non-classical HLA (E, G, MICA, MICB, DRA) at five resolution tiers (1x through 8x); (2) Specialized Immunogenetics sub-products including KIR gene typing, FCGR genotyping, molecular ABO Rh typing, CCR5 Δ32 detection, HPA platelet antigen genotyping, CMV IgG detection, TCR repertoire analysis, and hemoglobin beta gene sequencing; (3) Pharmacogenomics (PGX) testing — a CLIA/NY State-approved full-panel service; (4) COVID-19 testing via FDA EUA qRT-PCR; and (5) Advanced Genomic Sequencing Services including whole genome sequencing (PacBio HiFi, Illumina NovaSeq), Iso-Seq, single cell sequencing (10x Genomics), microbiome sequencing, optical genome mapping (BioNano Saphyr), RNA-seq, and microarray genotyping. Services are delivered through a multi-module client portal (clients.histogenetics.com) with configurable reporting formats (PDF, XLS, XML, TXT, HML, HGX) and delivery via FTP, ShareFile, email, or HTTP.
Differentiator
Problem solved
Functional benefit
Quantifiable outcome
- 100% concordance in ABO Rh algorithm validation study with 1000 Caucasian individuals
- +2 more outcomes
Companies that use HistoGenetics
Customer profileNamed customers6 records
Segments5 records
Ideal customer profiles5 records
HistoGenetics technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature5 records
HistoGenetics partnerships and signals
Strategic signalPartnerships
Five partnerships are on record, tiered core and supporting.
- IlluminacoreUses Illumina MiSeq and NovaSeq platforms for NGS-based HLA typing and genomic sequencing services. Provides high-throughput short-read sequencing capability for routine HLA testing and population-scale genetics studies.
- Pacific BiosciencescoreOperates largest fleet of Sequel II, Sequel IIe, and Sequel I instruments for SMRT sequencing. Uses PacBio Sequel and Revio platforms for whole gene HLA typing, KIR allele-level typing, and whole genome sequencing. Set the Gold Standard for HLA typing using SMRT technology.
- Oxford Nanopore TechnologiessupportingUses Oxford Nanopore GridION and P2 Solo platforms for third-generation sequencing capabilities, enabling long-read sequencing for genomic analysis.
- BioNano GenomicssupportingOperates BioNano Saphyr system for optical whole genome mapping. Enables identification of structural variations and analysis of complex genetic regions through ultra-high molecular weight DNA extraction, labeling, and imaging.
- 10x GenomicssupportingUses 10x Genomics Chromium platform for single-cell RNA sequencing, single-cell immuno-profiling, and single-cell ATAC-Seq analysis on Illumina sequencing platforms.
Scale indicators4 records
Recent moves6 records
Expansion highlights6 records
HistoGenetics competitors and assessment
Company assessmentBroad incumbents
- Eurofins Genomics: Large global genomic services provider with broad sequencing, HLA, and specialty lab offerings. Overlaps with HistoGenetics' genomic sequencing services menu at greater scale and broader portfolio.
- Labcorp: National clinical and specialty laboratory with pharmacogenomics, HLA, and genomic testing capabilities. Comparable as a CLIA-certified lab offering specialty genetic testing to enterprise healthcare customers.
- Sema4 (now part of GeneDx): Clinical genomics company offering hereditary, reproductive, and somatic genetic testing at scale. Comparable as a broad clinical genomics service provider adjacent to HistoGenetics' specialty HLA/molecular diagnostics.
- Quest Diagnostics: Major clinical diagnostics network offering HLA typing, pharmacogenomics, and advanced genomic sequencing. Comparable in delivering CLIA-certified specialty genetics services to hospitals and transplant programs.
- Natera: Clinical genetic testing company specializing in transplant monitoring (Prospera) and reproductive/oncology genomics. Comparable as a specialty genomic testing provider with transplant-monitoring overlap.
Emerging players
- Asuragen: Specialty molecular diagnostics company focused on PCR-based and NGS-based genetic testing reagents. Comparable in niche molecular genetic test development relevant to HistoGenetics' specialty testing portfolio.
Direct peers
- CareDx: Transplant-focused diagnostics company offering AlloSure and AlloMap testing for post-transplant monitoring. Comparable as a specialty diagnostics provider in the transplant care continuum where HistoGenetics offers engraftment monitoring and HLA typing.
- One Lambda (Thermo Fisher Scientific): Direct peer in HLA typing reagents, kits, and laboratory services for transplant immunogenetics. Competes head-to-head with HistoGenetics in donor registry and transplant-center HLA testing workflows.
- GenDx: Direct peer specializing in NGS-based HLA and KIR typing reagents and software. Competes with HistoGenetics in HLA sequencing-based typing services and SBT reagent markets.
- Immucor: Specialty transfusion and transplant diagnostics provider including molecular HLA and blood-group reagents. Comparable in molecular immunogenetics and blood-group typing product lines served by HistoGenetics.
Market position
Strengths4 records
Weaknesses5 records
Competitive moat6 records
Key risks5 records
Key highlights7 records
Customer concentration
HistoGenetics social profiles
Digital presenceHistoGenetics financial estimates
Financial estimateRevenue estimate
Valuation estimate
HistoGenetics leadership team
Management profileNumber of profiles
Profiles2 records
HistoGenetics funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
HistoGenetics M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about HistoGenetics
What does HistoGenetics do?
HistoGenetics provides HLA sequence-based typing (SBT) and a broader suite of immunogenetics, pharmacogenomics, and genomic sequencing services delivered through its CLIA-certified, high-complexity laboratory. Services include high-resolution HLA typing for classical and non-classical genes at multiple resolution levels (1x–8x), KIR and FCGR genotyping, molecular ABO Rh typing, engraftment monitoring, CLIA-approved pharmacogenomics testing, FDA EUA COVID-19 testing, and advanced sequencing (whole genome, single-cell, microbiome, optical mapping, RNA-Seq, microarray) for donor registries, transplant centers, HLA laboratories, cord blood centers, hospitals, and research institutions.
Is HistoGenetics a public or private company?
HistoGenetics is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was HistoGenetics founded?
HistoGenetics was founded in 2006. It employs 101 to 250 people.
Where is HistoGenetics based?
HistoGenetics is headquartered in Ossining, United States, in the North America region.
How does HistoGenetics make money?
Seven revenue lines are on record. HLA Typing Services are the primary driver. The others are KIR Gene Typing, pharmacogenomics Testing, genomic Sequencing Services, molecular ABO Rh Typing, COVID-19 Testing and additional Genetic Tests.
Who are HistoGenetics's main competitors?
Broad incumbents on record are Eurofins Genomics, Labcorp, Sema4 (now part of GeneDx), Quest Diagnostics and Natera. Asuragen is listed as an emerging player. Direct peers are CareDx, One Lambda (Thermo Fisher Scientific), GenDx and Immucor.
Does HistoGenetics have an API?
No public API is recorded for HistoGenetics.
What industry is HistoGenetics in?
HistoGenetics's product category is Immunogenetics & Genomic Testing Services. Its primary akta.pro industry code is HLAGAEAD, Genomics & Molecular Diagnostics (Trial Support), with a secondary code of HLAAAMAJ, Genomic & Multi-Omic Biomarkers (NGS panels, transcriptomics, proteomics, metabolomics). Its NAICS code is 621511 and its SIC code is 8071.