Bioseutica

What Bioseutica does

Bioseutica B.V. is a privately held Dutch ingredients company, founded in 1947 and headquartered in Zeewolde, the Netherlands, that manufactures natural proteins and enzymes — primarily extracted from hen egg-white and pancreatic sources — for sale into the global food, pharmaceutical, and animal-feed industries. Its core technology is a proprietary, patented solvent-free lysozyme extraction process using ion-exchange resin absorption, which is the only lysozyme production method certified by the Pasteur Texcell Institute to contain no risk of Avian Flu virus transfer. The portfolio spans raw egg proteins (Lysozyme, Avidin, Ovotransferrin, Ovalbumin, Ovomucoid), pancreatic proteases (multiple Trypsin grades, Pancreatin, Phospholipase A2), and branded specialty formulations targeting cheese production (LYSOLAC), winemaking (LYSOVIN), craft brewing (LYSOBIER), animal feed antibiotic-replacement (Entegard, Inovapure), nootropics (NA2R), cell-culture reagents (AQUATRYP), and drug delivery (AFFIAVIDIN). A patent-pending inhaled antifungal, AMCIPATRICIN (SPK-843), is in development for cystic fibrosis and immunocompromised patients.

The company generates revenue through B2B sales of ingredients and API-grade lysozyme under direct enterprise sales motions, with manufacturing and operating subsidiaries in Canada (Neova Technologies Inc., Abbotsford) and Switzerland (Fordras SA and Healiva SA, both in Lugano). Pricing is not publicly disclosed; standard terms are net-30 with up to 8-week production lead times, and lysozyme is sold at very low cost-in-use (roughly €0.04 per kg of finished cheese at ~5 ppm dosage). Its commercial position is anchored by long-running incumbency — used by 99% of Grana Padano DOP producers, over 85% of French hard cheese makers, and over 30 years of cheese-industry trust — and reinforced by a dense regulatory stack including US FDA GRAS (1998), EFSA opinion (2023), EU E1105 listing, GMP, FSSC 22000, HACCP, Kosher, Halal, ISO 9001/14001/18001, Swissmedic GDP, JECFA, and US TTB approvals for wine (2007) and beer (2008). The group is privately held by its founding-family and corporate entities, with no disclosed external equity or debt funding rounds.

Name

Bioseutica

Legal name

Bioseutica B.V.

Website

https://bioseutica.com

Company type

Private

Founded year

1947

Operating status

Operating

Headcount range

251–500 employees

Short description

Bioseutica is a privately held Dutch ingredients company, founded in 1947, that manufactures natural egg-derived and pancreatic proteins and enzymes — most notably lysozyme — for the global food, pharmaceutical, and animal-feed industries, with manufacturing operations in the Netherlands, Canada, and Switzerland.

Ownership category

akta.pro rank

Headquarters

HQ city

Zeewolde

HQ country

Netherlands

HQ region

Europe

Offices3 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Enzyme and Protein Product Sales: Bioseutica generates revenue through the sale of natural proteins and enzymes including lysozyme, avidin, ovotransferrin, trypsin, and specialty formulations to food, pharma, and feed industries. Products are sold as ingredients for food processing, pharmaceuticals, nutrition supplements, animal health, and diagnostics.
2. API Lysozyme (Active Pharmaceutical Ingredient): Pharmaceutical grade cGMP manufactured API Lysozyme suitable for use in healthcare and wellness products. Currently found in over-the-counter drugs for colds, inflammatory conditions, oral health, and skin healing products.
3. Specialty Formulation Ingredients: Specialty formulations including NA2R (natural nootropic), LYSOVIN for winemaking, LYSOLAC for dairy products, and Entegard range for livestock immunity, sold to specific industry applications.

Go-to-market motion1 record

Distribution channels2 records

Marketing channels6 records

Core offering

Bioseutica manufactures and sells natural proteins and enzymes derived from eggs and pancreatic sources using proprietary solvent-free processes. Its commercial portfolio spans lysozyme (including API and branded variants such as Lysolac, Lysovwin, Lysobier, Inovapure, LysOHT, Entegard, Lysoguard), avidin, ovotransferrin, ovalbumin, trypsin and pancreatin grades, phospholipase A2, and specialty formulations such as NA2R (nootropic), AQUATRYP (cell detachment), and AFFIAVIDIN (drug delivery), serving food, pharmaceutical, animal health, nutrition, and research customers worldwide.

Product overview

Bioseutica® is a leading ingredients company providing natural proteins and enzymes for food, pharma, and feed industries, operating for nearly 75 years with proprietary solvent-free processes. The portfolio centers on egg-derived proteins (lysozyme, avidin, ovotransferrin, ovalbumin) and pancreatic enzymes (trypsin, pancreatin, phospholipase A2). Key branded products include Lysolac® for cheese making, Lysobier® for craft beer preservation, Lysovin™ for winemaking, and Inovapure® and Entegard® for animal feed. Specialty offerings include NA2R® (nootropic), AQUATRYP™ (cell culture reagent), and AFFIAVIDIN (drug delivery). The pipeline includes amcipatricin for inhaled antifungal treatment. The group comprises Neova Technologies Inc. (Canada), Fordras SA (Switzerland), and Healiva SA (Switzerland).

Differentiator

Problem solved

Functional benefit

Brands

• LYSOZYME: Natural antimicrobial and antiviral enzyme derived from hen egg-white, used in foods and pharmaceuticals for antibacterial protection
• AVIDIN
• OVOTRANSFERRIN
• OVALBUMIN
• NA2R®
• LYSOLAC®
• LYSOVIN™
• LYSOBIER®
• Entegard®
• TRYPSIN
• Inovapure®
• AFFIAVIDIN
• AQUATRYP™
• LysOHT®
• AMCIPATRICIN
• PLA2 (Phospholipase A2)

Products and services

• Lysozyme (Lysozyme Hydrochloride) Natural antimicrobial and antiviral enzyme (1-4-Beta-N-acetylmuramidase, EC 3.2.1.17) derived from hen egg-white using patented solvent-free resin purification; GRAS-certified food additive used in food preservation and pharmaceutical applications.
• API Lysozyme Highest purity pharmaceutical-grade lysozyme produced from hen egg-white under stringent cGMP guidelines for use in OTC drugs for colds, inflammatory conditions, oral health, and skin healing.
• Inovapure Proprietary lysozyme-based feed brand offering potent antimicrobial benefits for livestock and pet formulations.
• Lysobier Lysozyme-based product for craft and micro brewers that preserves yeast, enhances quality, and prolongs shelf-life of unpasteurized brews by killing beer spoilers.
• Lysolac Lysozyme formulation for cheese making that prevents late blowing defects caused by Clostridium tyrobutyricum; USDA Organic approved for organic cheeses; effective at ~5 PPM dosage at approximately €0.04 per kilo of finished cheese.
• Lysovin Lysozyme-based winemaking additive that prevents wine contaminations, enables sulfite-free winemaking, enhances color/texture/aroma, and manages stuck fermentation; GRAS-certified for FDA, accepted by JECFA, Kosher certified.
• Avidin Glycoprotein extracted from egg white via ion-exchange or affinity chromatography with strong biotin-binding properties, used in diagnostics and clinical development.
• Ovotransferrin (Conalbumin) Glycoprotein (molecular weight 76,000) comprising ~13% of egg albumen protein; used as a lactoferrin substitute with high similarity to bovine and human lactoferrin for food and nutrition applications.
• Ovalbumin Freeze-dried lyophilised albumin powder purified in crystalline form, one of the most extensively characterised antigens used in immunology and research.
• Ovomucoid Egg white protein included in Bioseutica's egg proteins portfolio.
• Trypsin (multiple grades: I, II, IV, VI, 1:250) Highly valued workhorse protease extracted from pancreatic sources used across medical, pharmaceutical, and food industries; available in multiple activity specifications for industrial and research applications.
• Trypsin SE (Pancreatin) Safe and high quality protease complex for infant and follow-on formulae, medical food, hydrolysed whey protein, and hypo-allergenic infant formula production.
• Phospholipase A2 (PLA2) Hydrolase enzyme designed for food applications including dairy and baking processes.
• LysOHT Specialty lysozyme formulation in Bioseutica's products portfolio.
• Amcipatricin (SPK-843) Advanced R&D new semi-synthetic water-soluble polyene antibiotic (amcipatricin diascorbate) with potent broad-spectrum antifungal activity for inhalation treatment of severe fungal infections in cystic fibrosis or immunocompromised patients (patent pending).
• Affiavidin Specialty protein product for targeted drug delivery to cells or tissues with high biotin levels.
• Aquatryp Ready-to-use, gentle, non-mammalian, non-microbial enzymatic cell detachment reagent readily incorporated into routine cell culture protocols.
• Lysoguard Immune system dietary supplement derived from lysozyme.
• Entegard Lysozyme-based feed additive for poultry, swine, and other livestock designed to prevent antimicrobial resistance (AMR) and reduce antibiotics usage; demonstrated 50% methane emission reduction in cattle at 200g/tonne.
• NA2R Clinically proven natural nootropic ingredient derived from egg white proteins with optimised amino acid composition that increases brain serotonin levels, supporting cognitive function, mood stabilization, and well-being.

Quantifiable outcome

• 50% reduction in methane emissions when lysozyme incorporated into cattle feed at 200g/tonne
• +3 more outcomes

Named customers5 records

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

Five partnerships are on record, tiered core and minor.

• European Union (EFRO Program)coreStrategic or Co-development PartnerBioseutica leads a project to develop novel lysozyme product (bioactive protein) for the feed industry through extraction from residual feed streams within a circular economy approach. Initiative receives financial support from European Union through EFRO program Opportunities for West III, focusing on transition to fully circular and climate-neutral economy with milestone at end of program period in 2030.
• European Food Safety Authority (EFSA)coreOthersEFSA issued scientific opinion confirming Bioseutica's lysozyme from hen's eggs does not give rise to safety concerns for food applications including brewing, cheese production, and wine production.
• Pasteur Texcell InstitutecoreTechnology or IntegrationBioseutica is the only producer of lysozyme with patented methods certified to contain no risk for Avian Flu virus by Pasteur Texcell Institute.
• Development and Commercial Partners (AMCIPATRICIN)minorStrategic or Co-development PartnerBioseutica is actively seeking development and commercial partners for AMCIPATRICIN inhalation product to treat severe fungal infections in cystic fibrosis or immunocompromised patients.
• DCAT (Drug, Chemical & Associated Technologies Association)minorOthersBioseutica is a DCAT member, a global business development association for pharmaceutical development and manufacturing companies providing programs, events, and networking opportunities.

Scale indicators5 records

Recent moves6 records

Expansion highlights5 records

Broad incumbents

• DSM-Firmenich: Global ingredients major with food, feed, nutrition and pharma enzyme portfolios including lysozyme and bioprocessing technology. Comparable as a multi-vertical ingredient supplier with overlapping B2B go-to-market and stronger capital base.
• Novonesis (formerly Novozymes + Chr. Hansen): World's largest enzyme producer, with Chr. Hansen heritage in dairy cultures and food cultures (including anti-late-blowing solutions for cheese). Directly comparable to Bioseutica's enzyme + food-ingredient + dairy culture positioning, especially in cheese making.
• Kerry Group: Global taste and nutrition company supplying clean-label food ingredients and functional proteins to food and beverage manufacturers. Comparable to Bioseutica's specialty-ingredient positioning in cheese, wine and beer applications.
• Ingredion: Global ingredient solutions provider for food, beverage and animal nutrition with a clean-label, specialty ingredients focus. Comparable to Bioseutica's sales-led, multi-vertical ingredients distribution model.
• Alltech: Animal nutrition and health company offering feed additives that improve livestock performance, gut health and reduce antibiotic reliance. Closely comparable to Bioseutica's Entegard and Inovapure animal health and feed additive portfolio.
• Phibro Animal Health: Animal health and nutrition company including nutritional specialty products and antimicrobial alternatives. Comparable to Bioseutica's AMR-reduction and immune-support positioning in the livestock feed segment.
• Balchem: Specialty ingredient manufacturer across human nutrition & health and animal nutrition, with choline and functional-ingredient ranges. Comparable to Bioseutica's specialty/nootropic (NA2R) and animal-health positioning.

Direct peers

• AB Enzymes: Specialty enzyme manufacturer serving food, beverage and feed industries with comparable enzyme applications (baking, brewing, dairy, animal nutrition). Closest direct competitor in industrial enzyme ingredient supply for food and feed.
• Amano Enzyme: Japanese specialty enzyme manufacturer producing food-grade, pharmaceutical-grade, and diagnostic enzymes. Comparable to Bioseutica's API-grade and reagent-grade enzyme capabilities across lysozyme, protease and specialty enzyme lines.
• Lallemand: Global developer of yeast, bacteria and specialty cultures for food, beverage, animal nutrition and health applications. Comparable to Bioseutica's natural antimicrobial/late-blowing solutions for cheese and wine, and feed probiotic/yeast positioning.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/bioseutica
• LinkedInlinkedin.com/company/bioseutica

Compliance20 records

Revenue estimate

Valuation estimate

Number of profiles

Subsidiaries3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Bioseutica