What P1vital does

P1vital is a UK-based clinical technology company specializing in electronic Clinical Outcome Assessment (eCOA) platforms and neuroscience-based digital biomarkers for CNS clinical trials. The company combines validated cognitive and behavioral assessment instruments with electronic data capture to provide objective endpoint measures for pharmaceutical and biotechnology clients. Founded circa 2008 and headquartered in Wallingford, Oxfordshire, P1vital operates through two private limited entities (P1vital Limited and P1vital Products Limited) and serves pharmaceutical companies, CROs, and research institutions globally.

P1vital's product portfolio centers on the eCOA platform, which supports Patient Reported Outcomes (PRO), Clinician Reported Outcomes (ClinRO), Observer Reported Outcomes (ObsRO), and Performance Outcomes (PerfO) with device provisioning, real-time reporting, automated scheduling, and BYOD access. The flagship CNS science offering is the Facial Expression Recognition Task (FERT), a validated objective measure of emotional bias implemented in more than 45 clinical trials worldwide across depression, treatment-resistant depression, anxiety, bipolar disorder, schizophrenia, cognitive decline, dementia, and autistic spectrum disorders. The company also maintains a pre-validated Performance Rated Outcomes Library covering emotional processing, reward processing, memory, response impulsivity, verbal memory, and social cognition, plus neuroimaging solutions including fMRI paradigms. Operational compliance is supported by ISO 27001 and ISO 9001 certifications (UKAS URS accredited), Cyber Essentials, GDPR (with appointed DataRep as Article 27 representative), and 21 CFR Part 11 alignment.

P1vital generates revenue through two streams: subscription/recurring eCOA platform licensing and configuration services, plus professional services for CNS science consultancy including study design, task validation, implementation, analysis, interpretation, and reporting. Go-to-market is direct enterprise sales to pharma and CROs through the company website, scientific conferences, KOL referrals, and pre-competitive consortium participation. Pricing is quote-based and not publicly disclosed. Notable non-dilutive funding includes the €16M H2020 Innovative Medicines Initiative PRISMS award in 2016 (extended to €23M total with a €7M PRISMS2 award in 2024) and multiple SBRI Healthcare awards supporting research infrastructure.

Name

P1vital

Legal name

P1vital Limited and P1vital Products Limited

Website

https://p1vital.com

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

11–50 employees

Short description

P1vital is a UK-based clinical technology company providing electronic Clinical Outcome Assessment platforms and neuroscience-based digital biomarkers—including the Facial Expression Recognition Task (FERT)—for pharmaceutical companies and CROs conducting CNS clinical trials globally.

Ownership category

akta.pro rank

Product category

Electronic Clinical Outcome Assessment (eCOA) / CNS Digital Biomarkers

NAICS

Scientific Research and Development Services (5417), Other Scientific and Technical Consulting Services (54169)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

eCOA/ePRO/eDiary & Patient-Facing Data Collection (HLACAOAB)

akta.pro secondary industry

Data Management, Biostatistics & Statistical Programming FSP (HLAGAOAB)

Keywords

• Electronic clinical outcomes
• CNS clinical trials
• Digital biomarkers
• Behavioural cognitive assessment
• Neuroscience research services

Headquarters

HQ city

Wallingford

HQ country

United Kingdom

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Others

Revenue model

1. eCOA Technology Services: P1vital provides electronic Clinical Outcome Assessment platforms and services to pharmaceutical companies and CROs conducting clinical trials. Revenue is generated through platform licensing, configuration services, device provisioning, and ongoing support throughout clinical studies.
2. CNS Science and Consultancy Services: Full-service scientific solutions including consultancy, task build and validation, clinical study design, implementation, analysis, interpretation, and reporting. Work with key opinion leader network to enrich trial design.

Distribution channels1 record

Marketing channels4 records

Core offering

P1vital provides an electronic Clinical Outcome Assessment (eCOA) platform and neuroscience-based digital biomarker services for pharmaceutical, biotechnology and CRO clients conducting clinical trials. Its core offerings include the P1vital eCOA platform (supporting PRO, ClinRO, ObsRO and PerfO), CNS Science consultancy and validation services, the proprietary Facial Expression Recognition Task (FERT), a pre-validated cognitive and behavioural task library, and fMRI neuroimaging solutions. Together these enable objective, validated endpoint capture in CNS clinical trials spanning depression, anxiety, schizophrenia, dementia and related indications.

Product overview

P1vital offers a unified portfolio centred on P1vital eCOA, a configurable electronic Clinical Outcome Assessment platform, complemented by CNS Science Services providing neuroscience-based digital biomarkers and validated cognitive/behavioural tasks. The core offering includes the flagship Facial Expression Recognition Task (FERT), a Performance Rated Outcomes Library with multiple validated instruments across emotional processing, reward processing, memory, and social cognition domains, plus neuroimaging solutions. Supporting services include eLearning, helpdesk support, translations, licensing, and device provisioning. Together, these products enable pharmaceutical and biotech companies to capture high-quality endpoint data in clinical trials.

Differentiator

Problem solved

Functional benefit

Brands

• P1vital eCOA: Electronic Clinical Outcome Assessment platform capturing patient-reported, clinician-reported, observer-reported, and performance outcomes for clinical trials
• P1vital CNS Science
• P1vital FERT
• P1vital Performance Rated Outcomes

Products and services

• P1vital eCOA Full-suite electronic Clinical Outcome Assessment (eCOA) platform capturing Patient-Reported Outcomes (PRO), Clinician-Reported Outcomes (ClinRO), Observer-Reported Outcomes (ObsRO) and Performance Outcomes (PerfO). Configurable design with device provisioning, pre-validated questionnaire and task library, real-time reporting, automated scheduling and reminders, safety monitoring alerts and helpdesk support. Targeted at pharmaceutical, biotech and CRO sponsors of clinical trials.
• P1vital CNS Science Services Neuroscience-based scientific services covering consultancy, cognitive and behavioural task design and validation, clinical study design, implementation, analysis, interpretation and reporting. Provides scientifically validated digital biomarkers and expert scientific support for CNS clinical trials. Targeted at pharmaceutical, biotech and CRO sponsors requiring specialist CNS endpoint expertise.
• Facial Expression Recognition Task (FERT) Industry-recognised objective measure of emotional bias in patient populations, validated for depression, treatment-resistant depression, anxiety, bipolar disorder, schizophrenia, cognitive decline, dementia and autistic spectrum disorders. Sensitive to antidepressant and anxiolytic effects of CNS compounds across diverse mechanisms of action, with demonstrated test-retest reliability. Implemented in 45+ clinical trials worldwide.
• Neuroimaging Solutions Functional imaging paradigms and clinical-research expertise covering data acquisition to analysis, including fMRI solutions. Designed for sponsors requiring imaging-based CNS endpoints in clinical trials.

Quantifiable outcome

• Implemented in 45+ clinical trials worldwide
• +3 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability5 records

Feature4 records

Partnerships

Three partnerships are on record, tiered core and minor.

• European College of Neuropsychopharmacology (ECNP)coreStrategic or Co-development Partner · 1 January 2016Gerry Dawson has been a member of the executive committee of ECNP since 2017 and chairs its Experimental Medicine Network. This partnership provides access to key opinion leaders and enables participation in pre-competitive consortium opportunities.
• PRISMS Consortium (H2020 Innovative Medicines Initiative)coreStrategic or Co-development Partner · 1 January 2016In 2016, the ECNP Experimental Medicine Network (led by P1vital's co-founder) successfully bid for a €16M H2020 IMI award for PRISMS1 to develop new approaches to treatment of Schizophrenia, Alzheimer's disease and Major Depressive Disorder. Extended to 2024 with €7M additional funding for PRISMS2. This public-private partnership advances CNS drug development science.
• DataRepminorImplementation/ SI/ Consulting PartnerDataRep serves as P1vital's Data Protection Representative (DPR) under GDPR Article 27 for individuals in the EU and EEA, handling data protection inquiries and rights requests from EU-based individuals.

Scale indicators3 records

Recent moves5 records

Expansion highlights5 records

Broad incumbents

• Signant Health: Clinical trial technology provider offering eCOA, eConsent, patient engagement, and rater training solutions, including CNS-focused offerings (e.g., via Bracket acquisition). Competes with P1vital in CNS eCOA and scientific consultancy while also serving broader therapeutic areas.
• Clario: Global clinical trial technology company formed from the merger of ERT and Bioclinica, offering eCOA, imaging, cardiac safety, and respiratory solutions at scale. Provides broader eCOA infrastructure across all therapeutic areas while expanding CNS-specific modules, directly competing with P1vital's eCOA platform.
• Medidata (Dassault Systèmes): Major clinical trial technology platform offering Rave eCOA and a comprehensive suite of trial solutions used by most large pharma sponsors. Competes broadly with P1vital's eCOA offering and has been expanding digital endpoint capabilities that overlap with CNS trial workflows.
• WCG (Medavante-Prophase): WCG's Medavante-Prophase unit provides CNS-rated clinical assessments, electronic clinical outcome assessments, and rater training services for CNS trials. Direct overlap with P1vital's CNS Science Services and eCOA business in CNS-focused sponsors.

Emerging players

• Curebase: Decentralized clinical trial platform provider with growing CNS trial capabilities and digital data capture. More focused on DCT execution than CNS specialty science, but overlapping on the eCOA infrastructure layer and competing for CNS trial sponsors.

Direct peers

• YPrime: Clinical trial technology company offering eCOA, IRT, and patient engagement solutions with configurability comparable to P1vital's eCOA platform. Targets the same pharma/CRO enterprise buyers and increasingly adds CNS-relevant digital biomarker capabilities.
• Cogstate: Specialist in computerized cognitive testing for clinical trials and healthcare, with a validated cognitive test battery (Cogstate Brief Battery) used widely in CNS and neurodegeneration trials. Direct overlap with P1vital on validated digital cognitive/behavioural endpoints for CNS drug development.
• Cambridge Cognition: UK-based provider of cognitive assessment technology and digital endpoints for CNS clinical trials, with CANTAB battery of validated cognitive tests directly comparable to P1vital's Performance Rated Outcomes library. Both target pharma/CRO sponsors running CNS studies and compete on validated, regulatory-grade cognitive endpoints.

Market position

Strengths1 record

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/p1vital

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Funding overview

Funding rounds3 records

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about P1vital