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Masonic Medical Research Institute

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uuid000fkzw

Namestring
Masonic Medical Research Institute
Legal namestring
Masonic Medical Research Institute
Websiteurl
mmri.edu
Company typeenum
Private
Founded yearint
1958
Descriptiontext

Masonic Medical Research Institute (MMRI) is an independent 501(c)(3) medical research institute headquartered in Utica, New York, founded in 1958 by the New York State Grand Lodge of Free and Accepted Masons (incorporated 1947). It operates six principal investigator-led research laboratories (Kontaridis, Kessinger, Lin, McCarthy, Nystoriak, Wu) supported by six shared core facilities (Animal, FACS, Genetics, Histology, Imaging, iPSC), conducting basic and translational research across cardiovascular, neurocognitive, and autoimmune disease areas including congenital heart disease, heart failure, lupus, autism, Alzheimer's, Parkinson's, and PTSD. Core technical capabilities include molecular imaging probes, nanomedicine and targeted nanoparticles, AAV and modified mRNA gene delivery, iPSC-based disease modeling, and protein tyrosine phosphatase research (SHP2, PTP1B), with two issued/pending patents on gene therapy approaches to obesity and NASH.

MMRI's business model is event-driven nonprofit fundraising: primary inflows are competitive federal grants (NIH/NHLBI, DOD), disease-specific foundation grants (AHA, LADA), individual donations (including a $19.58/month "1958 Club" recurring program), corporate sponsorships (Adirondack Bank for the 1958 Gala), planned giving (Cornerstone Society), and community events (galas, Lupus Walk, Golf Classic, telethon). Outputs are disseminated via peer-reviewed publications in journals such as Nature Communications, Circulation, JCI, and Science Signaling; technology licensing of patented methods; the MV Biotech Collective regional alliance (SUNY Poly + Mohawk Valley Health System); and educational programs including a Summer Fellowship that trained 13 students in 2026. The customer base is effectively the scientific community, federal grantors, and regional donors, with no commercial product revenue.

Short descriptiontext

Masonic Medical Research Institute is an independent 501(c)(3) medical research institute in Utica, NY, operating six labs and six core facilities to study cardiovascular, neurocognitive, and autoimmune diseases. It funds operations via NIH/DOD/Foundation grants, donations, and fundraising events.

Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
51–100
akta.pro rankint
HeadquartersUtica, United States
HQ citystring
Utica
HQ countrystring
United States
HQ regionstring
North America
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
biomedical research services, cardiovascular disease research, autoimmune disease research, molecular imaging research, translational medicine research
Industry3 codes
1Disease-Specific Research & Support (e.g., Cancer, Diabetes, ALS)
CodeBPAGACAAPrimaryYes
2Neurogenetics & Rare Neurologic Diseases
CodeHLAKAIAOPrimaryNo
3Neurology/CNS Gene Therapies
CodeHLAAACAHPrimaryNo
NAICS code3 codes
  • Research and Development in Biotechnology (except Nanobiotechnology)541714
  • Research and Development in the Physical, Engineering, and Life Sciences54171
  • Scientific Research and Development Services5417
SIC code1 code
  • Services-Commercial Physical & Biological Research8731
Product category
Medical Research
GTM motion1 record

Each record includes

Type, Description, Source

Revenue model6 records
1Government Research Grants
TypeOthers
Description

Primary funding from federal agencies including NIH, NHLBI, and DOD through competitive grant applications supporting specific research projects.

mmri.edu
2Foundation and Association Grants
TypeOthers
Description

Funding from disease-specific foundations such as Lupus and Allied Diseases Association (LADA), American Heart Association, and others supporting research in respective disease areas.

mmri.edu
3Individual Donations and Fundraising
TypeGrants Donations
Description

Direct charitable contributions from individuals through online donations, event participation, telethons, and annual giving campaigns.

mmri.edu
4Corporate Giving and Event Sponsorships
TypeOthers
Description

Corporate sponsorships for events such as galas and walks, as well as corporate donations aligned with CSR and marketing goals.

mmri.edu
5Planned Giving and Legacy Donations
TypeGrants Donations
Description

Bequests, charitable trusts, retirement plan designations, and charitable gift annuities from donors structuring long-term legacy gifts.

mmri.edu
6Recurring Giving Programs
TypeSubscription Recurring
Description

Monthly recurring donation program (1958 Club) providing reliable ongoing funding at $19.58/month with exclusive donor club benefits.

mmri.edu
Marketing channels6 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels5 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure
GTM typeB2B
B2B
Offering typeServices
Services
Core offering1 text field

Masonic Medical Research Institute conducts collaborative basic and translational biomedical research in cardiovascular, neurocognitive, and autoimmune diseases through six specialized research laboratories supported by six core research facilities (Animal, FACS, Genetics, Histology, Imaging, iPSC). The institute develops proprietary molecular imaging probes, nanomedicine platforms, and gene therapy delivery systems, produces peer-reviewed publications, holds patents on gene therapy reagents, and licenses novel technologies to industry partners. It supplements its research mission with the Summer Fellowship educational program, annual fundraising galas, walks, and a telethon, and donation/planned giving services.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 3 values shown
  • NIH grants totaling $3.7 million+ awarded to individual labs
+2 more records
Product overview1 text field

Masonic Medical Research Institute (MMRI) is an independent medical research institute that operates as a single unified research organization, not a platform-plus-modules architecture. The institute's core offerings consist of six research laboratories conducting collaborative research in complex diseases and genetic disorders, supported by six core research facilities (Animal, FACS, Genetics, Histology, Imaging, and iPSC cores). Additional offerings include the Summer Fellowship educational program, annual fundraising events (Telethon, Galas, Lupus Walk), and philanthropic donation services. The research focuses on three main areas: cardiovascular diseases, neurocognitive disorders (autism, Alzheimer's, Parkinson's, PTSD), and autoimmune diseases (lupus, Type 1 diabetes, rheumatoid arthritis).

Product and service3 records
1MMRI Research Laboratories
CategoryResearch Laboratories
2MMRI Core Facilities
CategoryCore Research Facilities
3Summer Fellowship Program
Scale indicator13 records

Each record includes

Type, Value, Description, Source

Partnership3 partners
Strategic tierCoreTypeStrategic or Co-development PartnerAnnounced on2024-11-19
Description

Three regional institutions — MMRI, SUNY Polytechnic Institute, and Mohawk Valley Health System — signed a memorandum of agreement on November 19 to formally establish the MV Biotech Collective, a strategic alliance positioning the Mohawk Valley as a leader in biomedical innovation. The collective combines MMRI's scientific research, MVHS's clinical excellence, and SUNY Poly's academic innovation to pursue joint grant applications, AI-driven discovery acceleration, and creation of a biomedical hub. The group plans to form committees and develop a three, five, and 10-year strategic plan to drive entrepreneurship and regional economic growth.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

MMRI, in collaboration with Northwestern University, was awarded a grant from the National Institutes of Health (NIH) to develop innovative imaging strategies for improving detection and management of antibody-mediated rejection (AMR) following lung transplantation.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

MMRI and LADA have partnered on lupus research initiatives including annual Lupus Walks in Utica and a $200,000 grant awarded to MMRI for lupus research. LADA President and CEO Kathleen Arntsen announced the award on August 14, 2024. The partnership has produced three annual Lupus Walk events (2023, 2024, 2025) with over 250 participants.

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight5 records

Each record includes

Type, Description

Peers10 records
TypeDirect peer
Description

Independent nonprofit biomedical research institute in La Jolla, CA. Like MMRI, it operates multiple labs and core facilities, focuses on disease-specific research, and depends on NIH grants and philanthropic donations.

TypeDirect peer
Description

Independent nonprofit biomedical research institute focused on autoimmune disease, cardiovascular disease, and aging. Closely comparable to MMRI's cardiovascular-autoimmune-neurocognitive tri-disease portfolio and similar institute scale.

TypeDirect peer
Description

Independent nonprofit biomedical research institute in Philadelphia focused on cancer, immunology, and infectious disease. Comparable to MMRI as an independent research institute with multiple specialized labs and core facilities.

TypeDirect peer
Description

Independent nonprofit life science research organization focused on cardiovascular, neurological, and immunological diseases. Directly comparable to MMRI's tri-disease focus on cardiovascular, neurocognitive, and autoimmune disorders.

TypeDirect peer
Description

Independent nonprofit biomedical research institute focused on genetics and genomics. Comparable to MMRI's role as a genetic center for inherited sudden death syndromes and its Genetics Core facility.

TypeDirect peer
Description

Independent biomedical research institute in Grand Rapids, MI focused on cancer, Parkinson's, and metabolic disease. Similar in scale and structure to MMRI as a smaller, independently funded nonprofit research institute.

TypeDirect peer
Description

Independent research and educational institution in New York focused on cancer, neuroscience, and genetics. Comparable to MMRI as a nonprofit research institute with strong peer-reviewed publication output.

TypeDirect peer
Description

Independent nonprofit biological research institute in La Jolla, CA. Like MMRI, it operates as an independent research institute with disease-focused labs spanning cancer, neuroscience, and metabolic disease.

TypeDirect peer
Description

Independent nonprofit medical research organization focused on brain science, cell science, and immunology. Comparable to MMRI's multi-disease research model and collaborative lab-based structure.

TypeDirect peer
Description

Independent nonprofit biomedical research institute focused on gene regulation and regeneration. Comparable to MMRI as a privately funded research institute operating disease-focused labs.

Market position
Strengths4 records

Each record includes

Headline, Details, Source

Weaknesses4 records

Each record includes

Headline, Details, Source

Competitive moat5 records

Each record includes

Type, Details

Key risks5 records

Each record includes

Headline, Details, Source

Key highlights6 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers3 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment1 record

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile3 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
Yes
API detail
Has APIbool
No

Docs URL, Description

AI maturity
App detail

Has app

Feature7 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles6 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
No data
Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds1 record

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors1 record

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Masonic Medical Research Institute

Medical Researchmmri.edu

Masonic Medical Research Institute is an independent 501(c)(3) medical research institute in Utica, NY, operating six labs and six core facilities to study cardiovascular, neurocognitive, and autoimmune diseases. It funds operations via NIH/DOD/Foundation grants, donations, and fundraising events.

What Masonic Medical Research Institute does

Masonic Medical Research Institute (MMRI) is an independent 501(c)(3) medical research institute headquartered in Utica, New York, founded in 1958 by the New York State Grand Lodge of Free and Accepted Masons (incorporated 1947). It operates six principal investigator-led research laboratories (Kontaridis, Kessinger, Lin, McCarthy, Nystoriak, Wu) supported by six shared core facilities (Animal, FACS, Genetics, Histology, Imaging, iPSC), conducting basic and translational research across cardiovascular, neurocognitive, and autoimmune disease areas including congenital heart disease, heart failure, lupus, autism, Alzheimer's, Parkinson's, and PTSD. Core technical capabilities include molecular imaging probes, nanomedicine and targeted nanoparticles, AAV and modified mRNA gene delivery, iPSC-based disease modeling, and protein tyrosine phosphatase research (SHP2, PTP1B), with two issued/pending patents on gene therapy approaches to obesity and NASH.

MMRI's business model is event-driven nonprofit fundraising: primary inflows are competitive federal grants (NIH/NHLBI, DOD), disease-specific foundation grants (AHA, LADA), individual donations (including a $19.58/month "1958 Club" recurring program), corporate sponsorships (Adirondack Bank for the 1958 Gala), planned giving (Cornerstone Society), and community events (galas, Lupus Walk, Golf Classic, telethon). Outputs are disseminated via peer-reviewed publications in journals such as Nature Communications, Circulation, JCI, and Science Signaling; technology licensing of patented methods; the MV Biotech Collective regional alliance (SUNY Poly + Mohawk Valley Health System); and educational programs including a Summer Fellowship that trained 13 students in 2026. The customer base is effectively the scientific community, federal grantors, and regional donors, with no commercial product revenue.

Masonic Medical Research Institute firmographics

Firmographics
Name
Masonic Medical Research Institute
Legal name
Masonic Medical Research Institute
Website
https://mmri.edu
Company type
Private
Founded year
1958
Operating status
Operating
Headcount range
51–100 employees
Short description
Masonic Medical Research Institute is an independent 501(c)(3) medical research institute in Utica, NY, operating six labs and six core facilities to study cardiovascular, neurocognitive, and autoimmune diseases. It funds operations via NIH/DOD/Foundation grants, donations, and fundraising events.
Ownership category
akta.pro rank

Masonic Medical Research Institute industry classification

Industry
Product category
Medical Research
NAICS
Research and Development in Biotechnology (except Nanobiotechnology) (541714), Research and Development in the Physical, Engineering, and Life Sciences (54171), Scientific Research and Development Services (5417)
SIC
Services-Commercial Physical & Biological Research (8731)
akta.pro primary industry
Disease-Specific Research & Support (e.g., Cancer, Diabetes, ALS) (BPAGACAA)
akta.pro secondary industries
Neurogenetics & Rare Neurologic Diseases (HLAKAIAO), Neurology/CNS Gene Therapies (HLAAACAH)

Keywords

  • Biomedical research services
  • Cardiovascular disease research
  • Autoimmune disease research
  • Molecular imaging research
  • Translational medicine research

Where Masonic Medical Research Institute is headquartered

Location

Headquarters

HQ city
Utica
HQ country
United States
HQ region
North America

Offices1 record

Markets served

Masonic Medical Research Institute business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

  1. Government Research Grants: Primary funding from federal agencies including NIH, NHLBI, and DOD through competitive grant applications supporting specific research projects.
  2. Foundation and Association Grants: Funding from disease-specific foundations such as Lupus and Allied Diseases Association (LADA), American Heart Association, and others supporting research in respective disease areas.
  3. Individual Donations and Fundraising: Direct charitable contributions from individuals through online donations, event participation, telethons, and annual giving campaigns.
  4. Corporate Giving and Event Sponsorships: Corporate sponsorships for events such as galas and walks, as well as corporate donations aligned with CSR and marketing goals.
  5. Planned Giving and Legacy Donations: Bequests, charitable trusts, retirement plan designations, and charitable gift annuities from donors structuring long-term legacy gifts.
  6. Recurring Giving Programs: Monthly recurring donation program (1958 Club) providing reliable ongoing funding at $19.58/month with exclusive donor club benefits.

Go-to-market motion1 record

Distribution channels5 records

Marketing channels6 records

Masonic Medical Research Institute product offering

Product offering

Core offering

Masonic Medical Research Institute conducts collaborative basic and translational biomedical research in cardiovascular, neurocognitive, and autoimmune diseases through six specialized research laboratories supported by six core research facilities (Animal, FACS, Genetics, Histology, Imaging, iPSC). The institute develops proprietary molecular imaging probes, nanomedicine platforms, and gene therapy delivery systems, produces peer-reviewed publications, holds patents on gene therapy reagents, and licenses novel technologies to industry partners. It supplements its research mission with the Summer Fellowship educational program, annual fundraising galas, walks, and a telethon, and donation/planned giving services.

Product overview

Masonic Medical Research Institute (MMRI) is an independent medical research institute that operates as a single unified research organization, not a platform-plus-modules architecture. The institute's core offerings consist of six research laboratories conducting collaborative research in complex diseases and genetic disorders, supported by six core research facilities (Animal, FACS, Genetics, Histology, Imaging, and iPSC cores). Additional offerings include the Summer Fellowship educational program, annual fundraising events (Telethon, Galas, Lupus Walk), and philanthropic donation services. The research focuses on three main areas: cardiovascular diseases, neurocognitive disorders (autism, Alzheimer's, Parkinson's, PTSD), and autoimmune diseases (lupus, Type 1 diabetes, rheumatoid arthritis).

Differentiator

Problem solved

Functional benefit

Products and services

  • MMRI Research Laboratories
  • MMRI Core Facilities
  • Summer Fellowship Program

Quantifiable outcome

  • NIH grants totaling $3.7 million+ awarded to individual labs
  • +2 more outcomes

Companies that use Masonic Medical Research Institute

Customer profile

Named customers3 records

Segments1 record

Ideal customer profiles3 records

Masonic Medical Research Institute technology and API

Technology

Technology focussed Yes

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

Feature7 records

Masonic Medical Research Institute partnerships and signals

Strategic signal

Partnerships

Three partnerships are on record, tiered core.

  • MV Biotech Collective (with SUNY Polytechnic Institute and Mohawk Valley Health System)coreStrategic or Co-development Partner · 19 November 2024Three regional institutions — MMRI, SUNY Polytechnic Institute, and Mohawk Valley Health System — signed a memorandum of agreement on November 19 to formally establish the MV Biotech Collective, a strategic alliance positioning the Mohawk Valley as a leader in biomedical innovation. The collective combines MMRI's scientific research, MVHS's clinical excellence, and SUNY Poly's academic innovation to pursue joint grant applications, AI-driven discovery acceleration, and creation of a biomedical hub. The group plans to form committees and develop a three, five, and 10-year strategic plan to drive entrepreneurship and regional economic growth.
  • Northwestern UniversitycoreStrategic or Co-development PartnerMMRI, in collaboration with Northwestern University, was awarded a grant from the National Institutes of Health (NIH) to develop innovative imaging strategies for improving detection and management of antibody-mediated rejection (AMR) following lung transplantation.
  • Lupus and Allied Diseases Association (LADA)coreStrategic or Co-development PartnerMMRI and LADA have partnered on lupus research initiatives including annual Lupus Walks in Utica and a $200,000 grant awarded to MMRI for lupus research. LADA President and CEO Kathleen Arntsen announced the award on August 14, 2024. The partnership has produced three annual Lupus Walk events (2023, 2024, 2025) with over 250 participants.

Scale indicators13 records

Recent moves6 records

Expansion highlights5 records

Masonic Medical Research Institute competitors and assessment

Company assessment

Direct peers

  • Sanford Burnham Prebys: Independent nonprofit biomedical research institute in La Jolla, CA. Like MMRI, it operates multiple labs and core facilities, focuses on disease-specific research, and depends on NIH grants and philanthropic donations.
  • Oklahoma Medical Research Foundation: Independent nonprofit biomedical research institute focused on autoimmune disease, cardiovascular disease, and aging. Closely comparable to MMRI's cardiovascular-autoimmune-neurocognitive tri-disease portfolio and similar institute scale.
  • Wistar Institute: Independent nonprofit biomedical research institute in Philadelphia focused on cancer, immunology, and infectious disease. Comparable to MMRI as an independent research institute with multiple specialized labs and core facilities.
  • Gladstone Institutes: Independent nonprofit life science research organization focused on cardiovascular, neurological, and immunological diseases. Directly comparable to MMRI's tri-disease focus on cardiovascular, neurocognitive, and autoimmune disorders.
  • Jackson Laboratory: Independent nonprofit biomedical research institute focused on genetics and genomics. Comparable to MMRI's role as a genetic center for inherited sudden death syndromes and its Genetics Core facility.
  • Van Andel Institute: Independent biomedical research institute in Grand Rapids, MI focused on cancer, Parkinson's, and metabolic disease. Similar in scale and structure to MMRI as a smaller, independently funded nonprofit research institute.
  • Cold Spring Harbor Laboratory: Independent research and educational institution in New York focused on cancer, neuroscience, and genetics. Comparable to MMRI as a nonprofit research institute with strong peer-reviewed publication output.
  • Salk Institute for Biological Studies: Independent nonprofit biological research institute in La Jolla, CA. Like MMRI, it operates as an independent research institute with disease-focused labs spanning cancer, neuroscience, and metabolic disease.
  • Allen Institute: Independent nonprofit medical research organization focused on brain science, cell science, and immunology. Comparable to MMRI's multi-disease research model and collaborative lab-based structure.
  • Stowers Institute for Medical Research: Independent nonprofit biomedical research institute focused on gene regulation and regeneration. Comparable to MMRI as a privately funded research institute operating disease-focused labs.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

Masonic Medical Research Institute social profiles

Digital presence

Masonic Medical Research Institute financial estimates

Financial estimate

Revenue estimate

Valuation estimate

Masonic Medical Research Institute leadership team

Management profile

Number of profiles

Profiles6 records

Masonic Medical Research Institute funding detail

Funding detail

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

Masonic Medical Research Institute M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Masonic Medical Research Institute

What does Masonic Medical Research Institute do?

Masonic Medical Research Institute conducts collaborative basic and translational biomedical research in cardiovascular, neurocognitive, and autoimmune diseases through six specialized research laboratories supported by six core research facilities (Animal, FACS, Genetics, Histology, Imaging, iPSC). The institute develops proprietary molecular imaging probes, nanomedicine platforms, and gene therapy delivery systems, produces peer-reviewed publications, holds patents on gene therapy reagents, and licenses novel technologies to industry partners. It supplements its research mission with the Summer Fellowship educational program, annual fundraising galas, walks, and a telethon, and donation/planned giving services.

Is Masonic Medical Research Institute a public or private company?

Masonic Medical Research Institute is a private company. It is classified as nonprofit foundation owned and is currently operating.

When was Masonic Medical Research Institute founded?

Masonic Medical Research Institute was founded in 1958. It employs 51 to 100 people.

Where is Masonic Medical Research Institute based?

Masonic Medical Research Institute is headquartered in Utica, United States, in the North America region.

How does Masonic Medical Research Institute make money?

Six revenue lines are on record. Government Research Grants are the primary driver. The others are foundation and Association Grants, individual Donations and Fundraising, corporate Giving and Event Sponsorships, planned Giving and Legacy Donations and recurring Giving Programs.

Who are Masonic Medical Research Institute's main competitors?

Direct peers on record are Sanford Burnham Prebys, Oklahoma Medical Research Foundation, Wistar Institute, Gladstone Institutes, Jackson Laboratory, Van Andel Institute, Cold Spring Harbor Laboratory, Salk Institute for Biological Studies, Allen Institute and Stowers Institute for Medical Research.

Does Masonic Medical Research Institute have an API?

No public API is recorded for Masonic Medical Research Institute.

What industry is Masonic Medical Research Institute in?

Masonic Medical Research Institute's product category is Medical Research. Its primary akta.pro industry code is BPAGACAA, Disease-Specific Research & Support (e.g., Cancer, Diabetes, ALS), with a secondary code of HLAKAIAO, Neurogenetics & Rare Neurologic Diseases. Its NAICS code is 541714 and its SIC code is 8731.

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Live signals
BREAKING CNY BUSINESS NEWSMV Biotech Collective unites MMRI, MVHS, SUNY Poly core strengths – Central New York Business JournalThree regional institutions in Utica, New York—the Masonic Medical Research Institute (MMRI), SUNY Polytechnic Institute, and Mohawk Valley Health System—signed a memorandum of agreement on November 19 to formally establish the MV Biotech Collective, a strategic alliance aimed at positioning the Mohawk Valley as a leader in biomedical innovation. The collective will combine MMRI's scientific research, MVHS's clinical excellence, and SUNY Poly's academic innovation to pursue joint grant applications, AI-driven discovery acceleration, and the creation of a biomedical hub in the region. The group plans to form committees and develop a three, five, and 10-year strategic plan to drive entrepreneurship and regional economic growth.HeartCoronavirus spike protein activated natural immune response, damaged heart muscle cellsResearchers from the Masonic Medical Research Institute presented preliminary findings indicating that the SARS-CoV-2 spike protein causes heart muscle damage by activating natural immune responses and inflammation, independent of ACE2 receptor interaction. The study utilized lab mice and human heart cells to demonstrate that this mechanism leads to cardiac dysfunction and hypertrophic remodeling. These results provide a potential explanation for the high virulence of SARS-CoV-2 compared to other coronaviruses regarding cardiac injury.PR NewswireStudy Identifies the Molecular Mechanisms by which Noonan Syndrome RAF1 mutations cause Cardiac HypertrophyInvestigators from the Masonic Medical Research Institute, Weill Cornell Medicine, and Beth Israel Deaconess Medical Center have identified the molecular mechanisms by which RAF1 mutations in Noonan Syndrome patients cause hypertrophic cardiomyopathy, a dangerous thickening of the heart muscle. The study, published in the American Heart Association journal Circulation, found that two parallel signaling pathways—ERK5 and MEK1/2—are involved in the development of RAF1-associated HCM, revealing potential therapeutic targets for treatment.