What Lino Biotech does

Lino Biotech AG is a Swiss biotechnology company founded in 2020 and headquartered in Adliswil, Switzerland, that develops and commercializes focal molography — a label-free optical biosensing technology that measures coherent mass density via diffraction. The technology applies a spatial affinity lock-in principle to separate specific binding signals from environmental noise (temperature drift, non-specific binding, and matrix effects), enabling kinetic measurements directly in serum, plasma, cell lysate, and living cells where conventional SPR and BLI struggle. The flagship MACS Matchmaker instrument supports up to 64 simultaneous interactions on a single chip via DNA-directed immobilization (DDI), achieves sub-nanomolar KD resolution (0.3-0.8 nM), and delivers drift below 0.05 pg/mm²/min.

The company's product portfolio spans the MACS Matchmaker instrument, the MACS Sampler 768-well plate automation accessory, sensor chips, DNA adaptors, and a suite of application-specific assay panels targeting antibody developability: Polyreactivity (8- and 16-plex anchored to the Jain 2017 clinical-stage mAb benchmark), FcRn Species Panel, Fc Receptor Panel (8 Fc receptors including FcγRI, FcγRIIa/b, FcγRIIIa/b, FcεRI, FcεRII, and FcRn), Plasma Protein Binding (biologics up to 8-plex and small molecule up to 16-plex), DEL Hit Validation (up to 54 compounds per chip on-DNA without resynthesis), and PROTAC ternary complex characterization (up to 20 linker variants simultaneously). Revenue is generated through three streams: instrument sales (hardware), recurring consumables (chips, panels, kits sold via shop.lino-biotech.com), and application/service support. Pricing is not publicly disclosed.

Lino Biotech is a wholly-owned subsidiary of Miltenyi Biotec and serves drug discovery teams at biopharma and biotechnology companies engaged in antibody engineering, DNA-encoded library screening, and targeted protein degradation, alongside academic and research institutions. The company operates with 1-10 employees and pursues a sales-led go-to-market combining direct field sales (HubSpot-booked discovery calls), an e-commerce storefront, and Miltenyi Biotec's global distribution infrastructure. Scientific credibility is reinforced by an active peer-reviewed publication record in Analytical Chemistry, ACS Sensors, Biosensors, Journal of Medicinal Chemistry, and RSC Chemical Biology, plus conference presence at SLAS, PEGS, DEL Symposium, Festival of Biologics, ELRIG, BIO-Europe, and Drug Discovery Chemistry Europe.

Name

Lino Biotech

Legal name

Lino Biotech AG

Website

https://lino-biotech.com

Company type

Private

Founded year

2020

Operating status

Operating

Headcount range

1–10 employees

Short description

Lino Biotech AG is a Swiss subsidiary of Miltenyi Biotec that develops the MACS Matchmaker focal molography platform — a label-free biosensor enabling biomolecular interaction analysis directly in serum, lysate, and living cells for biopharma, biotech, and academic drug discovery customers.

Ownership category

akta.pro rank

Product category

Label-free Biosensor Instruments

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Biosensors & Lab-on-Chip (BioMEMS) (HDAHALAK)

akta.pro secondary industries

Molecular Biology & Genomics Instruments (PCR/qPCR, Sequencing, Microarrays) (HLAGAIAF), Multiplex & High-Throughput Diagnostics Platforms (microarrays, digital PCR, lab automation-enabled assays) (HLAAALAL)

Keywords

• Label-free biosensing
• Biomolecular interaction analysis
• Focal molography
• Antibody developability
• Drug discovery kinetics

Headquarters

HQ city

Zürich

HQ country

Switzerland

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Personnel, Supply Chain, Marketing or Sales, Operations

Revenue model

1. MACS Matchmaker Instrument Sales: Sale of the MACS Matchmaker label-free biosensor instrument to biopharma companies, biotechs, and academic labs performing biomolecular interaction analysis.
2. Consumables (Sensor Chips, Kits, DNA Adaptors): Recurring revenue from proprietary sensor chips, pre-conjugated ligand panels (Fc Receptor, Polyreactivity, Plasma Protein Binding), DNA adaptors, and ready-to-use kits. Consumables are sold via the online shop (shop.lino-biotech.com) and are designed for single-use on the MACS Matchmaker platform.
3. Service and Support: Application science support and service offerings for customers using the MACS Matchmaker platform, including training, demonstration, and technical support services.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

Lino Biotech develops and commercializes the MACS Matchmaker, a label-free biosensor instrument platform based on its proprietary focal molography technology. The platform measures biomolecular interaction kinetics directly in complex biological matrices such as serum, plasma, cell lysate, and living cells, supporting up to 64 simultaneous interactions per chip via DNA-directed immobilization. The company also sells proprietary sensor chips, DNA adaptors, application-specific assay panels (FcRn, Fc receptor, polyreactivity, plasma protein binding, DEL hit validation, PROTAC), capture reagents, and supporting services.

Product overview

Lino Biotech offers the MACS® Matchmaker, a label-free biosensor platform built on focal molography technology. The platform comprises the main MACS Matchmaker instrument with integrated fluorescence imaging and automated sample handling, complemented by a portfolio of application-specific panels (Polyreactivity Panel, FcRn Species Panel, Fc Receptor Panel, Plasma Protein Binding Panel, DEL Hit Validation, PROTAC/TPD Panel), capture systems (Anti-Fc, Anti-His-tag, Anti-biotin), and sensor chip consumables with DNA-directed immobilization. The platform enables up to 64 simultaneous biomolecular interactions per chip, with measurements possible directly in complex biological matrices including serum, plasma, cell lysate, and living cells. Optional MACS Sampler automation enables high-throughput screening workflows.

Differentiator

Problem solved

Functional benefit

Brands

• MACS Matchmaker: Label-free biosensor platform based on focal molography technology for biomolecular interaction analysis in complex biological matrices.

Products and services

• MACS Matchmaker Label-free biosensor instrument platform based on focal molography for biomolecular interaction analysis. Enables kinetics measurements in complex biological fluids (serum, cell lysates, living cells) with up to 64 simultaneous interactions per chip in single-cycle kinetics (SCK) and multi-cycle kinetics (MCK) modes. Sold to biopharma, biotech, and academic research customers.
• Sensor Chips Pre-conjugated sensor chips for the MACS Matchmaker platform featuring DNA-directed immobilization (DDI) for ligand attachment. Support 8-plex and 16-plex panel configurations with defined ligand sets. Consumable sold to MACS Matchmaker users.
• DNA Adaptors Oligonucleotide-based adaptor reagents for DNA-directed immobilization of ligands on sensor chips. Enable reversible, non-covalent capture of biomolecules. Consumable sold to MACS Matchmaker users.
• Kits Ready-to-use assay kits for specific applications on the MACS Matchmaker platform, including pre-conjugated panels and necessary reagents. Sold to biopharma and biotech customers.
• Polyreactivity Panel Developability screening panel that quantifies non-specific binding across 8 (Essentials) or 16 (Plus) liability axes including dsDNA, HSA, insulin, lysozyme, cardiolipin, heparin, and polyclonal human IgG. Returns a Polyreactivity Index anchored to the Jain et al. 2017 clinical-stage mAb benchmark in approximately 30 minutes. Used by antibody engineering teams in biopharma and biotech drug discovery.
• FcRn Species Panel Cross-species half-life prediction panel for antibody FcRn binding characterization across multiple species. Enables approximately one-hour kinetics measurement for antibody half-life assessment. Sold to antibody engineering and pharmacokinetics teams in biopharma.
• Fc Receptor Panel Effector function profiling panel covering activating, inhibitory, and polymorphic Fc receptors including FcγRI, FcγRIIa, FcγRIIb, FcγRIIIa, FcγRIIIb, FcεRI, FcεRII, and FcRn. Approximately one-hour kinetics for full effector function profile. Used by antibody engineering teams in biopharma and biotech.
• Plasma Protein Binding Panel Plasma binding screening panel available in biologics (up to 8-plex) and small molecule (up to 16-plex) configurations. Profiles candidate binding to plasma carrier proteins including HSA, α1-acid glycoprotein, and lipoproteins directly in undiluted human plasma in approximately one hour. Used by drug discovery and DMPK teams.
• DEL Hit Validation DNA-encoded library hit validation solution enabling on-DNA kinetic characterization of DEL hits directly from screen output without resynthesis. Supports up to 54 compounds per chip in a single injection. Used by DEL screening teams in biopharma and biotech.
• PROTAC Design / Targeted Protein Degradation Ternary complex characterization panel for PROTACs and molecular glues. Enables cooperativity measurement directly from binding data in cell lysate, with multiplexed screening of 20 linker variants simultaneously. Used by targeted protein degradation teams in biopharma.
• Anti-Fc Capture System Oligonucleotide-conjugated recombinant fusion proteins (Protein A/G and Protein A/G/L) for fast, reversible antibody capture via Fc or light-chain regions. Supports various IgG subclasses and species without chemical labeling. Sold as capture reagent for MACS Matchmaker users.
• Anti-His-tag Capture System Oligo Adapter trisNTA capture system for fast, reversible immobilization of His-tagged proteins. Based on oligonucleotide-conjugated trisNTA chelator head for sensor chip attachment. Sold as capture reagent for MACS Matchmaker users.
• Anti-biotin Capture System NeutrAvidin-based capture system for immobilization and kinetic characterization of biotinylated molecules. Provides robust, low-background platform for affinity studies. Sold as capture reagent for MACS Matchmaker users.
• MACS Sampler 768-well plate automation accessory for high-throughput sample handling on the MACS Matchmaker. Enables processing of approximately 50-100 candidates per day for routine triage or full overnight developability screening runs. Sold to high-throughput screening labs.
• Application Science Services and Support Application science support services for customers using the MACS Matchmaker platform, including training, demonstration, and technical support services from application scientists. Sold to biopharma and biotech customers alongside instrument and consumable purchases.

Quantifiable outcome

• Up to 500 kinetic measurements per day
• +6 more outcomes

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature10 records

Partnerships

One partnership is on record.

• Miltenyi BioteccoreOEM/ Whitelabel/ Licensing PartnerLino Biotech AG is a Miltenyi Biotec company. The MACS Matchmaker is branded and sold as a Miltenyi Biotec product, with the Lino Biotech website hosted at lino-biotech.com but linked from miltenyibiotec.com. The Miltenyi Biotec logo and brand assets (search, cart, account icons) are used on the Lino Biotech website. Miltenyi Biotec's global distribution network supports sales of the MACS Matchmaker platform. The company's LinkedIn page is linkedin.com/company/lino-biotech-ag.

Scale indicators6 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Cytiva (Biacore): Cytiva's Biacore line is the dominant surface plasmon resonance (SPR) platform for label-free biomolecular interaction analysis — the established incumbent whose pain points (matrix noise, drift, sequential throughput) focal molography directly attacks.
• Sartorius (FortéBio Octet): Sartorius's FortéBio Octet biolayer interferometry (BLI) platform is the other major label-free kinetics incumbent, widely used in antibody screening and characterization workflows that Lino Biotech's MACS Matchmaker targets.
• Carterra: Carterra's LSA (high-throughput SPR) platform competes directly in the antibody discovery and developability screening space, offering kinetic characterization at scale that overlaps with Lino's 64-plex workflow.
• Gator Bio: Gator Bio offers BLI-based label-free interaction analysis platforms (GatorPrime, GatorPlus) targeting antibody and biologics characterization — a direct functional peer in the kinetic analysis market.

Emerging players

• Nicoya Lifesciences: Nicoya offers ALIS (Active Learning Interferometric Scattering) and OpenSPR label-free instruments, positioning as an emerging alternative in the label-free biosensing space with overlapping workflows.
• Attana: Attana offers QCM-based label-free biosensor instruments for real-time biomolecular interaction analysis, targeting antibody and biomarker characterization workflows comparable to Lino's MACS Matchmaker applications.
• BioNavis: BioNavis provides multi-parameter SPR (MP-SPR) instruments for label-free interaction analysis and biomolecular kinetics, addressing similar antibody and small molecule characterization use cases.
• XanTec Bioanalytics: XanTec Bioanalytics supplies SPR sensor chips and instrumentation for label-free interaction analysis, competing in the consumables and instruments space that supports MACS Matchmaker's addressable workflow.

Broad incumbents

• Bruker: Bruker is a broad life sciences and analytical instrument incumbent offering label-free SPR products and adjacent biophysical characterization tools, with much wider product portfolio but overlapping biopharma customers.
• Thermo Fisher Scientific: Thermo Fisher is a broad life sciences tools incumbent whose biopharma instrumentation portfolio overlaps with the customer base Lino targets, although without a direct focal molography-equivalent product.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/lino-biotech-ag

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Lino Biotech