What Flownamics does

Flownamics, Inc. is a privately held Madison, Wisconsin–based (with firmographic reference to San Francisco) manufacturer founded in the early-to-mid 1990s that designs and sells automated sampling systems, liquid handlers, and consumable probes for the bioprocess industry. Its core technology is the patented Segmented On-line Sampling approach, which uses intelligent pinch valves and non-contact ultrasonic sensors to withdraw, segment, and deliver representative, sterile, cell-free or cell-containing samples from bioreactors to up to four on-line analyzers per system, with flagship Seg-Flow S3, S3G, and PS configurations multiplexing sampling from up to 8–16 vessels.

The company’s product portfolio spans sampling hardware (Seg-Flow S3/S3G/PS, Acquire, FISP probes including Sartorius Ambr 250–specific AM and AHT variants, dip tubes, StreamT single-use in-line ports), downstream handling (Director 4-channel liquid handler, FlowFrac fraction collectors, Peltier+/Chiller Plate temperature control, vial racks, sterile consumables), and integration modules (Sample-Mod S3, RAMAN-IM, Bioprocess Feeding Control, Automated Dispensing, TFF/ATF Sampling, FlowWeb OPC controller). Flownamics maintains validated integrations with Agilent, Beckman Coulter (Vi-CELL XR/BLU), Roche (Cedex Bio HT/HiRes), Nova Biomedical (BioProfile FLEX2), Waters, RedShiftBio, Endress+Hauser (Raman Rxn2), and YSI.

Revenue is generated through one-time hardware sales, recurring consumables (probes, vials, tubes), and optional software/integration packages, distributed via direct enterprise sales in North America and a global network of regional distributors covering 19+ countries. Pricing is quote-based, with no public e-commerce or self-serve channel; sales are driven by demo scheduling, industry conferences (RAFT, BPI East), and webinars targeting bioprocess manufacturers, cell and gene therapy developers, and process development laboratories.

Name

Flownamics

Legal name

Flownamics, Inc.

Website

https://flownamics.com

Company type

Private

Founded year

1993

Operating status

Operating

Headcount range

11–50 employees

Short description

Flownamics is a privately held Madison, Wisconsin–based manufacturer of patented automated bioreactor sampling systems, liquid handlers, and consumables. It serves bioprocess manufacturers, cell and gene therapy developers, and process development labs worldwide via direct sales and a global distributor network.

Ownership category

akta.pro rank

Product category

Bioprocess Automation Equipment

NAICS

Analytical Laboratory Instrument Manufacturing (334516), Measuring, Dispensing, and Other Pumping Equipment Manufacturing (333914)

SIC

Instruments For Meas & Testing Of Electricity & Elec Signals (3825)

akta.pro primary industry

Automation, Controls & Manufacturing Execution for Bioprocessing (SCADA/DCS/PLC/MES) (HLAAAJAE)

akta.pro secondary industries

Sample / Biorepository & Biobank Informatics (Chain-of-Custody) (HLAGAJAH), Sample Preparation, Storage & Cryogenics (Freezers, Cryovials, Cryostats) (HLAGAIAJ)

Keywords

• Automated bioprocess sampling
• Bioreactor sampling systems
• Cell-free sampling probes
• Bioprocess automation equipment
• Process analytical technology

Headquarters

HQ city

San Francisco

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Supply Chain, Marketing or Sales, Operations

Revenue model

1. Automated Sampling Hardware: Sale of automated sampling systems including Seg-Flow S3, Seg-Flow S3G, Seg-Flow PS, and Acquire. These systems handle automated sample withdrawal from bioreactors and delivery to analytical instruments. Hardware constitutes primary revenue stream with varying configurations and channel options.
2. Sampling Accessories and Consumables: FISP probes, dip tubes, ASR/ASR+ regulators, vial racks, sterile vials and conical tubes, and fraction collectors. Recurring revenue from consumables and replacement parts for existing installed base.
3. Liquid Handling Systems: Director liquid handler systems and related accessories for sample distribution to multiple analytical devices.
4. Software and Integration Services: FlowWeb control software and OPC server packages for system integration with SCADA/historian systems. Optional software packages expand system capabilities.

Go-to-market motion2 records

Distribution channels15 records

Marketing channels5 records

Core offering

Flownamics designs, manufactures, and sells automated bioprocess sampling systems that withdraw, handle, and deliver representative samples from bioreactors and fermenters to analytical instruments, based on its patented Segmented On-line Sampling Technology. Its portfolio includes the Seg-Flow S3, S3G, and PS sampling systems, the Acquire sampler with integrated fraction collector, the Director liquid handler, FISP cell-free sampling probes, sample cooling and fraction collection accessories, and the FlowWeb OPC controller software for SCADA integration.

Product overview

Flownamics offers a comprehensive portfolio of automated sampling systems and bioprocess automation solutions. The core product line centers on Seg-Flow automated sampling systems (S3, S3G, PS) which provide rapid, accurate sampling from bioreactors with patented Segmented On-line Sampling technology. Supporting products include the Director liquid handler, Acquire automated sampler with fraction collector, and various sampling probes (FISP series, Dip Tubes). The ecosystem includes temperature control devices (Peltier+, Chiller Plate), fraction collectors (FlowFrac 1000, FlowFrac-CE), and sample storage accessories (Vial Racks, Sterile Containers). Integration modules connect with major analytical platforms including Agilent, Nova Biomedical, Roche Cedex, Beckman Coulter Vi-CELL, RedShiftBio, Waters, and Endress+Hauser. The portfolio is controlled via FlowWeb software with OPC connectivity for SCADA integration. Recent expansions include feeding and dispensing applications for the Seg-Flow PS platform, addressing upstream and downstream bioprocess automation needs.

Differentiator

Problem solved

Functional benefit

Brands

• Seg-Flow®: Automated sampling system product line using patented Segmented Sampling Technology for bioprocess monitoring.
• Director™
• Acquire™
• Peltier+™
• FlowFrac™
• FISP®
• RAMAN-IM™
• FlowWeb™

Products and services

• Seg-Flow S3 Automated on-line sampling system providing rapid and accurate sampling for 8 vessels or process streams with sample delivery to 4 analyzers and/or fraction collectors for pharmaceutical and biotechnology bioprocess monitoring teams.
• Seg-Flow S3G Autosampling system for on-line pH and gas analysis featuring a sample fluid path that prevents gas diffusion for accurate gas analysis data when interfaced with analyzers with BGA functionality.
• Seg-Flow PS Sampling System Smallest and most versatile sampling system with patent-pending low shear method ideal for Cell and Gene Therapy applications. Modular design allows parallel sampling of up to 16 bioreactors with fully disposable fluid path.
• Acquire Automated Sampler with Fraction Collector Industry's first automated sampler with a fully integrated fraction collector that handles automated sampling applications requiring fraction collection, sending samples from up to 8 reactors to various sized well plates and vials.
• Director Liquid Handler First-of-its-kind compact liquid handler optimized for bioprocessing and cell line development that delivers individual samples to multiple analytical devices with auto-dilution capabilities and capacity for 384 samples.
• Peltier+ Sample Cooling System Compact and fully self-contained thermoelectric cooling system with dual independent temperature zones that maintains sample temperatures from -2 to 20 degrees Celsius without external chiller or coolant lines.
• Chiller Plate Temperature control device interfacing with a recirculating water bath that maintains samples at temperatures from -20 to 40 degrees Celsius and is compatible with Flownamics racks.
• Vial Racks Aluminum blocks with plastic outer shell designed for temperature-controlled sample storage, available for microtiter plates (2 plates), 2mL HPLC vials, 5mL vials, 15mL and 50mL conical tubes with custom configurations available.
• FISP Cell-Free Sampling Probe Cell-free sampling probe constructed of 316 stainless steel with tubular micro-porous membrane (0.2µm standard) for withdrawing sterile, cell-free samples from fermenters and bioreactors, available in D-Series (19 and 25mm ports) and F-Series (8, 12, and 19mm ports) configurations.
• FISP AM Cell-Free Sampling Probe Fully disposable cell-free sampling probe specifically designed for the Sartorius Ambr 250 Modular Vessel, delivered in sterile packaging with 0.2µm membrane for automated sterile cell-free sampling.
• FISP AHT Membrane Sampling Probe Fully disposable membrane sampling probe designed for the Sartorius Ambr 250 High Throughput Vessel that enables aseptic automated sampling from small bench-scale bioreactors.
• Dip Tubes Stainless steel probes for full broth cell-containing sampling that are autoclavable and available in 200, 350, and 450mm lengths with 6mm outside diameter, equipped with adjustable fitting for PG 13.5 port installation.
• FlowFrac 1000 Fraction Collector X-Y-Z fraction collector for collecting online samples from Seg-Flow systems, compatible with septum and non-septum applications, accommodates cooling devices, and operates standalone via USB.
• FlowFrac-CE Sample Collector Carousel Economical sample collector carousel for organizing and collecting samples, with compact design and optional cooling capability at 4 degrees Celsius with SamCooler.
• StreamT In-line Sampling Port Single-use, sterile-packaged, disposable in-line sampling port designed for seamless in-line integration with any process stream that achieves complete automation when integrated with the Seg-Flow PS.
• Bioprocess Feeding Control Precision feeding solution that delivers accurate volumes from a single stock solution to up to 6 bioreactors using a single-use syringe pump design offering superior accuracy compared to gravimetric systems.
• Automated Dispensing Systems Automated Seg-Flow PS application for dispensing fluids from a central vessel into individual vials or bags, reducing human error and supporting single-use workflows with scalable production capability.
• Sterile Vials and Conical Tubes with Septum Sterile sample containers available in 5-7mL vials, 15mL and 50mL conical tubes with septum caps, gamma radiated with double bagging for use with fraction collectors and liquid handling devices.
• FlowWeb OPC Controller Web-based OPC server software and controller for bioprocess data management that integrates data from multiple analytical instruments and exports to OPC-enabled SCADA systems, supporting OPC DA and OPC UA protocols.

Quantifiable outcome

• Reduces off-shift and weekend workloads through automated 24/7 sampling
• +2 more outcomes

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration13 records

Feature5 records

Partnerships

Ten partnerships are on record, tiered core.

• AgilentcoreTechnology or IntegrationIntegration partnership for Agilent 1260/1290 Infinity II Online LC Solution. Flownamics Seg-Flow S3 provides automated sampling that feeds into Agilent's online LC system for PAT applications. Combined system provides classical flow-through injection and feed injection for up to 8 bioreactors.
• Beckman Coulter (Vi-CELL BLU)coreTechnology or IntegrationIntegration combining Seg-Flow S3 with Beckman Coulter Vi-CELL BLU for fully automated on-line cell viability/counting for up to 8 bioreactors. System provides continuous automated trypan blue dye exclusion method analysis.
• Beckman Coulter (Vi-CELL XR)coreTechnology or IntegrationIntegration with Beckman Coulter Vi-CELL XR cell analyzer for automated cell viability measurements integrated with Seg-Flow sampling systems.
• Nova Biomedical (BioProfile FLEX2)coreTechnology or IntegrationIntegration of Seg-Flow S3 with Nova Biomedical BioProfile FLEX2 analyzer for automated on-line nutrient, metabolite, and cell analysis in bioprocess cultures.
• Roche (Cedex Bio HT)coreTechnology or IntegrationIntegration combining Seg-Flow S3 with Roche Cedex Bio HT Bioprocess Analyzer for automated real-time analysis of nutrients and metabolites in bioprocess monitoring.
• Roche (Cedex HiRes)coreTechnology or IntegrationIntegration with Roche Cedex HiRes Analyzer for automated on-line cell analysis including concentration, viability, aggregates, and morphological parameters.
• RedShiftBio (HaLCon)coreTechnology or IntegrationIntegration with RedShiftBio HaLCon Protein Analyzer for protein characterization applications. Combined system enables automated sample delivery for spectroscopic analysis.
• Waters (Patrol UPLC)coreTechnology or IntegrationIntegration with Waters PATROL UPLC Process Analysis System for online chromatography applications in bioprocess monitoring.
• Endress+Hauser (Raman Rxn2)coreTechnology or IntegrationRAMAN-IM integration with Endress+Hauser Raman Rxn2 Analyzer enables single Raman probe interfacing with up to 8 reactors through Seg-Flow sampling system for PAT monitoring.
• Sartorius (Ambr 250)coreTechnology or IntegrationFISP AM and FISP AHT sampling probes specifically designed for Sartorius Ambr 250 Modular and High Throughput vessels. Products developed to address port space limitations in small bench-scale bioreactors.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Hamilton Company: Hamilton's Process Analytics and Robotics divisions make automated liquid handling and sampling systems used in bioprocess monitoring. It is the closest direct competitor to Flownamics' Seg-Flow sampling platforms, particularly in cell culture and fermentation sampling workflows.
• Eppendorf: Eppendorf, via its DASGIP and BioFlo bioprocess lines, sells bioreactor and process monitoring systems used in cell culture and fermentation R&D. It directly competes with Flownamics for sampling automation budget at biotech and pharmaceutical process development teams.
• Repligen: Repligen specializes in bioprocessing tools including TFF/ATF systems and process analytics. Its ATF harvest systems are explicitly supported by Flownamics' TFF/ATF sampling module, and Repligen competes for similar bioprocess monitoring budgets.

Broad incumbents

• Beckman Coulter Life Sciences: Beckman Coulter sells Vi-CELL cell viability analyzers and broader life science instrumentation that Flownamics integrates with via its Seg-Flow system. As an analytical instrument incumbent, it competes for bioprocess monitoring budgets and could bundle competing sampling solutions with its analyzers.
• Sartorius: Sartorius is a major bioprocess equipment manufacturer whose Ambr 250 bioreactors are explicitly supported by Flownamics' FISP AM and FISP AHT probes. As a vertically integrated upstream supplier, Sartorius could develop or acquire competing sampling technology, making it both a key partner and a strategic threat.
• Cytiva: Cytiva (formerly GE Healthcare Life Sciences) offers a broad bioprocessing portfolio including bioreactors, filtration, and process analytics. Its Xcellerex bioreactor line competes in the same accounts Flownamics serves, and it has the scale to bundle end-to-end sampling and monitoring solutions.
• Tecan: Tecan is a leading liquid handling and laboratory automation vendor. Its Fluent and Freedom EVO platforms overlap with Flownamics' Director liquid handler in serving bioprocess sample preparation and analytical distribution workflows.
• Agilent Technologies: Agilent is a core analytical instrument partner (1260/1290 Infinity II Online LC) that Flownamics integrates with. As a broad life science instrumentation incumbent, Agilent could develop or acquire proprietary sampling technology, turning a partnership into a competitive threat.
• Merck KGaA (MilliporeSigma): MilliporeSigma operates one of the broadest bioprocess portfolios in the industry, including bioreactors, filters, and process analytics. Its Mobius bioreactor line and PAT offerings compete with Flownamics' core customer workflows and have the scale to displace niche specialists.

Others

• Roche (CustomBiotech / Cedex): Roche's Cedex Bio HT and Cedex HiRes analyzers are integrated with Flownamics' Seg-Flow S3 for on-line nutrient and cell analysis. While primarily a partner today, Roche's bioprocess analytics line overlaps with Flownamics' monitoring value proposition in pharma manufacturing accounts.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/flownamics-inc-

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Flownamics