Enzymes

What Enzymes does

Enzymes Inc is a privately held, family-owned contract manufacturer of enzyme-based dietary supplements, founded in 1985 and headquartered in Kansas City (Parkville), Missouri. The company operates from an NSF/ANSI 455-2-certified, FDA-registered, cGMP-compliant 35,000+ square-foot facility with ISO 7 cleanrooms, producing capsules, tablets, chewables, and powders at reported capacities of 3,000,000+ capsules per day, 1,000,000+ tablets per day, 85,000+ bottles per day, and 17,000+ kg of powder per day. Its technology platform centers on non-animal-derived enzyme formulations produced via microbial fermentation (primarily Aspergillus oryzae and Aspergillus niger), supported by five proprietary branded ingredients — Apple PrePectin™, pHysioProtease® (protected by US Patent 6,413,512 on the alpha-2-macroglobulin binding mechanism), ProteaseCW™, ProteaseGL™, and InflammEnz® — and five published clinical studies supporting InflammEnz® efficacy.

The company generates revenue through six integrated service streams: contract manufacturing (minimums starting at 50,000 capsules), R&D and formulation development (five-stage model), private label manufacturing (stock formulas, next-best-equivalents, and custom formulations), fulfillment and logistics (integrated with Shopify, WooCommerce, Amazon, and EDI), design services (packaging, label, and 3D rendering), and certification facilitation (Organic, Kosher, Halal, NSF, Informed Sport, Informed Choice, Gluten-Free, Non-GMO, NASC). Its go-to-market is B2B enterprise field sales targeting supplement brands, health practitioners, and retailers via quote-based engagement with dedicated account management.

Enzymes Inc traces its scientific lineage to Dr. Edward Howell's enzyme research beginning in the 1920s and the 1932 founding of National Enzyme Company (NEC); Lynn and Jim Greaves acquired the company in 2000 and operate it alongside an alliance with NEC, with Bryan Greaves joining as Vice President in 2012. The company's horizontal segmentation spans dietary supplements, animal nutrition, food and beverage, brewing and distilling, industrial processing, and cleaning applications.

Name

Enzymes

Legal name

Enzymes Inc

Website

https://enzymesinc.com

Company type

Private

Founded year

1985

Operating status

Operating

Headcount range

11–50 employees

Short description

Enzymes Inc is a family-owned, NSF-certified contract manufacturer of enzyme-based dietary supplements, offering vertically integrated manufacturing, R&D, private label, design, and fulfillment services from its Kansas City facility to supplement brands and practitioners.

Ownership category

akta.pro rank

Product category

Dietary Supplement Contract Manufacturing

NAICS

Food Manufacturing (311)

SIC

Miscellaneous Food Preparations & Kindred Products (2090), Malt Beverages (2082), Beverages (2080)

akta.pro primary industry

Enzymes & Processing Aids (Baking, Brewing, Dairy, Meat) (CRADAOAH)

akta.pro secondary industries

Brewing & Distilling Enzymes (AFAJAIAD), Dairy & Cheese Processing Enzymes (AFAJAIAB), Enzyme Premixes (Phytase, NSP Enzymes, Proteases) (AFADAGAF), Baking & Flour Treatment Enzymes (AFAJAIAA)

Keywords

• Contract manufacturing supplements
• Enzyme formulations
• Private label supplements
• Dietary supplement manufacturing
• Bulk enzyme supply

Headquarters

HQ city

Kansas City

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Operations, Personnel, Supply Chain, Technology or R&D, Infrastructure, Marketing or Sales

Revenue model

1. Contract Manufacturing Services: Manufacturing capsules, tablets, chewables, and powders for supplement brands. Revenue generated through production fees based on batch size, format, and complexity. Minimum orders start at 50,000 capsules.
2. R&D and Formulation Services: Custom formulation development, flavor work, pilot scale-up, and analytical validation. Five-stage development model from concept to scalable prototype.
3. Private Label Manufacturing: Ready-to-sell stock formulas, Next Best Equivalent (NBE) products matching competitors, and custom formulations. MOQ ranges from 500-2,000 units for stock formulas to 2,500+ for custom work.
4. Fulfillment and Logistics Services: Storage, order processing, pick-pack-ship, returns processing, and distribution. Integrated with Shopify, WooCommerce, Amazon, and other marketplace platforms.
5. Design Services: Packaging design, label design, logo design, 3D rendering, and print management for supplement brands.
6. Certification Services: Facilitation of certifications including Organic, Kosher, Halal, NSF, Informed Sport, Informed Choice, Gluten-Free, Non-GMO, and NASC for manufactured products.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels4 records

Core offering

Enzymes Inc is a vertically integrated contract manufacturer of enzyme-based dietary supplements, offering end-to-end capabilities including NSF-certified GMP manufacturing of capsules, tablets, chewables, and powders; custom R&D and formulation services; packaging and label design; private labeling with stock, NBE, and custom formulas; and integrated fulfillment with same-day shipping. The company also develops and sells proprietary enzyme ingredient brands (pHysioProtease®, Apple PrePectin™, ProteaseCW™, ProteaseGL™, InflammEnz®) and operates a professional practitioner line under ProEnzol®.

Product overview

Enzymes Inc operates as a vertically integrated contract manufacturing platform offering end-to-end supplement production services. The core offering includes manufacturing (capsules, tablets, chewables, powders), R&D formulation services, design/packaging services, private labeling, and fulfillment. The company differentiates through a portfolio of five proprietary ingredient brands—Apple PrePectin™ (prebiotic/postbiotic), pHysioProtease® (systemic proteolytic blend), ProteaseGL™ (gluten/casein digestion), ProteaseCW™ (dairy protein digestion), and InflammEnz® (inflammation support)—which are incorporated into their manufactured products and also sold as standalone ingredients. The company also maintains a professional practitioner line under the ProEnzol® sub-brand. Manufacturing capabilities include production of 3,000,000+ capsules, 1,000,000+ tablets, 85,000+ bottles, and 17,000+ kg of powder daily, with industry-low minimums starting at 50,000 capsules.

Differentiator

Problem solved

Functional benefit

Brands

• ProEnzol®: Professional line of enzyme supplements combining broad-spectrum non-animal enzymes with targeted botanicals, antioxidant phytonutrients, vitamins, and minerals for practitioners.
• NESS®
• National Enzyme Company (NEC)

Products and services

• Contract Manufacturing NSF-certified contract manufacturing for capsules, tablets, chewables, and powders with precision GMP controls. Production capacity of 3,000,000+ capsules/day, 1,000,000+ tablets/day, 85,000+ bottles/day, and 17,000+ kg of powder/day. Industry-low minimums starting at 50,000 capsules for supplement brands seeking end-to-end production.
• R&D Services Custom supplement formulation support including scientific formulation design, flavor science, analytical validation, and clinical research support. Five-stage development model from concept brief to scalable prototype for supplement brands.
• Design Services End-to-end packaging and label design including logo design, label design, 3D rendering, pre-press & digital proofing, print management, and regulatory review for FDA/DSHEA compliance for supplement brands.
• Private Labeling Ready-to-market supplement formulas across categories including digestive health, metabolic support, cardiovascular support, immune support, joint & mobility, sports & recovery. Three development paths: stock formulas (500-2,000 units), next best equivalent (NBE) products, and custom formulations (2,500+ units).
• Fulfillment Integrated fulfillment services including climate-controlled storage, same-day order processing, pick-pack-ship operations, custom packaging, returns management, and transparent monthly billing with EDI & API integrations. Achieves 72% same-day ship rate and 99.8% pick accuracy.
• Apple PrePectin™ Proprietary blend of Non-GMO apple pectin and apple fiber serving as a probiotic delivery system and prebiotic. Protects probiotic organisms from destruction in the digestive tract and produces short-chain fatty acids (acetate and butyrate) for gut health. Sold as a standalone ingredient for supplement brands and manufacturers.
• pHysioProtease® Proprietary blend of non-animal derived proteolytic enzymes formulated for systemic use. Binds to alpha-2-macroglobulin in the bloodstream to modulate inflammatory signaling, support immune function, and cardiovascular health. Provides up to 52x more systemic activity than common digestive protease blends under blood pH conditions. Protected by US Patent 6,413,512.
• ProteaseCW™ Proprietary blend of acid-resistant, non-animal derived digestive enzymes formulated to break down hard-to-digest casein and whey proteins in dairy foods and protein supplements. Calibrated mix of endo- and exopeptidases with DPP-IV activity for comprehensive dairy protein hydrolysis.
• ProteaseGL™ Proprietary blend of acid-resistant, non-animal derived digestive enzymes with substantial DPP-IV activity for breaking down gluten and casein peptides. Targets proline-rich regions in gluten and casein proteins to reduce immunogenic fragments and support digestive comfort. Verified via DPP-IV and HUT assays under gastric conditions.
• InflammEnz® Proprietary blend of non-animal-derived proteolytic enzymes clinically evaluated for supporting healthy inflammatory response and accelerating soft-tissue repair. Backed by 5 published clinical studies demonstrating a 77% response rate and 17% faster healing time.
• ProEnzol® Practitioner Line Professional practitioner line of enzyme-based supplements combining broad-spectrum non-animal enzymes with targeted botanicals, antioxidant phytonutrients, vitamins, and minerals. Sold exclusively through licensed health practitioners. Previously known as ProSol™ (1999-2020).

Quantifiable outcome

• Up to 52× more systemic activity than common protease blends (pHysioProtease®)
• +5 more outcomes

Named customers2 records

Segments7 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration5 records

Feature5 records

Partnerships

Ten partnerships are on record, tiered core.

• Lynn and Jim GreavescoreStrategic or Co-development Partner · 1 January 2000Family ownership acquisition of Enzymes Inc along with Dr. Howell's Genuine N•Zimes® line, forming alliance with National Enzyme Company (NEC). Lynn Greaves serves as Vice President of both companies.
• EurofinscoreTechnology or IntegrationISO/IEC 17025 accredited full-suite global testing laboratory providing identity, potency, purity, and stability testing with method validation support for Enzymes Inc products.
• IntertekcoreTechnology or IntegrationEnd-to-end nutraceutical testing partner providing stability studies and regulatory/claims support with global testing capabilities.
• Alkemist LabscoreTechnology or IntegrationBotanical and mushroom identification specialist using HPTLC and microscopy methods plus adulteration screening for ingredient verification.
• SORA LabscoreTechnology or IntegrationcGMP analytical and microbiology testing laboratory providing heavy metals analysis via ICP-MS for human and animal products.
• Certified LabscoreTechnology or IntegrationBroad compliance panels provider offering identity, microbiology, and contaminant testing with fast turnaround times.
• Great PlainscoreTechnology or IntegrationNutrition label testing laboratory providing vitamins, micronutrients/macronutrients and microbiology analysis.
• Venture LabscoreTechnology or IntegrationISO 17025 accredited chemistry and microbiology laboratory providing solid core potency and contaminant testing panels.
• National Enzyme Company (NEC)coreStrategic or Co-development PartnerStrategic alliance partner sharing Dr. Edward Howell's enzyme research legacy and Genuine N•Zimes® product line with Enzymes Inc.
• Clinical Research Partners (MDs, DCs, PhDs)coreStrategic or Co-development PartnerCollaborations with physicians, doctors of chiropractic, and PhDs guiding enzyme-based formulations and advancing therapeutic applications.

Scale indicators6 records

Recent moves9 records

Expansion highlights4 records

Market position

Competitive moat4 records

Key highlights7 records

Customer concentration

• Xx.com/enzymeswork

Compliance11 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Enzymes