Frontier Science
Frontier Science is a 1975-founded nonprofit that serves as the Statistical and Data Management Center for major NIH-funded clinical trial networks, providing end-to-end clinical trial data management, biostatistics, software, and regulatory compliance services to federally funded research networks, academic centers, and pharmaceutical companies.
- Company typePrivate
- Founded1975
- HeadquartersBrookline, United States
- Headcount251–500
- GTM typeB2B
- OfferingServices
What Frontier Science does
Frontier Science & Technology Research Foundation, Inc. (operating as Frontier Science / Frontier Science Foundation) is a New York-incorporated nonprofit founded in 1975 that provides end-to-end clinical trial data management, biostatistics, and research software services to federally funded clinical research networks, academic medical centers, pharmaceutical companies, and individual investigators. Its core service portfolio comprises six integrated lines: Clinical Trials Data Management, Biostatistics (including an Independent Statistical Center for Data Safety Monitoring Boards), Software Solutions, Monitoring & Auditing, Quality Assurance & Compliance, and Education & Training. Underlying technology includes the proprietary Laboratory Data Management System (LDMS), used by 350+ laboratories worldwide with a multi-year migration to a web/cloud architecture, the DataFax electronic data capture system, the open-source ASI Interpreter Java library for antiretroviral drug resistance algorithms, an Interactive Data Dashboard framework for NIH public repository data sharing, and the C3PNO Virtual Data Repository and Labelscape mobile app for ancillary workflows.
The organization operates from three U.S. offices (Amherst, NY as headquarters; Boston, MA; Madison, WI) plus international affiliate offices in Edinburgh, Athens, and Oslo, with research footprint spanning 18 countries across North America, South America, Africa, and Asia through NIH-funded networks. Frontier Science serves as Statistical and Data Management Center (SDMC) for major NIH-funded networks including ACTG, IMPAACT, PHACS, and CP-CTNet, and as a prime awardee for NCI's CASCADE Network ($25M award) and CP-CTNet DMACC ($12M award). Revenue is generated through multi-year government grants and contracts from NIH/NCI/NIAID and bilateral research collaborations, supplemented by service contracts with pharmaceutical firms and academic institutions; pricing is contract-based with no public pricing, and the organization holds SOC 2 Type 2 certification and operates under FDA, HIPAA, GDPR, and ICH regulatory regimes. Recent wins include integration into the NIH 2020 restructured HIV clinical trials networks as SDMC Principal Investigator for both ACTG and IMPAACT, and recognition via the White House Cancer Moonshot program for CASCADE.
Frontier Science firmographics
Firmographics- Name
- Frontier Science
- Legal name
- Frontier Science & Technology Research Foundation, Inc.
- Website
- https://frontierscience.org
- Company type
- Private
- Founded year
- 1975
- Operating status
- Operating
- Headcount range
- 251–500 employees
- Short description
- Frontier Science is a 1975-founded nonprofit that serves as the Statistical and Data Management Center for major NIH-funded clinical trial networks, providing end-to-end clinical trial data management, biostatistics, software, and regulatory compliance services to federally funded research networks, academic centers, and pharmaceutical companies.
- Ownership category
- akta.pro rank
Frontier Science industry classification
Industry- Product category
- Clinical Research Services
- NAICS
- Scientific Research and Development Services (5417), Research and Development in the Physical, Engineering, and Life Sciences (54171), Medical Laboratories (621511), Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- SIC
- Services-Commercial Physical & Biological Research (8731), Services-Medical Laboratories (8071)
- akta.pro primary industry
- Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF) (HLAGAJAM)
- akta.pro secondary industries
- Site Data Management Support (EDC/Source/SDV Readiness) (HLAGACAL), Biostatistics, Statistical Computing & Clinical Programming (SAS/R/Pipelines) (HLACAOAO)
Keywords
Where Frontier Science is headquartered
LocationHeadquarters
- HQ city
- Brookline
- HQ country
- United States
- HQ region
- North America
Offices6 records
Markets served
Frontier Science business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Technology or R&D, Operations, Infrastructure
Revenue model
- Government Research Grants and Contracts: Revenue primarily derived from NIH and NCI grant awards and contracts for clinical trials networks. Examples include the $12 million CP-CTNet DMACC award and $25 million CASCADE Network award from NCI.
- Data Management and Statistical Services: Provides comprehensive data management, biostatistics, and technical services to observational studies and clinical trials. Services billed through project contracts with research networks and institutions.
Go-to-market motion1 record
Distribution channels3 records
Marketing channels6 records
Frontier Science product offering
Product offeringCore offering
Frontier Science provides end-to-end clinical trial data management, biostatistics, and statistical center services to NIH-funded research networks, academic institutions, and pharmaceutical companies. The organization supports clinical trials across all phases — design, development, conduct, analysis, and dissemination — with proprietary software tools including the Laboratory Data Management System (LDMS), DataFax electronic data capture, and Independent Statistical Center capabilities.
Product overview
Frontier Science Foundation is a nonprofit organization offering a comprehensive suite of clinical trial data management and biostatistics services. Its core portfolio spans six integrated service lines: Clinical Trials Data Management, Biostatistics, Software Solutions, Monitoring & Auditing, Quality Assurance & Compliance, and Education & Training. Key software products include the Laboratory Data Management System (LDMS) used in over 350 laboratories globally, DataFax for fax-based data capture, the C3PNO Virtual Data Repository for NIDA cohort data sharing, and Labelscape for specimen label management. The Independent Statistical Center (ISC) provides dedicated IDMC and audit support. The company collaborates with major NIH-funded research networks including ACTG, IMPAACT, PHACS, CP-CTNet, and CASCADE, providing centralized data management, statistical analysis, and technology solutions across clinical studies worldwide.
Differentiator
Problem solved
Functional benefit
Brands
- Laboratory Data Management System (LDMS): Laboratory data management software used in over 350 laboratories worldwide for managing clinical trial specimen data
- Labelscape
- Independent Statistical Center (ISC)
Products and services
- Clinical Trials Data Management Comprehensive data management solutions for clinical trials of all sizes, covering study design support, data collection, migration, harmonization, quality control, monitoring, and real-time visualizations. For NIH-funded research networks, academic institutions, and pharmaceutical sponsors.
- Biostatistics Statistical services ranging from small specialized projects to complete end-to-end statistical support for all phases of clinical studies, including tables, figures, listings, interim reviews, and Data Safety Monitoring Board support. For clinical research networks and academic investigators.
- Software Solutions Custom and commercial software development and maintenance compliant with industry standards, including data management systems and mobile applications. For clinical trials networks and research institutions.
- Monitoring & Auditing Remote and on-site monitoring and auditing visits to ensure protocol adherence, participant safety, data integrity, and site readiness. For clinical trials networks and research institutions.
- Quality Assurance & Compliance Integrated quality management systems ensuring compliance with domestic and international research regulations including FDA, HIPAA, GDPR, and ICH guidelines. For clinical trials networks and research institutions.
- Education & Training Instructional programs and study documentation tailored to each specific study, curated by training specialists. For clinical trial site staff and study teams.
- Laboratory Data Management System (LDMS) Proprietary laboratory data management software used by over 350 laboratories worldwide for managing specimen tracking, laboratory data, and workflow for clinical research studies including HIV/AIDS, TB, and population health assessments. Underwent retro-validation in 2007 and migrated to a web/cloud version.
- DataFax Fax-based electronic data capture system for clinical trial data submission, with dedicated user support. For clinical research sites and trials.
- Independent Statistical Center (ISC) Specialized statistical support unit providing Independent Data Monitoring Committee (IDMC) services, risk-appropriate auditing, and independent statistical review for clinical trials. For clinical trial sponsors and DSMBs.
- Labelscape Mobile application for creating and printing specimen labels, used in clinical research laboratory settings. For laboratory and clinical trial staff.
- C3PNO Virtual Data Repository Virtual repository search tool linking laboratory, clinical, substance use, behavioral, and biological data from NIDA-funded cohorts to facilitate data sharing among researchers. For substance use and HIV researchers.
Quantifiable outcome
- 1,200+ clinical studies supported over five decades
- +4 more outcomes
Companies that use Frontier Science
Customer profileNamed customers12 records
Segments4 records
Ideal customer profiles3 records
Frontier Science technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature4 records
Frontier Science partnerships and signals
Strategic signalPartnerships
15 partnerships are on record, tiered core and minor.
- University of Wisconsin-MadisoncoreFive-year partnership as Data Management, Auditing, and Coordinating Center (DMACC) for the Cancer Prevention Clinical Trials Network (CP-CTNet). KyungMann Kim, PhD leads the DMACC at UW while Frontier Science leads centralized data management and reporting. Also collaborated on Independent Statistical Center (ISC) and CASCADE Network coordination.
- University of California, Los Angeles (UCLA)corePartnership on CASCADE Network where Dr. Anna Barbara Moscicki directs independent risk-appropriate auditing of network clinical trials. Also partners on C3PNO project and AIDS/substance abuse research initiatives.
- Johns Hopkins UniversitycoreCollaboration on Tuberculosis Report International Coordinating Center (TB-RICC) and RePORT International initiative for TB control and prevention research.
- Rutgers UniversitycoreCollaboration on Tuberculosis Report International Coordinating Center (TB-RICC) alongside Vanderbilt and Johns Hopkins for global TB research coordination.
- Vanderbilt UniversitycoreCollaboration on Tuberculosis Report International Coordinating Center (TB-RICC) alongside Rutgers and Johns Hopkins for global TB research coordination.
- ICAP at Columbia UniversitycorePartnership since 2015 on PHIA (Population-based HIV Impact Assessment) project providing LDMS installations, user support, training, and central database services across 14 sub-Saharan countries. Continues in PHIA 2 project.
- National Institute on Drug Abuse (NIDA)coreFunder of C3PNO (Collaborating Consortium of Cohorts Producing NIDA Opportunities) project, a coordination center for NIDA longitudinal cohorts studying substance use in context of HIV. Sue Siminski serves as co-Principal Investigator.
- National Institute of Allergy and Infectious Diseases (NIAID)corePrimary NIH institute funding HIV clinical trials networks (ACTG, IMPAACT) where Frontier Science serves as SDMC Principal Investigator. Funded restructured HIV clinical trials networks for next seven years.
- National Cancer Institute (NCI)coreAwarded $12 million CP-CTNet DMACC grant and $25 million CASCADE Network prime award to Frontier Science for cancer prevention clinical trials coordination and HIV/cervical cancer research.
- NIH-Funded Research NetworkscoreFrontier Science serves as Statistical and Data Management Center (SDMC) for ACTG and IMPAACT networks, with Marlene Cooper serving as SDMC Principal Investigator for both networks under NIAID restructuring.
- PHIA 2 Collaborating OrganizationsminorPHIA 2 consortium includes: African Population and Health Research Center, African Society for Laboratory Medicine, Clinical Pharmacology Laboratory at University of Cape Town, FHI 360, Institute for Global Health Sciences at UCSF, International Treatment Preparedness Coalition, Makerere University, Partnership for Supply Chain Management, PPD, Westat.
- Dana-Farber Cancer InstituteminorDr. Kathryn Gray previously worked as primary statistician for DFCI's Gynecologic Oncology Program providing statistical support for phase I-II clinical trials before joining Frontier Science.
- International Breast Cancer Study Group (IBCSG)minorDr. Kathryn Gray serves as senior statistician with IBCSG and sits on the translational research committee facilitating research design and statistical considerations for projects using biological materials.
- U.S. President's Emergency Plan for AIDS Relief (PEPFAR)minorPHIA surveys implemented under PEPFAR leadership alongside CDC and ICAP at Columbia University across sub-Saharan countries.
- Centers for Disease Control and Prevention (CDC)minorPartner on PHIA surveys alongside PEPFAR and ICAP for population-based HIV impact assessments.
Scale indicators7 records
Recent moves6 records
Expansion highlights5 records
Frontier Science competitors and assessment
Company assessmentDirect peers
- SCHARP (Statistical Center for HIV/AIDS Research & Prevention) at Fred Hutchinson Cancer Center: SCHARP serves as a Statistical and Data Management Center for NIH-funded HIV prevention trials (HPTN, HVTN, Microbicide Trials Network) and operates from an academic nonprofit base. Like Frontier Science, it provides EDC, biostatistics, and laboratory data management for multi-site, federally funded clinical trial networks—making it the closest analog in business model, customer profile, and scope.
- EMMES Corporation (now part of Clario): EMMES historically operated as a privately held contract research organisation serving NIH and academic sponsors with biostatistics, data management, and clinical operations support, closely mirroring Frontier Science's SDMC and central laboratory data services before its acquisition by Clario in 2021.
- Westat: Westat is a large, employee-owned research organisation providing statistical, data management, and clinical research services to U.S. federal agencies, including HHS, NIH, and CDC. Its mix of biostatistics, survey research, and federally contracted clinical studies overlaps closely with Frontier Science's NIH-funded data management focus.
- Rho, Inc. Rho is a clinical research organisation that focuses on biostatistics, data management, regulatory affairs, and safety services for NIH, academic, and biotech sponsors, paralleling Frontier Science's core service portfolio with similar customer types and SDMC-style engagements.
- RTI International: RTI International is a nonprofit research institute providing biostatistics, clinical trial operations, and health research services to federal and commercial clients. Its mission-driven, research-oriented model and federal grant revenue mix are structurally similar to Frontier Science's nonprofit SDMC operations.
Broad incumbents
- Clario: Clario (formed from ERT and the post-acquisition EMMES business) is a clinical trial technology and endpoint services company providing eCOA, cardiac safety, imaging, and respiratory solutions, with EMMES-aligned data management capability. It is a broad incumbent competing in adjacent workflow services.
- ICON plc: ICON is a leading global CRO with extensive biostatistics, data management, and clinical operations services. It competes for the same trial sites and statistical centre business that Frontier Science seeks, particularly for phase III registrational trials.
- IQVIA: IQVIA is the largest global commercial contract research organisation, offering EDC, CTMS, biostatistics, central laboratory, and full clinical operations capabilities across all therapeutic areas. Frontier Science competes only partially for commercial biopharma trials, but IQVIA defines the competitive ceiling for clinical trial data management and biostatistics.
- PPD (Thermo Fisher Scientific): PPD, now part of Thermo Fisher Scientific, is a top global CRO providing biostatistics, clinical data management, and laboratory services across all phases. Its broad commercial reach and growing federal business make it an incumbent competitor to Frontier Science in any mixed-funded portfolio.
- Medidata Solutions (Dassault Systèmes): Medidata provides the Rave EDC/CTMS and eCOA platforms used across most large commercial clinical trials. Its technology is the principal alternative to Frontier Science's proprietary EDC, LDMS, and DataFax stacks in any data capture RFP.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
Frontier Science social profiles
Digital presenceFrontier Science compliance and trust
Trust signalCompliance1 record
Frontier Science financial estimates
Financial estimateRevenue estimate
Valuation estimate
Frontier Science leadership team
Management profileNumber of profiles
Profiles9 records
Frontier Science funding detail
Funding detailFunding overview
Funding rounds
Investors
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Frontier Science M&A and investment
M&A and investmentM&A
Investments
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Frequently asked questions about Frontier Science
What does Frontier Science do?
Frontier Science provides end-to-end clinical trial data management, biostatistics, and statistical center services to NIH-funded research networks, academic institutions, and pharmaceutical companies. The organization supports clinical trials across all phases — design, development, conduct, analysis, and dissemination — with proprietary software tools including the Laboratory Data Management System (LDMS), DataFax electronic data capture, and Independent Statistical Center capabilities.
Is Frontier Science a public or private company?
Frontier Science is a private company. It is classified as nonprofit foundation owned and is currently operating.
When was Frontier Science founded?
Frontier Science was founded in 1975. It employs 251 to 500 people.
Where is Frontier Science based?
Frontier Science is headquartered in Brookline, United States, in the North America region.
How does Frontier Science make money?
Two revenue lines are on record. Government Research Grants and Contracts are the primary driver. The others are data Management and Statistical Services.
Who are Frontier Science's main competitors?
Direct peers on record are SCHARP (Statistical Center for HIV/AIDS Research & Prevention) at Fred Hutchinson Cancer Center, EMMES Corporation (now part of Clario), Westat, Rho, Inc. and RTI International. Broad incumbents are Clario, ICON plc, IQVIA, PPD (Thermo Fisher Scientific) and Medidata Solutions (Dassault Systèmes).
Does Frontier Science have an API?
No public API is recorded for Frontier Science.
What industry is Frontier Science in?
Frontier Science's product category is Clinical Research Services. Its primary akta.pro industry code is HLAGAJAM, Clinical Trial Informatics (EDC/CTMS/eCOA/eTMF), with a secondary code of HLAGACAL, Site Data Management Support (EDC/Source/SDV Readiness). Its NAICS code is 5417 and its SIC code is 8731.