RotaChrom

What RotaChrom does

RotaChrom Technologies PLC is a Hungary-headquartered industrial chromatography company founded in 2014 that develops, manufactures, and sells centrifugal partition chromatography (CPC) platforms for liquid-liquid purification. The company serves pharmaceutical, biotechnology, nutraceutical, botanical, cosmetic, and fine chemical manufacturers globally through direct enterprise field sales, supported by regional sales contacts covering Europe/ROW, South America/ROW, Asia-Pacific, and the US/Canada, and complemented by channel partnerships such as Inkarp in India.

RotaChrom's core technology is silica-free, liquid-liquid CPC in which separation occurs between two immiscible liquid solvent systems rather than on a solid stationary phase, eliminating irreversible adsorption and enabling total sample recovery. The product portfolio spans four platforms designed for true scale-up on a common technology base: CPC Modeler (benchtop, 250 mL rotor) for method development, GMP-rCPC (pilot, 2.2 L rotor), Continuous CPC (dual-rotor, 4.4 L) for continuous manufacturing in multiple dual-mode (MDM) operation, and iCPC (industrial, 23 L rotor) with fully integrated automated solvent preparation, recovery, and regeneration. Platforms carry Pharma GMP, cGMP, 21 CFR Part 11, GAMP 5, CE, UKCA, UL/CSA/NRTL, ATEX Zone 2/C1D2, IECEx, EN 10204 3.1, ASME BPE, and FDA-compliant wetted parts certifications. Two digital tools — an in silico CPC Simulator and a free TCO Calculator — support method development and investment decisions, alongside expert-led method development, feasibility, and process engineering services.

Revenue is generated primarily through quote-based capital equipment sales of CPC systems and complementary solvent handling modules, supplemented by professional services revenue from method development and process engineering engagements; pricing is not publicly disclosed. The company has raised approximately HUF 3.6 billion (~USD 11.5 million combined) across a Series A in 2017 and a Series B in 2020, operates from a Kecskemét headquarters and Dabas R&D laboratory in Hungary, with a North American subsidiary headquartered in Irvine, California, an Equipment Reference Facility in Denver, Colorado, and an Asia-Pacific application support hub in Kuala Lumpur. RotaChrom employs 51–100 people and holds the registered RotaChrom® trademark in the USA and EU.

Name

RotaChrom

Legal name

RotaChrom Technologies PLC

Website

https://rotachrom.com

Company type

Private

Founded year

2014

Operating status

Operating

Headcount range

51–100 employees

Short description

RotaChrom Technologies PLC is a Hungary-based industrial chromatography company founded in 2014 that develops and sells centrifugal partition chromatography (CPC) platforms for liquid-liquid purification to pharmaceutical, biotech, nutraceutical, botanical, cosmetic, and fine chemical manufacturers worldwide.

Ownership category

akta.pro rank

Product category

Preparative Chromatography Equipment

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826), Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Analytical Instruments & Chromatography Systems (HLAGAIAA)

akta.pro secondary industry

GMP Scale-Up, Tech Transfer & Process Validation (PPQ) (HLAGAHAL)

Keywords

• Centrifugal partition chromatography
• Industrial chromatography equipment
• Pharmaceutical purification systems
• Liquid-liquid separation platforms
• Preparative chromatography instruments

Headquarters

HQ city

Budapest

HQ country

Hungary

HQ region

Europe

Offices5 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Supply Chain, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. Industrial CPC Hardware Systems: Sale of Centrifugal Partition Chromatography platforms at various scales: benchtop (CPC Modeler), pilot-scale (GMP-rCPC), continuous dual-rotor (Continuous CPC), and industrial-scale (iCPC with solvent handling). Each platform is complemented by solvent handling modules, turn-key add-ons, and automation solutions. Revenue is generated through direct enterprise sales with customization for specific purification, separation, isolation, and remediation tasks.
2. Expert-Led Services: Comprehensive technical services including chromatography method development, R&D collaboration, process engineering, downstream integration, feasibility studies, and technical transfer support. Services are designed to de-risk purification journeys and minimize scale-up risks, validation efforts, and operational disruption for customers adopting CPC technology.

Go-to-market motion1 record

Distribution channels4 records

Marketing channels8 records

Core offering

RotaChrom manufactures and sells industrial-scale Centrifugal Partition Chromatography (CPC) instruments — silica-free, liquid-liquid preparative chromatography systems — at benchtop, pilot, continuous, and industrial scales for pharmaceutical, biotech, nutraceutical, botanical, cosmetics, and fine chemical manufacturers. Its offering pairs CPC hardware with integrated automated solvent preparation and recycling, in silico CPC Simulator and TCO Calculator digital tools, and expert-led method development, feasibility, R&D collaboration, and technical transfer services.

Product overview

RotaChrom offers a platform of centrifugal partition chromatography (CPC) systems designed for scalable liquid-liquid purification across pharmaceutical, biotech, nutraceutical, and botanical industries. The product portfolio includes four core CPC instruments spanning from research to industrial scale: the CPC Modeler (benchtop, 250 mL rotor) for method development, GMP-rCPC (pilot-scale, 2.2 L rotor) for production validation, Continuous CPC (dual-rotor, 4.4 L) for continuous manufacturing, and iCPC (industrial-scale, 23 L rotor) with integrated solvent handling for large-scale production. The systems are complemented by digital tools including the CPC Simulator for in-silico method modeling and the free TCO Calculator for total cost of ownership analysis. All systems share the same CPC technology principles enabling seamless scale-up without re-engineering, and are supported by method development and process engineering services.

Differentiator

Problem solved

Functional benefit

Products and services

• CPC Modeler Benchtop-sized Centrifugal Partition Chromatography platform with a 250 mL rotor volume and 1–50 mL/min flow rate, supporting throughput from milligrams to grams per cycle. Pharma GMP compliant (Eudralex Volume 4), ASME BPE-compliant with FDA-compliant 316L stainless steel flow path. Designed for method development and entry-level production with seamless scale-up to the GMP-rCPC, Continuous CPC, and iCPC without re-engineering, including an integrated in silico CPC Simulator for modeling purification strategies.
• GMP-rCPC Pilot-scale Centrifugal Partition Chromatography platform with a 2.2 L rotor and 100–300 mL/min flow rate, supporting throughput from grams to hundreds of grams per cycle in both ascending and descending operation. Fully Pharma GMP compliant (Eudralex Volume 4) with 21 CFR Part 11, GAMP 5, CE, UKCA, and UL/CSA/NRTL certifications, EN 10204 3.1 material traceability for wetted parts. Bridges method development on the CPC Modeler and continuous/industrial production on Continuous CPC and iCPC.
• Continuous CPC Dual-rotor Centrifugal Partition Chromatography system built on two interconnected GMP-rCPC units in dual-mode dual-rotor (MDM-CPC) configuration, enabling continuous compound injection, seamless fraction collection, and continuous manufacturing. Provides 4.4 L total rotor volume, 500 mL/min flow rate, 300 mL/min continuous injection, and throughput from hundreds of grams to kilograms per cycle. Pharma GMP compliant with ATEX Zone 2 / IECEx Zone 2, CE, and UKCA certifications.
• iCPC with Solvent Preparation and Recycling System Industrial-scale Centrifugal Partition Chromatography platform combining the world's largest commercially available CPC instrument (iCPC, 23 L rotor) with a fully automated solvent preparation, recovery, and regeneration system. PLC-controlled for precise parameter tuning and multi-skid integration, delivering throughput up to 20 kg/day, loading capacity up to 1200 g per cycle, and up to 90% solvent recovery. Built from 316L stainless steel and PEEK components, ATEX Zone 2/C1D2 compliant.
• CPC Simulator Interactive in silico simulator for understanding Centrifugal Partition Chromatography separation principles. Models solvent systems, partition coefficients, phase ratios, rotation speed, and operating modes and shows their impact on yield, purity, and cycle time, enabling customers to predict and optimize purification performance before physical implementation.
• TCO Calculator Free web-based calculator for estimating total operational cost of CPC equipment, including depreciation, solvent consumption, yield, throughput, and purity projections. Used by prospective customers to evaluate total cost of ownership before investing in CPC hardware.
• Chromatography Method Development Services Expert-led service offering to test and validate CPC suitability for specific separation needs, enabling customers to develop purification methods that can scale across the CPC Modeler, GMP-rCPC, Continuous CPC, and iCPC platforms.
• Process Engineering & Downstream Integration Services Process engineering and downstream integration services that design and optimize industrial-scale CPC workflows, support technical transfer, and integrate CPC into customers' downstream processing lines.
• R&D Collaboration & Feasibility Studies On-demand R&D collaboration and feasibility study services that provide data-driven insights into complex purification challenges, helping customers de-risk adoption of CPC technology and accelerate time-to-market.

Quantifiable outcome

• Throughput up to 20 kg/day at industrial scale with >99% purity and loading capacity of 1200 g per cycle
• +6 more outcomes

Named customers6 records

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature8 records

Partnerships

Five partnerships are on record, tiered core and notable.

• InkarpcoreChannel Partner/ Reseller/ Distributor · 1 July 2025Strategic partnership with Inkarp to bring industrial-scale CPC solutions to India for pharmaceutical, biotechnology, and research sectors. Announced July 2025, this partnership enables RotaChrom to access the Indian market through a local partner with established distribution networks and customer relationships in the region.
• CycloLabcoreStrategic or Co-development Partner · 1 March 2021Strategic partnership with CycloLab for remdesivir purification using cyclodextrin-based CPC methods. The collaboration was announced in March 2021 to increase production of COVID-19 treatment. CycloLab contributed cyclodextrin expertise while RotaChrom provided the CPC purification platform, enabling scalable and efficient production of remdesivir — a key COVID-19 therapeutic at the time. Multiple media outlets covered this partnership as a significant contribution to pandemic response efforts.
• Red Mesa Science & RefiningcoreStrategic or Co-development Partner · 1 March 2021Partnership with Red Mesa Science & Refining showcasing the use of industrial-scale CPC for high-purity cannabinoid production. Featured in a Forbes article (May 2025) titled 'Red Mesa Aims to Rethink Hemp-Derived Cannabinoid Refining Methods,' highlighting how RotaChrom's CPC technology sets standards in botanical/cannabinoid purification.
• HAU ProcessingnotableStrategic or Co-development Partner · 1 March 2021HAU Processing implemented RotaChrom's leading industrial-scale chromatography hemp purification system, expanding its production capacity for botanical extract processing. Announced in March 2021 in Marijuana Times and other trade publications.
• G-APS (Global Alliance for Botanical Extracts Processing Standards)notableStrategic or Co-development Partner · 1 December 2020RotaChrom participated in forming the G-APS (Global Alliance for Botanical Extracts Processing Standards) alongside other leading global equipment manufacturers, aiming to set international standards for botanical extracts processing. Announced December 2020, covered by Star Tribune, Yahoo Finance, Arizona Republic, and multiple trade publications.

Scale indicators11 records

Recent moves8 records

Expansion highlights6 records

Broad incumbents

• Agilent Technologies: Agilent is a global analytical instrumentation leader with broad chromatography (HPLC, GC, SFC) and bioprocessing offerings. It is a broad incumbent because it competes with RotaChrom in pharma purification workflows through prep-LC and biomolecule characterization solutions, though it does not specialize in industrial CPC.
• Sartorius: Sartorius supplies bioprocessing and downstream purification equipment (filtration, chromatography, fluid management) to pharma manufacturers. It is a broad incumbent because it overlaps with RotaChrom in pharma/biotech downstream purification even though its core offerings are filtration and platform bioprocess systems.
• Cytiva (Danaher): Cytiva, part of Danaher, provides bioprocessing and downstream purification solutions including ÄKTA chromatography platforms for pharma and biotech manufacturers. It is a broad incumbent because it competes with RotaChrom's CPC systems for downstream purification capex in biologics manufacturing.
• Waters Corporation: Waters is a major chromatography and mass spectrometry supplier serving pharmaceutical, clinical, and chemical markets. It is a broad incumbent because its prep-LC and purification portfolios overlap with RotaChrom's pharma/biotech downstream purification applications.
• Shimadzu Scientific Instruments: Shimadzu produces HPLC and preparative chromatography systems used in pharmaceutical, food, and chemical analysis. It is a broad incumbent because its preparative LC instruments compete with RotaChrom's CPC platforms for industrial and analytical chromatography budgets.
• Thermo Fisher Scientific: Thermo Fisher offers comprehensive analytical instruments, chromatography columns, and bioproduction solutions through brands like Thermo Scientific and Patheon. It is a broad incumbent because its chromatography and bioprocessing portfolios overlap with RotaChrom's pharma and biotech target customers.

Direct peers

• Biotage: Biotage provides purification systems (flash chromatography, prep-LC, and work-up tools) used in pharma discovery, development, and manufacturing. It is a direct peer because RotaChrom's CPC platforms compete for the same downstream purification budget in pharma and botanical extraction customers.
• Gilson: Gilson manufactures preparative chromatography and liquid handling instruments targeted at pharma, biotech, and academic purification workflows. It is a direct peer because RotaChrom's CPC instruments serve the same preparative chromatography use cases for similar scientific customer profiles.
• Yamazen Science: Yamazen distributes and develops preparative chromatography and CPC systems in Japan and globally. It is a direct peer because it competes with RotaChrom's CPC instruments in pharma, natural product, and research purification segments.
• Armen Instrument: Armen Instrument is a long-standing centrifugal partition chromatography (CPC) equipment maker founded by the inventor of CPC. It is the most direct technical peer because its CPC instruments compete head-to-head with RotaChrom's CPC Modeler, GMP-rCPC, and Continuous CPC products.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/RotaChrom
• Xx.com/rotachrom
• LinkedInlinkedin.com/company/rotachrom

Compliance13 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles13 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about RotaChrom