Developer docs
API playgroundTry for free, no card

Search company profiles

MRC LMS

Full company profile

uuid000ljwa

Namestring
MRC LMS
Legal namestring
LMS Laboratory of Medical Sciences
Websiteurl
lms.mrc.ac.uk
Company typeenum
Private
Founded yearint
1913
Operating statusenum
Operating
Ownership categoryenum
Headcount rangeband
101–250
akta.pro rankint
HeadquartersLondon, United Kingdom
HQ citystring
London
HQ countrystring
United Kingdom
HQ regionstring
Europe
Markets served

Serves global market

Offices1 record

Each record includes

City, Country, Type, Description, Source

Keyword5 values
biomedical research, clinical research training, genomics research, PhD programmes, discovery science
Industry1 code
1Clinical CROs (Phase I–IV)
CodeHLAGAAAAPrimaryYes
NAICS code3 codes
  • Scientific Research and Development Services5417
  • Research and Development in the Physical, Engineering, and Life Sciences54171
  • Research and Development in Biotechnology (except Nanobiotechnology)541714
SIC code1 code
  • Services-Commercial Physical & Biological Research8731
Product category
Biomedical Research Services
GTM motion2 records

Each record includes

Type, Description, Source

Revenue model3 records
1MRC Core Funding
TypeSubscription Recurring
Description

The MRC Laboratory of Medical Sciences is a core-funded institute of the Medical Research Council (MRC), part of UK Research and Innovation (UKRI). This provides the primary institutional funding for operations and research.

lms.mrc.ac.uk
2External Research Grants
TypeGrants Donations
Description

Funding from external bodies including Cancer Research UK, British Heart Foundation, Wellcome Trust, NIHR Imperial Biomedical Research Centre, European Research Council, Academy of Medical Sciences, and other grant-making organizations.

lms.mrc.ac.uk
3PhD Program Support
TypeProfessional Services
Description

PhD programs offer students a generous, tax-free stipend of £26,500 per year for four years and cover tuition fees and research consumables. Visa costs covered for overseas students.

lms.mrc.ac.uk
Marketing channels6 records

Each record includes

Title, Type, Stage, Description, Source

Distribution channels3 records

Each record includes

Title, Type, Scope, Target buyer, Description, Source

Cost components5 values
Personnel, Technology or R&D, Operations, Infrastructure, Supply Chain
GTM typeB2B
B2B
Offering typeServices
Services
Brand1 of 2 records shown
1Chain Florey Programme
Description

A clinician scientist training programme named in honor of Howard Florey and Ernst Chain, Nobel Prize winners for penicillin development

lms.mrc.ac.uk
+1 more record
Core offering1 text field

MRC LMS is a publicly funded biomedical research institute that conducts discovery science to advance understanding of human health and disease, bridging fundamental biology with translational and clinical research. It operates core research facilities (Bioinformatics, Flow Cytometry, Genomics, MR Imaging, Metabolomics, Microscopy, Proteomics, and others) and offers research training programmes (PhD, Chain Florey clinician scientist, postdoctoral, and graduate pathways) hosted at Imperial College London's Hammersmith campus.

Differentiator
Functional benefit
Problem solved
Quantifiable outcome1 of 4 values shown
  • Returned genetic diagnosis to many families with previously unexplained heart disease
+3 more records
Product overview1 text field

MRC Laboratory of Medical Sciences (LMS) is a research institute offering training programmes and research infrastructure rather than commercial products. Its portfolio includes: the Science Technology Graduate Programme for early-career graduates; three PhD Training Programmes (Core, Transdisciplinary, and Team Science); the Chain Florey Clinician Scientist Programme providing structured clinical academic career development; postdoctoral training with various fellowship schemes; and Core Research Facilities providing access to advanced technologies including bioinformatics, genomics, imaging, and proteomics platforms. These offerings are interconnected through the institute's research groups and facilities, enabling discovery science for human health.

Product and service5 records
1PhD Programme
CategoryResearch Training
Description

Funded doctoral research training programme at MRC LMS, providing PhD students with mentorship, access to core research facilities, and integration with Imperial College London for advanced biomedical discovery science.

2Chain Florey Clinician Scientist Programme
CategoryResearch Training
Description

Clinician scientist training programme managed by Aurelie Tromp at MRC LMS, offering funded research fellowships for medical clinicians pursuing research careers.

3Postdoctoral Training
CategoryResearch Training
Description

Postdoctoral research positions at MRC LMS, providing early-career researchers with project-based research roles, access to core facilities, and mentorship from group heads.

4Graduate Programme
CategoryResearch Training
Description

Graduate-level research training programme at MRC LMS, offering structured research experience and exposure to the institute's thematic research areas.

5Core Research Facilities
CategoryCore Research Infrastructure
Description

Shared core research facilities operated by MRC LMS for institute researchers and collaborators, spanning Bioinformatics, Flow Cytometry, Genomics, MR Imaging, Metabolomics, Microscopy, Proteomics, and related capabilities supporting discovery and translational science.

Scale indicator4 records

Each record includes

Type, Value, Description, Source

Partnership11 partners
1SAMURII (Strategic Alliance of MRC-University Research Investments at Imperial)
Strategic tierCoreTypeStrategic or Co-development PartnerAnnounced on2021-08-03
Description

Joint initiative between LMS and the Institute of Clinical Sciences to support interdisciplinary PhD studentships. Jointly funded by LMS and ICS, the scheme develops new partnerships with focus on innovation across traditional discipline boundaries.

lms.mrc.ac.uk
Strategic tierCoreTypeStrategic or Co-development Partner
Description

LMS is part of the Institute of Clinical Sciences within Imperial College London's Faculty of Medicine. PhD students are enrolled through Imperial College, giving access to the Graduate School's resources and training. Students benefit from Imperial's infrastructure while conducting research at LMS facilities.

3Imperial Institute of Chemical Biology
Strategic tierSecondaryTypeStrategic or Co-development Partner
Description

Collaborative partner in SAMURII PhD studentships, working with LMS researchers on projects spanning therapeutic resistance in cancer and other interdisciplinary challenges.

lms.mrc.ac.uk
Strategic tierSecondaryTypeStrategic or Co-development Partner
Description

External partner in SAMURII studentships, collaborating on structural investigation of chromatin reprogramming and organization in development research.

Strategic tierSecondaryTypeStrategic or Co-development Partner
Description

Partner in SAMURII studentship programme focusing on measuring heterogeneity of drug uptake at the single-cell level.

Strategic tierMinorTypeStrategic or Co-development Partner
Description

Industrial collaborator with LMS researchers developing microfluidics-mass spectrometry platform for single-cell biomedical challenges.

Strategic tierCoreTypeStrategic or Co-development Partner
Description

LMS researchers utilize UK Biobank's large-scale biomedical database for research, including cardiac MRI imaging data from almost 50,000 participants for cardiovascular genomics studies.

Strategic tierSecondaryTypeStrategic or Co-development Partner
Description

Collaborating institution in companion study published in Nature Cell Biology applying high-resolution genome mapping to human cells.

Strategic tierMinorTypeStrategic or Co-development Partner
Description

Contributing institution to senescent cell research study published in Nature Cell Biology.

10University of Tübingen (M3 Research Centre), Germany
Strategic tierMinorTypeStrategic or Co-development Partner
Description

Collaborating institution contributing to research on exploiting senescent cell vulnerabilities for anticancer therapy.

lms.mrc.ac.uk
Strategic tierSecondaryTypeStrategic or Co-development Partner
Description

International academic partner collaborating on research including En1 gene regulation studies with Professor Stefan Mundlos.

Recent move6 records

Each record includes

Date, Type, Title, Description, Source

Expansion highlight4 records

Each record includes

Type, Description

Peers10 records
1European Molecular Biology Laboratory (EMBL)
TypeDirect peer
Description

Intergovernmental research organisation for molecular life sciences with comparable core facility infrastructure, training programmes, and translational research portfolio. EMBL-EBI is a direct collaborator on the Vaquerizas lab's epigenomics work.

2The Institute of Cancer Research (ICR)
TypeDirect peer
Description

UK research institute focused on cancer biology with strong overlap in molecular biology, structural biology (helicase research), and clinical translation. Operates a similar mix of discovery science and clinical academic training.

TypeDirect peer
Description

UK-based genomics and biomedical research institute with strong overlap in genomics, epigenomics, and large-scale data-driven disease research. Similar funding mix (Wellcome + grants) and similar training/PhD offerings.

TypeDirect peer
Description

US biomedical and genomic research institute with overlapping focus on cardiovascular genomics (James Ware holds a Visiting Scientist appointment there). Comparable in scale, technology platform depth, and translational genomics ambitions.

TypeDirect peer
Description

Berlin-based molecular genetics research institute collaborating with LMS on gene regulation studies (Mundlos lab). Comparable in basic discovery science focus, training programmes, and core facility model.

TypeBroad incumbent
Description

LMS's host institution and parent faculty within which it operates. Provides broader graduate training infrastructure and clinical academic pathways that complement LMS's specialised research training.

TypeDirect peer
Description

MRC-funded biomedical research institute near Cambridge focused on signalling, epigenetics, and immunology. Operates the same MRC core-funded model with comparable training programmes and facility access.

TypeDirect peer
Description

Sister MRC institute in Cambridge focused on molecular biology and structural biology research. Operates under identical MRC/UKRI funding model with comparable size, training programmes, and track record of breakthrough discoveries and Nobel-calibre outputs.

TypeDirect peer
Description

London-based biomedical discovery science institute with a similar mix of research groups, training programmes, and core technology platforms. Both are major UK biomedical research organisations with overlapping disease focus areas and shared talent pools.

TypeDirect peer
Description

CRUK-funded cancer research institute with overlapping funders (Cancer Research UK also funds LMS via Discovery Programme Awards). Similar model of charity-funded discovery science plus training pipelines.

Market position
Strengths5 records

Each record includes

Headline, Details, Source

Weaknesses4 records

Each record includes

Headline, Details, Source

Competitive moat5 records

Each record includes

Type, Details

Key risks6 records

Each record includes

Headline, Details, Source

Key highlights7 records

Each record includes

Headline, Details, Source

Customer concentration

Classification, Details

Named customers3 records

Each record includes

Name, Industry, Type, Use case, Source, UUID

Segment4 records

Each record includes

Title, Type, Primary, Description, Pain point addressed, Use case, Source

Ideal customer profile2 records

Each record includes

Profile, Firmographic size, Sales motion, Sales cycle length, Buying structure, Purchase trigger, Buyer persona, Geography, Industry vertical, Primary use case, Description, Pain points, Evidence proof points, Target buyer

Technology focused
Yes
API detail
Has APIbool
No

Docs URL, Description

AI capability5 records

Each record includes

Type, Description, Source

AI maturity
App detail

Has app

Feature3 records

Each record includes

Title, Differentiator, Description, Source

Core technology
Revenue estimate
Valuation estimate
Number of profiles
Profiles5 records

Each record includes

Name, Designation, Designation category, Overview, Profile commentary, Source

No data
Compliance2 records

Each record includes

Name, Class, Description

Funding overview

Funding stage, Last funding date, Total funding USD

Funding rounds

Each record includes

Round, Amount USD, Date, Pre money valuation, Total investors, Investors, News

Investors

Each record includes

Name, Type, Date of entry, Rounds participated, Website

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Each record includes

Name, Acquisition type, Announced date, Completed date, Status, Website, News

Investment

Each record includes

Name, Round, Announced date, Lead investor, Website, News

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

MRC LMS

Biomedical Research Serviceslms.mrc.ac.uk

MRC LMS firmographics

Firmographics
Name
MRC LMS
Legal name
LMS Laboratory of Medical Sciences
Website
https://lms.mrc.ac.uk
Company type
Private
Founded year
1913
Operating status
Operating
Headcount range
101–250 employees
Ownership category
akta.pro rank

MRC LMS industry classification

Industry
Product category
Biomedical Research Services
NAICS
Scientific Research and Development Services (5417), Research and Development in the Physical, Engineering, and Life Sciences (54171), Research and Development in Biotechnology (except Nanobiotechnology) (541714)
SIC
Services-Commercial Physical & Biological Research (8731)
akta.pro primary industry
Clinical CROs (Phase I–IV) (HLAGAAAA)

Keywords

  • Biomedical research
  • Clinical research training
  • Genomics research
  • PhD programmes
  • Discovery science

Where MRC LMS is headquartered

Location

Headquarters

HQ city
London
HQ country
United Kingdom
HQ region
Europe

Offices1 record

Markets served

MRC LMS business model

Business model
GTM type
B2B
Offering type
Services
Cost components
Personnel, Technology or R&D, Operations, Infrastructure, Supply Chain

Revenue model

  1. MRC Core Funding: The MRC Laboratory of Medical Sciences is a core-funded institute of the Medical Research Council (MRC), part of UK Research and Innovation (UKRI). This provides the primary institutional funding for operations and research.
  2. External Research Grants: Funding from external bodies including Cancer Research UK, British Heart Foundation, Wellcome Trust, NIHR Imperial Biomedical Research Centre, European Research Council, Academy of Medical Sciences, and other grant-making organizations.
  3. PhD Program Support: PhD programs offer students a generous, tax-free stipend of £26,500 per year for four years and cover tuition fees and research consumables. Visa costs covered for overseas students.

Go-to-market motion2 records

Distribution channels3 records

Marketing channels6 records

MRC LMS product offering

Product offering

Core offering

MRC LMS is a publicly funded biomedical research institute that conducts discovery science to advance understanding of human health and disease, bridging fundamental biology with translational and clinical research. It operates core research facilities (Bioinformatics, Flow Cytometry, Genomics, MR Imaging, Metabolomics, Microscopy, Proteomics, and others) and offers research training programmes (PhD, Chain Florey clinician scientist, postdoctoral, and graduate pathways) hosted at Imperial College London's Hammersmith campus.

Product overview

MRC Laboratory of Medical Sciences (LMS) is a research institute offering training programmes and research infrastructure rather than commercial products. Its portfolio includes: the Science Technology Graduate Programme for early-career graduates; three PhD Training Programmes (Core, Transdisciplinary, and Team Science); the Chain Florey Clinician Scientist Programme providing structured clinical academic career development; postdoctoral training with various fellowship schemes; and Core Research Facilities providing access to advanced technologies including bioinformatics, genomics, imaging, and proteomics platforms. These offerings are interconnected through the institute's research groups and facilities, enabling discovery science for human health.

Differentiator

Problem solved

Functional benefit

Brands

  • Chain Florey Programme: A clinician scientist training programme named in honor of Howard Florey and Ernst Chain, Nobel Prize winners for penicillin development
  • Science Technology Graduate Programme

Products and services

  • PhD Programme Funded doctoral research training programme at MRC LMS, providing PhD students with mentorship, access to core research facilities, and integration with Imperial College London for advanced biomedical discovery science.
  • Chain Florey Clinician Scientist Programme Clinician scientist training programme managed by Aurelie Tromp at MRC LMS, offering funded research fellowships for medical clinicians pursuing research careers.
  • Postdoctoral Training Postdoctoral research positions at MRC LMS, providing early-career researchers with project-based research roles, access to core facilities, and mentorship from group heads.
  • Graduate Programme Graduate-level research training programme at MRC LMS, offering structured research experience and exposure to the institute's thematic research areas.
  • Core Research Facilities Shared core research facilities operated by MRC LMS for institute researchers and collaborators, spanning Bioinformatics, Flow Cytometry, Genomics, MR Imaging, Metabolomics, Microscopy, Proteomics, and related capabilities supporting discovery and translational science.

Quantifiable outcome

  • Returned genetic diagnosis to many families with previously unexplained heart disease
  • +3 more outcomes

Companies that use MRC LMS

Customer profile

Named customers3 records

Segments4 records

Ideal customer profiles2 records

MRC LMS technology and API

Technology

Technology focussed Yes

API detail

Has API
No
API docs
API detail

Core technology

AI maturity

App detail

AI capability5 records

Feature3 records

MRC LMS partnerships and signals

Strategic signal

Partnerships

Eleven partnerships are on record, tiered core, secondary and minor.

  • SAMURII (Strategic Alliance of MRC-University Research Investments at Imperial)coreStrategic or Co-development Partner · 3 August 2021Joint initiative between LMS and the Institute of Clinical Sciences to support interdisciplinary PhD studentships. Jointly funded by LMS and ICS, the scheme develops new partnerships with focus on innovation across traditional discipline boundaries.
  • Imperial College LondoncoreStrategic or Co-development PartnerLMS is part of the Institute of Clinical Sciences within Imperial College London's Faculty of Medicine. PhD students are enrolled through Imperial College, giving access to the Graduate School's resources and training. Students benefit from Imperial's infrastructure while conducting research at LMS facilities.
  • Imperial Institute of Chemical BiologysecondaryStrategic or Co-development PartnerCollaborative partner in SAMURII PhD studentships, working with LMS researchers on projects spanning therapeutic resistance in cancer and other interdisciplinary challenges.
  • Rosalind Franklin InstitutesecondaryStrategic or Co-development PartnerExternal partner in SAMURII studentships, collaborating on structural investigation of chromatin reprogramming and organization in development research.
  • MRC Centre for Environment and HealthsecondaryStrategic or Co-development PartnerPartner in SAMURII studentship programme focusing on measuring heterogeneity of drug uptake at the single-cell level.
  • VWR International LimitedminorStrategic or Co-development PartnerIndustrial collaborator with LMS researchers developing microfluidics-mass spectrometry platform for single-cell biomedical challenges.
  • UK BiobankcoreStrategic or Co-development PartnerLMS researchers utilize UK Biobank's large-scale biomedical database for research, including cardiac MRI imaging data from almost 50,000 participants for cardiovascular genomics studies.
  • ETH ZürichsecondaryStrategic or Co-development PartnerCollaborating institution in companion study published in Nature Cell Biology applying high-resolution genome mapping to human cells.
  • Institute of Oncology Research (IOR), Bellinzona, SwitzerlandminorStrategic or Co-development PartnerContributing institution to senescent cell research study published in Nature Cell Biology.
  • University of Tübingen (M3 Research Centre), GermanyminorStrategic or Co-development PartnerCollaborating institution contributing to research on exploiting senescent cell vulnerabilities for anticancer therapy.
  • Max Planck Institute for Molecular GeneticssecondaryStrategic or Co-development PartnerInternational academic partner collaborating on research including En1 gene regulation studies with Professor Stefan Mundlos.

Scale indicators4 records

Recent moves6 records

Expansion highlights4 records

MRC LMS competitors and assessment

Company assessment

Direct peers

  • European Molecular Biology Laboratory (EMBL): Intergovernmental research organisation for molecular life sciences with comparable core facility infrastructure, training programmes, and translational research portfolio. EMBL-EBI is a direct collaborator on the Vaquerizas lab's epigenomics work.
  • The Institute of Cancer Research (ICR): UK research institute focused on cancer biology with strong overlap in molecular biology, structural biology (helicase research), and clinical translation. Operates a similar mix of discovery science and clinical academic training.
  • Wellcome Sanger Institute: UK-based genomics and biomedical research institute with strong overlap in genomics, epigenomics, and large-scale data-driven disease research. Similar funding mix (Wellcome + grants) and similar training/PhD offerings.
  • Broad Institute of MIT and Harvard: US biomedical and genomic research institute with overlapping focus on cardiovascular genomics (James Ware holds a Visiting Scientist appointment there). Comparable in scale, technology platform depth, and translational genomics ambitions.
  • Max Planck Institute for Molecular Genetics: Berlin-based molecular genetics research institute collaborating with LMS on gene regulation studies (Mundlos lab). Comparable in basic discovery science focus, training programmes, and core facility model.
  • Babraham Institute: MRC-funded biomedical research institute near Cambridge focused on signalling, epigenetics, and immunology. Operates the same MRC core-funded model with comparable training programmes and facility access.
  • MRC Laboratory of Molecular Biology (LMB): Sister MRC institute in Cambridge focused on molecular biology and structural biology research. Operates under identical MRC/UKRI funding model with comparable size, training programmes, and track record of breakthrough discoveries and Nobel-calibre outputs.
  • Francis Crick Institute: London-based biomedical discovery science institute with a similar mix of research groups, training programmes, and core technology platforms. Both are major UK biomedical research organisations with overlapping disease focus areas and shared talent pools.
  • Cancer Research UK Cambridge Institute: CRUK-funded cancer research institute with overlapping funders (Cancer Research UK also funds LMS via Discovery Programme Awards). Similar model of charity-funded discovery science plus training pipelines.

Broad incumbents

  • Imperial College London Faculty of Medicine: LMS's host institution and parent faculty within which it operates. Provides broader graduate training infrastructure and clinical academic pathways that complement LMS's specialised research training.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

MRC LMS social profiles

Digital presence

MRC LMS compliance and trust

Trust signal

Compliance2 records

MRC LMS financial estimates

Financial estimate

Revenue estimate

Valuation estimate

MRC LMS leadership team

Management profile

Number of profiles

Profiles5 records

MRC LMS funding detail

Funding detail

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

MRC LMS M&A and investment

M&A and investment

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about MRC LMS

What does MRC LMS do?

MRC LMS is a publicly funded biomedical research institute that conducts discovery science to advance understanding of human health and disease, bridging fundamental biology with translational and clinical research. It operates core research facilities (Bioinformatics, Flow Cytometry, Genomics, MR Imaging, Metabolomics, Microscopy, Proteomics, and others) and offers research training programmes (PhD, Chain Florey clinician scientist, postdoctoral, and graduate pathways) hosted at Imperial College London's Hammersmith campus.

Is MRC LMS a public or private company?

MRC LMS is a private company. It is classified as state government owned and is currently operating.

When was MRC LMS founded?

MRC LMS was founded in 1913. It employs 101 to 250 people.

Where is MRC LMS based?

MRC LMS is headquartered in London, United Kingdom, in the Europe region.

How does MRC LMS make money?

Three revenue lines are on record. MRC Core Funding is the primary driver. The others are external Research Grants and phD Program Support.

Who are MRC LMS's main competitors?

Direct peers on record are European Molecular Biology Laboratory (EMBL), The Institute of Cancer Research (ICR), Wellcome Sanger Institute, Broad Institute of MIT and Harvard, Max Planck Institute for Molecular Genetics, Babraham Institute, MRC Laboratory of Molecular Biology (LMB), Francis Crick Institute and Cancer Research UK Cambridge Institute. Imperial College London Faculty of Medicine is listed as a broad incumbent.

Does MRC LMS have an API?

No public API is recorded for MRC LMS.

What industry is MRC LMS in?

MRC LMS's product category is Biomedical Research Services. Its primary akta.pro industry code is HLAGAAAA, Clinical CROs (Phase I–IV). Its NAICS code is 5417 and its SIC code is 8731.

Unlock the full company data

50 free credits on sign-up, no credit card required.

Contact sales
Live signals
Mirage News3D Genome Mapping in Immune Cells Unveils Autoimmune GenesResearchers from the MRC Laboratory of Medical Sciences and Imperial College London, in collaboration with institutions across Europe and the USA, have identified over 100 genes linked to autoimmune conditions such as Crohn's disease by mapping 3D DNA folding in rare immune cells called ILC3s. The team developed a new technology called mini-Capture Hi-C that allowed analysis of these rare cells, identifying both known disease genes and approximately 50 genes not previously associated with Crohn's disease. Among the newly identified genes is CLN3, previously linked only to the neurodegenerative disorder Batten disease, revealing a previously unrecognized role in the immune system that could inform future treatments.Mirage NewsNovel Method Unlocks Rare Immune Cells for StudyA study led by researchers at Cincinnati Children's and the MRC Laboratory of Medical Sciences developed a new genomic method to analyze three-dimensional DNA interactions in rare immune cells, specifically ILC3s, which are linked to autoimmune diseases. The approach revealed that DNA regulatory elements can influence gene activity over long distances and differ between cell types, aiding understanding of disease mechanisms. The study identified over 100 candidate genes associated with Crohn's disease risk, including CLN3, raising questions about its potential role in immune regulation and neurodevelopmental pathways.GenengnewsGenome Mapping Reveals Autoimmune Disease Risk Genes in Innate Lymphoid CellsResearchers from Cincinnati Children's Hospital and the MRC Laboratory of Medical Sciences at Imperial College London published a study in Nature Genetics using a low-input Promoter Capture Hi-C method to map long-distance DNA interactions in rare immune cells called ILC3s, overcoming previous limitations that required millions of cells. The analysis linked Crohn's disease risk variants to over 100 candidate genes in ILC3s, including CLN3 (a gene typically associated with Batten disease), demonstrating that disease risk variants may regulate genes far from their genomic location. The researchers extended this approach to five additional autoimmune conditions, creating a catalog of ILC3-linked risk genes that could help move genetic findings from association toward mechanistic understanding of autoimmune diseases.Mirage NewsScientists Uncover Dormant Cancer Cells' HideoutsResearchers at the MRC Laboratory of Medical Sciences, Imperial College London and UCL Genetics Institute created a detailed map of breast cancer tumours, identifying distinct neighbourhoods of proliferating and dormant cancer cells. The study, published in Genome Medicine, found that dormant 'quiescent' cancer cells are surrounded by protective immune and connective cells that may shield them from chemotherapy and allow recurrence. The findings suggest future therapies may need to target both cancer cell states and their surrounding protective microenvironments to prevent tumour relapse.News-MedicalExploiting a new weakness in 'zombie-like' cells to treat senescence-associated diseasesResearchers identified a new weakness in senescent cells, exploiting GPX4-dependent ferroptosis to kill them. Testing 10,000 covalent compounds, they found three drugs that block GPX4, reducing tumor size and improving survival in three mouse cancer models. The approach could complement existing cancer treatments.EIN PresswireVivan Therapeutics and the MRC Laboratory of Medical Sciences Announce a Pioneering PartnershipVivan Therapeutics and the MRC Laboratory of Medical Sciences have announced a pioneering research partnership to investigate how KRAS mutations, diabetes, and diet influence chemotherapy responses in cancer patients. Vivan Therapeutics will contribute its automated in vivo screening platform, which uses genetically modified fruit flies carrying human cancer mutations to rapidly test hundreds of thousands of drug combinations. The collaboration aims to develop personalized cancer treatment recommendations specifically for patients with Type 2 diabetes or obesity, supported by the MRC's Business Engagement Fund.PharmiWeb.comVivan Therapeutics and the MRC Laboratory of Medical Sciences Announces a Pioneering Partnership to Explore How Specific Cancer Mutations, Diabetes & Diet Influence Drug ResponseVivan Therapeutics and the MRC Laboratory of Medical Sciences announced a partnership to investigate how KRAS gene mutations, diabetes, and diet influence responses to cancer drugs. The collaboration will use Vivan's fly model platform to test how different Ras mutations respond to treatments in metabolic contexts. The initiative aims to develop personalized cancer therapies for patients with conditions like obesity and diabetes.Imperial College LondonMoving Tips from our New Neighbours at HammersmithThe MRC Laboratory of Medical Sciences at Imperial College London completed its move to a new purpose-built facility on the Hammersmith campus in September 2022. The National Heart and Lung Institute is scheduled to follow later this year, aiming to consolidate research groups within the same building to enhance collaboration and morale.SiliconANGLEArtificial intelligence used to predict death rates of heart patients - SiliconANGLEResearchers at the MRC London Institute of Medical Sciences used machine learning to predict mortality in pulmonary hypertension patients, achieving 80% accuracy on MRI scans versus 60% for doctors. The AI analyzed over 30,000 data points per heartbeat, and the UK is testing such medical AI applications.