What Bioteck does

Bioteck S.p.A. is a privately held Italian medical device manufacturer founded in 1995 and headquartered in Arcugnano (Vicenza), with its primary R&D and production operations at a 2,000+ square-meter multifunctional facility in Riva presso Chieri (Turin) that includes 250 square meters of clean rooms. The company designs, develops, and produces biological tissue substitutes for regenerative surgery across three medical specialties: dentistry (periodontal, peri-implant, and bone-regeneration applications), orthopedics (cartilage and bone regeneration, joint infiltration), and neurosurgery (spinal and dural procedures). Its core technology is Zymo-Teck®, a patented enzymatic deantigenation process (UIBM no. 0001413858) that makes equine-derived bone and pericardium tissue biocompatible without chemical solvents or high temperatures, followed by beta-ray sterilization; this platform underlies the company's 15+ branded products including Heart®, MeRG®, Flex Cortical Sheet, H42®, CHondroGrid®, Osteoxenon®, Bio-Gen®, Calcitos®, Xenomatrix®, Activabone®, Angiostad®, and Synt®.

Bioteck generates revenue exclusively through direct sales and a network of qualified distribution partners operating in over 70 countries, selling to a long-tail base of healthcare professionals (surgeons, dentists, periodontists, hospitals). Pricing is not publicly disclosed and is handled through commercial inquiry. The company is ISO 13485:2016 certified (through 2028), holds ANVISA certification for Brazil, and is pursuing FDA and CFDA clearances for US and China entry. Cumulative operating scale includes 2,000,000+ pieces used in regenerative interventions, 500+ clinical scientific publications, and 2,000+ surgeries documented in peer-reviewed literature with follow-up to 13 years, supporting clinical-evidence-based marketing through the Bioteck Academy training platform and active participation in major industry congresses (EAO, IDS, ESSKA, EUROPERIO). Recent product launches — H42® (2023), Flex Cortical Sheet (2024), CHondroGrid® (2025), and Heart®/MeRG® (2026) — indicate ongoing portfolio expansion into adjacent regenerative-medicine categories.

Name

Bioteck

Legal name

BIOTECK S.p.A.

Website

https://bioteck.com

Company type

Private

Founded year

1995

Operating status

Operating

Headcount range

11–50 employees

Short description

Bioteck is an Italian privately held medical device manufacturer (founded 1995) that designs and produces equine-derived tissue substitutes for regenerative dentistry, orthopedics, and neurosurgery, sold through distribution partners in 70+ countries. Its proprietary Zymo-Teck® enzymatic process underpins 15+ branded products including bone grafts, membranes, and hydrogels.

Ownership category

akta.pro rank

Product category

Regenerative Medicine Medical Devices

NAICS

Surgical Appliance and Supplies Manufacturing (339113), Biological Product (except Diagnostic) Manufacturing (325414)

SIC

Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842), Biological Products, (No Disgnostic Substances) (2836)

akta.pro primary industry

Tissue-Engineered Constructs & Scaffolds (natural/synthetic biomaterials) (HLAAAGAB)

akta.pro secondary industries

Cartilage, Bone & Musculoskeletal Regeneration (HLAAAGAH), Bone Graft Substitutes & Orthobiologics (Synthetic/Allograft/DBM) (HLAHAEAG), Periodontal Regeneration (GTR/EMD/Biologics) (HLABACAI), Regenerative Immunology & Inflammation Modulation (pro-regenerative biologics) (HLAAAGAL)

Keywords

• Bone graft substitutes
• Regenerative medicine devices
• Collagen membranes
• Equine tissue grafts
• Dental biomaterials

Headquarters

HQ city

Arcugnano

HQ country

Italy

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Supply Chain, Operations, Personnel, Marketing or Sales

Revenue model

1. Medical Devices Sales: Bioteck generates revenue through the sale of biological medical devices including bone grafts, collagen membranes, hydrogels, and other tissue substitutes for regenerative surgery applications in dentistry, orthopedics, and neurosurgery.

Go-to-market motion1 record

Distribution channels2 records

Marketing channels6 records

Core offering

Bioteck designs, develops, and manufactures biological and synthetic tissue substitutes — including bone grafts, collagen membranes, hydrogels, bone pastes, and an infiltrative collagen device — for regenerative surgery in dentistry, orthopedics, and neurosurgery. Products are produced from equine-derived tissues processed through the company's proprietary Zymo-Teck® enzymatic deantigenation technology and sold under multiple branded lines.

Product overview

Bioteck is a medical device manufacturer specializing in regenerative medicine and tissue substitutes since 1995. The company operates as a portfolio of distinct product lines across three medical specialties: Dentistry (periodontal treatments, bone grafts, membranes), Orthopedics (bone pastes, cartilage regeneration, joint treatments), and Neurosurgery (spine and dural substitutes). The core technology platform is Zymo-Teck®, a proprietary enzymatic deantigenation process that makes equine-derived tissues biocompatible while preserving collagen and mineral components. Key products include: H42® collagen hydrogel for periodontal pockets; Flex Cortical Sheet flexible bone sheets; Heart® pericardium membrane; MeRG® collagen membrane for cartilage defects; Bio-Gen® hydrolyzed collagen bone graft; Osteoxenon® preserved collagen bone graft; CHondroGrid® hydrolyzed collagen for joint injection; plus synthetic lines (Synt® beta-TCP) and bone pastes (Activabone®, Angiostad®). Products are sold in over 70 countries worldwide.

Differentiator

Problem solved

Functional benefit

Brands

• Heart®: Biological membrane obtained from equine pericardium for bone regeneration surgical procedures
• MeRG®
• H42®
• Osteoxenon®
• Bio-Gen®
• Flex Cortical Sheet
• CHondroGrid®
• Calcitos®
• Xenomatrix®
• Awayr®
• Synt®
• Zymo-Teck®
• Osteoplant® Spine
• Heart® DM
• Activabone®
• Bioteck Academy

Products and services

• H42® Collagen Hydrogel Innovative collagen-based hydrogel in syringe for the non-surgical treatment of periodontal and peri-implant pockets. Extruded via luer-lock syringe with compatible needles (Gauge 20-27). Targets dental professionals treating periodontal disease.
• Flex Cortical Sheet Flexible cortical bone sheets derived from equine bone via Zymo-Teck® enzymatic deantigenation. Becomes flexible upon hydration in saline solution. Sizes 21-25 x 23-27 mm, available in 3 thicknesses for periodontal/peri-implant, horizontal GBR/alveolar preservation, and complex GBR applications. Acts as barrier for up to 6 months.
• Heart® Pericardium Membrane Biological membrane obtained from authentic equine pericardium with multi-layer structure and identical surfaces on both sides. Provides bone graft protection for 3-4 months while acting as substrate for tissue regeneration. Suitable for GBR/GTR procedures in dentistry, orthopedics and neurosurgery.
• MeRG® Collagen Membrane Double-layer collagen membrane (type I from equine tendon) for guided regeneration of osteochondral defects. Used with bone marrow stimulation techniques (microfractures). For Grade III-IV cartilage lesions with subchondral bone involvement, defect size >2cm², depth 5-6mm.
• Osteoxenon® Bone Graft Heterologous bone graft with preserved collagen. Enzymatic deantigenation via Zymo-Teck® process preserves bone collagen and mineral component. Enables total remodeling with patient's bone.
• Bio-Gen® Bone Graft Hydrolyzed collagen heterologous bone graft. Natural, biocompatible and osteoconductive scaffold for complete bone remodeling.
• CHondroGrid® Infiltrative Device Infiltrative device made of hydrolyzed collagen for pain relief and functional recovery of major joints and musculo-tendineous-ligamentous structures.
• Calcitos® Bone Substitute Slow-absorbing equine bone substitute obtained by heat treatment. Long-lasting bone substitute for regenerative procedures.
• Osteoplant® Spine Biological bone graft for spine surgery with total biocompatibility, ideal osteoconduction, and complete remodeling.
• Heart® DM Dural Matrix Biological matrix for dural replacement in neurosurgery.
• Xenomatrix® Collagen Matrix Three-dimensional collagen matrix for guided tissue regeneration.
• Synt® Synthetic Bone Graft Synthetic bone graft line based on beta-tricalcium phosphate for regenerative surgery.
• Activabone® Bone Paste New generation visco-modulated bone pastes for orthopedic applications.
• Angiostad® Bone Paste Biocompatible and osteopromotive bone pastes for bone regeneration in orthopedics.
• Awayr® Perfusion System Perfusion system capable of saturating any type of porous biomaterial with biological fluids or solutions, addressing the risk of air remaining in traditionally soaked biomaterials.

Quantifiable outcome

• 500+ clinical scientific publications support product efficacy
• +2 more outcomes

Named customers1 record

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Two partnerships are on record, tiered minor and core.

• Laboratorios NormonminorChannel Partner/ Reseller/ Distributor · 1 January 2023Bioteck collaborated with Laboratorios Normon at the XX SECIB Congress in Spain (2023) for the distribution and promotion of products in the Spanish market.
• Qualified Commercial Partners (70+ countries)coreChannel Partner/ Reseller/ Distributor · 1 January 2013Bioteck maintains a network of qualified and prestigious commercial partners in over 70 countries who handle local sales, distribution, and customer support for Bioteck medical devices.

Scale indicators5 records

Recent moves10 records

Expansion highlights4 records

Direct peers

• Geistlich Pharma: Swiss-headquartered leader in dental bone regeneration and collagen membranes (Bio-Oss®, Bio-Gide®). Highly comparable to Bioteck in serving dental/oral surgeons with xenogeneic and collagen-based regenerative materials in the same GBR/periodontal use cases.
• Integra LifeSciences: US-listed regenerative medicine specialist in dural repair (DuraGen®), neurosurgery, and orthopedic soft tissue. Directly comparable to Bioteck's Heart® DM dural membrane and Osteoplant® Spine portfolio, with overlap in neurosurgery and regenerative biologics.
• RTI Surgical: Tissue-based implant manufacturer producing allograft and xenograft bone grafts, sports medicine, and surgical specialties. Comparable to Bioteck in selling tissue-derived regenerative materials across orthopedics, dental, and surgical channels.
• LifeNet Health: Non-profit tissue banking organization providing allograft bone grafts, dermal matrices, and cardiac/orthopedic tissue implants. Comparable to Bioteck in processing biological tissue into regenerative surgical products, though primarily human-derived rather than equine.
• botiss biomaterials: German dental regeneration specialist offering bone grafts (cerabone®, maxgraft®), collagen membranes (Jason®), and soft-tissue substitutes for GBR and periodontal applications. Closely comparable niche competitor to Bioteck's dental product lines.
• NovaBone Products: US-based manufacturer of synthetic bone graft substitutes (calcium phosphosilicate-based NovaBone®) sold across dental, orthopedic, and trauma channels. Comparable niche peer to Bioteck in delivering regenerative bone graft materials to dental and orthopedic surgeons, with a primarily synthetic focus.

Broad incumbents

• Stryker: Global orthopedic and surgical medtech incumbent with broad regenerative medicine and biologics offerings. Comparable as a large established player overlapping Bioteck in orthopedic bone graft substitutes and surgical implants, but with vastly broader product portfolio.
• Medtronic: Largest medical device company globally with significant spine, neurosurgery, and biologics businesses (INFUSE® bone graft). Comparable in serving the same spine and neurosurgery customers as Bioteck's Osteoplant® Spine and Heart® DM, but at massive scale.
• Johnson & Johnson (DePuy Synthes): Orthopedic and neurosurgery franchise of J&J offering trauma, spine, sports medicine, and biologics. Comparable to Bioteck in orthopedic and neurosurgical regenerative materials, but as part of a multi-billion-dollar diversified medtech portfolio.
• Zimmer Biomet: Global orthopedic reconstructive and surgical devices leader with regenerative and biologic offerings. Overlaps with Bioteck in orthopedic bone graft substitutes and sports medicine regenerative products.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• YouTubeyoutube.com/channel/UCQR6xnoJBYW5ADRDM3qyDfA

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Bioteck