KeyHIE

What KeyHIE does

KeyHIE (Keystone Health Information Exchange) is a Danville, Pennsylvania-based Health Information Organization founded in 2005 that operates a regional health information exchange platform serving healthcare providers and health plans across Pennsylvania and New Jersey. The platform is built around a centralized exchange of clinical documents, secure provider-to-provider messaging, role-based notifications for hospital admissions, ER visits, and preventative care reminders, EHR publishing, and a gateway to the eHealth Exchange (Sequoia Project) and the PA Patient & Provider Network (P3N). KeyHIE offers modular products including a Clinical Document Viewer, Summary Viewer, DIRECT Secure Messaging, Notifications & Information Delivery Service, Role-Based Notifications, EHR Publisher, ACO Partnering, PA Navigate, Payor Partnering, and KeyHIE Transform modules tailored to EMS providers and Long-Term Post-Acute Care/Home Health providers. Governance is provided by a board and steering committee composed of executives from major participating systems including Geisinger, Guthrie, Penn State Health, Wellspan Evangelical Community Hospital, Highmark Health, and others.

The organization serves over 8.6 million patients and provides access to over 10 million electronic health records through a single online login. Its technology stack emphasizes interoperability (clinical document exchange, FHIR-based integrations) and security (HIPAA, HITECH, NIST 800-53, TLS 1.2), with strategic technology partnerships including Life Image for diagnostic imaging, NextGate for EMPI/patient matching, and VorroHealth for EMS data delivery.

KeyHIE's revenue model is subscription-based: healthcare facilities sign a Memorandum of Understanding to become participants, with annual subscription fees covering access to the HIE network and its product modules. The go-to-market is enterprise field sales targeting hospitals, physician practices, hospice, long-term care, urgent care centers, EMS providers, and health plans. The organization is privately held, incorporated in Pennsylvania as KeyHIE Inc. in 2013, and operates with 11-50 employees. KeyHIE is a consortium-governed entity rather than a venture-backed startup, with Geisinger serving as a founding/backing organization and multiple board and steering committee representatives drawn from participating member systems.

Name

KeyHIE

Legal name

KeyHIE Inc.

Website

https://keyhie.org

Company type

Private

Founded year

2005

Operating status

Operating

Headcount range

11–50 employees

Short description

KeyHIE (Keystone Health Information Exchange) is a Pennsylvania-based Health Information Organization founded in 2005 that operates a regional health information exchange platform, enabling secure clinical document sharing, notifications, and EHR interoperability for healthcare providers, payers, and EMS/LTPAC organizations across Pennsylvania and New Jersey, serving 8.6 million+ patients.

Ownership category

akta.pro rank

Product category

Health Information Exchange

SIC

Services-Health Services (8000), Services-Misc Health & Allied Services, Nec (8090)

akta.pro primary industry

HIE Platforms & Network Services (Community/Regional/National) (HLACABAB)

akta.pro secondary industries

Patient-Mediated Exchange & Personal Health Data Access (Blue Button, SMART on FHIR) (HLACABAN), API Management & Developer Portals for Health Data (HLACABAD), Health Information Exchange & Public Health Data Integration (HLAJAJAD)

Keywords

• Health information exchange
• Clinical interoperability
• Care coordination
• Secure health messaging
• Electronic health records

Headquarters

HQ city

Danville

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Marketing or Sales

Revenue model

1. Healthcare Provider Membership/Subscription: KeyHIE operates as a Health Information Organization (HIO) governed by a Memorandum of Understanding. Member organizations (hospitals, physicians, health plans, etc.) pay to participate and gain access to the HIE network for secure health information exchange.

Pricing tiers

Go-to-market motion1 record

Distribution channels1 record

Marketing channels4 records

Core offering

KeyHIE (Keystone Health Information Exchange) operates a Health Information Organization (HIO) platform that enables secure, interoperable exchange of patient health records among healthcare providers across Pennsylvania and New Jersey. Healthcare facilities become KeyHIE participants by signing a Memorandum of Understanding and receive access to clinical document exchange, role-based notifications, DIRECT secure messaging, EHR publishing, and care coordination tools serving over 8.6 million patients and 10 million+ electronic health records.

Product overview

KeyHIE (Keystone Health Information Exchange) is a comprehensive health information exchange platform offering a modular portfolio of products and services designed to facilitate interoperability across healthcare providers. The core offering centers on the PA Patient & Provider Network (P3N), a statewide health information exchange network, supplemented by specialized modules including clinical document viewing, secure messaging, EHR publishing, care coordination tools (ACO Partnering, PA Navigate, Payor Partnering), notification services (Role-Based Notifications, KeyHIE Notifications), and specialized data transformation for EMS and LTPAC/Home Health providers. The platform connects hundreds of participating providers and offers access to over 10 million electronic health records across Pennsylvania and New Jersey, serving over 8.6 million patients.

Differentiator

Problem solved

Functional benefit

Brands

• PA Navigate: Care coordination service
• PA Patient & Provider Network (P3N)
• KeyHIE Transform

Products and services

• PA Patient & Provider Network (P3N) Pennsylvania statewide health information exchange network connecting providers across the Commonwealth and serving as KeyHIE's core offering for cross-organizational patient data sharing.
• Clinical Document Viewer Web-based tool enabling healthcare providers to view clinical documents exchanged through the KeyHIE network, including lab results, summary of care records, and specialist consult documents.
• DIRECT Secure Messaging Secure messaging service that enables healthcare provider-to-provider communication and information exchange within the KeyHIE network using the DIRECT Trust protocol.
• EHR Publisher Service enabling provider EHR systems to publish clinical data to the KeyHIE exchange so records are accessible to other participating providers.
• eHealth Exchange Gateway (The Sequoia Project) Gateway service connecting KeyHIE to the eHealth Exchange network operated by The Sequoia Project, enabling national-level health information exchange.
• KeyHIE Notifications & Information Delivery Service Real-time notification service delivering clinically relevant patient information such as hospital admissions, ER visits, and preventative care reminders to healthcare providers.
• Role-Based Notifications/Reminders Notification service that sends real-time clinically relevant information to patients, physicians, and healthcare professionals including hospital admissions, ER visits, and preventative care reminders.
• Summary Viewer High-level summary view of clinical documents specific to each patient, including lab-test results, summary of care records, and specialist consult documents, accessible via web browser on laptop, desktop, or iPad.
• KeyHIE Transform – EMS providers Specialized data transformation and delivery service for Emergency Medical Services (EMS) providers enabling real-time patient information delivery during emergency response.
• KeyHIE Transform – LTPAC & Home Health Data transformation service for Long-Term Post-Acute Care (LTPAC) and Home Health providers to enable care coordination and real-time information delivery.
• PA Navigate

Named customers9 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature7 records

Partnerships

Three partnerships are on record, tiered core.

• GuthriecoreStrategic or Co-development Partner · 6 April 2021Guthrie, a healthcare system, joined KeyHIE as a participant member to contribute to and access the health information exchange network serving Pennsylvania and New Jersey.
• Penn State HealthcoreStrategic or Co-development Partner · 6 April 2021Penn State Health joined KeyHIE to participate in the health information exchange network, enabling care coordination across the KeyHIE provider community.
• Life ImagecoreTechnology or Integration · 29 October 2019KeyHIE partnered with Life Image to implement a first-of-its-kind FHIR-based imaging app enabling the first national implementation of sharing diagnostic imaging content in a provider portal. This partnership allows patients to request, store, and share breast health records through KeyHIE's system-wide network using Geisinger's Mammosphere software.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• HealthShare Exchange: Regional health information exchange serving the Greater Philadelphia and PA/NJ area. Closest geographic and operational peer to KeyHIE - both operate community HIE platforms serving overlapping provider networks in the mid-Atlantic.
• CRISP (Chesapeake Regional Information System for our Patients): Maryland-based regional HIE serving providers, hospitals, and state agencies. Closely comparable operating model - nonprofit/government-anchored HIE offering clinical data exchange, notifications, and population health tools across a defined state footprint.
• Indiana Health Information Exchange (IHIE): One of the largest and longest-running U.S. HIEs, founded in 2004. Comparable to KeyHIE on longevity, scale of records managed, and diversified product set spanning clinical messaging, analytics, and population health.
• CORHIO: Colorado Regional Health Information Organization - state-anchored HIE providing clinical data exchange, notifications, and care coordination tools. Highly comparable nonprofit regional HIE operating model with subscription-based participant funding.
• Manifest MedEx: California-based nonprofit HIE offering clinical data exchange, notifications, and quality reporting to providers, health plans, and ACOs. Comparable scale and product portfolio to KeyHIE, focused on a defined state geography.
• Health Current: Arizona health information exchange serving providers, hospitals, and health plans with clinical document exchange, alerts, and population health tools. Direct peer as a state-focused HIE with subscription membership model.
• MiHIN (Michigan Health Information Network Shared Services): Michigan's state-designated HIE offering Active Care Relationship Service, notifications, and statewide interoperability. Comparable to KeyHIE in serving as state-level infrastructure for clinical data exchange among diverse provider types.
• CyncHealth: Nebraska and Iowa-based HIE (formerly Nebraska Health Information Initiative). Comparable regional HIE model with provider, health plan, and state agency participants exchanging clinical data across a defined multi-state footprint.

Broad incumbents

• CommonWell Health Alliance: National EHR-vendor-led interoperability network (founded by Cerner, athenahealth, etc.) providing person-record lookup and document exchange across participating EHRs. Broader incumbent competing with regional HIEs on cross-organization data exchange.
• Bamboo Health (formerly Appriss Insights): Real-time care intelligence and health information network connecting providers, payers, pharmacies, and government agencies. Broader incumbent with overlapping capabilities in care coordination notifications and behavioral health data exchange.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutu.be/uGADVs41ujU
• LinkedInlinkedin.com/company/keystone-health-information-exchange-inc

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles11 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about KeyHIE