Hybrigenics Services
Hybrigenics Services is a French bio-research services firm providing fee-for-service yeast two-hybrid protein interaction screening and synthetic nanobody (VHH) selection to academic, pharmaceutical, and agro-science customers worldwide via proprietary ULTImate Y2H, YChemH, and Hybribody platforms.
- Company typePrivate
- Founded2000
- HeadquartersÉvry, France
- Headcount11–50
- GTM typeB2B
- OfferingServices
What Hybrigenics Services does
Hybrigenics Services SAS is a privately held French bio-research services company headquartered at the Genopole Biopark in Evry-Courcouronnes, with regional offices in Boston (USA) and Kobe (Japan). Founded approximately 25 years ago, the company provides fee-for-service protein interaction discovery and synthetic nanobody (VHH) selection for academic research institutes, pharmaceutical and biotechnology companies, and agro-science laboratories worldwide. Its core technology platforms — ULTImate Y2H™ for exhaustive yeast two-hybrid screening of protein-protein, protein-DNA, protein-RNA, and small molecule interactions; YChemH for drug target deconvolution; Y2HChem for molecular glue and PROTAC interaction profiling; and Hybribody™ for animal-free synthetic nanobody selection — are supported by a content library spanning more than 130 cDNA libraries across 35 species, including 600+ human E3 ligases and a 14-million-clone cyclic peptide collection.
The company generates revenue primarily through professional services contracts: each customer engagement is a custom research project with quote-based pricing determined by service type, library complexity, and experimental scope. Sales are conducted directly via in-house scientific experts, with regional offices supporting North American and Japanese customers, and demand generation driven largely by scientific conference participation, customer publication showcasing, and a website resource center. The business has accumulated 3,000+ customers and 10,000+ screens over its history, with 700+ peer-reviewed customer publications as of 2025. Hybrigenics Services operates without disclosed institutional funding or a parent company, led by President Jean-Christophe Rain, and has expanded selectively through academic partnerships (e.g., Institut Curie, ANR-funded consortia) and one channel partnership for reagent commercialization (Nanotag GmbH for Ub-Selectors).
Hybrigenics Services firmographics
Firmographics- Name
- Hybrigenics Services
- Legal name
- Hybrigenics Services SAS
- Website
- https://hybrigenics-services.com
- Company type
- Private
- Founded year
- 2000
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Hybrigenics Services is a French bio-research services firm providing fee-for-service yeast two-hybrid protein interaction screening and synthetic nanobody (VHH) selection to academic, pharmaceutical, and agro-science customers worldwide via proprietary ULTImate Y2H, YChemH, and Hybribody platforms.
- Ownership category
- akta.pro rank
Hybrigenics Services industry classification
Industry- Product category
- Contract Research Services
- NAICS
- Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- SIC
- Services-Commercial Physical & Biological Research (8731)
- akta.pro primary industry
- High-Throughput Screening & Assay Platforms (HTS/HCS, phenotypic screening) (HLAAAIAA)
- akta.pro secondary industries
- Target Identification & Validation Platforms (omics-driven, chemoproteomics, genetic validation) (HLAAAIAI), Library & Diversity Generation Platforms (display libraries, DNA-encoded libraries for biologics, variant libraries) (HLAAAIAL), Protein Engineering & Directed Evolution Platforms (enzyme/therapeutic protein optimization) (HLAAAIAC)
Keywords
Where Hybrigenics Services is headquartered
LocationHeadquarters
- HQ city
- Évry
- HQ country
- France
- HQ region
- Europe
Offices3 records
Markets served
Hybrigenics Services business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Technology or R&D, Marketing or Sales
Revenue model
- Protein Interaction Screening Services: Fee-for-service scientific research services providing Y2H-based protein interaction screening, drug target identification, and molecular glue/PROTAC discovery using proprietary platforms and libraries.
- Nanobody Selection and Validation Services: Custom synthetic nanobody (VHH) selection, validation, and affinity maturation services using proprietary synthetic library and animal-free technologies.
Go-to-market motion1 record
Distribution channels3 records
Marketing channels5 records
Hybrigenics Services product offering
Product offeringCore offering
Hybrigenics Services is a fee-for-service contract research organization performing protein-protein interaction discovery and synthetic nanobody (VHH) selection for academic, pharmaceutical, and agricultural researchers. Core platforms include ULTImate Y2H™ for exhaustive protein-protein/DNA/RNA/small molecule interaction screening, YChemH for drug target deconvolution, Y2HChem for molecular glue and PROTAC interaction profiling, and Hybribody™ for animal-free custom nanobody selection, validation, and affinity maturation, supported by a 130+ cDNA library collection spanning 35 species.
Product overview
Hybrigenics Services is a research service provider offering a comprehensive portfolio of protein interaction discovery and nanobody selection platforms. The core offering centers on the ULTImate Y2H™ yeast two-hybrid technology platform for protein-protein interaction screening, complemented by the YChemH and Y2HChem platforms for drug target identification and molecular glue/PROTAC discovery. The Hybribody™ platform provides synthetic nanobody (VHH) selection, validation, and affinity maturation services using a proprietary library of over 3 billion variants. Supporting these platforms is an extensive collection of specialized cDNA libraries (130+ from 35+ species), including human E3 ligase library (600+ full-length ligases) and cyclic peptides library (14 million clones), enabling proteome-wide and targeted screening approaches for pharmaceutical, biotechnology, and academic research customers.
Differentiator
Problem solved
Functional benefit
Brands
- Hybribody™: Proprietary synthetic and humanized VHH library for customized nanobody selection, validation and affinity maturation projects.
- ULTImate Y2H™
- YChemH™
Products and services
- ULTImate Y2H™ Protein Interaction Discovery Fee-for-service yeast two-hybrid (Y2H) screening that identifies protein-protein interactions as well as protein-DNA, protein-RNA, and small bioactive molecule interactions by screening customer-specified bait proteins against high-complexity cDNA libraries. Targets academic and pharma researchers needing unbiased, exhaustive interactome mapping without building in-house Y2H infrastructure.
- YChemH Drug-Target Deconvolution Chemical yeast three-hybrid screening service that identifies the protein targets of customer-supplied small bioactive molecules and elucidates their mode of action. Targeted at pharmaceutical and biotech researchers conducting polypharmacology studies, mechanism-of-action research, and drug target identification programs.
- Y2HChem Molecular Glues & PROTAC Interaction Discovery Y2H-based screening service that identifies protein-protein interactions induced by small molecules, supporting molecular glue and PROTAC discovery and development programs. Targets pharma and biotech discovery teams working on targeted protein degradation and induced-proximity therapeutics.
- Hybribody™ Custom Nanobody (VHH) Selection, Validation and Affinity Maturation Custom synthetic and humanized VHH nanobody selection service using a proprietary library of over 3 billion variants, combining phage display with yeast two-hybrid for intrabody enrichment. Includes conformational intrabody selection, yeast-display–based affinity maturation, and minibody (Fc-fused VHH) production. Animal-free technology for use by academic, pharma, and diagnostic researchers.
- Ub-Selectors Ubiquitin Nanobodies Ubiquitin-chain- and monoubiquitination-specific nanobodies developed using Hybrigenics' Hybribody technology and commercially distributed via Nanotag GmbH. Sold to life science researchers for ubiquitin-chain recognition, ubiquitylome analysis, and related research reagent applications.
Quantifiable outcome
- 700+ customer publications in peer-reviewed journals demonstrating scientific impact
- +3 more outcomes
Companies that use Hybrigenics Services
Customer profileNamed customers10 records
Segments3 records
Ideal customer profiles3 records
Hybrigenics Services technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature5 records
Hybrigenics Services partnerships and signals
Strategic signalPartnerships
Five partnerships are on record, tiered minor and core.
- ANR MachActAssembly Project ConsortiumminorCollaborative ANR-funded research project with Alexis Gautreau laboratory (École Polytechnique/CNRS) and Raphael Guerois (I2BC) focusing on molecular machines assembly factors for cell migration in cancer research, using ULTImate Y2H screening.
- Institut CuriecoreCollaborative development of synthetic nanobody library with researchers Franck Perez and Sandrine Moutel at Institut Curie, Paris. This partnership contributed to the NaLi-H1 universal synthetic library of humanized nanobodies published in eLife 2016, which remains a cornerstone of Hybrigenics' Hybribody platform.
- European Network TauImmune (TAME)minorEuropean doctoral training network advancing tau pathology research in Alzheimer's disease. Hybrigenics hosts secondments as part of this network, working on phospho-Tau-targeting nanobodies for diagnostic applications.
- EU Marie Skłodowska-Curie Actions - ENDONANO ITNminorEuropean Industrial Doctorate training network bringing together academic and industrial partners to advance understanding of tau pathology in Alzheimer's disease and support development of new diagnostic strategies. Hybrigenics hosts secondments for doctoral researchers.
- Nanotag GmbHminorNanotag GmbH commercializes Ubiquitin Selector Nanobodies developed by Hybrigenics. These reagents were selected using Hybrigenics' Hybribody technology to recognize ubiquitin chains and monoubiquitination, and are now available for purchase through Nanotag.
Scale indicators7 records
Recent moves6 records
Expansion highlights5 records
Hybrigenics Services competitors and assessment
Company assessmentDirect peers
- Dualsystems Biotech: Swiss Y2H and split-ubiquitin protein-interaction services company. Historically a direct competitor whose yeast activities were acquired by Hybrigenics in 2013; the residual IP, projects, and customer relationships make it the closest comparable operator in yeast-based PPI screening.
- MoBiTec: German supplier of yeast two-hybrid tools, screening libraries, and yeast-based services. Comparable as a yeastspecialist PPI service provider targeting academic and industrial customers in Europe.
- ProtaGene: Protein-interaction and proteomics services company. Comparable as a specialist CRO focused on yeast and mammalian protein-interaction work for pharma and academic customers.
- Creative Biolabs: US-based CRO offering custom antibody discovery, protein engineering, and protein-interaction services. Comparable as a direct service competitor for academic and pharma customers needing custom antibody and PPI work.
Broad incumbents
- Eurofins Discovery: France-headquartered global CRO arm of Eurofins offering protein sciences, screening and antibody services. Comparable as a broad-incumbent CRO that overlaps with Hybrigenics on biopharma and academic protein-interaction and custom reagent work.
- GenScript: Global biotech CRO with custom protein, antibody, and cell-line services. Overlaps with Hybrigenics on pharma and academic buyers needing custom protein-interaction and antibody-discovery services at industrial scale.
- Charles River Laboratories: Large global CRO with broad discovery and safety-assessment services. Comparable as a diversified incumbent whose biopharma services compete with Hybrigenics for the same target-ID and custom screening budget.
Emerging players
- Biocytogen: Asia-based antibody-discovery CRO with extensive phage-display and nanobody capabilities. Comparable as an emerging player in the same nanobody/VHH service market that Hybrigenics' Hybribody platform addresses.
- Harbour BioMed: Biopharma and platform services company with a heavy nanobody/VHH franchise and transgenic鼠/全人源 antibody platforms. Overlaps with Hybrigenics on the upstream nanobody-discovery service layer for therapeutic and diagnostic programs.
Others
- Nanotag Biotechnologies: German reagent company commercializing ubiquitin-specific nanobodies selected via Hybrigenics' Hybribody technology. Comparable as an enabling downstream commercializer that converts Hybrigenics' service output into catalog reagents, illustrating the platform's product path.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
Hybrigenics Services social profiles
Digital presenceHybrigenics Services financial estimates
Financial estimateRevenue estimate
Valuation estimate
Hybrigenics Services leadership team
Management profileNumber of profiles
Profiles1 record
Hybrigenics Services subsidiaries and ownership
Company hierarchySubsidiaries1 record
Hybrigenics Services funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Hybrigenics Services M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Hybrigenics Services
What does Hybrigenics Services do?
Hybrigenics Services is a fee-for-service contract research organization performing protein-protein interaction discovery and synthetic nanobody (VHH) selection for academic, pharmaceutical, and agricultural researchers. Core platforms include ULTImate Y2H™ for exhaustive protein-protein/DNA/RNA/small molecule interaction screening, YChemH for drug target deconvolution, Y2HChem for molecular glue and PROTAC interaction profiling, and Hybribody™ for animal-free custom nanobody selection, validation, and affinity maturation, supported by a 130+ cDNA library collection spanning 35 species.
Is Hybrigenics Services a public or private company?
Hybrigenics Services is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was Hybrigenics Services founded?
Hybrigenics Services was founded in 2000. It employs 11 to 50 people.
Where is Hybrigenics Services based?
Hybrigenics Services is headquartered in Évry, France, in the Europe region.
How does Hybrigenics Services make money?
Two revenue lines are on record. Protein Interaction Screening Services are the primary driver. The others are nanobody Selection and Validation Services.
Who are Hybrigenics Services's main competitors?
Direct peers on record are Dualsystems Biotech, MoBiTec, ProtaGene and Creative Biolabs. Broad incumbents are Eurofins Discovery, GenScript and Charles River Laboratories. Emerging players are Biocytogen and Harbour BioMed. Nanotag Biotechnologies is listed as an others.
Does Hybrigenics Services have an API?
No public API is recorded for Hybrigenics Services.
What industry is Hybrigenics Services in?
Hybrigenics Services's product category is Contract Research Services. Its primary akta.pro industry code is HLAAAIAA, High-Throughput Screening & Assay Platforms (HTS/HCS, phenotypic screening), with a secondary code of HLAAAIAI, Target Identification & Validation Platforms (omics-driven, chemoproteomics, genetic validation). Its NAICS code is 541714 and its SIC code is 8731.