MBS

What MBS does

MBS (Molecular Biology Systems B.V.) is a Dutch biotechnology company founded in 2015 and headquartered in Goes, Netherlands, that develops and commercializes patented ultra-fast PCR and qPCR instrumentation under the NextGenPCR™ and cyQlone™ brands. Its core technology replaces conventional temperature ramping with a patented three-zone heating architecture in which samples shuttle between fixed-temperature zones for denaturation, annealing, and extension, enabling 30-cycle, 3-temperature PCR in as little as two minutes for short fragments and supporting both 96-well and 384-well SBS-format plates. The platform is complemented by proprietary consumables (ultra-thin polypropylene microplates, EZtrieve variants, heat seals, and sealing/imaging/pipetting anvils), accessory equipment (Semiautomatic Heat Sealer, Bio1000F Blue Light Imager), and an expanding assay and reagent portfolio covering SARS-CoV-2 RT-PCR and sequencing library prep, MPXV amplification and library prep, 16S rDNA full-gene amplification, and Arctic Fox HF and RT-PCR chemistry master mixes. Validated integrations with Oxford Nanopore (MinION) sequencing and BMG Labtech plate readers position the system within end-to-end genomic surveillance and microbiome workflows.

MBS monetizes through a quote-based sale of instruments, a recurring stream of proprietary consumables and reagents, and software (QuickDetect) for automated endpoint analysis. The company sells directly via website-driven demo requests and a verified-customer e-commerce flow, but the majority of geographic reach is delivered through more than ten exclusive regional distributors covering Western and Central Europe, North America, China, Israel, the Czech Republic, Russia, India, Singapore, Thailand, Korea, Taiwan, the UAE, Australia, and New Zealand, among others. End customers are primarily clinical and public health laboratories (e.g., University College Dublin's National Virus Reference Laboratory for mpox surveillance, Laboratorio di Servicio in Aruba for high-volume SARS-CoV-2 testing), academic medical centers (Amsterdam UMC, Radboud UMC, Rigshospitalet Copenhagen), and applied research institutions (University of Bielefeld, University of Groningen, Fontys, Rudolf Meier Lab). ISO 13485:2016 certification (2023) underwrites the company's positioning for regulated medical-device and IVD-adjacent procurement channels.

Name

MBS

Legal name

Molecular Biology Systems B.V.

Website

https://nextgenpcr.com

Company type

Private

Founded year

2015

Operating status

Operating

Headcount range

11–50 employees

Short description

MBS (Molecular Biology Systems) develops and sells patented ultra-fast PCR thermal cyclers and qPCR systems based on three-zone heating technology, serving clinical, public health, and academic research laboratories worldwide through a global network of regional distributors and proprietary consumables.

Ownership category

akta.pro rank

Product category

PCR Instruments

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826), Electromedical & Electrotherapeutic Apparatus (3845)

akta.pro primary industry

Molecular Diagnostics (PCR/qPCR, NGS-based assays) (HLAAALAA)

Keywords

• Ultra-fast PCR instruments
• Thermal cycler technology
• Molecular diagnostics equipment
• QPCR systems
• PCR consumables and reagents

Headquarters

HQ city

Goes

HQ country

Netherlands

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Supply Chain, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Instrument Sales: Sale of NextGenPCR™ Thermal Cycler and cyQlone™ qPCR instruments. The company sells proprietary instruments that form the core platform for ultrafast PCR.
2. Consumables: Proprietary microplates (96-well and 384-well), sealing anvils (sealing, imaging, pipetting), heat seals (clear and EZtrieve), and other accessories required for running the NextGenPCR system.
3. Assays and Reagent Kits: Ready-to-use PCR chemistry kits including SARS-CoV-2 RT-PCR Reagent Kit, MPXV Amplification Primer Panel, MPXV Sequencing Library Prep Kit, 16S rDNA Full Gene Amplification Kit, Arctic Fox HF Chemistry, and RT-PCR Chemistry.
4. Accessory Equipment: Semiautomatic Heat Sealer for plate sealing and Bio1000F Blue Light Imager for endpoint fluorescence detection.

Pricing tiers

Go-to-market motion2 records

Distribution channels10 records

Marketing channels8 records

Core offering

MBS designs, manufactures, and sells the NextGenPCR™ ultra-fast PCR thermal cycler and the cyQlone™ ultra-fast qPCR system, both built on patented three-zone heating technology that performs 30-cycle PCR in as little as 2 minutes. The instruments are paired with proprietary SBS-format microplates, sealing and imaging anvils, heat seals, and a suite of ready-to-use assay kits (SARS-CoV-2, MPXV, 16S rDNA) plus Arctic Fox HF and RT-PCR chemistry master mixes for clinical diagnostics, public health surveillance, and life science research customers.

Product overview

MBS (Molecular Biology Systems) offers the NextGenPCR™ platform, a portfolio of ultra-fast PCR instruments and associated consumables, assays, and software. The core of the portfolio is the NextGenPCR™ Thermal Cycler — an endpoint PCR instrument using patented three-zone heating technology that eliminates temperature ramping, achieving 30-cycle PCR in as little as 2 minutes for short fragments. The cyQlone™ Ultra Fast qPCR System extends the same thermal engine with 6-channel real-time fluorescence detection, delivering results in 9 minutes for 96 samples. Supporting the instruments is a suite of proprietary consumables including specialized SBS-format microplates (standard and EZtrieve formats), heat seals, and sealing/imaging/pipetting anvils, plus accessory equipment (Semiautomatic Heat Sealer, Bio1000F Blue Light Imager). The assay portfolio includes SARS-CoV-2 RT-PCR and sequencing library prep kits, MPXV amplification primer panel and sequencing library prep kit (for mpox genomic surveillance), a 16S rDNA Full Gene Amplification Kit for bacterial microbiome analysis, and Arctic Fox HF and RT-PCR chemistry master mixes. QuickDetect software automates endpoint fluorescence analysis. The platform is validated for integration with Oxford Nanopore sequencing (library prep workflows up to 400% faster) and BMG Labtech FLUOstar Omega plate readers for fluorescence detection.

Differentiator

Problem solved

Functional benefit

Brands

• NextGenPCR™: Ultra-fast PCR thermal cycler product line and patented technology platform
• cyQlone™

Products and services

• NextGenPCR™ Thermal Cycler Ultra-fast endpoint PCR thermal cycler using patented three-zone heating technology that eliminates temperature ramping, delivering 30-cycle 3-temperature PCR in as little as 2 minutes for short fragments. Accepts both 96-well and 384-well SBS-format plates with a footprint under 20 cm wide, targeting clinical, public health, and life science research laboratories.
• cyQlone™ Ultra Fast qPCR System The world's fastest SBS-format real-time qPCR system built on the patented NextGenPCR thermal cycling engine. Provides 6-channel real-time fluorescence detection, 96-sample throughput, signal readout in 20 milliseconds per channel per cycle, and results in just 9 minutes for clinical and research qPCR workflows.
• QuickDetect Software Automated measurement and analysis software for endpoint fluorescence detection on NextGenPCR instruments, enabling automated result calls based on predetermined thresholds for laboratory users.
• NextGenPCR™ Semiautomatic Heat Sealer Semiautomatic heat sealer for sealing NextGenPCR microplates prior to thermal cycling, used by laboratories running the NextGenPCR platform.
• Bio1000F Blue Light Imager Blue light gel documentation system for detection of amplified PCR products from NextGenPCR plates, serving as an alternative to fluorescent dye-based real-time detection for laboratory users.
• NextGenPCR™ Microplates Proprietary SBS-format microplates with ultra-thin polypropylene wells for use with NextGenPCR thermal cyclers, available in 96-well and 384-well formats with 5 µL and 20 µL volume options to enable rapid heat transfer.
• NextGenPCR™ EZtrieve Microplates Specialized microplate format designed for easy sample retrieval after PCR amplification on the NextGenPCR system.
• NextGenPCR™ Sealing Anvil Sealing anvil for securing NextGenPCR microplate seals during thermal cycling, required consumable for the NextGenPCR workflow.
• NextGenPCR™ Imaging Anvil Anvil designed for use during imaging of NextGenPCR microplates on the Bio1000F Blue Light Imager.
• NextGenPCR™ Pipetting Anvil Anvil designed to assist with pipetting operations in NextGenPCR microplate workflows.
• NextGenPCR™ Clear Heat Seals Clear heat seals for NextGenPCR microplates providing secure sealing during thermal cycling.
• NextGenPCR™ EZtrieve Heat Seals Heat seals designed to work with EZtrieve microplates for easy sample retrieval after amplification.
• NextGenPCR™ SARS-CoV-2 RT-PCR Reagent Kit (100 rxn) RT-PCR reagent kit for direct detection of SARS-CoV-2 from clinical samples without RNA extraction, validated on nasopharyngeal swabs with 99.4% sensitivity and 98.5% specificity versus reference methods and producing results in 27 minutes.
• NextGenPCR™ SARS-CoV-2 Sequencing Library Prep Kit 96RXN Library preparation kit for SARS-CoV-2 whole-genome nanopore sequencing using a tiling PCR approach, enabling ultrafast genomic surveillance workflows with up to 400% increased data output per day.
• NextGenPCR™ MPXV Amplification Primer Panel 96RXN Amplification primer panel for Monkeypox virus (MPXV) whole-genome sequencing using an amplicon tiling approach with 88 primer sets in 2 amplicon pools (~2.5 kb amplicons), enabling multiplex of up to 20 samples per Nanopore flowcell for mpox variant surveillance.
• NextGenPCR™ MPXV Sequencing Library Prep Kit 96RXN Complete library preparation kit for MPXV whole-genome sequencing on the Oxford Nanopore platform, designed for rapid mpox virus genomic surveillance.
• NextGenPCR™ 16S rDNA Full Gene Amplification Kit (RUO) 96RXN PCR kit for ultrafast amplification of the full-length 16S rDNA gene (V1–V9 regions) in ≤21 minutes of cycling time using Arctic Fox HF polymerase master mix, enabling same-day real-time 16S nanopore sequencing for species-level bacterial identification.
• NextGenPCR™ Arctic Fox HF Chemistry-2x 1.0ML Proprietary high-fidelity Arctic Fox polymerase master mix for use in NextGenPCR workflows, providing robust high-fidelity PCR amplification of both short and long genomic templates.
• NextGenPCR™ RT-PCR Chemistry-2x 1.0ML Two-step RT-PCR chemistry master mix for reverse transcription and PCR amplification in NextGenPCR instruments.

Quantifiable outcome

• 2-minute 30-cycle PCR for some fragments vs. 50-150 minutes for conventional systems
• +7 more outcomes

Named customers8 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature6 records

Partnerships

19 partnerships are on record, tiered minor, core and regional.

• Avans University of Applied SciencesminorStrategic or Co-development Partner · 1 August 2024Collaboration for 'Viva La Vaginoom' citizen science project at Lowlands festival. Used NextGenPCR for vaginal microbiome analysis, mapping microbiome within 3 hours instead of typical 6-7 hours.
• National Science AgendaminorStrategic or Co-development Partner · 1 August 2024Partner in Lowlands Science initiative enabling citizen science projects including Viva La Vaginoom using NextGenPCR technology.
• Velocidy BiocoreChannel Partner/ Reseller/ Distributor · 19 February 2020Velocidy Bio is the exclusive distributor of NextGenPCR instruments, accessories, and consumables in the United States and Canada. The partnership focuses on delivering solutions that decrease time-to-results for biological laboratories and accelerate protocols from hours to minutes.
• Canon BioMedicalcoreChannel Partner/ Reseller/ Distributor · 23 April 2018Canon BioMedical, a wholly owned subsidiary of Canon U.S.A., was the initial distributor partner for NextGenPCR in US and Canada, focusing on empowering biomedical research and healthcare communities.
• AMPLITECHregionalChannel Partner/ Reseller/ Distributor · 1 December 2017Distributor for NextGenPCR in France, Belgium, Luxembourg, and Switzerland, serving in vitro diagnostic testing market including cytogenetics, molecular genetics, and pathology labs.
• CAMLABregionalChannel Partner/ Reseller/ Distributor · 6 October 2017UK distributor for NextGenPCR, first shown at Lab Innovations at Birmingham NEC. CAMLAB is the UK's leading independent scientific instrumentation distributor.
• PreMed LabregionalChannel Partner/ Reseller/ Distributor · 19 September 2017Exclusive distributor for NextGenPCR in China.
• Pronto DiagnosticsregionalChannel Partner/ Reseller/ Distributor · 19 September 2017Exclusive distributor for NextGenPCR in Israel.
• YBUXregionalChannel Partner/ Reseller/ Distributor · 19 September 2017Exclusive distributor for NextGenPCR in Czech Republic.
• AlbiogenregionalChannel Partner/ Reseller/ Distributor · 19 September 2017Exclusive distributor for NextGenPCR in Russian Federation.
• Isogen Life SciencecoreChannel Partner/ Reseller/ Distributor · 8 July 2017Exclusive distributor for NextGenPCR in Benelux and Spain, with facilities in De Meern (Netherlands) and Temse (Belgium/Luxembourg).
• Amsterdam UMC (Amsterdam University Medical Centre)coreStrategic or Co-development PartnerCollaboration with department of Medical Microbiology & Infectious Disease Prevention to develop novel and fast typing method for monkeypox virus genomic surveillance. Led to first pediatric case characterization in Netherlands.
• Rigshospitalet CopenhagencoreStrategic or Co-development PartnerCollaboration with Danish researchers to optimize and validate amplicon-based sequencing approach for MPXV, inspired by SARS-CoV-2 Midnight Protocol and ARTIC network. Enabled multiplex of up to 20 samples per flowcell.
• Vrije Universiteit AmsterdamminorStrategic or Co-development PartnerPart of 'From Women For Women' consortium with Vrije Universiteit Amsterdam, supported by Yoni, for research into Lactobacillus crispatus and vaginal health.
• BKBminorStrategic or Co-development PartnerPartner in Lowlands Science initiative for citizen science projects.
• New ScientistminorStrategic or Co-development PartnerPartner in Lowlands Science initiative for science communication and citizen science projects.
• Oxford Nanopore TechnologiescoreTechnology or IntegrationNextGenPCR combined with MinION sequencer enables ultrafast nanopore sequencing workflows. PCR library prep reduced to 27 minutes for SARS-CoV-2 Midnight protocol. Up to 400% more data output per day.
• University of BielefeldcoreStrategic or Co-development PartnerAcademic collaboration with Prof. Dr. Christian Kaltschmidt's lab for development of ultra-fast RT-PCR protocol for SARS-CoV-2 detection using NextGenPCR. Published results demonstrated 16-minute one-step RT-PCR protocol.
• University of GroningenminorStrategic or Co-development PartnerPublished research evaluation of NextGenPCR instrument showing equivalent sensitivity to standard Eppendorf Mastercycler Nexus while being 3x faster for E. coli detection in urinary tract infection samples.

Scale indicators7 records

Recent moves10 records

Expansion highlights6 records

Broad incumbents

• Thermo Fisher Scientific: Thermo Fisher (Applied Biosystems) offers ProFlex, Veriti, QuantStudio and QuantStudio real-time systems. It is the dominant PCR instrument vendor globally and sets competitive benchmarks on throughput, assays, and service depth.
• Bio-Rad Laboratories: Bio-Rad is one of the largest PCR/qPCR instrument manufacturers (CFX, T100, QX200), with deep installed bases in research and clinical labs. Its broad portfolio and global service network make it MBS's primary incumbent benchmark in thermal cycling.
• Qiagen: Qiagen offers Rotor-Gene Q, QIAquant, and companion sample-prep/extraction reagents that compete end-to-end with NextGenPCR. Its integrated sample-to-result offering is the primary workflow competitor MBS must displace in molecular diagnostic labs.
• Agilent Technologies: Agilent's AriaMx and Bravo platforms compete in research qPCR with a similar emphasis on throughput and ease-of-use. Its larger analytical instruments portfolio gives it cross-sell advantages MBS lacks.
• Roche Diagnostics: Roche's LightCycler systems are a flagship qPCR platform widely used in clinical diagnostics. Roche competes with MBS on clinical qPCR workflow speed, IVD positioning, and regulated assay menus.
• Eppendorf: Eppendorf's Mastercycler family (including Nexus and X50) is a benchmark conventional thermal cycler; the University of Groningen validation study explicitly benchmarked NextGenPCR against the Mastercycler Nexus. Comparable product category and lab customer base.

Others

• Oxford Nanopore Technologies: Oxford Nanopore is a strategic technology integration partner for MBS's library-prep workflows (validated up to 400% more data/day), not a direct competitor. Included as an adjacent ecosystem participant that anchors NextGenPCR's nanopore sequencing value proposition.

Direct peers

• Analytik Jena: Analytik Jena (Biometra) makes a direct line of thermal cyclers (TAdvanced, TRIO, qTOWER) targeting the same PCR/qPCR customer segments as MBS. Closely comparable product architecture and mid-market lab positioning.
• Bio Molecular Systems: Australian company offering Mic qPCR, a compact real-time PCR cycler for research and diagnostic markets. Closest small-company direct competitor to NextGenPCR in product positioning, target customer, and emphasis on speed/simplicity.

Emerging players

• Stilla Technologies: Stilla focuses on digital PCR (Naica system), serving clinical and research molecular diagnostics customers. Adjacent technology category with overlapping customer base; represents a next-gen upgrade path MBS may eventually compete with.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights3 records

Customer concentration

• YouTubeyoutube.com/watch?v=mqnlLnWvaOo
• LinkedInlinkedin.com/company/molecular-biology-systems
• Facebookfacebook.com/nextgenpcr

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles5 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about MBS