Sepiatec

What Sepiatec does

Sepiatec GmbH is a Berlin-based developer and manufacturer of preparative chromatography systems founded in 2000 and operating as a wholly-owned subsidiary of Swiss laboratory equipment manufacturer BÜCHI Labortechnik AG. The company builds instruments based on two underlying separation technologies, High Performance Liquid Chromatography (HPLC) and Supercritical Fluid Chromatography (SFC), and sells them to pharmaceutical and biotechnology companies as well as research institutions internationally. Its product portfolio spans four categories: preparative SFC systems for chiral separations (SFC-50, SFC-250, SFC-660); modular SFC-M5 platforms for chiral and achiral separations (SFC-M5 50, SFC-M5 250); 8-column parallel screening systems (Sepmatix 8x HPLC, Sepmatix 8x HPLC prep, Sepmatix 8x SFC) built on patented FlowControl valve technology; and the Sepbox 2D-2000 automated compound isolation system based on a patented 2D HPLC-SPE architecture that processes up to 2,000 mg of natural extract per run.

The company's technology differentiation rests on two registered patents (Sepmatix FlowControl and 2D HPLC-SPE combination) that enable 8x parallel separations from a single pump pair and automated natural-product purification in days rather than weeks. The SFC-M5 system integrates autosampler, heatable column oven, DAD detector, and touch-screen control in a 92 cm benchtop footprint, with the Sepbox 2D-2000 reportedly achieving above 90% recovery rates across polar and non-polar substances. An integration partnership with Advion extends the SFC-50, SFC-250, and SFC-M5 platforms with mass-directed and mass-confirmed fractionation via the expression CMS compact mass spectrometer.

Sepiatec operates as a private German limited liability company (HRB 77048, Berlin-Charlottenburg) with 11-50 employees at its Berlin-Adlershof headquarters on Johann-Hittorf-Strasse 8, under a three-person management team of Holger Gumm, Manuel Schindler, and Pius Schuler. Revenue is generated through direct sales and an international distributor network, with pricing handled on a custom quote basis under multi-year contracts. No public revenue, funding, or headcount-growth disclosures are available in the source data.

Name

Sepiatec

Legal name

Sepiatec GmbH

Website

https://sepiatec.com

Company type

Private

Founded year

2000

Operating status

Operating

Headcount range

11–50 employees

Short description

Sepiatec GmbH, a Berlin-based BÜCHI subsidiary, designs and manufactures preparative SFC and HPLC chromatography systems and 8-column parallel screening platforms for pharmaceutical, biotechnology, and research-institution customers globally.

Ownership category

akta.pro rank

Product category

Preparative Chromatography Instrumentation

NAICS

Analytical Laboratory Instrument Manufacturing (334516)

SIC

Laboratory Analytical Instruments (3826)

akta.pro primary industry

Analytical Instruments & Chromatography Systems (HLAGAIAA)

akta.pro secondary industries

Downstream Processing & Purification Technologies (chromatography, filtration, centrifugation) (HLAAAJAB), CMC & Pharmaceutical Development (Formulation/Process/Analytical Development) (HLAIALAD)

Keywords

• Preparative chromatography systems
• Supercritical fluid chromatography
• Chiral separation instruments
• High-throughput HPLC screening
• Natural compound isolation

Headquarters

HQ city

Berlin

HQ country

Germany

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Supply Chain, Operations, Infrastructure, Marketing or Sales, Others

Revenue model

1. Chromatography Equipment Sales: Sale of preparative SFC and HPLC systems including SFC-50, SFC-250, SFC-660, SFC-M5 series, Sepmatix 8x parallel systems, and Sepbox 2D compound isolation systems. Systems are sold directly and through international distributors.

Pricing tiers

Go-to-market motion2 records

Distribution channels2 records

Marketing channels4 records

Core offering

Sepiatec designs, manufactures, and sells preparative chromatography systems used for substance separation and purification in pharmaceutical, biotechnology, and research workflows. Its offerings cover chiral preparative SFC systems, modular SFC chiral/achiral systems, 8-column parallel HPLC and SFC screening systems, and the Sepbox 2D automated compound isolation platform, all built on patented HPLC/SFC flow-control and 2D separation technologies.

Product overview

Sepiatec develops and manufactures chromatography systems based on High Performance Liquid Chromatography (HPLC) and Supercritical Fluid Chromatography (SFC) technologies. The product portfolio includes three categories: (1) Preparative SFC systems for chiral and achiral separations including SFC-50, SFC-250, SFC-660, and SFC-M5 variants (SFC-M5 50 and SFC-M5 250); (2) 8x parallel HPLC and SFC screening systems including Sepmatix 8x HPLC, Sepmatix 8x HPLC prep, and Sepmatix 8x SFC for rapid method development; (3) Compound isolation systems including Sepbox 2D-2000 for automated natural product purification. These systems serve pharmaceutical and biotech companies as well as research institutions for substance separation and purification applications.

Differentiator

Problem solved

Functional benefit

Products and services

• SFC-50 Preparative SFC System Compact chromatography system for preparative separations on small columns using supercritical fluid chromatography (SFC), equipped with two 400 bar high-pressure pumps with 30 ml pump heads and total flow up to 50 ml/min at 40% modifier portion. Targeted at pharmaceutical and biotech laboratories performing chiral and achiral preparative separations.
• SFC-250 Preparative SFC System Compact benchtop preparative SFC unit measuring 72 x 60 x 88 cm with two 150 ml high-pressure pumps, total flow up to 250 ml/min at 40% modifier portion, and an integrated 15.6 inch touch-screen system controller. Targeted at pharmaceutical and biotech labs requiring mid-range preparative separations in a small footprint.
• SFC-660 Preparative SFC System High-throughput preparative SFC system with three 400 bar pumps (400 ml CO2 pump, 250 ml modifier pump, 150 ml add-on pump), total flow up to 660 ml/min at 40% modifier portion, compact 150 x 68 x 178 cm footprint, and an integrated CO2 recycling module to reduce operating cost. Designed for higher-volume preparative separations in pharmaceutical and biotech production-support workflows.
• SFC-M5 50 Preparative SFC System Preparative SFC system separating chiral and achiral samples. Main module accepts up to three high-pressure pumps, with integrated autosampler, heatable column oven for up to 10 columns (4-16 mm ID, 250 mm length), DAD detector (190-720 nm). Collector module includes post heater, back pressure regulator, and gas-liquid separator, supporting up to 195 fractions. Targeted at laboratories needing a configurable SFC platform for small-column preparative work.
• SFC-M5 250 Preparative SFC System Preparative SFC system separating chiral and achiral samples on larger columns. Includes CO2 and modifier pumps with 150 ml pump heads at 400 bar, heatable column oven for up to 10 columns (15-30 mm ID, 250 mm length), DAD detector (190-720 nm), and a carousel fraction collector for vessels from 10 to 500 ml. Built for higher-volume chiral/achiral preparative separations.
• Sepmatix 8x HPLC Screening System HPLC screening system with eight columns running in parallel using one external HPLC pump and patented Sepmatix FlowControl. Includes autosampler, 8x Diode Array Detector with independent spectrometer modules (195-390 nm), and optional column oven in a 55 x 55 x 90 cm footprint. Targeted at pharmaceutical/biotech labs accelerating chiral and achiral method development.
• Sepmatix 8x HPLC prep Preparative System Preparative version of Sepmatix 8x HPLC with HPLC pump equipped with a 100 ml pump head (max 400 bar) and per-channel flow rates of 3.0-8.0 ml/min. Compact collector module houses 8x fraction collectors, each holding up to 6 deep-well microtiter plates. Targeted at labs needing parallel preparative HPLC to scale screened methods.
• Sepmatix 8x SFC Parallel Screening System First SFC system with eight separating columns running in parallel. Uses patented FlowControl for precise 8-channel flow division and the Chiral Column Screening Wizard software that displays up to 80 chromatograms simultaneously. Designed for pharmaceutical and biotech laboratories running high-throughput chiral method development using SFC.
• Sepbox 2D-2000 Compound Isolation System Automated two-dimensional separation system based on a patented combination of High Performance Liquid Chromatography (HPLC) and Solid Phase Extraction (SPE). Designed to isolate compounds from up to 2,000 mg of natural extract and to deliver purified results in days instead of weeks or months, with up to 576 fractions per run and above 90% recovery for polar and non-polar substances. Targeted at research institutes and biotech/pharma natural product discovery programs.

Quantifiable outcome

• Isolation of compounds with speed unachievable with conventional chromatography methods
• +4 more outcomes

Named customers3 records

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

Feature4 records

Partnerships

Two partnerships are on record, tiered core.

• BÜCHI Labortechnik AGcoreOEM/ Whitelabel/ Licensing PartnerSepiatec is a subsidiary company of Swiss lab equipment manufacturer BÜCHI Labortechnik AG. BÜCHI provides corporate backing and presumably distributes Sepiatec products through its global network.
• AdvioncoreTechnology or IntegrationAdvion's expression CMS compact mass spectrometer integrates with Sepiatec's SFC-M5, SFC-250, and SFC-50 systems for mass-directed, mass-confirmed, and UV-controlled fractionation. The integration enables fractionation of UV-inactive targets.

Scale indicators6 records

Recent moves5 records

Expansion highlights4 records

Direct peers

• Shimadzu Corporation: Shimadzu manufactures preparative HPLC and SFC systems (Nexera series) widely used in pharmaceutical and natural product research. Directly comparable product overlap with Sepiatec's SFC-50/250/660 and M5 series for chiral and achiral separations.
• Agilent Technologies: Agilent provides a broad portfolio of HPLC, SFC (formerly Aurora SFC), GC, and mass spectrometry instruments used in pharmaceutical, biotech, and research labs. Competes directly with Sepiatec's preparative SFC and 8x parallel screening systems.
• Teledyne ISCO: Teledyne ISCO produces CombiFlash and ACCQ Prep SFC/HPLC purification systems for pharmaceutical and natural product chemists. Directly comparable to Sepiatec's preparative chromatography and compound isolation portfolio.
• Waters Corporation: Waters is a global leader in HPLC, UPLC, and SFC chromatography instruments, columns, and software for pharmaceutical and biotech customers. Directly competes with Sepiatec across preparative and analytical chromatography categories serving the same enterprise R&D end market.
• Gilson: Gilson specializes in preparative HPLC, SFC, and automated purification systems (PLC, VERITY) targeting pharmaceutical and natural product discovery. Closely comparable to Sepiatec's preparative SFC and compound isolation (Sepbox) offerings.
• JASCO Corporation: JASCO manufactures analytical and preparative HPLC/SFC instruments (LC-4000 series) with strong adoption in chiral separations and pharmaceutical research. Directly competes with Sepiatec in SFC-based chiral purification.

Broad incumbents

• BUCHI Labortechnik AG: Parent company of Sepiatec; BÜCHI is a Swiss laboratory equipment manufacturer offering evaporation, extraction, and preparative chromatography solutions. Provides corporate backing, distribution, and adjacent separation technology that complements Sepiatec's product line.
• Thermo Fisher Scientific: Thermo Fisher offers chromatography instruments and consumables (Vanquish HPLC/SFC, Dionex) as part of its massive life sciences portfolio. Overlaps with Sepiatec on HPLC/SFC systems but competes broadly rather than specializing in preparative niche.

Others

• Advion: Advion manufactures compact mass spectrometers (expression CMS) that integrate with Sepiatec's SFC systems for mass-directed fractionation. Functions as a complementary technology/integration partner rather than direct competitor.

Emerging players

• Chiral Technologies (Daicel): Daicel/Chiral Technologies leads the chiral stationary phase and chiral separation services market that Sepiatec's chiral SFC systems serve. Partial overlap: Sepiatec sells instruments, Daicel sells columns and separation services for chiral drug development.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/sepiatec-gmbh

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Sepiatec