SiliCycle

What SiliCycle does

SiliCycle, now operating as Zeochem Silica Materials Inc. following its August 2025 acquisition by Zeochem Group, is a specialty manufacturer of silica-based functionalized materials founded in 1995 in Quebec City, Canada. The company's core competency is grafting organic molecules onto silica gel matrices to produce functionalized silicas for chromatography, purification, organic synthesis, catalysis, and analytical chemistry. Its product portfolio spans metal scavengers (SiliaMetS), functionalized silica gels (SiliaBond), spherical and irregular silica gels (SiliaSphere, SiliaFlash), heterogeneous catalysts (SiliaCat), flash and SPE cartridges (SiliaSep, SiliaPrep, SiliaPrepX), HPLC columns (SiliaChrom), TLC plates (SiliaPlate), flow-through purification cartridges (E-PAK), and emerging peptide synthesis and purification platforms (SiPPS, ResiPure ADVANCED). Manufacturing is ISO 9001:2015 certified with full traceability and regulatory documentation for pharmaceutical customers.

The company serves pharmaceutical drug discovery, development, and manufacturing organizations (including Pfizer, Merck, Johnson & Johnson, Abbott, GlaxoSmithKline, Genentech, Eli Lilly, Bristol-Myers Squibb, Amgen, and Novartis), CROs and CMOs (BioVectra, AMRI, Dr. Reddy's, Syngene), academic and research institutions (MIT, Stanford, Harvard, Yale, UCSF), and analytical, environmental, and food testing labs across 100 countries. The business model is primarily a one-time product sale of consumable materials, with quote-based, volume-tiered pricing and products available from laboratory to multi-ton industrial scale. Go-to-market combines direct enterprise sales with regional coverage in the Americas and EMEA, e-commerce, technical content marketing, and active trade-show presence (CPHI, TIDES, Analytica, IOPC, PREP, RSC). Services include a metal scavenging screening offering, custom R&D, and OEM/private-label manufacturing. Post-acquisition, SiliCycle is positioned within Zeochem Group's specialty chemicals platform, leveraging the parent's European infrastructure and global supply network.

Name

SiliCycle

Legal name

Zeochem Silica Materials Inc.

Website

https://silicycle.com

Company type

Private

Founded year

1995

Operating status

Operating

Headcount range

101–250 employees

Ownership category

akta.pro rank

Product category

Specialty Silica Materials

NAICS

Other Chemical Product and Preparation Manufacturing (3259)

SIC

Chemicals & Allied Products (2800), Miscellaneous Chemical Products (2890)

akta.pro primary industry

Reagents, Chemicals & Assay Kits (Buffers, Antibodies, ELISA, Enzymes) (HLAGAIAI)

akta.pro secondary industry

Bioprocess Consumables & Reagents (resins, membranes, media components, buffers) (HLAAAJAI)

Keywords

• Silica-based chromatography
• Metal scavenger products
• Functionalized silica gels
• Peptide synthesis resins
• HPLC column manufacturing

Headquarters

HQ city

Clarke City

HQ country

Canada

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Silica-based Products Sales: Sale of specialty silica-based products including functionalized silicas, metal scavengers, chromatography products, peptide synthesis and purification materials. Products sold in various formats from bulk quantities to pre-packed cartridges and columns.

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels6 records

Core offering

SiliCycle develops, manufactures, and sells specialty silica-based products for chromatography, purification, organic synthesis, catalysis, and analytical chemistry. The portfolio spans bulk functionalized silicas (SiliaMetS metal scavengers, SiliaBond reagents), pre-packed flash cartridges, SPE cartridges, TLC plates, HPLC columns, E-PAK flow-through purification cartridges, and emerging products such as SiPPS for solid-phase peptide synthesis and ResiPure ADVANCED for peptide purification. Offerings are sold from laboratory scale (grams) to multi-ton industrial quantities to pharmaceutical, biotech, CRO/CMO, academic, and industrial customers.

Product overview

SiliCycle offers a comprehensive portfolio of silica-based products and specialty chemicals for chromatography, purification, organic synthesis, catalysis, and analytical chemistry applications. The product portfolio includes both bulk silica formats (bare and functionalized) and pre-packed formats including flash cartridges, E-PAK flow purification cartridges, SPE cartridges, TLC plates, and HPLC columns. Key product lines include SiPPS for solid-phase peptide synthesis, ResiPure ADVANCED for peptide purification, SiliaMetS metal scavengers, SiliaBond functionalized silica gels, SiliaCat heterogeneous catalysts, SiliaFlash/SiliaSphere silica gels, SiliaSep flash cartridges, SiliaPlate TLC plates, SiliaPrep/SiliaPrepX sample preparation products, and SiliaChrom HPLC columns. The company, part of the Zeochem Group founded in 1995 and headquartered in Quebec City, Canada, serves pharmaceutical, biotechnology, chemical, food, and environmental industries worldwide.

Differentiator

Problem solved

Functional benefit

Products and services

• SiPPS - Silica-Phase for Peptide Synthesis Innovative silica-based resin for solid-phase peptide synthesis (SPPS) engineered to enhance efficiency and sustainability through reduced solvent consumption and compatibility with green solvents, suitable for both batch and continuous-flow operations and targeted at pharmaceutical peptide manufacturing.
• ResiPure ADVANCED High-performance functionalized spherical silica with C18, C8, and C4 reversed-phase options designed for peptide purification, offering pH stability up to 13, exceptional chemical and mechanical stability, and scalability from laboratory to industrial production.
• SiliaMetS Metal Scavengers Silica-grafted metal scavengers for removing precious metal catalysts and heavy metal contamination from reaction mixtures, available in multiple chemistries including Thiol, Thiourea, Cysteine, Diamine, DMT, Triamine, and Imidazole for various metals such as Pd, Pt, Ru, Ag, and Hg.
• SiliaBond Functionalized Silica Gels Complete range of functionalized silica gels including chromatographic phases (C18, C8, C4, Cyano, Phenyl, fluorinated), organic scavengers, reagents for organic synthesis, ion exchange phases, acids, bases, and linkers.
• SiliaCat Heterogeneous Catalysts Silica-supported heterogeneous catalysts for organic synthesis reactions including Suzuki, Heck, Sonogashira, and Stille couplings, selective debenzylation, and selective hydrogenation.
• SiliaFlash Irregular Silica Gels Irregular silica gels for flash chromatography available in various particle sizes (5-20 to 800-1200 microns) and pore diameters (30-300 Angstroms) for laboratory to industrial scale purification.
• SiliaSphere Spherical Silica Gels Spherical silica gels for analytical and preparative chromatography, available as bare silica or bonded phases including C18, C8, C4, Cyano, Amine, and ion exchange chemistries, offering consistent particle shape for better flow characteristics.
• SiliaSep Flash Cartridges Pre-packed flash chromatography cartridges available in normal phase, reversed-phase, ion exchange, and metal scavenger formats for automated purification workflows across a wide range of scales.
• SiliaPlate TLC Plates Thin layer chromatography plates with glass, aluminum, or plastic backings available in analytical, HPTLC, and preparative formats with various stationary phases.
• SiliaPrep Silica-Based SPE Silica-based solid-phase extraction cartridges and well plates for sample preparation, available in reversed-phase, normal phase, ion exchange, and specialty chemistries.
• SiliaPrepX Polymeric SPE Polymeric SPE cartridges and well plates for sample preparation including SCX, WCX, SAX, WAX, DVB, and HLB phases.
• SiliaChrom HPLC Columns High-performance liquid chromatography columns and guard cartridges for analytical and preparative applications with bare silica, reversed-phase, and normal-phase options.
• E-PAK Purification Cartridges Fixed-bed radial flow adsorption cartridges for large-scale metal purification and flow-through purification processes in pharmaceutical manufacturing, available in lab, pilot, and commercial scales (1 cm to 100 cm cartridge sizes).
• SiliaCarb Activated Carbons Activated carbon products for purification and decolorization applications in chemical processing.
• StreamXtract Precious Metals Recovery Technology offering for recovery of precious metals from process streams, enabling efficient metal reclamation and recycling.
• SiliaQuick QuEChERS QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) products for sample preparation in food safety and environmental testing applications.
• Metal Scavenging Screening Service Screening service to identify optimal metal scavenger for specific purification applications and process conditions.
• R&D Services Custom research and development services for specialized silica-based chemistry solutions and custom product development.
• OEM & Private Label Services Custom manufacturing and private labeling services for companies seeking customized silica-based products.

Quantifiable outcome

• Pd levels reduced from >4000 ppm to 139 ppm using SiliaMetS R51030B
• +5 more outcomes

Named customers24 records

Segments8 records

Ideal customer profiles5 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature7 records

Partnerships

One partnership is on record.

• Zeochem GroupcoreOthersSiliCycle was acquired by Zeochem Group in August 2025. Now operates as Zeochem Silica Materials Inc. The acquisition enhances SiliCycle's global network, supply reliability, and provides access to expanded expertise. SiliCycle remains the brand name for chromatography and purification products.

Scale indicators3 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Biotage: Direct competitor in flash chromatography cartridges (SiliaSep vs. Biotage Isolera/Snap), SPE cartridges, and metal scavenging. Customer testimonials explicitly reference switching from or comparing against Biotage products, making it the closest direct peer.
• Phenomenex: Direct competitor in HPLC columns (SiliaChrom vs. Luna/Kinetex), SPE cartridges, and silica-based chromatography consumables serving the same pharma and analytical lab customers.
• Restek Corporation: Direct competitor in chromatography columns, SPE, and related consumables for pharmaceutical, environmental, and food safety applications — overlapping significantly with SiliCycle's analytical lab and sample preparation lines.
• Purolite (Ecolab Life Sciences): Direct peer in functionalized resin/scavenger technology for pharmaceutical purification. Both companies offer scavenger and chromatography media solutions targeting metal removal and API purification workflows.

Broad incumbents

• Agilent Technologies: Large incumbent offering Bond Elut SPE cartridges, HPLC columns, and sample preparation products that overlap with SiliaPrep, SiliaChrom, and SiliaPlate. Competes through bundled instrument-plus-consumable offerings.
• Thermo Fisher Scientific: Broad incumbent selling HyperSep SPE, HPLC consumables, and chromatography products through its laboratory products and life sciences segments. Competes across essentially all of SiliCycle's product categories.
• Waters Corporation: Major chromatography and analytical instrument vendor with overlapping consumables (columns, SPE, Oasis) that compete with SiliaChrom, SiliaPrep, and related SiliCycle product lines in pharma QC and development labs.
• Merck KGaA / Sigma-Aldrich (Life Science): Broad incumbent with the largest catalog of silica-based reagents, scavengers, chromatography media, and SPE products. Direct overlap with SiliaBond, SiliaMetS, and SiliaSep product lines, sold at global scale.

Others

• Avantor (VWR): Distributor and manufacturer of laboratory and bioprocessing consumables. While not a direct product competitor, Avantor's distribution scale and OEM/private-label capabilities overlap with SiliCycle's OEM services and global e-commerce reach.

Emerging players

• Cytiva (Danaher): Increasingly active in bioprocess chromatography and purification consumables, including in the peptide and oligonucleotide space. An emerging competitor as peptide and oligonucleotide therapeutics manufacturing scales.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/@SiliCycle
• LinkedInlinkedin.com/company/silicycle
• Xx.com/SiliCycle_Inc
• Facebookfacebook.com/silicycle

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about SiliCycle