Human Immunome Project

What Human Immunome Project does

The Human Immunome Project (HIP) is a US-registered 501(c)(3) nonprofit scientific initiative founded in 2016 (as the Human Vaccines Project) and re-incorporated under its current name in 2022. Headquartered in New York with a European entity (Stichting Europe) in Noordwijk, Netherlands, HIP operates with 1-10 employees and is governed by an independent board. The organization is building the world's largest and most diverse immunological dataset—targeting approximately 225,000 participants tracked longitudinally over five years—combined with publicly available AI models that predict immune responses to vaccines, infections, and therapeutics. Its intended users span the global scientific research community, pharmaceutical and biotech companies, clinicians, and healthcare systems.

HIP's core product is a three-part platform: (1) the Immune Monitoring Kit (IM-Kit), a standardized multi-omic diagnostic tool combining genomics, epigenomics, transcriptomics, proteomics, and metabolomics assays; (2) the planned Global Immunological Dataset, generated across 10+ pilot sites in Africa, Australia, Asia, Europe, the Middle East, North America, and South America, with 75% of sites planned for low- and middle-income countries; and (3) predictive AI models of the human immune system, phased from predictive ML (Phase 1) through health trajectory models (Phase 2) to mechanistic computable models (Phase 3). These components are supported by a federated data infrastructure—anchored by the DZNE Swarm Learning Hub in Europe—that preserves data ownership with local investigators, and by the Scientific Partner Network of 10 founding institutions across five continents.

HIP's business model is donation- and grant-based rather than commercial. The organization accepts tax-deductible contributions from individuals, foundations, and corporations, and receives in-kind support such as reagents and equipment from partners including three Danaher subsidiaries. All generated datasets and AI models are released as free and open scientific resources, with no product or service sales. Go-to-market is community-led: HIP convenes research institutions via the Scientific Partner Network, engages populations through clinical study sites, and generates awareness through scientific publications, conference presence (World Economic Forum, Cold Spring Harbor Banbury Center), and earned media coverage. Operating geographies span the United States, Netherlands, Japan, Israel, Nicaragua, and a broader global footprint across seven regions.

Name

Human Immunome Project

Legal name

Human Immunome Project

Website

https://humanimmunomeproject.org

Company type

Private

Founded year

2022

Operating status

Operating

Headcount range

1–10 employees

Short description

Human Immunome Project is a US-registered 501(c)(3) nonprofit that builds a global multi-omic immunological dataset of ~225,000 participants and publicly available AI models to predict immune responses, serving the research, pharmaceutical, and clinical communities worldwide.

Ownership category

akta.pro rank

Product category

Systems Immunology Research

NAICS

Health Care and Social Assistance (62)

SIC

Services-Medical Laboratories (8071)

akta.pro primary industry

Real-World Data (RWD) / Real-World Evidence (RWE) & Observational Research Platforms (HLACAOAM)

akta.pro secondary industries

Data Aggregation, Interoperability & APIs for RPM (FHIR/IoMT Gateways) (HLACAFAO), AI/Analytics for RPM (Risk Stratification, Alerts, Predictive) (HLACAFAM)

Keywords

• Systems immunology research
• Multi-omic immune profiling
• Immunological data platform
• AI drug discovery
• Biomedical research nonprofit

Headquarters

HQ city

New York

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure, Others

Revenue model

1. Donations and Philanthropy: As a US-registered 501(c)(3) nonprofit organization, HIP relies on donations from individuals, foundations, and corporations. Donations are tax-deductible. The organization has received support from entities including Danaher subsidiaries (reagents, assays, equipment) and the Michelson Medical Research Foundation (research grants).

Go-to-market motion1 record

Distribution channels1 record

Marketing channels5 records

Core offering

HIP is a global nonprofit initiative that decodes the human immunome by combining standardized multi-omic immune profiling (via the proprietary Immune Monitoring Kit) with AI/machine learning models, producing the world's largest immunological dataset from approximately 225,000 globally diverse participants and publicly available AI models that predict immune responses. Deliverables include the IM-Kit assay, the global immunological dataset, predictive AI models, the Scientific Partner Network, and the Federated Data Infrastructure — all made available as free and open resources to the scientific community, pharmaceutical industry, and clinicians.

Product overview

The Human Immunome Project (HIP) is a global nonprofit research initiative—not a traditional software company—that is building infrastructure for human immune system research. The core offering consists of three interconnected elements: (1) the Immune Monitoring Kit (IM-Kit), a physical diagnostic tool combining multiple high-resolution assays for standardized multi-omic immune profiling; (2) a planned global immunological dataset of ~225,000 participants spanning diverse populations; and (3) publicly available AI models that integrate multi-modal immune data to predict health states and responses. These components are supported by a Scientific Partner Network of 10 leading research institutions and a federated data infrastructure. The portfolio represents an open-science approach to decoding human immunity, analogous to the Human Genome Project but for the immune system.

Differentiator

Problem solved

Functional benefit

Products and services

• Immune Monitoring Kit (IM-Kit) Standardized, multi-omic clinical lab tool that combines multiple high-resolution assays (genomics, epigenomics, transcriptomics, proteomics, metabolomics) into one clinical kit, designed to capture comprehensive immunological data from global populations at scale for use by research institutions and pharma.
• Global Immunological Dataset World's largest, most representative and comprehensive immunological dataset planned to include approximately 225,000 participants tracked longitudinally over 5 years, capturing thousands of immunological parameters per individual across cells, transcripts, antibodies, proteins, epigenetic modifications, and metabolites, made available as a free and open public resource.
• AI Models of the Human Immune System Publicly available artificial intelligence models that integrate multi-modal immunological data to predict immune states and individual responses to vaccines, infections, therapeutics, and disease conditions across diverse populations.
• Scientific Partner Network A global collaboration network of 10 founding research institutions across 5 continents advancing standardized protocols, data frameworks, and coordinated systems immunology research, including the European Hub via DZNE/ImmunoSensation2/Swarm Learning Consortium.
• Federated Data Infrastructure Distributed data architecture that enhances security while ensuring data ownership remains with the local investigators who produced the data, enabling privacy-preserving collaborative AI applications across the Scientific Partner Network.

Quantifiable outcome

• HIP's approach enables simultaneous diagnosis of multiple diseases (COVID-19, HIV, lupus, type 1 diabetes, flu vaccination status) from blood samples using machine learning of B and T cell receptor sequences
• +1 more outcomes

Named customers3 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

AI capability5 records

Feature4 records

Partnerships

18 partnerships are on record, tiered core, strategic, honorary, advisory and supporting.

• Allen InstitutecoreStrategic or Co-development Partner · 29 September 2025Part of the 10 founding institutional members of HIP Scientific Partner Network. The Allen Institute is a 501(c)(3) nonprofit research organization dedicated to understanding life and advancing health through bold moonshot initiatives combining big science, team science, and open science.
• DZNE / ImmunoSensation2 / Swarm Learning ConsortiumcoreStrategic or Co-development Partner · 29 September 2025Collectively serve as the European Hub for HIP. DZNE (German Center for Neurodegenerative Diseases) hosts the Swarm Learning Hub for privacy-preserving collaborative AI applications. ImmunoSensation2 at University of Bonn contributes immunological research capabilities. Includes the Consortium on Swarm Learning for Precision Medicine in Infectious Diseases and Pandemic Preparedness.
• Human Functional Genomics ProjectcoreStrategic or Co-development Partner · 29 September 2025Coordinated from Radboud University Medical Center in Nijmegen, Netherlands. Large-scale project to identify genetic and environmental factors impacting inter-individual variation in immune responses. International network of nine academic institutions on four continents investigating more than 25 cohorts of healthy populations and immune-mediated diseases.
• HypoVax GlobalcoreStrategic or Co-development Partner · 29 September 2025Global knowledge hub tackling vaccine hyporesponsiveness through a platform mobilizing researchers working in diverse vaccine-related fields, focused on the Global South. Initiated through a Spinoza Prize awarded to Professor Maria Yazdanbakhsh of Leiden University Medical Center.
• RIKENcoreStrategic or Co-development Partner · 29 September 2025Japan's largest comprehensive research institution (National Research and Development Agency) with world-class research centers and institutes. Founded in 1917, renowned for high-quality research across diverse scientific disciplines.
• Stanford Medicine (Center for Human Systems Immunology)coreStrategic or Co-development Partner · 29 September 2025Part of the Center for Human Systems Immunology at Stanford Medicine. A leader in biomedical revolution with tradition of leadership in pioneering research, creative teaching protocols, and effective clinical therapies, leveraging proximity to Silicon Valley entrepreneurial ecosystem.
• Sustainable Sciences Institute (SSI)coreStrategic or Co-development Partner · 29 September 2025Nonprofit dedicated to developing scientific research capacity in areas with pressing health problems. Headquartered in Oakland, California with main research center in Nicaragua. For over 25 years has carried out infectious disease research and provided on-site scientific training. Coordinates 21-year Pediatric Dengue Cohort Study in Managua.
• Technion - Israel Institute of TechnologycoreStrategic or Co-development Partner · 29 September 2025Home institution of Co-CSO Shai Shen-Orr. Systems Immunology & Precision Medicine Laboratory at Technion focuses on developing novel analytics for studying the immune system and applying these tools to investigate drivers of immune variation and advance immune-based precision medicine.
• WEHI (Walter and Eliza Hall Institute of Medical Research)coreStrategic or Co-development Partner · 29 September 2025Australian medical research institute where brilliant minds collaborate for over 100 years making transformative discoveries in cancer, infection and immunity, and lifelong health.
• Yale University (CSEI)coreStrategic or Co-development Partner · 29 September 2025Home institution of Co-CSO John Tsang. Yale Center for Systems and Engineering Immunology (CSEI) is a world-class center for systems, quantitative, and synthetic immunology, bringing together faculty from School of Medicine, School of Engineering, and Faculty of Arts and Sciences.
• Michelson Medical Research FoundationstrategicStrategic or Co-development Partner · 29 September 2025Partner in awarding $150,000 research grants annually to early-career scientists advancing human immunology, vaccine discovery, and immunotherapy research. Has awarded grants to multiple scientists including Dr. Omar Abudayyeh, Dr. Caleb Lareau, and Dr. Yuzhong Liu.
• Danaher Corporation (Beckman Coulter Life Sciences, Abcam, SCIEX)coreStrategic or Co-development Partner · 3 December 2024Three Danaher subsidiaries providing HIP access to reagents, assays, and equipment to generate advanced and standardized immunological data from diverse populations worldwide. This partnership supports development of Immune Monitoring Kits (IMKs) combining multiple tests to assess immune function.
• Eric SchmidthonoraryOthers · 1 November 2022Former Google CEO served as Honorary Co-Chair of the Human Immunome AI Summit in late 2022, which convened over 60 leading biomedical and AI scientists to outline how to decode and model the immune system.
• Cold Spring Harbor Laboratory (Banbury Center)strategicStrategic or Co-development Partner · 1 November 2022Prestigious venue hosting HIP's first Scientific Partner Network gathering in November 2025, historically significant as the site where the Human Genome Project strategy was incubated. The Banbury Center has convened 800+ meetings with 20,000+ experts including 84 Nobel laureates.
• Baillie GiffordadvisoryOthersInvestment company providing impact analysis support. Senior Impact Analyst Maria Souza serves on HIP Impact Committee, facilitating improved engagement from companies with wider healthcare ecosystem, thought leaders, NGOs, and government agencies globally.
• Peter Doherty, PhD (Nobel Laureate)honoraryOthersNobel laureate co-chaired the Human Immunome AI Summit in late 2022 that outlined the vision for HIP.
• Eric Topol, MDhonoraryOthersFounder of Scripps Research Translational Institute and renowned cardiologist/keynoted the Human Immunome AI Summit in late 2022. Provided insights on the Mal-ID diagnostic framework published in Science 2025.
• La Caixa FoundationsupportingOthersSpanish foundation that hosted presentation of HIP's research plan in November 2023. HIP Into Action Conference was hosted at CosmoCaixa Museum of Science by CaixaResearch Institute and HIP.

Scale indicators7 records

Recent moves7 records

Expansion highlights4 records

Emerging players

• CytoReason: AI company building computational models of the human immune system for drug development. Co-CSO Shai Shen-Orr is Chief Scientist of CytoReason, making it a closely connected peer. Operates commercially where HIP operates as nonprofit, but pursues overlapping scientific goals in immune AI modeling.
• Immunai: AI-driven company building a database of immune system behaviors for drug discovery. Pursues the same multi-omic + AI approach to decoding the immune system as HIP, but operates as a venture-backed commercial entity serving pharma clients.

Direct peers

• Scripps Research Translational Institute: Translational research institute founded by Eric Topol (HIP advisor) focused on precision medicine through multi-omic profiling and digital health. The Mal-ID immune diagnostic framework was published in Science by Scripps Research scientists in collaboration with HIP affiliates, making it a direct scientific collaborator and methodological peer.
• Allen Institute for Cell Science: Sister Allen Institute division building open-access reference datasets of cellular behavior. Operates the same nonprofit, big-science, open-data model as HIP, and shares the same parent organization (Allen Institute), making it a direct operational and methodological peer.
• Human Cell Atlas: Global nonprofit consortium building a comprehensive reference map of all human cells, including immune cells, using multi-omic profiling. Same open-science, multi-institutional, federated-data model as HIP, with similar ambition to create a foundational biomedical reference dataset.
• Allen Institute for Immunology: Nonprofit research division dedicated to decoding the immune system through deep profiling and AI. Both HIP and Allen Institute for Immunology pursue systems immunology with similar scientific goals, and Allen Institute is a founding member of HIP's Scientific Partner Network.

Broad incumbents

• Chan Zuckerberg Initiative (CZI): Philanthropic initiative funding large-scale biomedical research, including the Human Cell Atlas and immune-related work. Operates a much larger, broader scope than HIP, but pursues the same open-science model of building shared biomedical infrastructure for the research community.
• Foundation Medicine: Acquired by Roche; built one of the largest clinical genomic databases used to inform cancer treatment. Comparable in building a reference molecular dataset that pharma and clinicians pay to access, but in oncology rather than immunology, and via a commercial model rather than nonprofit.
• Wellcome Leap: Nonprofit program of the Wellcome Trust funding bold, multi-year biomedical research programs at scale, including immune resilience and healthspan. Same nonprofit, big-ticket, mission-driven model as HIP but with broader program scope and significantly more capital.

Others

• 10x Genomics: Provider of single-cell and multi-omic profiling technologies (including CITE-seq and TCR/BCR sequencing) that HIP depends on for its IM-Kit assays. Indirectly comparable as an enabling technology provider rather than direct competitor, but shapes the ecosystem in which HIP operates.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/ImmunomePro
• YouTubeyoutube.com/playlist?list=PLLairPAdu9Yo3w_zK-KJs5A64n1Ftw9Aa
• LinkedInlinkedin.com/company/humanimmunomeproject
• Instagraminstagram.com/humanimmunomeproject

Revenue estimate

Valuation estimate

Number of profiles

Profiles10 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about Human Immunome Project