Bioactive

What Bioactive does

BioActive Natural Health Pty Ltd is an Australian biotech company headquartered in Perth that develops and commercializes plant-based bioactive supplements for women's menstrual and hormonal health through its consumer brand Hey Sister!. Its core technology is Khapregesic®, a proprietary preparation derived from Khaya senegalensis (African mahogany) grown and manufactured in Australia, validated by a published randomized double-blind placebo-controlled trial and an ongoing menopause efficacy study. The product portfolio spans the OG Range and Life Range across four lifecycle segments (teen, reproductive, perimenopause, menopause), complemented by at-home diagnostic test kits, wellness teas, period underwear via partnership, and educational accessories.

The company operates a direct-to-consumer e-commerce model through heysister.com with Shopify-powered checkout, global shipping to 100+ countries, and a Subscribe + Save subscription layer that drives recurring revenue. Pricing ranges from $11.50 USD for diagnostic kits to $160 USD for a 9-cycle bulk bottle, with bundle and subscription discounts (3-cycle bundle at $60 instead of $80) and a money-back guarantee on the first transaction. Distribution is augmented by an independent stockist channel, while marketing relies on owned content (Hey Sister! Journal), email newsletters, organic social, and earned media placements in Vogue Australia, InStyle, Urban List, and The West Australian. Customer concentration is highly diffuse across individual female consumers globally.

Commercially, BioActive has remained private since its 2012 founding with a single disclosed 2017 funding round from Melbourne Angels. The company has prioritized clinical validation (MTick certification, peer-reviewed publications) and lifecycle product extension as its primary growth levers, with expansion signals across geographies, age segments, and adjacent diagnostics. No management team, M&A, or institutional capital events beyond the 2017 angel round are disclosed in the available data.

Name

Bioactive

Legal name

BioActive Natural Health Pty Ltd

Website

https://bioactivelab.com.au

Company type

Private

Founded year

2012

Operating status

Operating

Headcount range

11–50 employees

Short description

BioActive Natural Health Pty Ltd is an Australian biotech company that sells plant-based women's health supplements under the Hey Sister! brand, using proprietary Khapregesic® (Khaya senegalensis) to address period pain, PMS, and menopause via global DTC e-commerce.

Ownership category

akta.pro rank

Product category

Women's Herbal Health Supplements

NAICS

Food (Health) Supplement Retailers (456191)

SIC

Medicinal Chemicals & Botanical Products (2833)

akta.pro primary industry

Women’s Health Supplements (Prenatal, Menopause, Hormonal) (CRADAGAK)

akta.pro secondary industries

Menstrual Pain Relief & Period Care Supplements (CRABAIAJ), Herbal & Botanical Supplements (CRADAGAD)

Keywords

• Plant-based supplements
• Women's health supplements
• Menstrual pain relief
• Menopause supplements
• Herbal health products

Headquarters

HQ city

Perth

HQ country

Australia

HQ region

Oceania

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Technology or R&D, Marketing or Sales, Personnel

Revenue model

1. E-commerce Product Sales: Direct-to-consumer sales of period pain relief, PMS, and menopause products through owned e-commerce platform. Subscription model (Subscribe + Save) provides recurring revenue with discount incentives. One-time purchase and bundle options available.
2. Wellness Accessories & Diagnostics: Sale of complementary wellness products including test kits (FSH perimenopause test, UTI test, vaginal pH test), tea products, books, and accessories. These products cross-sell to the core customer base.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels4 records

Core offering

BioActive Natural Health Pty Ltd, operating under the consumer brand Hey Sister!, develops, manufactures, and sells plant-based dietary supplements for women's menstrual and hormonal health. Its products are built around Khapregesic®, a proprietary single-ingredient preparation derived from Khaya senegalensis (African mahogany), traditionally used in Western herbal medicine to relieve period pain, PMS symptoms, bloating, mild anxiety, mood swings, and menopausal symptoms across life stages from adolescence through menopause.

Product overview

BioActive Natural Health Pty Ltd operates primarily through its consumer brand Hey Sister!, a women's health platform offering plant-based supplements for period pain, PMS, and menopause symptoms. The product portfolio consists of two main supplement ranges: the OG Range (original formulations with Khapregesic® as the hero ingredient) and the Life Range (products with added nutrients targeting teens, midlife women, and those at various life stages). The portfolio also includes diagnostic test kits (FSH, UTI, vaginal pH), wellness teas, period underwear, educational resources, and accessories. Products are sold through e-commerce with subscription options, with clinical trials supporting the efficacy of the core Khapregesic® ingredient. The company is headquartered in Australia with global shipping to markets including the United States.

Differentiator

Problem solved

Functional benefit

Brands

• OG Range: Original period pain and PMS relief products
• Life Range
• Khapregesic®

Products and services

• Hey Sister! Original Period Pain & PMS Relief (OG Range)

Quantifiable outcome

• Randomized double-blind placebo-controlled trial demonstrating safety and efficacy for period pain relief (Lopresti A. et al., PMC12266064)
• +2 more outcomes

Named customers1 record

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature1 record

Partnerships

One partnership is on record.

• Love LunaminorOthersLove Luna Teen Period Ready Bikini Brief Pack is sold alongside Hey Sister! products as a complementary wellness accessory. Love Luna provides period underwear products for teenagers, bundled with Hey Sister! teen-focused offerings.

Scale indicators2 records

Recent moves6 records

Expansion highlights7 records

Direct peers

• Care/of: US DTC personalized vitamin and supplement brand with subscription model and quiz-driven recommendations. Comparable in DTC subscription mechanics, quiz-driven personalization, and digitally-native women's supplement experience.
• WelleCo: Australian premium women's wellness supplement brand founded by Elle Macpherson, sold DTC and via stockists with a focus on women's hormonal and midlife health. Directly comparable in target demographic (women's hormonal and menopausal health), Australian origin, and premium DTC positioning.
• Ritual: US-based DTC multivitamin and women's health supplement brand with subscription model and clinical-grade positioning. Comparable in subscription-led DTC motion, clinical evidence emphasis, and women's health lifecycle SKUs (prenatal, women's multivitamin).
• Perelel Health: US DTC women's health supplement brand covering prenatal, hormonal, and menopause stages with physician-formulated products. Comparable in lifecycle women's health positioning, clinical credibility marketing, and DTC subscription model.
• Moon Juice: US plant-based wellness and adaptogen supplement brand sold DTC at premium price points, targeting women's hormonal, mood and stress needs. Comparable in plant-based/botanical hero ingredients, premium DTC positioning, and women's hormonal health messaging.
• The Beauty Chef: Australian-founded, plant-based wellness supplement brand selling direct-to-consumer via owned e-commerce with a subscription model. Highly comparable to Hey Sister! in geography, plant-based botanical positioning, premium DTC pricing, and lifecycle wellness framing for women.

Broad incumbents

• Nature's Way: Large US-based herbal and botanical supplement company with extensive women's health product lines. Comparable as a broad incumbent in standardized botanical supplements and a likely competitor for Khapregesic®-adjacent women's health indications in retail channels.
• Blackmores: Australia's largest supplements company with deep pharmacy distribution and a broad women's health range including menstrual and menopause products. Comparable as the dominant Australian herbal/women's supplements incumbent that Hey Sister! competes against for shelf, practitioner, and consumer mindshare.
• Swisse Wellness: Major Australian supplements brand owned by H&H Group with broad women's wellness ranges and omni-channel retail distribution. Comparable as a broad incumbent in Australian women's health supplements with significantly larger marketing and distribution reach.

Others

• Elagen: UK-based women's health supplement brand focused on hormonal, PMS, and menopause support sold via DTC and stockists. Comparable as a regional (UK) women's hormonal and menopause botanical supplement brand that may overlap with Hey Sister! in European channel expansion.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/khapregesic
• LinkedInlinkedin.com/company/bioactive-laboratories-pty-ltd.

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds1 record

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Bioactive