Therenva
Therenva SAS, a Rennes-based subsidiary of Ziehm Imaging, develops AI-driven pre-operative planning (EndoSize) and intra-operative navigation (EndoNaut) software for endovascular and structural heart procedures, serving hospitals and medical device manufacturers across 40+ countries.
- Company typePrivate
- Founded2017
- HeadquartersRennes, France
- Headcount11–50
- GTM typeB2B
- OfferingSoftware
What Therenva does
Therenva SAS is a Rennes, France-based medical imaging software company founded in 2017 that develops AI-driven planning and navigation tools for endovascular and structural heart procedures. Its portfolio consists of two regulated products: EndoSize, a pre-operative planning workstation for sizing and selecting aortic, peripheral, and cardiovascular devices, and EndoNaut, an intra-operative navigation system that fuses pre-operative CT/CTA imaging with live fluoroscopy for image-guided endovascular interventions. The underlying technology stack includes patented AI algorithms for image registration, automated centerline extraction, 2D panorama stitching for peripheral workflows, and predictive vascular deformation modeling, supported by a corpus of more than 1 million case plans and 200 peer-reviewed publications.
The company serves two distinct customer segments. End users are vascular surgeons, interventional radiologists, and interventional cardiologists at hospitals and academic medical centers, with documented deployments across 40+ countries for EndoSize and 50+ markets for EndoNaut. The second segment is medical device manufacturers: Therenva has established integration partnerships with 13 device companies including Artivion, Cook Medical, Endologix, Medtronic, and Terumo, embedding its sizing modules into device selection and procurement workflows. Since becoming a subsidiary of Ziehm Imaging GmbH (Nuremberg, Germany), EndoNaut is now natively integrated into Ziehm's C-arm platform, providing an OEM-embedded distribution channel alongside direct hospital sales.
Therenva's regulatory positioning spans FDA 510(k) clearance, CE MDR certification (Class IIa/IIb), and additional approvals from NMPA (China) and Ninsho (Japan), enabling global commercialization. Revenue mechanics combine hospital software licensing (perpetual and subscription) with device-partner integration agreements and OEM royalties through the Ziehm channel. The company's commercial scale is modest (11-50 employees) and no revenue, funding, or valuation data is publicly disclosed.
Therenva firmographics
Firmographics- Name
- Therenva
- Legal name
- Therenva SAS
- Website
- https://therenva.com
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Therenva SAS, a Rennes-based subsidiary of Ziehm Imaging, develops AI-driven pre-operative planning (EndoSize) and intra-operative navigation (EndoNaut) software for endovascular and structural heart procedures, serving hospitals and medical device manufacturers across 40+ countries.
- Ownership category
- akta.pro rank
Therenva industry classification
Industry- Product category
- Medical Imaging Software (Cardiovascular)
- NAICS
- Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (3345)
- SIC
- Surgical & Medical Instruments & Apparatus (3841)
- akta.pro primary industry
- Radiology AI, CAD & Advanced Visualization Software (HLAHABAJ)
- akta.pro secondary industries
- Interventional Radiology & Image-Guided Therapy Systems (HLAHABAG), Medical Imaging AI (HDAAAEAH), AI Orchestration & Imaging Analytics Platforms (Model Management/Triage) (HLACALAG)
Keywords
Where Therenva is headquartered
LocationHeadquarters
- HQ city
- Rennes
- HQ country
- France
- HQ region
- Europe
Offices2 records
Markets served
Therenva business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Operations
Revenue model
- EndoSize software licensing: EndoSize is sold as a software medical device with CE mark (Class IIa), FDA 510(k) clearance, NMPA and Ninsho approvals. The product is offered with a 15-day free trial and likely follows a subscription or perpetual license model targeting hospitals and physicians. EndoSize is used in more than 40 countries and is not eligible for reimbursement in Europe.
- EndoNaut software licensing: EndoNaut is sold as a Class IIb medical device software under CE mark (MDR) and FDA 510(k) clearance. It is integrated with Ziehm C-arm systems and distributed through the Ziehm partner network globally. Pricing is quote-based, not publicly disclosed. EndoNaut is not eligible for reimbursement in Europe.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Freemium | Annual | 15-day free trial available for EndoSize |
Go-to-market motion2 records
Distribution channels3 records
Marketing channels4 records
Therenva product offering
Product offeringCore offering
Therenva develops and sells AI-based medical imaging software for cardiovascular procedures, including EndoSize for pre-operative case planning of endovascular and structural heart interventions (TAVI/TAVR, TMVR, EVAR, TEVAR, peripheral) and EndoNaut for intra-operative image fusion navigation compatible with any C-arm system. The software combines AI, deep learning, and biomechanical simulation to automate vessel/valve segmentation, centerline extraction, and 3D/2D image fusion, reducing radiation dose and contrast use during procedures. Both products are sold as regulated medical device software (FDA 510(k) cleared, CE marked under EU MDR) to hospitals, healthcare professionals, and medical device manufacturers.
Product overview
Therenva offers two core medical software platforms: EndoSize for pre-operative case planning and EndoNaut for intra-operative navigation. EndoSize is a modular planning solution comprising Vascular Edition (Peripheral, Aorto-Iliac, Thoracic, Thoraco-abdominal modules) and Structural Heart Edition (TAVI, TMVR modules). EndoNaut is an image fusion navigation system with Aorto-Iliac and Peripheral modules. Both platforms integrate with PACS/NAS systems, C-arm hardware, and DICOM standards. Both products carry FDA 510(k) clearance and CE marking under EU MDR.
Differentiator
Problem solved
Functional benefit
Brands
- EndoSize: AI-based software for endovascular and structural heart procedure planning including TAVI/TAVR and TMVR treatments. Available in 15 languages.
- EndoNaut
Products and services
- EndoSize Pre-operative AI-based planning software for endovascular and structural heart procedures, including TAVI/TAVR, TMVR, EVAR, TEVAR, and peripheral interventions. Provides automated measurements, centerline extraction, vessel and valve segmentation, and device sizing. FDA 510(k) cleared and CE marked (Class IIa). Sold as a Class IIa medical device software to hospitals, physicians, and medical device manufacturers. Available in 15 languages with a 15-day free trial.
- EndoNaut Intraoperative image fusion and navigation system for endovascular procedures, compatible with any mobile or fixed C-arm. Provides real-time 3D image fusion, AI-based registration of fluoroscopy and CT, predictive vascular deformation overlay, and 2D panorama stitching. FDA 510(k) cleared and CE marked (Class IIb). Marketed and distributed globally through the Ziehm Imaging partner network.
- EndoSize Vascular Edition Planning module within the EndoSize platform for peripheral, aorto-iliac, thoracic, and thoraco-abdominal endovascular procedures. Includes automatic vessel segmentation, centerline creation, stent-graft device selection, and 3D visualization. Sold as a dedicated edition to vascular surgeons and interventional radiologists, and customized for device manufacturer partners.
- EndoSize Structural Heart Edition Planning module within the EndoSize platform for TAVI/TAVR and TMVR procedures. Features automatic AI-based aortic and mitral valve segmentation, aortic root analysis, and 3D virtual stent representation for transcatheter heart valve planning. Customized for device manufacturer partners including Artivion and Terumo Aortic.
- EndoNaut Aorto-Iliac Module Intraoperative 3D image fusion navigation module for aorto-iliac endovascular procedures including EVAR, B/FEVAR, TEVAR, and recanalization/embolization. Combines AI-based image registration with stiff guidewire predictive vascular deformation overlay for accurate intra-operative navigation.
- EndoNaut Peripheral Module Intraoperative 2D panorama navigation module for peripheral artery disease procedures. Features automatic panorama creation by stitching fluoroscopic and angiographic images, lesion marking, and ready-made AI-based 2D image fusion that synchronizes live image views with panoramas to decrease contrast and X-ray dose.
Quantifiable outcome
- >50% decrease in X-ray dose during endovascular procedures using EndoNaut
- +4 more outcomes
Companies that use Therenva
Customer profileNamed customers18 records
Segments2 records
Ideal customer profiles1 record
Therenva technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration4 records
AI capability7 records
Feature6 records
Therenva partnerships and signals
Strategic signalPartnerships
Four partnerships are on record, tiered core.
- Ziehm Imaging GmbHcoreZiehm Imaging GmbH is the parent company of Therenva. EndoNaut image fusion technology is natively integrated into Ziehm C-arm systems, distributed through Ziehm's global partner network including Ziehm France and Ziehm Spain. Therenva's headquarters are located separately in Rennes, France.
- Université Rennes 1coreUniversité Rennes 1 is listed as an R&D institutional partner, collaborating with Therenva to build next-generation navigation systems and advance medical imaging technology.
- Ziehm France (Subsidiary)coreZiehm France is a subsidiary of Ziehm Imaging that serves as a sales and distribution partner for Therenva products in France. They showcase Therenva innovations at French congresses such as SCVE.
- Ziehm Spain (Subsidiary)coreZiehm Spain is a subsidiary of Ziehm Imaging that serves as a sales and distribution partner for Therenva products in Spain, showcasing integrated AI-based image fusion at SEACVE and other events.
Scale indicators11 records
Recent moves6 records
Expansion highlights6 records
Therenva competitors and assessment
Company assessmentDirect peers
- Materialise: Materialise offers the Mimics and 3-matic medical imaging suites, including cardiovascular and endovascular planning modules, and competes with EndoSize on 3D anatomical reconstruction and device sizing for hospital and device-OEM users.
- Pie Medical Imaging: Pie Medical Imaging (now part of Philips) provides 3D cardiovascular planning and simulation software for structural heart and vascular procedures, directly overlapping with Therenva's EndoSize Vascular and Structural Heart Editions in pre-operative case sizing.
- TeraRecon: TeraRecon (now a ConcertAI company) provides advanced visualization and AI orchestration for radiology, including vascular and cardiac workflows, competing with EndoSize/EndoNaut on enterprise imaging analytics platforms used by hospitals.
- HeartFlow: HeartFlow provides AI-driven cardiovascular imaging analysis (FFR-CT) and is increasingly expanding into coronary and broader cardiovascular planning — a comparable AI-first workflow targeting vascular and structural heart disease.
- Cydar Medical (Endeavor): Cydar Medical offers cloud-based 3D image fusion and augmented reality guidance for endovascular surgery, directly competing with EndoNaut on AI-based 2D/3D image fusion and intra-operative navigation in the OR/hybrid suite.
Broad incumbents
- Siemens Healthineers (syngo.via): Siemens syngo.via is an enterprise imaging post-processing platform that includes vascular and cardiac CT/MR analysis modules, competing broadly with Therenva's advanced visualization and planning capabilities inside a much larger imaging-IT offering.
- GE Healthcare (Edison/AW): GE Healthcare's AW workstation and Edison platform provide advanced visualization and AI applications across cardiovascular and radiology, overlapping with EndoSize/EndoNaut in enterprise hospital imaging workflows.
- Philips (IntelliSpace Portal): Philips IntelliSpace Portal is an enterprise advanced visualization platform covering cardiac, vascular, and oncology workflows, with cardiovascular planning features that overlap with EndoSize as part of a much broader imaging-IT portfolio.
Emerging players
- Centerline Biomedical: Centerline Biomedical develops an intra-operative 3D guidance system for endovascular procedures, addressing the same image-guided therapy workflow as EndoNaut, with a more focused but narrower commercial footprint.
- Remedy Logic: Remedy Logic provides AI-driven medical imaging analysis, including vascular and procedural planning tools, intersecting with Therenva's AI segmentation and planning capabilities in the broader cardiovascular imaging AI category.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks1 record
Key highlights7 records
Customer concentration
Therenva social profiles
Digital presenceTherenva compliance and trust
Trust signalCompliance3 records
Therenva financial estimates
Financial estimateRevenue estimate
Valuation estimate
Therenva leadership team
Management profileNumber of profiles
Profiles3 records
Therenva subsidiaries and ownership
Company hierarchySubsidiaries1 record
Therenva funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Therenva M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Therenva
What does Therenva do?
Therenva develops and sells AI-based medical imaging software for cardiovascular procedures, including EndoSize for pre-operative case planning of endovascular and structural heart interventions (TAVI/TAVR, TMVR, EVAR, TEVAR, peripheral) and EndoNaut for intra-operative image fusion navigation compatible with any C-arm system. The software combines AI, deep learning, and biomechanical simulation to automate vessel/valve segmentation, centerline extraction, and 3D/2D image fusion, reducing radiation dose and contrast use during procedures. Both products are sold as regulated medical device software (FDA 510(k) cleared, CE marked under EU MDR) to hospitals, healthcare professionals, and medical device manufacturers.
Is Therenva a public or private company?
Therenva is a private company. It is classified as corporate owned and is currently operating.
When was Therenva founded?
Therenva was founded in 2017. It employs 11 to 50 people.
Where is Therenva based?
Therenva is headquartered in Rennes, France, in the Europe region.
How does Therenva make money?
Two revenue lines are on record. EndoSize software licensing is the primary driver. The others are endoNaut software licensing.
Who are Therenva's main competitors?
Direct peers on record are Materialise, Pie Medical Imaging, TeraRecon, HeartFlow and Cydar Medical (Endeavor). Broad incumbents are Siemens Healthineers (syngo.via), GE Healthcare (Edison/AW) and Philips (IntelliSpace Portal). Emerging players are Centerline Biomedical and Remedy Logic.
Does Therenva have an API?
No public API is recorded for Therenva.
What industry is Therenva in?
Therenva's product category is Medical Imaging Software (Cardiovascular). Its primary akta.pro industry code is HLAHABAJ, Radiology AI, CAD & Advanced Visualization Software, with a secondary code of HLAHABAG, Interventional Radiology & Image-Guided Therapy Systems. Its NAICS code is 334510 and its SIC code is 3841.