What Plasma Biotal does

Plasma Biotal Ltd. is a UK-based specialty biomaterials manufacturer founded in April 1991 in Tideswell, Derbyshire, operating as a subsidiary of Plasma Group Science. The company produces medical-grade synthetic calcium phosphate powders under the CAPTAL® brand (hydroxyapatite variants including 'S' Sintered, 'R' Reactor Grade, 'HT' Microspheres, 'ACP' amorphous precursors, plus β-tricalcium phosphate) and supplies proprietary BIOTAL® hydroxyapatite coating services for orthopaedic implants. Its core technology combines chemical synthesis, thermal treatment, particle engineering, and specialised plasma spraying to achieve ≥95% phase purity and ≥90% crystallinity in powders, with ~85% crystallinity in coatings — a specification tied to preserved lattice structure and claimed superior to standard plasma spray approaches.

The company runs two ISO 13485-certified UK manufacturing sites (Tideswell headquarters and Buxton, the latter operational since 2021 and expanded 45% in early 2024) and a jointly-controlled Indian operation, Plasma Biotal India Pvt. Ltd. (PBIL, est. 2017, Pune), giving it a UK-Asia dual-coast manufacturing footprint. Its customer base spans four primary segments: orthopaedic device manufacturers (the largest historical segment, supported by FDA Masterfiles for coatings since 2005 and powders since 2022), dental companies (bone grafts and remineralisation), research institutions (over 1,300 supported studies), and — newly enabled by the 2024 ISO scope expansion — cosmetics and dermal filler manufacturers using CAPTAL® HT microspheres. Ancillary revenue lines include bespoke calcium phosphate product development (custom phase composition, crystallinity, morphology) and ISO 13485-aligned quality and materials testing services (XRD, XRF, ICP-MS, SEM, FTIR, particle/density/coating testing).

Commercially, Plasma Biotal operates as a sales-led B2B supplier with a direct, quote-based pricing model — orders range from single kilograms for research to multi-tonne for industrial customers — mediated through technical consultation and supplemented by industry event presence at OMTEC, AAOS, and Advanced Ceramics Show. Revenue, headcount (11–50 employees), funding history, and capital structure are not publicly disclosed; parent ownership by Plasma Group Science, no disclosed institutional investment, and an India JV with Biorad Medisys Pvt. Ltd. form the principal corporate facts. The business model carries no SaaS or recurring subscription component and depends on customer device regulatory cycles, but is buffered by long-qualified supplier relationships and a 30-year clinical track record.

Name

Plasma Biotal

Legal name

Plasma Biotal Ltd.

Website

https://plasma-biotal.com

Company type

Private

Founded year

1991

Operating status

Operating

Headcount range

11–50 employees

Short description

Plasma Biotal Ltd manufactures medical-grade synthetic calcium phosphate powders (hydroxyapatite and β-TCP) under the CAPTAL® brand and provides proprietary BIOTAL® hydroxyapatite coating services for orthopaedic, dental, research, and aesthetics customers from ISO 13485-certified UK and India facilities.

Ownership category

akta.pro rank

Product category

Medical Biomaterials

NAICS

Surgical Appliance and Supplies Manufacturing (339113), Dental Equipment and Supplies Manufacturing (339114)

SIC

Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842), Dental Equipment & Supplies (3843)

akta.pro primary industry

Bone Graft Substitutes & Orthobiologics (Synthetic/Allograft/DBM) (HLAHAEAG)

akta.pro secondary industries

Dental Implants & Prosthodontic Components (Implants/Abutments/Prosthetics) (HLAHAEAE), Dental Implant Surgery & Bone Grafting (HLABAEAB)

Keywords

• Medical grade calcium phosphates
• Hydroxyapatite biomaterials
• Orthopaedic implant coatings
• Beta tricalcium phosphate powders
• Bespoke biomaterial manufacturing

Headquarters

HQ city

Tideswell

HQ country

United Kingdom

HQ region

Europe

Offices3 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Supply Chain, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Medical-Grade Calcium Phosphate Powders: Sale of proprietary CAPTAL® branded hydroxyapatite and β-TCP powders to medical device manufacturers, research institutions, and dental companies. Products sold in various configurations including sintered, unsintered, spherical, angular morphologies with custom particle sizes.
2. Hydroxyapatite Coating Services: Bioactive hydroxyapatite coating services for orthopaedic implants including specialist masking, validated grit blasting, and 100% final inspection. Fully validated process compliant with ISO 13779-2 standards.
3. Bespoke Product Development: Custom calcium phosphate product development services including biphasic calcium phosphates, trace elemental substitutions, and novel ceramic constructs for specific customer applications.

Pricing tiers

Go-to-market motion3 records

Distribution channels2 records

Marketing channels5 records

Core offering

Plasma Biotal manufactures and supplies medical-grade synthetic calcium phosphate powders under the CAPTAL® brand (hydroxyapatite, β-TCP, and amorphous variants) and provides proprietary BIOTAL® hydroxyapatite coating services for orthopaedic implants. Its offering also includes bespoke calcium phosphate product development and ISO 13485-compliant quality and materials testing services for medical device manufacturers, dental companies, and research institutions.

Product overview

Plasma Biotal offers a portfolio of medical-grade synthetic calcium phosphate products under the CAPTAL® brand, centred on hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) materials. The product line includes various powder formulations (CAPTAL® 'S', 'R', 'R-Sintered', 'HT', and ACP variants) optimised for applications including orthopaedic coatings, bone grafts, dental treatments, cosmetics/dermal fillers, and 3D printing. The CAPTAL® Hydroxyapatite Coating service applies these materials to medical implants. Supporting services include bespoke product development and ISO 13779/ISO 13485-compliant quality and testing services. The portfolio is unified by the CAPTAL® brand and shared biomaterial expertise.

Differentiator

Problem solved

Functional benefit

Brands

• CAPTAL: Product range of medical-grade synthetic calcium phosphate powders including CAPTAL S (Sintered Hydroxyapatite), CAPTAL R (Reactor Grade), CAPTAL HT (High Temperature Microspheres), CAPTAL ACP (Amorphous Calcium Phosphate), and CAPTAL β-TCP (Beta-Tricalcium Phosphate).
• BIOTAL Coating
• CAPTAL Hydroxyapatite Coating

Products and services

• CAPTAL® 'S' Sintered Hydroxyapatite Powder Crystalline, densified hydroxyapatite powder available in angular and spherical (Spray Grade) morphologies, thermally stable to 1300°C. Used for plasma and thermal spray coating of orthopaedic implants. Dv50 particle size range: 20–90 µm.
• CAPTAL® 'R' Reactor Grade Hydroxyapatite Unsintered, micron-scale hydroxyapatite powder with high surface area (6–20 m²/g) and dendritic crystalline structure. Optimised for bone cements, injectable products, 3D printing feedstock, and drug delivery systems. Average particle size ~4 µm, crystallinity 85–95%.
• CAPTAL® 'HT' Microspheres Densified hydroxyapatite microspheres optimised for flowability and injectability. Used in bioactive dermal fillers, injectable therapies, additive manufacturing, and HPLC chromatography. Phase purity ≥95%, crystallinity >75%.
• CAPTAL® 'ACP 1.67' Amorphous Calcium Phosphate High-purity, non-crystalline precursor with Ca:P ratio of 1.67 that converts to crystalline hydroxyapatite under sintering conditions. Available in spherical (Dv50: 15–30 µm) or angular granules (Dv50: 60–500 µm). Surface area 50–90 m²/g.
• CAPTAL® 'R-Sintered' Hydroxyapatite Powders Highly crystalline, densified angular hydroxyapatite powder with >95% crystallinity. Small particle size (<10 µm) suitable for 3D printing. Meets ISO 13779-6 requirements.
• Beta-Tricalcium Phosphate (β-TCP) High-purity crystalline β-TCP (Ca:P ratio 1.5) that is osteoconductive, osteoinductive, and fully resorbable. Used in regenerative bone and dental therapies. Phase purity ≥95%, available in 15–30 µm or 1–5 µm particle sizes. Certified to ASTM F1088-23.
• CAPTAL® 'ACP 1.50' Amorphous Tricalcium Phosphate High-purity amorphous precursor with Ca:P ratio of 1.50. Crystallises to β-TCP when heated above 900°C. Available in spherical (Dv50: 15–30 µm) or angular granules (Dv50: 60–500 µm).
• CAPTAL® Sintered Discs Pressed and sintered crystalline ceramic constructs available in HA, β-TCP, or combination. Ideal for tissue culture applications in musculoskeletal research. Available in 12 mm or 24 mm diameters, 2–5 mm thickness, in fully dense or microporous forms.
• CAPTAL® Hydroxyapatite Coating (BIOTAL® Coating Service) Bioactive hydroxyapatite coating service for orthopaedic implants using plasma and thermal spraying, with class-leading crystallinity (~85%) from a proprietary process that preserves the HA lattice. Provides long-term mechanical fixation between implant and bone. All coatings comply with ISO 13779 standards.
• Bespoke Products & Development Custom calcium phosphate product development service including phase composition tuning, crystallinity control, physical characteristics/morphology customisation, and bespoke sintered constructs. In-house engineering team supports new product commercialisation.
• Quality & Testing Services Comprehensive materials testing and characterisation services for medical device compliance. Includes composition testing (XRD, XRF, ICP-MS), powder properties (particle size, density, BET, flow testing), coating properties (tensile/shear testing, hardness, dissolution), and qualitative analysis (SEM, FTIR, optical microscopy, bioburden).

Quantifiable outcome

• 99% survivorship rate at 20-year follow-up for HA-coated hip implants (Freeman femoral component)
• +2 more outcomes

Named customers4 records

Segments4 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

One partnership is on record.

• Biorad Medisys Pvt LtdcoreStrategic or Co-development Partner · 1 January 2017Joint venture partnership establishing Plasma Biotal India Pvt Ltd (PBIL) in Pune, India. Biorad Medisys provides local market expertise and manufacturing infrastructure while Plasma Biotal contributes coating technology and quality systems. The JV enables local supply of high-quality HA coatings to the Asian market.

Scale indicators5 records

Recent moves11 records

Expansion highlights6 records

Direct peers

• Geistlich Pharma: Swiss leader in dental bone regeneration (Bio-Oss®, Bio-Gide®). Comparable in serving dental bone graft and regeneration markets with biomaterials, although Geistlich's portfolio is xenograft-based rather than synthetic calcium phosphate.
• CAM Bioceramics: Dutch manufacturer of calcium phosphate biomaterials (hydroxyapatite, β-TCP, BCP) for orthopaedic, dental and craniomaxillofacial applications. Closest comparable in terms of product portfolio, regulatory positioning and customer base.
• DOT GmbH: German specialist in plasma-spray coating of hydroxyapatite and other bioceramic coatings on medical implants. Directly comparable coating services offering for orthopaedic implant manufacturers.
• Biomatlante: French specialty manufacturer of synthetic calcium phosphate bone graft substitutes (MBCP® biphasic technology). Directly competes with Plasma Biotal in synthetic bone graft materials for orthopaedic and dental indications.
• Himed: US-based supplier of calcium phosphate powders and plasma-spray HA coating services for orthopaedic and dental implants. Direct competitor in the HA coating service market with comparable regulatory and quality positioning.

Broad incumbents

• Stryker: Major orthopaedic and medical device company with HA-coated implant offerings. Comparable through overlap in orthopaedic implant surface technology and as a potential customer of Plasma Biotal coating services.
• Zimmer Biomet: Global orthopaedic implant leader that uses HA coatings on certain product lines. While not a direct biomaterial peer, Zimmer Biomet represents both a key customer segment for Plasma Biotal and an example of large-scale in-sourcing potential.
• Evonik Industries: German specialty chemicals company with a healthcare biomaterials portfolio including calcium phosphate and bioresorbable polymers. Comparable through overlap in medical-grade calcium phosphate chemistry, but operating at much larger scale with broader product lines.
• Institut Straumann: Global dental implant leader with regenerative materials portfolio. Comparable through overlap in dental bone graft and biomaterial markets where Plasma Biotal serves dental customers.

Emerging players

• Orchid Orthopedic Solutions: Contract manufacturer offering orthopaedic implant surface treatments including HA coatings and other value-added services. Comparable in HA coating service delivery but with a broader contract manufacturing remit.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Plasma Biotal