Illumination Health
Illumination Health operates a rheumatology-focused clinical informatics platform and the ENRGY practice-based research network, aggregating real-world data from 700+ rheumatologists across 27 U.S. states to deliver clinical trial services, real-world evidence, and FDA-cleared Remote Therapeutic Monitoring to pharmaceutical companies, academic institutions, and rheumatology practices.
- Company typePrivate
- Founded-
- HeadquartersHoover, United States
- Headcount11–50
- GTM typeB2B
- OfferingSoftware
What Illumination Health does
Illumination Health operates a rheumatology-focused clinical informatics platform combined with the ENRGY (Excellence Network in RheumatoloGY) practice-based research network, aggregating real-world data from 700+ rheumatologists across 27 U.S. states and 1M+ active patients into what the company describes as the world's largest prospective rheumatology data repository. The underlying technology stack is a single-platform electronic health record conjoined with an integrated Electronic Data Capture (EDC) system that pre-populates fields from a normalized data warehouse mapped to the PCORnet Common Data Model and hosted on Amazon Web Services. Supporting modules include the Floodlight data visualization tool, the Flashlight CohortBuilder for patient feasibility, the Bridge provider education platform integrated with Microsoft Teams, and 14 rheumatology-specific clinical algorithms that automate decision support and care workflows. PERx (Patient Engagement Rx), an FDA-cleared Software as a Medical Device powered by Arthritis Power technology, provides Remote Therapeutic Monitoring that is reimbursable by insurance programs including Medicare.
The company monetizes through four primary streams: contracted clinical trial and research services to pharmaceutical and biotech clients (Pfizer and AstraZeneca are named partners); study-specific compensation and recurring participation income paid to ENRGY network member practices; data and analytics services offering real-time dashboards and linkage to external claims and health-plan sources; and usage-based RTM reimbursement flowing through rheumatology practices using PERx. Brian Owens serves as President and Jeffrey R. Curtis MD MS MPH is the senior research leader, holding a joint appointment at the University of Alabama at Birmingham, which functions as the company's principal academic collaboration partner. Illumination Health is headquartered in Hoover, Alabama, operates as a private for-profit entity, and does not have any disclosed funding rounds, M&A activity, or public ownership structure in the available data.
Illumination Health firmographics
Firmographics- Name
- Illumination Health
- Legal name
- Illumination Health
- Website
- https://illumination.health
- Company type
- Private
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Illumination Health operates a rheumatology-focused clinical informatics platform and the ENRGY practice-based research network, aggregating real-world data from 700+ rheumatologists across 27 U.S. states to deliver clinical trial services, real-world evidence, and FDA-cleared Remote Therapeutic Monitoring to pharmaceutical companies, academic institutions, and rheumatology practices.
- Ownership category
- akta.pro rank
Illumination Health industry classification
Industry- Product category
- Healthcare Informatics & Clinical Research
- NAICS
- Scientific Research and Development Services (5417), Offices of Physicians (62111)
- SIC
- Services-Offices & Clinics Of Doctors Of Medicine (8011), Services-Health Services (8000)
- akta.pro primary industry
- Real-World Data (RWD) / Real-World Evidence (RWE) & Observational Research Platforms (HLACAOAM)
- akta.pro secondary industries
- eCOA/ePRO/eDiary & Patient-Facing Data Collection (HLACAOAB), Medication Adherence, Digital Therapeutics & Remote Coaching (condition-specific programs) (HLALAFAF)
Keywords
Where Illumination Health is headquartered
LocationHeadquarters
- HQ city
- Hoover
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Illumination Health business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure
Revenue model
- Clinical Trial and Research Services: Provides comprehensive research services to pharmaceutical companies and healthcare organizations including retrospective, prospective interventional and non-interventional studies. Revenue generated through study-specific compensation and contracted research engagements.
- Remote Therapeutic Monitoring (RTM) Reimbursement: Illumination Health's PERx RTM program enables rheumatology practices to provide Remote Therapeutic Monitoring to patients, reimbursable by many insurance programs including Medicare. Insurance provides monthly reimbursement both for data transmission and staff time spent monitoring the app-based data stream.
- Physician Network Participation Income: ENRGY network members receive income streams for participation in research activities plus study-specific compensation. For rheumatology practices not initially part of ENRGY, the PBRN model extends participation opportunities with associated income.
- Data and Analytics Services: Provides real-time, real-world evidence observation of de-identified patients with customized visual dashboards. Offers data linkages with external sources such as health plan and claims data.
Go-to-market motion2 records
Distribution channels3 records
Marketing channels4 records
Illumination Health product offering
Product offeringCore offering
Illumination Health operates a rheumatology-focused healthcare informatics platform that combines a proprietary single-platform EHR integrated with an Electronic Data Capture (EDC) system, patient-reported outcomes tooling, and real-world evidence analytics. The company runs the ENRGY (Excellence Network in RheumatoloGY) practice-based research network of 700+ rheumatologists across 27 U.S. states, providing clinical trial, observational research, and data analytics services to pharmaceutical companies. It also offers PERx, an FDA-cleared Software as a Medical Device (SaMD) for Remote Therapeutic Monitoring reimbursable by insurance.
Product overview
Illumination Health offers a unified platform combining a proprietary physician network (ENRGY - 700+ rheumatologists across 27 states) with data analytics infrastructure and specialized tools. The core Illumination Health Platform aggregates EHR data, patient-reported outcomes, and remote monitoring into a comprehensive data warehouse. Supporting tools include Floodlight (data visualization), Flashlight CohortBuilder (patient cohort identification), Bridge Provider Education (CME delivery), and PERx (FDA-cleared remote therapeutic monitoring app). The platform utilizes 14 clinical algorithms for decision support and integrates with PCORnet, external EDC systems, and claims data sources.
Differentiator
Problem solved
Functional benefit
Brands
- ENRGY: The Excellence Network in RheumatoloGY - the only U.S. rheumatology community practice-based research network (PBRN) supported by Illumination Health, consisting of 700+ rheumatology providers across 27 states.
- PERx
Products and services
- Illumination Health Platform Unified informatics platform that aggregates electronic health records, patient-reported outcomes, and remote monitoring data from rheumatology practices into a comprehensive data warehouse. Serves pharmaceutical companies, healthcare systems, and research organizations seeking real-world rheumatology evidence and clinical trial support.
- ENRGY (Excellence Network in RheumatoloGY) Practice-based research network (PBRN) of 700+ rheumatology providers across 27 U.S. states that supplies real-world data and participates in clinical studies. Provides the physician backbone for real-world evidence generation and rapid patient recruitment for sponsors.
- Clinical Trial & Research Services Comprehensive research services delivered to pharmaceutical companies and healthcare organizations, including clinical trials, prospective observational studies, implementation science, and quality improvement projects. Operates as a Clinical Research Organization combined with a rheumatology PBRN.
- PERx (Patient Engagement Rx) Remote Therapeutic Monitoring FDA-cleared Software as a Medical Device (SaMD) mobile app enabling rheumatology practices to provide Remote Therapeutic Monitoring to patients. Collects patient-reported outcomes between visits and supports insurance reimbursement for data transmission and staff monitoring time.
Quantifiable outcome
- Single-point contracting and central IRB with quick turnaround dramatically shortens time to study activation
- +2 more outcomes
Companies that use Illumination Health
Customer profileNamed customers7 records
Segments4 records
Ideal customer profiles3 records
Illumination Health technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration4 records
AI capability6 records
Feature7 records
Illumination Health partnerships and signals
Strategic signalPartnerships
Eleven partnerships are on record, tiered core, secondary and major.
- University of Alabama at BirminghamcoreAcademic research collaboration with Division of Clinical Immunology & Rheumatology at UAB. Multiple joint publications on COVID-19 vaccine response, medication adherence, lupus management, and rheumatoid arthritis outcomes. Jeffrey R. Curtis MD MS MPH holds appointments at both Illumination Health and UAB.
- FASTER MedicinecoreHealthcare research organization collaborating on rheumatology studies. Multiple joint publications with Illumination Health authors including studies on dermatomyositis, medication validation, and COVID-19 vaccine response.
- BendcaresecondaryHealthcare organization mentioned in multiple joint publications with Illumination Health on rheumatology medication studies and validation of new medication user definitions.
- AstraZenecamajorMajor pharmaceutical company collaborating on the AZ-BEGONIA study examining adherence to EULAR recommendations and management of systemic lupus erythematosus in community-based rheumatology practices.
- PfizermajorMajor pharmaceutical company collaborating on research examining characteristics, treatments, and outcomes of patients with dermatomyositis from large nationwide U.S. cohorts.
- Amazon Web Services (AWS)coreCloud infrastructure provider hosting Illumination Health's data warehouse and platform. All data is stored securely on AWS servers.
- PCORnetcorePCORnet Distributed Research Network infrastructure partner. Data is mapped to PCORnet Common Data Model (CDM) enabling participation in the PCORnet DRN for multi-site patient-centered research across Clinical Research Networks.
- Arthritis Power (CreakyJoints)corePatient-powered research network providing the underlying technology for Illumination Health's PERx Remote Therapeutic Monitoring app. PERx is powered by Arthritis Power technology.
- Global Healthy Living FoundationsecondaryNon-profit patient advocacy organization collaborating on multiple rheumatology research publications including COVID-19 vaccine uptake and hesitancy studies.
- University of PennsylvaniasecondaryAcademic medical center collaborating on dermatomyositis research and other rheumatology studies with Illumination Health.
- University of Nebraska Medical CentersecondaryAcademic medical center collaborating on multiple rheumatology publications including COVID-19 impacts, treatment interruption, and telemedicine use studies.
Scale indicators7 records
Recent moves6 records
Expansion highlights5 records
Illumination Health competitors and assessment
Company assessmentDirect peers
- Castor: eClinical/eCOA platform for clinical trials serving academic and pharma sponsors. Direct peer across the EDC + patient-reported outcomes layer of Illumination Health's tech stack.
- Veradigm: EHR-anchored clinical research and real-world data network (formerly part of Allscripts). Comparable as it uses ambulatory EHR data to deliver research-grade datasets to pharma, intersecting with Illumination Health's integrated EHR approach.
- OM1: Specialty real-world evidence and AI analytics company spanning rheumatology, immunology, neurology, and other therapeutic areas. Direct peer given overlapping pharma RWE use cases, specialty focus, and provider-data network model.
- Clinerion: Patient network and real-world data platform for clinical research, serving pharma with feasibility, recruitment, and RWE. Comparable as a network-mediated RWE provider operating with PBRN-style health-system partnerships.
- Medable: Decentralized clinical trial and eCOA/ePRO platform for pharma sponsors. Comparable across the eCOA/PRO/EDC stack and pharma customer overlap, even though Illumination Health's emphasis is on specialty real-world data vs. Medable's DCT focus.
- ConcertAI: Specialty real-world data and AI SaaS for oncology and other therapeutic areas serving pharma and providers. Overlaps with Illumination Health's specialty RWE + clinical-decision-support positioning and pharma-centric revenue model.
- TriNetX: Global health research network connecting pharma sponsors with real-world patient data from healthcare organizations. Highly comparable as a federated RWE platform with pharma clients, EDC integration, and cohort-building tools that compete directly with Illumination Health's Floodlight and Flashlight CohortBuilder.
- Flatiron Health: Specialty-focused real-world evidence platform (originally oncology) using EHR-derived data and provider networks to serve pharma R&D. Directly comparable model of specialty deep vertical + integrated EHR + pharma research services.
Broad incumbents
- PPD (Thermo Fisher Scientific): Global CRO now part of Thermo Fisher, offering clinical research and real-world evidence services to pharma. Broad incumbent competitor for the same pharmaceutical study budget that funds Illumination Health's RWE engagements.
- IQVIA: Largest global contract research organization with integrated RWE, real-world data, and EDC capabilities. Broad incumbent competing across all of Illumination Health's enterprise sales motions and therapeutic verticals, with materially deeper resources.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat3 records
Key risks7 records
Key highlights7 records
Customer concentration
Illumination Health social profiles
Digital presenceIllumination Health financial estimates
Financial estimateRevenue estimate
Valuation estimate
Illumination Health leadership team
Management profileNumber of profiles
Profiles2 records
Illumination Health funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Illumination Health M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Illumination Health
What does Illumination Health do?
Illumination Health operates a rheumatology-focused healthcare informatics platform that combines a proprietary single-platform EHR integrated with an Electronic Data Capture (EDC) system, patient-reported outcomes tooling, and real-world evidence analytics. The company runs the ENRGY (Excellence Network in RheumatoloGY) practice-based research network of 700+ rheumatologists across 27 U.S. states, providing clinical trial, observational research, and data analytics services to pharmaceutical companies. It also offers PERx, an FDA-cleared Software as a Medical Device (SaMD) for Remote Therapeutic Monitoring reimbursable by insurance.
Is Illumination Health a public or private company?
Illumination Health is a private company. It is classified as unknown and is currently operating.
When was Illumination Health founded?
Illumination Health was founded in -1. It employs 11 to 50 people.
Where is Illumination Health based?
Illumination Health is headquartered in Hoover, United States, in the North America region.
How does Illumination Health make money?
Four revenue lines are on record. Clinical Trial and Research Services are the primary driver. The others are remote Therapeutic Monitoring (RTM) Reimbursement, physician Network Participation Income and data and Analytics Services.
Who are Illumination Health's main competitors?
Direct peers on record are Castor, Veradigm, OM1, Clinerion, Medable, ConcertAI, TriNetX and Flatiron Health. Broad incumbents are PPD (Thermo Fisher Scientific) and IQVIA.
Does Illumination Health have an API?
No public API is recorded for Illumination Health.
What industry is Illumination Health in?
Illumination Health's product category is Healthcare Informatics & Clinical Research. Its primary akta.pro industry code is HLACAOAM, Real-World Data (RWD) / Real-World Evidence (RWE) & Observational Research Platforms, with a secondary code of HLACAOAB, eCOA/ePRO/eDiary & Patient-Facing Data Collection. Its NAICS code is 5417 and its SIC code is 8011.